Optimal management of malignant epidural spinal cord compression

Hematology/Oncology Clinics of North America

Volumn 24, Issue 3, 2010, Pages 537-551

  Sun, Hai ^a   Nemecek, Andrew N ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Epidural; Malignant; Management; Neoplasm; Spinal cord compression

Indexed keywords

CORTICOSTEROID; DEXAMETHASONE; STEROID; VASCULOTROPIN;

CANCER CHEMOTHERAPY; CANCER DIAGNOSIS; CANCER PATIENT; CLINICAL FEATURE; CLINICAL PRACTICE; CLINICAL TRIAL; DIFFERENTIAL DIAGNOSIS; DRUG DOSE TITRATION; DRUG EFFICACY; DRUG MEGADOSE; DRUG WITHDRAWAL; EPIDEMIOLOGICAL DATA; HUMAN; IMAGE DISPLAY; LOADING DRUG DOSE; LYMPHOMA; MULTIPLE MYELOMA; NONHUMAN; OPTIMAL DRUG DOSE; PALLIATIVE THERAPY; PATHOPHYSIOLOGY; PRACTICE GUIDELINE; PRIORITY JOURNAL; REVIEW; SPINAL CORD COMPRESSION; SPINAL CORD DECOMPRESSION; SPINAL CORD METASTASIS; STEREOTACTIC RADIOSURGERY; SURGICAL APPROACH; SYMPTOM;

EID: 77952895178     PISSN: 08898588     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.hoc.2010.03.011     Document Type: Review

References (59)

1. Cole J.S., Patchell R.A. Metastatic epidural spinal cord compression. Lancet Neurol 2008, 7:459-466.
2. Bach F., Larsen B.H., Rohde K., et al. Metastatic spinal cord compression. Occurrence, symptoms, clinical presentations and prognosis in 398 patients with spinal cord compression. Acta Neurochir 1990, 107:37-43.
3. Byrne T.N. Spinal cord compression from epidural metastases. N Engl J Med 1992, 327:614-619. [see comment].
4. Loblaw D.A., Laperriere N.J., Mackillop W.J. A population-based study of malignant spinal cord compression in Ontario. Clin Oncol (R Coll Radiol) 2003, 15:211-217.
5. Quinn J.A., DeAngelis L.M. Neurologic emergencies in the cancer patient. Semin Oncol 2000, 27:311-321.
6. Aaron A.D. The management of cancer metastatic to bone. JAMA 1994, 272:1206-1209.
7. Helweg-Larsen S., Sorensen P.S., Kreiner S. Prognostic factors in metastatic spinal cord compression: a prospective study using multivariate analysis of variables influencing survival and gait function in 153 patients. Int J Radiat Oncol Biol Phys 2000, 46:1163-1169.
8. Raffel C., Neave V.C., Lavine S., et al. Treatment of spinal cord compression by epidural malignancy in childhood. Neurosurgery 1991, 28:349-352.
9. Gilbert R.W., Kim J.H., Posner J.B. Epidural spinal cord compression from metastatic tumor: diagnosis and treatment. Ann Neurol 1978, 3:40-51.
10. Schiff D., O'Neill B.P., Wang C.H., et al. Neuroimaging and treatment implications of patients with multiple epidural spinal metastases. Cancer 1998, 83:1593-1601.
11. Li K.C., Poon P.Y. Sensitivity and specificity of MRI in detecting malignant spinal cord compression and in distinguishing malignant from benign compression fractures of vertebrae. Magn Reson Imaging 1988, 6:547-556.
12. Arguello F., Baggs R.B., Duerst R.E., et al. Pathogenesis of vertebral metastasis and epidural spinal cord compression. Cancer 1990, 65:98-106.
13. Siegal T. Spinal cord compression: from laboratory to clinic. Eur J Cancer 1995, 31A:1748-1753.
14. Benton R.L., Whittemore S.R. VEGF165 therapy exacerbates secondary damage following spinal cord injury. Neurochem Res 2003, 28:1693-1703.
15. Denis F. The three column spine and its significance in the classification of acute thoracolumbar spinal injuries. Spine 1983, 8:817-831.
16. Findlay G.F. The role of vertebral body collapse in the management of malignant spinal cord compression. J Neurol Neurosurg Psychiatr 1987, 50:151-154.
17. Heldmann U., Myschetzky P.S., Thomsen H.S. Frequency of unexpected multifocal metastasis in patients with acute spinal cord compression. Evaluation by low-field MR imaging in cancer patients. Acta Radiol 1997, 38:372-375.
18. Helweg-Larsen S., Sorensen P.S. Symptoms and signs in metastatic spinal cord compression: a study of progression from first symptom until diagnosis in 153 patients. Eur J Cancer 1994, 30A:396-398.
19. Martenson J.A., Evans R.G., Lie M.R., et al. Treatment outcome and complications in patients treated for malignant epidural spinal cord compression (SCC). J Neurooncol 1985, 3:77-84.
20. Torma T. Malignant tumors of the spine and spinal epidural space: a study based on 250 histologically verified cases. Acta Chir Scand Suppl 1957, 225:1-176.
21. Loughrey G.J., Collins C.D., Todd S.M., et al. Magnetic resonance imaging in the management of suspected spinal canal disease in patients with known malignancy. Clin Radiol 2000, 55:849-855.
22. Kienstra G.E., Terwee C.B., Dekker F.W., et al. Prediction of spinal epidural metastases. Arch Neurol 2000, 57:690-695.
23. Ruckdeschel J.C. Early detection and treatment of spinal cord compression. Oncology (Williston Park) 2005, 19:81-86. [discussion: 86].
24. Sorensen S., Helweg-Larsen S., Mouridsen H., et al. Effect of high-dose dexamethasone in carcinomatous metastatic spinal cord compression treated with radiotherapy: a randomised trial. Eur J Cancer 1994, 30A:22-27.
25. Vecht C.J., Haaxma-Reiche H., van Putten W.L., et al. Initial bolus of conventional versus high-dose dexamethasone in metastatic spinal cord compression. Neurology 1989, 39:1255-1257.
26. Barron K.D., Hirano A., Araki S., et al. Experiences with metastatic neoplasms involving the spinal cord. Neurology 1959, 9:91-106.
27. Constans J.P., de Divitiis E., Donzelli R., et al. Spinal metastases with neurological manifestations. Review of 600 cases. J Neurosurg 1983, 59:111-118.
28. Klimo P., Thompson C.J., Kestle J.R., et al. A meta-analysis of surgery versus conventional radiotherapy for the treatment of metastatic spinal epidural disease. Neuro Oncol 2005, 7:64-76.
29. Maranzano E., Bellavita R., Rossi R., et al. Short-course versus split-course radiotherapy in metastatic spinal cord compression: results of a phase III, randomized, multicenter trial. J Clin Oncol 2005, 23:3358-3365. [see comment].
30. Rades D., Stalpers L.J., Veninga T., et al. Evaluation of five radiation schedules and prognostic factors for metastatic spinal cord compression. J Clin Oncol 2005, 23:3366-3375.
31. Sze W.M., Shelley M.D., Held I., et al. Palliation of metastatic bone pain: single fraction versus multifraction radiotherapy-a systematic review of randomised trials. Clin Oncol (R Coll Radiol) 2003, 15:345-352. [see comment].
32. Peters L.J. The ESTRO Regaud lecture. Inherent radiosensitivity of tumor and normal tissue cells as a predictor of human tumor response. Radiother Oncol 1990, 17:177-190.
33. Greenberg H.S., Kim J.H., Posner J.B. Epidural spinal cord compression from metastatic tumor: results with a new treatment protocol. Ann Neurol 1980, 8:361-366.
34. Fourney D.R., Abi-Said D., Lang F.F., et al. Use of pedicle screw fixation in the management of malignant spinal disease: experience in 100 consecutive procedures. J Neurosurg 2001, 94:25-37.
35. Gokaslan Z.L., York J.E., Walsh G.L., et al. Transthoracic vertebrectomy for metastatic spinal tumors. J Neurosurg 1998, 89:599-609.
36. Harrington K.D. Anterior cord decompression and spinal stabilization for patients with metastatic lesions of the spine. J Neurosurg 1984, 61:107-117.
37. Hosono N., Yonenobu K., Fuji T., et al. Vertebral body replacement with a ceramic prosthesis for metastatic spinal tumors. Spine 1995, 20:2454-2462.
38. North R.B., LaRocca V.R., Schwartz J., et al. Surgical management of spinal metastases: analysis of prognostic factors during a 10-year experience. J Neurosurg Spine 2005, 2:564-573.
39. Overby M.C., Rothman A.S. Anterolateral decompression for metastatic epidural spinal cord tumors. Results of a modified costotransversectomy approach. J Neurosurg 1985, 62:344-348.
40. Siegal T., Siegal T., Robin G., et al. Anterior decompression of the spine for metastatic epidural cord compression: a promising avenue of therapy?. Ann Neurol 1982, 11:28-34.
41. Siegal T., Tiqva P., Siegal T. Vertebral body resection for epidural compression by malignant tumors. Results of forty-seven consecutive operative procedures. J Bone Joint Surg Am 1985, 67:375-382.
42. Sundaresan N., Galicich J.H., Bains M.S., et al. Vertebral body resection in the treatment of cancer involving the spine. Cancer 1984, 53:1393-1396.
43. Wang J.C., Boland P., Mitra N., et al. Single-stage posterolateral transpedicular approach for resection of epidural metastatic spine tumors involving the vertebral body with circumferential reconstruction: results in 140 patients. J Neurosurg Spine 2004, 1:287-298. Invited submission from the Joint Section Meeting on Disorders of the Spine and Peripheral Nerves, March 2004.
44. Weigel B., Maghsudi M., Neumann C., et al. Surgical management of symptomatic spinal metastases. Postoperative outcome and quality of life. Spine 1999, 24:2240-2246.
45. Young R.F., Post E.M., King G.A. Treatment of spinal epidural metastases. Randomized prospective comparison of laminectomy and radiotherapy. J Neurosurg 1980, 53:741-748.
46. Patchell R.A., Tibbs P.A., Regine W.F., et al. Direct decompressive surgical resection in the treatment of spinal cord compression caused by metastatic cancer: a randomised trial. Lancet 2005, 366:643-648. [see comment].
47. Tokuhashi Y., Matsuzaki H., Toriyama S., et al. Scoring system for the preoperative evaluation of metastatic spine tumor prognosis. Spine 1990, 15:1110-1113. [see comment].
48. Tomita K., Kawahara N., Kobayashi T., et al. Surgical strategy for spinal metastases. Spine 2001, 26:298-306. [see comment].
49. van der Linden Y.M., Dijkstra S.P., Vonk E.J., et al. Prediction of survival in patients with metastases in the spinal column: results based on a randomized trial of radiotherapy. Cancer 2005, 103:320-328.
50. Bartels R.H., Feuth T., van der Maazen R., et al. Development of a model with which to predict the life expectancy of patients with spinal epidural metastasis. Cancer 2007, 110:2042-2049.
51. Tokuhashi Y., Matsuzaki H., Oda H., et al. A revised scoring system for preoperative evaluation of metastatic spine tumor prognosis. Spine 2005, 30:2186-2191.
52. Chaichana K.L., Woodworth G.F., Sciubba D.M., et al. Predictors of ambulatory function after decompressive surgery for metastatic epidural spinal cord compression. Neurosurgery 2008, 62:683-692. [discussion: 683-92].
53. Jackson R.J., Loh S.C., Gokaslan Z.L. Metastatic renal cell carcinoma of the spine: surgical treatment and results. J Neurosurg 2001, 94:18-24. [erratum appears in J Neurosurg 2001 Apr;94(2 Suppl):340].
54. Ogihara S., Seichi A., Hozumi T., et al. Prognostic factors for patients with spinal metastases from lung cancer. Spine 2006, 31:1585-1590. [see comment].
55. Sciubba D.M., Gokaslan Z.L. Diagnosis and management of metastatic spine disease. Surg Oncol 2006, 15:141-151.
56. Degen J.W., Gagnon G.J., Voyadzis J.M., et al. CyberKnife stereotactic radiosurgical treatment of spinal tumors for pain control and quality of life. J Neurosurg Spine 2005, 2:540-549.
57. Fourney D.R., Schomer DF, Nader R., et al. Percutaneous vertebroplasty and kyphoplasty for painful vertebral body fractures in cancer patients. J Neurosurg 2003, 98:21-30.
58. Boogerd W., van der Sande J.J., Kroger R., et al. Effective systemic therapy for spinal epidural metastases from breast carcinoma. Eur J Cancer Clin Oncol 1989, 25:149-153.
59. Sinoff C.L., Blumsohn A. Spinal cord compression in myelomatosis: response to chemotherapy alone. Eur J Cancer Clin Oncol 1989, 25:197-200.