Oxidation of short and medium chain C2-C8 fatty acids in Sprague-Dawley rat colonocytes

Gut

Volumn 40, Issue 3, 1997, Pages 400-405

  Jorgensen J R ^a,b   Clausen, M R ^a   Mortensen, P B ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health   (Denmark)

Author keywords

colon; fatty acid oxidation; kinetic constants; short chain fatty acids; ulcerative colitis

Indexed keywords

SHORT CHAIN FATTY ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; COLON; INTESTINE CELL; ISOTOPE LABELING; MALE; NONHUMAN; OXIDATION; PRIORITY JOURNAL; RAT;

EID: 0030975356     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.40.3.400     Document Type: Article

References (22)

1. Clausen MR, Mortensen PB. Kinetic studies on the metabolism of short-chain fatty acids and glucose by isolated colonocytes. Gastroenterology 1994; 106: 423-32.
2. Clausen MR, Mortensen PB. Kinetic studies on colonocyte metabolism of short chain fatty acids and glucose in ulcerative colitis. Gut 1995; 37: 684-9.
3. Roediger WEW. Utilization of nutrients by isolated epithelial cells of the rat colon. Gastroenterology 1982; 83: 424-9.
4. Roediger WEW. Role of anaerobic bacteria in the metabolic welfare of the colonic mucosa in man. Gut 1980; 21: 793-8.
5. Harig JM, Soergel KH, Komorowski RA, Wood CM. Treatment of diversion colitis with short-chain fatty acid irrigation. N Engl J Med 1989; 320: 23-8.
6. Steinhart AH, Brzezinski A, Baker JP. Treatment of refractory ulcerative proctosigmoiditis with butyrate enemas. Am J Gastroenterol 1994; 89: 179-83.
7. Scheppach W, Sommer H, Kirchner T, Paganelli G-M, Bartram P, Christi S, et al. Effect of butyrate enemas on the colonic mucosa in distal ulcerative eolitis. Gastroenterology 1992; 103: 51-6.
8. Senagore AJ, MacKeigan JM, Scheider M, Ebrom JS. Short-chain fatty acid enemas: A cost-effective alternative in the treatment of nonspecific proctosigmoiditis. Dis Colon Rectum 1992; 35: 923-7.
9. Steinhart AH, Hiruki T, Brzezinski A, Baker JP. Treatment of left-sided ulcerative colitis with butyrate enemas: a randomized controlled trial. Gastroenterology 1995; 104 (suppl 4): A3511.
10. Roediger WEW. The colonic epithelium in ulcerative colitis: an energy deficiency disease? Lancet 1980; ii: 712-5.
11. Chapman MAS, Grahn MF, Boyle MA, Hutton M, Rogers J, Williams NS. Butyrate oxidation is impaired in the colonic mucosa of sufferers of quiescent ulcerative colitis. Gut 1994; 35: 73-6.
12. Finnie IA, Taylor BA, Rhodes JM. Heal and colonic epithelial metabolism in quiescent ulcerative colitis: increased glutamine metabolism in distal colon but no defect in butyrate metabolism. Gut 1993; 34: 1552-8.
13. Hove H, Mortensen PB. Influence of intestinal inflammation (IBD) and small and large bowel length on fecal short-chain fatty acids and lactate. Dig Dis Sci 1995; 40: 1372-80.
14. Roediger WEW, Truelove SC. Method of preparing isolated colonic epithelial cells (colonocytes) for metabolic studies. Gut 1979; 20: 484-8.
15. Krebs HA, Henseleit K. Undersuchungen über die harnstoffbildung im tierkörper. Hoppe-Seyler's Z Physiol Chem 1932; 210: 33-66.
16. Stryer L, ed. Biochemistry. San Francisco: WH Freeman, 1975.
17. McGarry JD, Foster DW. Regulation of hepatic fatty acid oxidation and ketone body production. Ann Rev Biochem 1980; 49: 395-420.
18. Kim YS, Tsao D. Effects of sodium butyrate and dimethylsulfoxide on biochemical properties of human colon cancer cells. Cancer 1980; 45 (suppl 5): 185-92.
19. Whitehead RH, Young GP, Bhathal PS. Effects of short chain fatty acids on a new human colon carcinoma cell line (LIM1215). Gut 1986; 27: 1457-63.
20. Dexter DL, Lev R, McKendall GR, Mitchell P, Calabres P. Sodium butyrate-induced alteration of growth properties and glycogen level in cultured human colon carcinoma cells. J Histochem 1984; 16: 137-49.
21. Kruh J. Effects of sodium buryrate, a new pharmacological agent, on cells in culture. Mol Cell Biochem 1982; 42: 65-82.
22. Bartram H-P, Scheppach W, Englert S, Dusel G, Richter A, Richter F, et al. Effects of deoxycholic acid and butyrate on mucosal prostaglandin E2 release and cell proliferation in the human sigmoid colon. JPEN J Parenter Enteral Nutr 1995; 19: 182-6.