p120-Catenin is transcriptionally downregulated by FOXC2 in non-small cell lung cancer cells

Molecular Cancer Research

Volumn 8, Issue 5, 2010, Pages 762-774

  Mortazavi, Fariborz ^a,b   An, Jiabin ^a   Dubinett, Steven ^b   Rettig, Matthew ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATENIN; CIS ACTING ELEMENT; LUCIFERASE; MESSENGER RNA; P 120 CATENIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FOXC2; TRANSCRIPTION FACTOR FOXL1; UNCLASSIFIED DRUG; UVOMORULIN; DELTA CATENIN; FORKHEAD TRANSCRIPTION FACTOR; FOXL1 PROTEIN, HUMAN; REPRESSOR PROTEIN;

AMPLICON; ARTICLE; BINDING SITE; CANCER CELL; CELL IMMORTALIZATION; CHROMOSOME 11; CONTROLLED STUDY; DOWN REGULATION; EPITHELIUM CELL; GENE ACTIVITY; GENE DELETION; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LUNG NON SMALL CELL CANCER; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; REPORTER GENE; RNA INTERFERENCE; TRANSCRIPTION INITIATION SITE; TRANSCRIPTION REGULATION; TRANSCRIPTION TERMINATION; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; LUNG TUMOR; METABOLISM; NON SMALL CELL LUNG CANCER; PATHOLOGY; PHYSIOLOGY; RESPIRATORY TRACT MUCOSA; TRANSFORMED CELL LINE; TUMOR CELL LINE;

CARCINOMA, NON-SMALL-CELL LUNG; CATENINS; CELL LINE, TRANSFORMED; CELL LINE, TUMOR; DOWN-REGULATION; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LUNG NEOPLASMS; PROMOTER REGIONS, GENETIC; REPRESSOR PROTEINS; RESPIRATORY MUCOSA; RNA INTERFERENCE; RNA, MESSENGER; TRANSCRIPTION, GENETIC;

EID: 77952919218     PISSN: 15417786     EISSN: None     Source Type: Journal    
DOI: 10.1158/1541-7786.MCR-10-0004     Document Type: Article

References (22)

1. Davis MA, Ireton RC, Reynolds AB. A core function for p120-catenin in cadherin turnover. J Cell Biol 2003;163:525-534
2. Reynolds AB, Carnahan RH. Regulation of cadherin stability and turnover by p120ctn: implications in disease and cancer. Semin Cell Dev Biol 2004;15:657-663
3. Reynolds AB. p120-catenin: past and present. Biochim Biophys Acta 2007;1773:2-7.
4. Wang EH, Liu Y, Xu HT, et al. Abnormal expression and clinicopathologic significance of p120-catenin in lung cancer. Histol Histopathol 2006;21:841-847
5. Ireton RC, Davis MA, van HJ, et al. A novel role for p120 catenin in E-cadherin function. J Cell Biol 2002;159:465-476
6. Xiao K, Allison DF, Buckley KM, et al. Cellular levels of p120 catenin function as a set point for cadherin expression levels in microvascular endothelial cells. J Cell Biol 2003;163:535-545
7. Xiao K, Oas RG, Chiasson CM, Kowalczyk AP. Role of p120-catenin in cadherin trafficking. Biochim Biophys Acta 2007;1773:8-16.
8. Kelly KF, Spring CM, Otchere AA, Daniel JM. NLS-dependent nuclear localization of p120ctn is necessary to relieve Kaiso-mediated transcriptional repression. J Cell Sci 2004;117:2675-2686
9. Bellovin DI, Bates RC, Muzikansky A, Rimm DL, Mercurio AM. Altered localization of p120 catenin during epithelial to mesenchymal transition of colon carcinoma is prognostic for aggressive disease. Cancer Res 2005;65:10938-10945
10. Chung Y, Lam AK, Luk JM, et al. Altered E-cadherin expression and p120 catenin localization in esophageal squamous cell carcinoma. Ann Surg Oncol 2007;14:3260-3267
11. Liu Y, Xu HT, Dai SD, Wei Q, Yuan XM, Wang EH. Reduction of p120 (ctn) isoforms 1 and 3 is significantly associated with metastatic progression of human lung cancer. APMIS 2007;115:848-856
12. Bremnes RM, Veve R, Gabrielson E, et al. High-throughput tissue microarray analysis used to evaluate biology and prognostic significance of the E-cadherin pathway in non-small-cell lung cancer. J Clin Oncol 2002;20:2417-2428
13. Boyd KE, Farnham PJ. Coexamination of site-specific transcription factor binding and promoter activity in living cells. Mol Cell Biol 1999; 19:8393-8399
14. Shang Y, Hu X, DiRenzo J, Lazar MA, Brown M. Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription. Cell 2000;103:843-852
15. Sandelin A, Alkema W, Engstrom P, Wasserman WW, Lenhard B. JASPAR: an open-access database for eukaryotic transcription factor binding profiles. Nucleic Acids Res 2004;32: D91-94.
16. Winnier GE, Kume T, Deng K, et al. Roles for the winged helix transcription factors MF1 and MFH1 in cardiovascular development revealed by nonallelic noncomplementation of null alleles. Dev Biol 1999;213:418-431
17. Mani SA, Yang J, Brooks M, et al. Mesenchyme Forkhead 1 (FOXC2) plays a key role in metastasis and is associated with aggressive basal-like breast cancers. Proc Natl Acad Sci U S A 2007;104:10069-10074
18. Madison BB, McKenna LB, Dolson D, Epstein DJ, Kaestner KH. FoxF1 and FoxL1 link hedgehog signaling and the control of epithelial proliferation in the developing stomach and intestine. J Biol Chem 2009;284:5936-5944
19. Liu Y, Li QC, Miao Y, et al. Ablation of p120-catenin enhances invasion and metastasis of human lung cancer cells. Cancer Sci 2009;100:441-448
20. Anastasiadis PZ. p120-ctn: a nexus for contextual signaling via Rho GTPases. Biochim Biophys Acta 2007;1773:34-46.
21. van HJ, van RF. Diverse functions of p120ctn in tumors. Biochim Biophys Acta 2007;1773:78-88.
22. Hayashi H, Sano H, Seo S, Kume T. The Foxc2 transcription factor regulates angiogenesis via induction of integrin β3 expression. J Biol Chem 2008;283:23791-23800