Predictors of ambulatory function after decompressive surgery for metastatic epidural spinal cord compression

Neurosurgery

Volumn 62, Issue 3, 2008, Pages 683-691

  Chaichana, Kaisorn L ^a,b   Woodworth, Graeme F ^a   Sciubba, Daniel M ^a   McGirt, Matthew J ^a   Witham, Timothy J ^a   Bydon, Ali ^a   Wolinsky, Jean Paul ^a   Gokaslan, Ziya ^a  

^a JOHNS HOPKINS HOSPITAL   (United States)

^b Department of Neurosurgery ^*  (United States)

Author keywords

Metastatic spine tumors; Outcome; Predictors; Walking

Indexed keywords

ADULT; AGED; ARTICLE; COMPARATIVE STUDY; COMPRESSION FRACTURE; CONFIDENCE INTERVAL; CONTROLLED STUDY; DECOMPRESSION SURGERY; FEMALE; FISHER EXACT TEST; FOLLOW UP; HUMAN; HUMAN TISSUE; INSTITUTIONAL CARE; LAMINECTOMY; LIQUORRHEA; MAJOR CLINICAL STUDY; MALE; MOBILIZATION; MULTIVARIATE ANALYSIS; NEUROLOGY; OUTCOME ASSESSMENT; PATHOLOGY; POSTOPERATIVE COMPLICATION; POSTOPERATIVE PERIOD; PREDICTOR VARIABLE; PREOPERATIVE PERIOD; PRIORITY JOURNAL; PROPORTIONAL HAZARDS MODEL; PSEUDOMENINGOCELE; RETROPERITONEAL HEMORRHAGE; RETROSPECTIVE STUDY; RISK FACTOR; SPINAL CORD COMPRESSION; STATISTICAL SIGNIFICANCE; SYMPTOM; TERTIARY HEALTH CARE; UNIVERSITY HOSPITAL; VERTEBRA FRACTURE; WALKING; WOUND DEHISCENCE;

FEMALE; GAIT DISORDERS, NEUROLOGIC; HUMANS; MALE; MIDDLE AGED; OUTCOME ASSESSMENT (HEALTH CARE); PROGNOSIS; RECOVERY OF FUNCTION; REPRODUCIBILITY OF RESULTS; RETROSPECTIVE STUDIES; SENSITIVITY AND SPECIFICITY; SPINAL CORD COMPRESSION; SPINAL NEOPLASMS; TREATMENT OUTCOME;

EID: 42449127614     PISSN: 0148396X     EISSN: None     Source Type: Journal    
DOI: 10.1227/01.neu.0000317317.33365.15     Document Type: Article

References (52)

1. Aaron AD: The management of cancer metastatic to bone. JAMA 272:1206-1209, 1994.
2. Altman DG: Practical Statistics for Medical Research. New York, Chapman & Hall/CRC, 1991.
3. Anonymous: Cancer Facts and Figures 2005. Atlanta, American Cancer Society, 2005.
4. Baird TA, Parsons MW, Phanh T, Butcher KS, Desmond PM, Tress BM, Colman PG, Chambers BR, Davis SM: Persistent poststroke hyperglycemia is independently associated with infarct expansion and worse clinical outcome. Stroke 34:2208-2214, 2003.
5. Barber M, Wright F, Stott DJ, Langhorne P: Predictors of early neurological deterioration after ischaemic stroke: A case-control study. Gerontology 50:102-109, 2004.
6. Barron KD, Hirano A, Araki S, Terry RD: Experiences with metastatic neoplasms involving the spinal cord. Neurology 9:91-106, 1959.
7. Black P: Spinal metastasis: Current status and recommended guidelines for management. Neurosurgery 5:726-746, 1979.
8. Bucala R, Tracey KJ, Cerami A: Advanced glycosylation products quench nitric oxide and mediate defective endothelium-dependent vasodilatation in experimental diabetes. J Clin Invest 87:432-438, 1991.
9. Byrne TN: Spinal cord compression from epidural metastases. N Engl J Med 327:614-619, 1992.
10. Cotton BA, Pryor JP, Chinwalla I, Wiebe DJ, Reilly PM, Schwab CW: Respiratory complications and mortality risk associated with thoracic spine injury. J Trauma 59:1400-1409, 2005.
11. Delattre JY, Arbit E, Rosenblum MK, Thaler HT, Lau N, Galicich JH, Posner JB: High dose versus low dose dexamethasone in experimental epidural spinal cord compression. Neurosurgery 22:1005-1007, 1988.
12. Delattre JY, Arbit E, Thaler HT, Rosenblum MK, Posner JB: A dose-response study of dexamethasone in a model of spinal cord compression caused by epidural tumor. J Neurosurg 70:920-925, 1989.
13. Dempsey RJ, Baskaya MK, Combs DJ, Donaldson D, Rao AM, Prasad MR: Effect of hyperglycemia on reperfusion-associated recovery of intracellular pH and high energy phosphates after transient cerebral ischemia in gerbils. Neurol Res 18:546-552, 1996.
14. Findlay GF: Adverse effects of the management of malignant spinal cord compression. J Neurol Neurosurg Psychiatry 47:761-768, 1984.
15. Fourney DR, Abi-Said D, Lang FF, McCutcheon IE, Gokaslan ZL: Use of pedicle screw fixation in the management of malignant spinal disease: Experience in 100 consecutive procedures. J Neurosurg 94:25-37, 2001.
16. Galasko CSB: The Anatomy and Pathway of Skeletal Metastasis. Boston, G. K. Hall, 1981.
17. Gerszten PC, Welch WC: Current surgical management of metastatic spinal disease. Oncology (Williston Park) 14:1013-1030, 2000.
18. Gilbert RW, Kim JH, Posner JB: Epidural spinal cord compression from metastatic tumor: Diagnosis and treatment. Ann Neurol 3:40-51, 1978.
19. Gokaslan ZL, Aladag MA, Ellerhorst JA: Melanoma metastatic to the spine: A review of 133 cases. Melanoma Res 10:78-80, 2000.
20. Gokaslan ZL, York JE, Walsh GL, McCutcheon IE, Lang FF, Putnam JB Jr, Wildrick DM, Swisher SG, Abi-Said D, Sawaya R: Transthoracic vertebrectomy for metastatic spinal tumors. J Neurosurg 89:599-609, 1998.
21. Hsu SS, Meno JR, Zhou JG, Gordon EL, Winn HR: Influence of hyperglycemia on cerebral adenosine production during ischemia and reperfusion. Am J Physiol 261:H398-H403, 1991.
22. Jackson RJ, Loh SC, Gokaslan ZL: Metastatic renal cell carcinoma of the spine: Surgical treatment and results. J Neurosurg 94:18-24, 2001.
23. Jain NB, Sullivan M, Kazis LE, Tun CG, Garshick E: Factors associated with health-related quality of life in chronic spinal cord injury. Am J Phys Med Rehabil 86:387-396, 2007.
24. Kawai N, Keep RF, Betz AL, Nagao S: Hyperglycemia induces progressive changes in the cerebral microvasculature and blood-brain barrier transport during focal cerebral ischemia. Acta Neurochir Suppl 71:219-221, 1998.
25. Klimo P Jr, Kestle JR, Schmidt MH: Treatment of metastatic spinal epidural disease: A review of the literature. Neurosurg Focus 15:E1, 2003.
26. Klimo P Jr, Thompson CJ, Kestle JR, Schmidt MH: Ameta-analysis of surgery versus conventional radiotherapy for the treatment of metastatic spinal epidural disease. Neuro Oncol 7:64-76, 2005.
27. Koehler PJ: Use of corticosteroids in neuro-oncology. Anticancer Drugs 6:19-33, 1995.
28. Lavyne MH, Bilsky MH: Epidural steroids, postoperative morbidity, and recovery in patients undergoing microsurgical lumbar discectomy. J Neurosurg 77:90-95, 1992.
29. Li PA, Liu GJ, He QP, Floyd RA, Siesjö BK: Production of hydroxyl free radical by brain tissues in hyperglycemic rats subjected to transient forebrain ischemia. Free Radic Biol Med 27:1033-1040, 1999.
30. Loblaw DA, Perry J, Chambers A, Laperriere NJ: Systematic review of the diagnosis and management of malignant extradural spinal cord compression: The Cancer Care Ontario Practice Guidelines Initiative's Neuro-Oncology Disease Site Group. J Clin Oncol 23:2028-2037, 2005.
31. Lundin A, Magnuson A, Axelsson K, Nilsson O, Samuelsson L: Corticosteroids preoperatively diminishes damage to the C-fibers in microscopic lumbar disc surgery. Spine 30:2362-2368, 2005.
32. Marcus RB Jr, Million RR: The incidence of myelitis after irradiation of the cervical spinal cord. Int J Radiat Oncol Biol Phys 19:3-8, 1990.
33. Nishikawa T, Edelstein D, Du XL, Yamagishi S, Matsumura T, Kaneda Y, Yorek MA, Beebe D, Oates PJ, Hammes HP, Giardino I, Brownlee M: Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Nature 404:787-790, 2000.
34. Ogihara S, Seichi A, Hozumi T, Oka H, Ieki R, Nakamura K, Kondoh T: Prognostic factors for patients with spinal metastases from lung cancer. Spine 31:1585-1590, 2006.
35. Patchell RA, Tibbs PA, Regine WF, Payne R, Saris S, Kryscio RJ, Mohiuddin M, Young B: Direct decompressive surgical resection in the treatment of spinal cord compression caused by metastatic cancer: A randomised trial. Lancet 366:643-648, 2005.
36. Pittas AG, Siegel RD, Lau J: Insulin therapy for critically ill hospitalized patients: A meta-analysis of randomized controlled trials. Arch Intern Med 164:2005-2011, 2004.
37. Ronen J, Goldin D, Itzkovich M, Bluvshtein V, Gelernter I, Gepstein R, David R, Livshitz A, Catz A: Outcomes in patients admitted for rehabilitation with spinal neurological lesions following intervertebral disc herniation. Spinal Cord 42:621-626, 2004.
38. Rovlias A, Kotsou S: The influence of hyperglycemia on neurological outcome in patients with severe head injury. Neurosurgery 46:335-343, 2000.
39. Sandalcioglu IE, Gasser T, Asgari S, Lazorisak A, Engelhorn T, Egelhof T, Stolke D, Wiedemayer H: Functional outcome after surgical treatment of intramedullary spinal cord tumors: Experience with 78 patients. Spinal Cord 43:34-41, 2005.
40. Schaberg J, Gainor BJ: A profile of metastatic carcinoma of the spine. Spine 10:19-20, 1985.
41. Sciubba DM, Gokaslan ZL: Diagnosis and management of metastatic spine disease. Surg Oncol 15:141-151, 2006.
42. Sciubba DM, Gokaslan ZL, Suk I, Suki D, Maldaun MV, McCutcheon IE, Nader R, Theriault R, Rhines LD, Shehadi JA: Positive and negative prognostic variables for patients undergoing spine surgery for metastatic breast disease. Eur Spine J 16:1659-1667, 2007.
43. Sorensen S, Borgesen SE, Rohde K, Rasmusson B, Bach F, Boge-Rasmussen T, Stjernholm P, Larsen BH, Agerlin N, Gjerris F: Metastatic epidural spinal cord compression. Results of treatment and survival. Cancer 65:1502-1508, 1990.
44. Sundaresan N, Galicich JH, Lane JM: Harrington rod stabilization for pathological fractures of the spine. J Neurosurg 60:282-286, 1984.
45. Taneichi H, Kaneda K, Takeda N, Abumi K, Satoh S: Risk factors and probability of vertebral body collapse in metastases of the thoracic and lumbar spine. Spine 22:239-245, 1997.
46. Tokuhashi Y, Matsuzaki H, Oda H, Oshima M, Ryu J: A revised scoring system for preoperative evaluation of metastatic spine tumor prognosis. Spine 30:2186-2191, 2005.
47. Tokuhashi Y, Matsuzaki H, Toriyama S, Kawano H, Ohsaka S: Scoring system for the preoperative evaluation of metastatic spine tumor prognosis. Spine 15:1110-1113, 1990.
48. Tomita T, Galicich JH, Sundaresan N: Radiation therapy for spinal epidural metastases with complete block. Acta Radiol Oncol 22:135-143, 1983.
49. Tracey F, Crawford VL, Lawson JT, Buchanan KD, Stout RW: Hyperglycaemia and mortality from acute stroke. Q J Med 86:439-446, 1993.
50. Vecht CJ, Haaxma-Reiche H, van Putten WL, de Visser M, Vries EP, Twijnstra A: Initial bolus of conventional versus high-dose dexamethasone in metastatic spinal cord compression. Neurology 39:1255-1257, 1989.
51. Witham TF, Khavkin YA, Gallia GL, Wolinsky JP, Gokaslan ZL: Surgery insight: Current management of epidural spinal cord compression from metastatic spine disease. Nat Clin Pract Neurol 2:87-116, 2006.
52. Zygun DA, Steiner LA, Johnston AJ, Hutchinson PJ, Al-Rawi PG, Chatfield D, Kirkpatrick PJ, Menon DK, Gupta AK: Hyperglycemia and brain tissue pH after traumatic brain injury. Neurosurgery 55:877-882, 2004.