Histological changes in the pancreas following administration of ethanolic extract of Alchornea cordifolia leaf in alloxan-induced diabetic wistar rats

Nigerian Journal of Physiological Sciences

Volumn 24, Issue 2, 2009, Pages 153-155

  Eliakim Ikechukwu, C F ^a   Obri, A I ^a  

^a UNIVERSITY OF CALABAR   (Nigeria)

Author keywords

Alchornea cordifolia; Diabetes mellitus; Pancreas; Wistar rats

Indexed keywords

ALCOHOL; ANTIDIABETIC AGENT; PLANT EXTRACT; SOLVENT;

ANIMAL; ARTICLE; CELL PROLIFERATION; CHEMISTRY; DRUG EFFECT; EUPHORBIA; EXPERIMENTAL DIABETES MELLITUS; PANCREAS; PANCREAS ISLET BETA CELL; PATHOLOGY; PLANT LEAF; RAT; REGENERATION; TIME; WISTAR RAT; DIABETES MELLITUS, EXPERIMENTAL; DRUG EFFECTS; EUPHORBIACEAE;

ANIMALS; CELL PROLIFERATION; DIABETES MELLITUS, EXPERIMENTAL; ETHANOL; EUPHORBIACEAE; HYPOGLYCEMIC AGENTS; INSULIN-SECRETING CELLS; PANCREAS; PLANT EXTRACTS; PLANT LEAVES; RATS; RATS, WISTAR; REGENERATION; SOLVENTS; TIME FACTORS;

EID: 77952892697     PISSN: 0794859X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Anderson, J. R. (1985) Muir's Textbook of Pathology. ELBS. 12th ed. pp. 20-63.
2. Chakravarthy, B. K.; Gupta, S. and Gambhir, S. S. (1980). Pancreatic beta cell regeneration: A novel antidiabetic mechanism of Pepercarpus marsupium. India J. Pharm. 12:123-128.
3. De Fronzo, R. A.; Bonadonna, R. C. and Ferannini (1997) Pathogenesis of NIDDM, International textbook of Diabetes Mellitus 2nd ed. Chichester John Wiley, England pp. 635-712.
4. Guyton, A. C. and Hall, J. E. (2002). Textbook of Medical Physiology. 10th ed. SB Saunders Company, London. pp. 884-897.
5. Kumar, P. and Clark, M. (2005). Clinical Medicine. Elsevier Saunders. 6th ed. p1107, 1148.
6. Lillie, R. D. (1954). Histopathologic Technic and Practical Histochemistry. McGraw-Hill Company, Toronto. p.114.
7. Olaleye, M. T.; Kolawole, A. O. and Ajele, J. O. (2007). Antioxidant Properties and Glutathione S-Transferases Inhibitory Activity of A. cordifolia leaf Extract in Acetaminophen Induced Liver Injury. Iranian J. Pharm. Ther. 6: 63-66.
8. Osadebe, P. O. and Okoye, F. B. C. (2003). Anti-inflammatory effects of crude ethanolic extract & fractions of A. cordifolia leaves J. thnopharm. 9: 19-24.
9. Rhodin, J. A. G. (1974). Histology. Oxford. 1st ed. pp. 600-602.
10. Szkudelski, T. (2001). The Mechanism of alloxan and Streptozotocin action in beta cells of the rat pancreas. Physiol. Res. 50(6): 537-546.
11. Ugochukwu, N. H. and Babady, N. E. (2003). Anti-hyperglycaemic effect of aqueous and ethanolic extracts of Gongronena latifolium leaves on glucose and glycogen metabolism in liver of normal and streptozotocin induced diabetic rats. Life Sc. 73: 1925-1938.
12. Wheater, P. R.; Burkitt, H. G. and Daniels, V. G. (1987). Functional Histology, ELBS 2nd ed. pp. 272-273.
13. WHO (1980). Expert Committee on diabetes mellitus. Second report. Technical report series, 646, Geneva, 12.