Proinsulin processing and transplanted islets

American Journal of Transplantation

Volumn 10, Issue 6, 2010, Pages 1495-

  Rickels, M R ^a   Naji, A ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EXENDIN 4; HEMOGLOBIN A1C; INSULIN; PROINSULIN;

GRAFT RECIPIENT; HUMAN; HYPERGLYCEMIA; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RELEASE; INSULIN TREATMENT; LETTER; PANCREAS ISLET BETA CELL; PANCREAS ISLET TRANSPLANTATION; PRIORITY JOURNAL; PROTEIN PROCESSING; ADULT; FEMALE; MALE; METABOLISM; MIDDLE AGED; PROCEDURES;

ADULT; FEMALE; HUMANS; INSULIN; ISLETS OF LANGERHANS TRANSPLANTATION; MALE; MIDDLE AGED; PROINSULIN;

EID: 77952915352     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/j.1600-6143.2010.03069.x     Document Type: Letter

References (5)

1. Klimek AM, Soukhatcheva G, Thompson DM et al. Impaired proinsulin processing is a characteristic of transplanted islets. Am J Transplant 2009 9 : 2119 2125.
2. Hostens K, Ling ZD, Van Schravendijk C, Pipeleers D. Prolonged exposure of human beta-cells to high glucose increases their release of proinsulin during acute stimulation with glucose or arginine. J Clin Endocrinol Metab 1999 84 : 1386 1390.
3. McDonald CG, Ryan EA, Paty BW et al. Cross-sectional and prospective association between proinsulin secretion and graft function after clinical islet transplantation. Transplantation 2004 78 : 934 937.
4. Rickels MR, Mueller R, Markman JF, Naji A. Effect of GLP-1 on beta- and alpha-cell function in isolated islet and whole pancreas transplant recipients. J Clin Endocrinol Metab 2009 94 : 181 189.
5. Rickels MR, Mueller R, Teff KL, Naji A. Beta-cell secretory capacity and demand in recipients of islet, pancreas and kidney transplants. J Clin Endocrinol Metab 2010 doi :.