Clostridium difficile-associated disease in allogeneic hematopoietic stem-cell transplant recipients: Risk associations, protective associations, and outcomes

Clinical Transplantation

Volumn 24, Issue 2, 2010, Pages 192-198

  Dubberke, Erik R ^a   Reske, Kimberlay A ^a   Srivastava, Anand ^a   Sadhu, Justin ^a   Gatti, Robert ^a   Young, Rebecca M ^a   Rakes, Lauren C ^a   Dieckgraefe, Brian ^a   DiPersio, John ^a   Fraser, Victoria J ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Clostridium difficile; Epidemiology; Hematopoietic stem cell transplant

Indexed keywords

CEPHALOSPORIN; GROWTH FACTOR;

ADULT; AGED; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ARTICLE; BLOODSTREAM INFECTION; CASE CONTROL STUDY; CLINICAL ARTICLE; CLOSTRIDIUM DIFFICILE; CLOSTRIDIUM DIFFICILE INFECTION; CONTROLLED STUDY; DISEASE SEVERITY; DRUG USE; FEMALE; GRAFT RECIPIENT; GRAFT VERSUS HOST REACTION; HUMAN; INFECTION PREVENTION; INFECTION RISK; MALE; MORTALITY; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RISK ASSESSMENT; RISK FACTOR; RISK REDUCTION;

ADULT; AGED; CASE-CONTROL STUDIES; CLOSTRIDIUM DIFFICILE; CROSS INFECTION; ENTEROCOLITIS, PSEUDOMEMBRANOUS; FEMALE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INTESTINAL MUCOSA; KAPLAN-MEIERS ESTIMATE; LOGISTIC MODELS; MALE; MIDDLE AGED; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; RISK FACTORS; YOUNG ADULT;

EID: 77952941505     PISSN: 09020063     EISSN: 13990012     Source Type: Journal    
DOI: 10.1111/j.1399-0012.2009.01035.x     Document Type: Article

References (19)

1. Altclas J, Requejo A, Jaimovich G, Milovic V, Feldman L. Clostridium difficile infection in patients with neutropenia. Clin Infect Dis 2002, 34:723.
2. Avery R, Pohlman B, Adal K. High prevalence of diarrhea but infrequency of documented Clostridium difficile in autologous peripheral blood progenitor cell transplant recipients. Bone Marrow Transplant 2000, 25:67.
3. Bilgrami S, Feingold JM, Dorsky D. Incidence and outcome of Clostridium difficile infection following autologous peripheral blood stem cell transplantation. Bone Marrow Transplant 1999, 23:1039.
4. Chakrabarti S, Lees A, Jones SG, Milligan DW. Clostridium difficile infection in allogeneic stem cell transplant recipients is associated with severe graft-versus-host disease and non-relapse mortality. Bone Marrow Transplant 2000, 26:871.
5. Dettenkofer M, Ebner W, Bertz H. Surveillance of nosocomial infections in adult recipients of allogeneic and autologous bone marrow and peripheral blood stem-cell transplantation. Bone Marrow Transplant 2003, 31:795.
6. Gorschluter M, Glasmacher A, Hahn C. Clostridium difficile infection in patients with neutropenia. Clin Infect Dis 2001, 33:786.
7. Hanna H, Raad I, Gonzalez V. Control of nosocomial Clostridium difficile transmission in bone marrow transplant patients. Infect Control Hosp Epidemiol 2000, 21:226.
8. Kavan P, Sochor M, Nyc O. Pseudomembraneous clostridium after autologous bone marrow transplantation. Bone Marrow Transplant 1998, 21:521.
9. Tomblyn M, Gordon L, Singhal S. Rarity of toxigenic Clostridium difficile infections after hematopoietic stem cell transplantation: implications for symptomatic management of diarrhea. Bone Marrow Transplant 2002, 30:517.
10. van Kraaij MG, Dekker AW, Verdonck LF. Infectious gastro-enteritis: an uncommon cause of diarrhoea in adult allogeneic and autologous stem cell transplant recipients. Bone Marrow Transplant 2000, 26:299.
11. Yuen KY, Woo PC, Liang RH. Clinical significance of alimentary tract microbes in bone marrow transplant recipients. Diagn Microbiol Infect Dis 1998, 30:75.
12. Blot E, Escande MC, Besson D. Outbreak of Clostridium difficile-related diarrhoea in an adult oncology unit: risk factors and microbiological characteristics. J Hosp Infect 2003, 53:187.
13. Garner JS, Jarvis WR, Emori TG, Horan TC, Hughes JM. CDC definitions for nosocomial infections, 1988. Am J Infect Control 1988, 16:128.
14. Glucksberg H, Storb R, Fefer A. Clinical manifestations of graft-versus-host disease in human recipients of marrow from HL-A-matched sibling donors. Transplantation 1974, 18:295.
15. Dubberke ER, Sadhu J, Gatti R. Severity of Clostridium difficile-associated disease (CDAD) in allogeneic stem cell transplant recipients: evaluation of a CDAD severity grading system. Infect Control Hosp Epidemiol 2007, 28:208.
16. Kyne L, Farrell RJ, Kelly CP. Clostridium difficile. Gastroenterol Clin North Am 2001, 30:753.
17. Hill GR, Crawford JM, Cooke KR, Brinson YS, Pan L, Ferrara JL. Total body irradiation and acute graft-versus-host disease: the role of gastrointestinal damage and inflammatory cytokines. Blood 1997, 90:3204.
18. Roghmann MC, McCarter RJ, Brewrink J, Cross AS, Morris JG. Clostridium difficile infection is a risk factor for bacteremia due to vancomycin-resistant enterococci (VRE) in VRE-colonized patients with acute leukemia. Clin Infect Dis 1997, 25:1056.
19. Zar FA, Bakkanagari SR, Moorthi KM, Davis MB. A comparison of vancomycin and metronidazole for the treatment of Clostridium difficile-associated diarrhea, stratified by disease severity. Clin Infect Dis 2007, 45:302.