Antispasmodic and spasmolytic effects of methanolic extract from seeds of garcinia kola on isolated rat small intestine

Nigerian Journal of Physiological Sciences

Volumn 24, Issue 2, 2009, Pages 111-116

  Udia, P M ^a   Braide, V B ^a   Owu, D U ^a  

^a UNIVERSITY OF CALABAR   (Nigeria)

Author keywords

Acetylcholine; Antispasmodic effect; Garcinia kola; Small intestine

Indexed keywords

ACETYLCHOLINE; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; BARIUM CHLORIDE; BARIUM DERIVATIVE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CHLORIDE; CHOLINERGIC RECEPTOR BLOCKING AGENT; CHOLINERGIC RECEPTOR STIMULATING AGENT; GASTROINTESTINAL AGENT; PLANT EXTRACT; PRAZOSIN; PROPRANOLOL;

ANIMAL; ARTICLE; DOSE RESPONSE; DRUG EFFECT; GARCINIA KOLA; GASTROINTESTINAL MOTILITY; IN VITRO STUDY; PLANT SEED; RAT; SMALL INTESTINE; SMOOTH MUSCLE; DRUG EFFECTS;

ACETYLCHOLINE; ADRENERGIC ALPHA-ANTAGONISTS; ADRENERGIC BETA-ANTAGONISTS; ANIMALS; BARIUM COMPOUNDS; CHLORIDES; CHOLINERGIC AGONISTS; DOSE-RESPONSE RELATIONSHIP, DRUG; GARCINIA KOLA; GASTROINTESTINAL AGENTS; GASTROINTESTINAL MOTILITY; INTESTINE, SMALL; MUSCLE, SMOOTH; PARASYMPATHOLYTICS; PLANT EXTRACTS; PRAZOSIN; PROPRANOLOL; RATS; SEEDS; IN VITRO TECHNIQUES;

EID: 77952930963     PISSN: 0794859X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Adaramoye, O. A. and Adeyemi, E. O. (2006). Hepatoprotection of D-galactosemine- induced toxicity in mice by purified fractions from Garcinia kola seeds. Basic & Clin. Pharmacol. & Toxicol. 98: 135- 141.
2. Adaramoye, O. A. and Adeyemi, E. O. (2006b). Hypoglycaemic and hypolipidaemic effects of fractions from Kolaviron, a biflavonoid complex from Garcinia kola in streptozotocin- induced diabetes mellitus rats. J. Pharm. and Pharmacol. 58: 121-128.
3. Adaramoye, O. A., Farombi, E. O., Nssien, M., Idowu, S. O., Ademowo, O, G. and Adeyemi, E, O. (2008). Hepatoprotective activity of purified fractions from Garcinia kola seeds in mice intoxicated with carbon tetrachloride. J Med Food. 11(3): 544-50.
4. Agil, M., Khan, I. Z., Ahmed, M. B. and Ishikura, N. (1994). A Novel Glycoside - 5,6,7 - Trimethoxy Flavone 4'-B-B-D- Glycoside from Buchnera hispida. Disc. and Innov. 6: 343 - 345.
5. Akpantah, A. O., Oremosu, A. A., Noronha, C. C., Ekanem, T. B. and Okanlawon, A. O. (2005). Effects of Garcinia kola seed extract on ovulation, ocetrous cycle and foetal development in cyclic female Sprague-Dawley rats. Niger. J. Physiol. Sci. 20(1-2): 58 - 62.
6. Belluco, P., Gaion, R. M., Marangno, I. and Darigo, P. (1993), Quercetin and vascular spasm. Pharmacol. Res. 27: 71 - 72.
7. Braide, V. B. (1989). Antispasmodic extracts from seeds of Garcina kola. Fitoterapia, LX: 123 -129.
8. Braide, V. B. (1993): Anti-inflammatory effect of kolaviron, a biflavonoid of Garcinia kola seeds. Fitoterapia; LXIV: 433 -36.
9. Daiziel, J. M. (1956). Useful Plants of Tropical Africa. Crown Agents, London.
10. Di Carlo, G., Autoye, G., Mascolo, N., Meli, R. and Carpasso, F. (1993). Effects of flavonoids on small intestinal transit in mice. Pharmacol. Res. 27:37 - 38.
11. Eka, O. U. (1986). Isolation of pure caffeine from Cola nitida and chemical composition of Garcinia kola. Niger. J. Physiol. Sci. 10: 94 - 98.
12. Esomonu, U. G., EL-Taalu, A. B., Amuka, J. A., Ndodo, N. D., Salim, M. A. and Atiku, M. K. (2005). Effect of ingestion of ethanol extract of Garcinia kola Seed on erythrocytes in Wistar rats. Niger. J. Physiol. Sci. 20(1-2): 30 -32.
13. Farombi, E. O, Shrotriya, S. and Surh, Y. J. (2009). Kolaviron inhibits dimethyl nitrosamine-induced liver injury by suppressing COX-2 and iNOS expression via NF-kappaB and AP-1. Life Sci. 84(5-6): 149-55.
14. Farombi, E. O., Abarikwu, S. O., Adedara, I. A. and Oyeyemi, M. O. (2007). Curcumin and kolaviron ameliorate di-n- butylphthalate-induced testicular damage in rats. Basic Clin Pharmacol Toxicol. 100(1): 43-48.
15. Hussain. R. A. and Waterman, P. G. (1982). Lactones, flavonoids and benzophones from Garcinia conrauna and Garcinia mianni. Phytochemistry, 21: 1393 - 1396
16. Iwu, M. M. (1985). Antihepatotoxic constituents of Garcinia kola seeds. Experientia. 41: 699 - 700.
17. Kabangu, L., Galeffi, C., Aonzo, E., Nicoletti, M. and Messana, L. (1987). New biflavone from the bark of G. kola. Planta Medica 11: 275 - 277.
18. Ogata, N., Baba, T. and Shibata, T. (1993). Demonstration of antidiarrheal and antimotility effects of wood creasote. Int. J. Expt. Clin. Pharmacol. 46: 173 - 180.
19. Olatunde, F. E., Hansen, M., Rain-Haren, P. and Dragsted, L. O. (2002). Commonly consumed and naturally occurring substances affect bio makers of oxidative stress and DNA-damage in healthy rats. Food Chem. Toxicol. 42: 1315 - 1322.
20. Olatunde, F. E., Akanni, O. O. and Emerole, G. O. (2002b). Antioxidant and scavenging activity of flavonoid extract (kolaviron) of Garcinia kola seeds. Pharmaceut. Biol. 40: 107 - 116.
21. Orie, N. N. and Ekon, E. U. A. (1993). The bronchodilator effect of Garcinia kola. East African Med. J. 70: 143 - 145.
22. Rodriguez, R., Lasheres, B. and Cenarruzabeitia, E. (1986). Pharmacological activity of Prunus spinosa on isolated tissue preparations. Planta Medica. 4: 256 - 259.
23. Terashima, K., Takaya, Y. and Niwa, M. (2002). Powerful antioxidant agents based on garcionic acid from Garcinia kola. Bioorg. Med. Chem. 10(5): 1619 - 1625.