Sex and regional differences in decrease of serotonin-immunoreactive cells by parachlorophenylalanine in rat raphe nuclei

Neuroscience Research

Volumn 67, Issue 1, 2010, Pages 33-39

  Ito, Hiroyuki ^a   Yamanouchi, Korehito ^a  

^a WASEDA UNIVERSITY   (Japan)

Author keywords

5 HT immunoreactive cell; Parachlorophenylalanine; Raphe nuclei; Sex difference

Indexed keywords

FENCLONINE; SODIUM CHLORIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN REGION; CELL COUNT; CELL DENSITY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DORSAL RAPHE NUCLEUS; FEMALE; GONADECTOMY; IMMUNOHISTOCHEMISTRY; MALE; MEDIAN RAPHE NUCLEUS; NONHUMAN; PRIORITY JOURNAL; RAPHE MAGNUS NUCLEUS; RAT; SEROTONINERGIC NERVE CELL; SEX DIFFERENCE; TISSUE DISTRIBUTION;

ANIMALS; FEMALE; FENCLONINE; HYPOTHALAMUS; IMMUNOHISTOCHEMISTRY; MALE; NERVE FIBERS; ORCHIECTOMY; ORGAN SPECIFICITY; OVARIECTOMY; RAPHE NUCLEI; RATS; RATS, WISTAR; SEROTONIN; SEX FACTORS;

EID: 77952887373     PISSN: 01680102     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neures.2010.02.002     Document Type: Article

References (35)

1. Aghajanian G.K., Kuhar M.J., Roth R.H. Serotonin-containing neuronal perikarya and terminals: differential effects of P-chlorophenylalanine. Brain Res. 1973, 54:85-101.
2. Alenina N., Kikic D., Todiras M., Mosienko V., Qadri F., Plehm R., Boye P., Vilianovitch L., Sohr R., Tenner K., Hortnagl H., Bader M. Growth retardation and altered autonomic control in mice lacking brain serotonin. Proc. Natl. Acad. Sci. U.S.A. 2009, 106:10332-10337.
3. Azmitia E.C., Segal M. An autoradiographic analysis of the differential ascending projections of the dorsal and median raphe nuclei in the rat. J. Comp. Neurol. 1978, 179:641-667.
4. Bourgoin S., Oliveras J.L., Bruxelle J., Hamon M., Besson J.M. Electrical stimulation of the nucleus raphe magnus in the rat. Effects on 5-HT metabolism in the spinal cord. Brain Res. 1980, 194:377-389.
5. Carlsson M., Svensson K., Eriksson E., Carlsson A. Rat brain serotonin: biochemical and functional evidence for a sex difference. J. Neural Transm. 1985, 63:297-313.
6. Carlsson M., Carlsson A. In vivo evidence for a greater brain tryptophan hydroxylase capacity in female than in male rats. Naunyn Schmiedebergs Arch. Pharmacol. 1988, 338:345-349.
7. Carlsson M., Carlsson A. A regional study of sex differences in rat brain serotonin. Prog. Neuropsychopharmacol. Biol. Psychiatry 1988, 12:53-61.
8. Carlton S.M., Steinman J.L., Hillman G.R., Willis W.D. Differential effects of p-chlorophenylalanine on indoleamines in brainstem nuclei and spinal cord of rats. II. Identification of immunohistochemically stained structures using computer-assisted image enhancement techniques. Brain Res. 1987, 426:310-322.
9. Harvey J.A., Gal E.M. Septal tryptophan-5-hydroxylase: divergent response to raphe lesions and parachlorophenylalanine. Science 1974, 183:869-871.
10. Kakeyama M., Yamanouchi K. Female sexual behaviors in male rats with dorsal raphe nucleus lesions: treatment with p-chlorophenylalanine. Brain Res. Bull. 1993, 30:705-709.
11. Kakeyama M., Umino A., Nishikawa T., Yamanouchi K. Decrease of serotonin and metabolite in the forebrain and facilitation of lordosis by dorsal raphe nucleus lesions in male rats. Endocr. J. 2002, 49:573-579.
12. Kanno K., Shima S., Ishida Y., Yamanouchi K. Ipsilateral and contralateral serotonergic projections from dorsal and median raphe nuclei to the forebrain in rats: immunofluorescence quantitative analysis. Neurosci. Res. 2008, 61:207-218.
13. Kato R. Serotonin content of rat brain in relation to sex and age. J. Neurochem. 1960, 5:202.
14. Knapp S., Mandell A.J. Parachlorophenylalanine-its three phase sequence of interactions with the two forms of brain tryptophan hydroxylase. Life Sci. I 1972, 11:761-771.
15. Koe B.K., Weissman A. p-Chlorophenylalanine: a specific depletor of brain serotonin. J. Pharmacol. Exp. Ther. 1966, 154:499-516.
16. Kojima M., Sano Y. Sexual differences in the topographical distribution of serotonergic fibers in the anterior column of rat lumbar spinal cord. Anat. Embryol. (Berl.) 1984, 170:117-121.
17. Kornum B.R., Licht C.L., Weikop P., Knudsen G.M., Aznar S. Central serotonin depletion affects rat brain areas differently: a qualitative and quantitative comparison between different treatment schemes. Neurosci. Lett. 2006, 392:129-134.
18. Maekawa F., Tsukahara S., Tsukamura H., Maeda K.-I., Yamanouchi K. Prevention of inhibitory effect of dorsal raphe nucleus lesions on ovulation and LH surge by 5-HT 2A/2C receptor agonists in female rats. Neurosci. Res. 1999, 35:291-298.
19. Matsumoto T., Yamanouchi K. Effects of p-chlorophenylalanine on male sexual behavior in female rats with mesencephalic raphe nuclei lesions. Endocr J. 1997, 44:383-388.
20. McEwen B. Estrogen actions throughout the brain. Recent Prog. Horm. Res. 2002, 57:357-384.
21. Nishizawa S., Benkelfat C., Young S.N., Leyton M., Mzengeza S., de Montigny C., Blier P., Diksic M. Differences between males and females in rates of serotonin synthesis in human brain. Proc. Natl. Acad. Sci. U.S.A. 1997, 94:5308-5313.
22. Parent A., Descarries L., Beaudet A. Organization of ascending serotonin systems in the adult rat brain. A radioautographic study after intraventricular administration of [3H]5-hydroxytryptamine. Neuroscience 1981, 6:115-138.
23. Patisaul H.B., Fortino A.E., Polston E.K. Sex differences in serotonergic but not gamma-aminobutyric acidergic (GABA) projections to the rat ventromedial nucleus of the hypothalamus. Endocrinology 2008, 149:397-408.
24. Paxinos G., Watson C. The Rat Brain in Stereotaxic Coordinates 1998, Academic Press, New York. 4th ed.
25. Paxinos G., Watson C. The Rat Brain in Stereotaxic Coordinates 2007, Academic Press, New York. 6th ed.
26. Ramos A.J., Tagliaferro P., Lopez E.M., Pecci Saavedra J., Brusco A. Neuroglial interactions in a model of para-chlorophenylalanine-induced serotonin depletion. Brain Res. 2000, 883:1-14.
27. Rosecrans J.A. Differences in brain area 5-hydroxytryptamine turnover and rearing behavior in rats and mice of both sexes. Eur. J. Pharmacol. 1970, 9:379-382.
28. Sanders-Bush E., Gallager D.A., Sulser F. On the mechanism of brain 5-hydroxytryptamine depletion by p-chloroamphetamine and related drugs and the specificity of their action. Adv. Biochem. Psychopharmacol. 1974, 10:185-194.
29. Steinman J.L., Carlton S.M., Haber B., Willis W.D. Differential effects of p-chlorophenylalanine on indoleamines in brainstem nuclei and spinal cord of rats. I. Biochemical and behavioral analysis. Brain Res. 1987, 426:297-309.
30. Tohyama I., Kameyama M., Kimura H. Quantitative morphometric analysis of two types of serotonin-immunoreactive nerve fibres differentially responding to p-chlorophenylalanine treatment in the rat brain. Neuroscience 1988, 26:971-991.
31. Törk I. Raphe nuclei and serotonin containing systems. The Rat Nervous System 1985, 43-78. Academic Press, Australia. G. Paxinos (Ed.).
32. Vaccari A., Brotman S., Cimino J., Timiras P.S. Sex differentiation of neurotransmitter enzymes in central and peripheral nervous systems. Brain Res. 1977, 132:176-185.
33. Walther D.J., Peter J.U., Bashammakh S., Hörtnagl H., Voits M., Fink H., Bader M. Synthesis of serotonin by a second tryptophan hydroxylase isoform. Science 2003, 299:76.
34. Weissman M.M., Olfson M. Depression in women: implications for health care research. Science 1995, 269:799-801.
35. Yamanouchi K. Brain mechanisms inhibiting the expression of heterotypical sexual behavior in rats. Neural Control of Reproduction-Physiology and Behavior 1997, 219-235. Japan Scientific Society Press, Tokyo. K.-I. Maeda, H. Tsukamura, A. Yokoyama (Eds.).