Improved membrane transport of astaxanthine by liposomal encapsulation

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 75, Issue 2, 2010, Pages 154-161

  Peng, Chiung Huei ^a   Chang, Chi Huang ^a   Peng, Robert Y ^a,b   Chyau, Charng Cherng ^a  

^a HUNGKUANG UNIVERSITY   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Antioxidative enzymes; Blood Brain Barrier; Cell cycle arrest; Hepatoma cells; Nanoencapsulation; Radiation therapy

Indexed keywords

ASTAXANTHIN; CATALASE; GLUTATHIONE TRANSFERASE; SUPEROXIDE DISMUTASE;

ANIMAL CELL; ARTICLE; CANCER RADIOTHERAPY; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL MEMBRANE TRANSPORT; CELL STRAIN HEPG2; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG CAPSULE; DRUG FORMULATION; DRUG STABILITY; DRUG STRUCTURE; DRUG TRANSPORT; EMBRYO; ENZYME ACTIVATION; GAMMA RADIATION; HUMAN; HUMAN CELL; LIPOSOMAL DELIVERY; MOLECULAR SIZE; MOUSE; NONHUMAN; PROTEIN EXPRESSION;

ANIMALS; ANTIOXIDANTS; BIOLOGICAL AVAILABILITY; BIOLOGICAL TRANSPORT; CELL LINE; CELL LINE, TUMOR; CHEMOTHERAPY, ADJUVANT; COMBINED MODALITY THERAPY; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG STABILITY; G1 PHASE; GAMMA RAYS; HUMANS; LIPOSOMES; MICE; MICE, INBRED BALB C; PARTICLE SIZE; SOLUBILITY; TIME FACTORS; XANTHOPHYLLS;

EID: 77952950640     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2010.03.004     Document Type: Article

References (16)

1. Naguib Y.M. Antioxidant activities of astaxanthine and related carotenoids. J. Agric. Food Chem. 2000, 48:1150-1154.
2. Lorenz R.T., Cysewski G.R. Commercial potential for Haematococcus microalgae as a natural source of astaxanthine. Trends Biotechnol. 2000, 18(4):160-167.
3. Nakano T., Tosa M M., Takeuchi M. Improvement of biochemical features in fish health by red yeast and synthetic astaxanthine. J. Agric. Food Chem. 1995, 43:1570-1573.
4. Amar E.C., Kiron V., Satoh S., Watanabe T. Enhancement of innate immunity in rainbow trout (Oncorhynchus mykiss Walbaum) associated with dietary intake of carotenoids from natural products. Fish Shellfish Immunol. 2004, 16(4):527-537.
5. Kistler A., Liechti H., Pichard L., Wolz E., Oesterhelt G., Hayes A., Maurel P. Metabolism and CYP-inducer properties of astaxanthine in man and primary human hepatocytes. Arch. Toxicol. 2002, 75(11-12):665-675.
6. Jyonouchi H., Sun S., Iijima K., Gross M.D. Antitumor activity of astaxanthin and its mode of action. Nutr. Cancer 2000, 36(1):59-65.
7. Rao A.R., Sarada R., Ravishankar G.A. Stabilization of astaxanthine in edible oils and its use as an antioxidant. J. Sci. Food Agric. 2007, 87(6):957-965.
8. Ikeda Y., Tsuji S S., Satoh A., Ishikura M., Shirasawa T., Shimizu T. Protective effects of astaxanthine on 6-hydroxydopamine-induced apoptosis in human neuroblastoma SH-SY5Y cells. J. Neurochem. 2008, 107:1730-1740.
9. Pintea A., Diehl H.A., Momeu C., Aberle L., Socaciu C. Incorporation of carotenoid esters into liposomes. Biophys. Chem. 2005, 118::7-14.
10. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 1976, 72:248-254.
11. Marklund S., Marklund G. Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur. J. Biochem. 1974, 47:469-474.
12. Cohen D., Dembiec D., Marcus J. Measurement of catalase activity in tissue extracts. Ann. Biochem. 1970, 34:30-38.
13. Habig W.H., Pabst M.J., Jakoby W.B. Glutathione S-transferase, the first enzymatic step in mercapturic acid formation. J. Biol. Chem. 1974, 249:7130-7139.
14. Chang C.-H., Peng C.-H., Chen K.-C., Huang H.-B., Chiu W.-T., Peng R.Y. Shock membrane electropotential drops and limited diffusive distance of β-amyloids in cerebral neurons are detrimental enhancement to Alzheimer's diseases. Coll. Surf. B: Biointerf. 2009, 73:339-345.
15. Yuan F., Dellian M., Fukumura D., Leunig M., Berk D.A., Torchilin V.P., Jain R.K. Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size. J. Can. Res. 1995, 55:3752-3756.
16. Nagayasua A., Uchiyama K., Kiwada H. The size of liposomes: a factor which affects their targeting efficiency to tumors and therapeutic activity of liposomal antitumor drugs. Adv. Drug Deliv. Rev. 1999, 40:75-87.