Concise synthesis of C 2-symmetrical 2,6-disubstituted morpholines by N → O Boc migration under SL-PTC conditions

Organic Process Research and Development

Volumn 14, Issue 3, 2010, Pages 705-711

  Albanese, Domenico ^a   Landini, Dario ^a   Penso, Michele ^b   Tagliabue, Aaron ^a   Carlini, Emanuele ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b CNR   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 77952948387     PISSN: 10836160     EISSN: 1520586X     Source Type: Journal    
DOI: 10.1021/op1000435     Document Type: Article

References (24)

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21. 1H NMR of 11a proved to be identical to that previously published (ref 7).
22. Morpholines have been shown to be enantiomerically pure by HPLC on chiral column. Racemic morpholines have been prepared as analytical standards from the ring opening of racemic epoxides.
23. Retention times for the racemic mixture: 20.6, 24.2, 28.8, 30.8 min.
24. Retention times for the racemic mixture: 18.6, 20.2, 22.5, 25.2 min.