Quantification by computerized morphometry of tissue levels of sulfomucins and sialomucins in diversion colitis in rats

Acta Cirurgica Brasileira

Volumn 25, Issue 3, 2010, Pages 231-240

  Martinez, Carlos Augusto Real ^a,b   Nonose, Ronaldo ^c   Spadari, Ana Paula Pimentel ^a   Máximo, Felipe Rodrigues ^a   Priolli, Denise Gonçalves ^c   Pereira, José Aires ^c   Margarido, Nelson Fontana ^d  

^a USF   (Brazil)

^b Sao Francisco University Hospital HUSF   (Brazil)

^c UNIVERSIDADE SÃO FRANCISCO   (Brazil)

^d UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Colitis; Colon; Colostomy; Computer assisted; Image processing; Mucins; Rats; Sialomucins

Indexed keywords

ALCIAN BLUE; DIAMINE; SIALOMUCIN; SULFOMUCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLITIS; COLON FISTULA; COLON MUCOSA; COLOSTOMY; CONTROLLED STUDY; HISTOCHEMISTRY; IMAGE PROCESSING; MALE; MORPHOMETRICS; NONHUMAN; PROTEIN EXPRESSION; RAT;

ALCIAN BLUE; ANIMALS; COLITIS; COLON; COLORING AGENTS; COLOSTOMY; FECES; GASTROINTESTINAL TRANSIT; IMAGE PROCESSING, COMPUTER-ASSISTED; INTESTINAL MUCOSA; MALE; MUCINS; RANDOM ALLOCATION; RATS; RATS, WISTAR; SIALOMUCINS; TIME FACTORS;

EID: 77952924270     PISSN: 01028650     EISSN: 16782674     Source Type: Journal    
DOI: 10.1590/S0102-86502010000300004     Document Type: Article

References (34)

1. Glotzer DJ, Glick ME, Goldman H. Proctitis following diversion of fecal stream. Gastroenterology. 1981;80:438-441
2. Kiely EM, Ajayi NA, Wheele RA, Malone M. Diversion procto-colitis: response to treatment with short-chain fatty acids. J Pediatr Surg. 2001;36:1514-1517 (Pubitemid 32927658)
3. Giardiello, FM, Lazenby, AJ, Bayless, TM. The new colitides: collagenous, lymphocytic, and diversion colitis. Gastroenterol Clin N Am. 1995;24:717-729
4. Biondo-Simões MLP, Greca FH, Ioshi S, Abicalaffe MD, Colnaghi MC, Mattos e Silva E, Yamasaki ES, Smaniotto G. Colite do cólon excluso: modelo experimental em ratos. Acta Cir Bras. 2000;15(Supl. 3):7-11.
5. Keli E, Bouchoucha M, Devroede G, Carnot F, Ohrant T, Cugnenc PH. Diversion-related experimental colitis in rats. Dis Colon Rectum. 1997;40:222-228
6. Deplancke B, Gaskins HR. Microbial modulation of innate defense: goblet-cells and the intestinal mucus layer. Am J Clin Nutr. 2001;73:1131S-41S.
7. Finnie IA, Dwarakanath AS, Taylor BA, Rhodes JM. Colonic mucins synthesis is increased by sodium butyrate. Gut. 1995;36:93-99
8. Gaudier E, Rival M, Buisine M, Robineau I, Hoebler C. Butyrate enemas upregulate Muc genes expression but decrease adherent mucus thickness in mice colon. Physiol Res. 2009;59:111-119
9. Gaudier E, Forestier L, Gouyer V, Huet G, Julien R, Hoebler C. Butyrate regulation of glycosylation-related gene expression: evidence for galectin-1 upregulation in human intestinal epithelial goblet cells. Biochem Biophys Res Commun. 2004;325:1044-1051 (Pubitemid 39487976)
10. Habib NA, Dawson PN, Krausz T, Blount MA, Kersten D, Wood CB. A study of histochemical changes in mucus from patients with ulcerative colitis, Crohn's disease and diverticular disease of the colon. Dis Colon Rectum. 1986;29:15-17
11. Agawa S, Muto T, Murioka Y. Mucin abnormality of colonic mucosa in ulcerative colitis associated with carcinoma and/or dysplasia. Dis Colon Rectum. 1988;31:387-389
12. Allen DC, Connolly NS, Biggart JD. Mucin profiles in ulcerative colitis with dysplasia and carcinoma. Histopathology. 1988;13:413-424 (Pubitemid 18260522)
13. Castro MA, Ferreira U, Martins MH, Stoppiglia RM, Netto NR Jr. Histological and histochemical changes of the intestinal mucosa at the urothelial-enteric anastomotic site. Int Braz J Urol. 2006;32(2):222-227 (Pubitemid 43732900)
14. Shimamoto C, Hirata I, Takao Y, Takiuchi H, Morikawa H, Nakagawa Y, Katsu K. Alteration of colonic mucin after ureterosigmoidostomy. Dis Colon Rectum. 2000;43:526-531
15. Crissey MM, Steele GD, Gittes RF. Rat model for carcinogenesis in ureterosigmoidostomy. Science. 1980;207:1079-1080
16. Martinez CAR, Waisberg J, Palma RT, Silva FZ, Cimerman G, Goffi FS. Morphometric study of gastric mucosa in dogs submitted to proximal gastric vagotomy, splenectomy or proximal gastric vagotomy associated with splenectomy. Acta Cir Bras. 2002;17:289-298
17. Priolli DG, Margarido NF, Martinez CAR, Rotta CM, Stephani SM. Edema quantification by computerized morphometry as an evaluation parameter for the resistance of colon anastomoses. Acta Cir Bras. 2003;18:398-406.
18. Grupta RB, Harpaz N, Itzkowitz S, Hossain S, Matula S, Kornbluth A, Bodian C, Ullman T. Histologic inflammation is a risk factor for progression to colorectal neoplasia in ulcerative colitis: a cohort study. Gastroenterology. 2007;133:1099-1105 (Pubitemid 47494461)
19. Swidsinski A, Loening-Bauke V, Theissig F, Engelhardt H, Bengmark S, Koch S, Lochs H, Dorfel Y. Comparative study of the intestinal mucus barrier in normal and inflamed colon. Gut. 2007;56:343-350 (Pubitemid 46579762)
20. Filipe MI. Value of histochemical reactions for mucosubstances in the diagnosis of certain pathological conditions of the colon and rectum. Gut. 1969;10:577-586
21. Filipe MI. The value of a study of the mucosubstances in rectal biopsies from patients with carcinoma of the rectum and lower sigmoid in the diagnosis of premalignant mucosa. J Clin Pathol. 1972;25:123-128
22. Hatayama H, Iwashita J, Kuwajima A, Abe T. The short chain fatty acid, butyrate, stimulates MUC2 mucin production in the human colon cancer cell line, LS174T. Biochem Biophys Res Commun. 2007;356:599-603. (Pubitemid 46499006)
23. Roediger WE. The starved colon: diminished mucosal nutrition, diminished absorption, and colitis. Dis Colon Rectum. 1990;33:858-862
24. Blottiere HM, Buecher B, Galmiche JP, Chewrbut C. Molecular analysis of the effect of short-chain fatty acids on intestinal cell proliferation. Proc Nutr Soc. 2003;62:101-106 (Pubitemid 36569815)
25. Roy CC, Kien CL, Bouthillier L, Levy E. Short-chain fatty acids: ready for prime time? Nutr Clin Pract. 2006;21:351-366
26. Brownlee IA, Knight J, Dettmar PW, Pearson JP. Action of reactive oxygen species on colonic mucus secretions. Free Radic Biol Med. 2007;43:800-808 (Pubitemid 47411490)
27. Hamer HM, Jonkers D, Venema K, Vanhoutvin S, Troost FJ, Brummer TJ. Review article: the role of butyrate on colonic function. Aliment Pharmacol Ther. 2008;27:104-109 (Pubitemid 350256609)
28. Jørgensen JR, Clausen MR, Mortensen PB. Oxidation of short and medium chain C2-C8 fatty acids in Sprague-Dawley rat colonocytes. Gut. 1997;40:400-405
29. Roediger WE, Nance S. Metabolic induction of experimental ulcerative colitis by inhibition of fatty acid oxidation. Br J Exp Pathol. 1986;67:773-782 (Pubitemid 17212913)
30. Corfield AP, Myerscough N, Bradfield N, Corfield Cdo A, Gough M, Clamp JR, Durdey P, Warren BF, Bartolo DC, King KR, Williams JM. Colonic mucins in ulcerative colitis: evidence for loss of sulfation. Glycoconj J. 1996;13:809-822 (Pubitemid 26354274)
31. Souza MV, Priolli DG, Portes AV, Cardinalli IA, Pereira JA, Martinez CAR. Evaluation by computerized morphometry of histopathological alterations of the colon wall in segments with and without intestinal transit in rats. Acta Cir Bras. 2008;23:417-424
32. Daly K, Shirazi-Beechey SP. Microarray analysis of butyrate regulated genes in colonic epithelial cells. DNA Cell Biol. 2006;25:49-62. (Pubitemid 43089752)
33. Shimotoyodome A, Meguro S, Hase T, Tokimitsu I, Sakata T. Short chain fatty acids but not lactate or succinate stimulate mucus release in the rat colon. Comp Biochem Physiol A Mol Integr Physiol. 2000;125:525-531 (Pubitemid 30330771)
34. Van der Sluis M, De Koning BA, De Bruijn AC, Velcich A, Meijerink JP, Van Goudoever JB, Büller HA, Dekker J, Van Seuningen I, Renes IB, Einerhand AW. Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection. Gastroenterology. 2006;131:117-129 (Pubitemid 44015753)