NMDA and AMPA receptors contribute to the maintenance of substance P-induced thermal hyperalgesia

Neuroscience Research

Volumn 67, Issue 1, 2010, Pages 18-24

  Nakayama, Tomohiro ^a   Naono, Rumi ^a,b   Ikeda, Tetsuya ^a   Nishimori, Toshikazu ^a  

^a UNIVERSITY OF MIYAZAKI   (Japan)

^b JAPAN SOCIETY FOR THE PROMOTION OF SCIENCE   (Japan)

Author keywords

AMPA; NMDA; Protein kinase inhibitor; Scratching behavior; SP; Thermal hyperalgesia

Indexed keywords

ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; AMPA RECEPTOR; AMPA RECEPTOR ANTAGONIST; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; SUBSTANCE P;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; HYPERALGESIA; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RAT; RESPONSE TIME; SCRATCHING; STIMULUS RESPONSE; THERMAL STIMULATION;

ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; ANIMALS; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; CYCLIC AMP-DEPENDENT PROTEIN KINASES; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HOT TEMPERATURE; HYPERALGESIA; INJECTIONS, SPINAL; MALE; N-METHYLASPARTATE; PROTEIN KINASE C; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, AMPA; RECEPTORS, N-METHYL-D-ASPARTATE; SUBSTANCE P;

EID: 77952886291     PISSN: 01680102     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neures.2010.01.006     Document Type: Article

References (30)

1. Battaglia G., Rustioni A. Coexistence of glutamate and substance P in dorsal root ganglion neurons of the rat and monkey. J. Comp. Neurol. 1988, 277:302-312.
2. Benoliel R., Tanaka M., Caudle R.M., Iadarola M.J. Co-localization of N-methyl-d-aspartate receptor and substance P (Neurokinin-1) receptors in rat spinal cord. Neurosci. Lett. 2000, 291:61-64.
3. Coderre T.J., Yashpal K. Intracellular messengers contributing to persistent nociception and hyperalgesia induced by l-glutamate and substance P in the rat formalin pain model. Eur. J. Neurosci. 1994, 6:1328-1334.
4. De Biasi S., Rustioni A. Glutamate and substance P coexist in primary afferent terminals in the superficial laminae of spinal cord. Proc. Natl. Acad. Sci. 1988, 85:7820-7824.
5. Dirig D.M., Yaksh T.L. Thermal hyperalgesia in rat evoked by intrathecal substance P at multiple stimulus intensities reflects an increase in the gain of nociceptive processing. Neurosci. Lett. 1996, 220:93-96.
6. Endo D., Ikeda T., Ishida Y., Yoshioka D., Nishimori T. Effect of intrathecal administration of hemokinin-1 on the withdrawal response to noxious thermal stimulation of the rat hind paw. Neurosci. Lett. 2006, 392:114-117.
7. Ferguson S.S. Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling. Pharmacol. Rev. 2001, 53:1-24.
8. Frenk H., Bossut D., Urca G., Mayer D.J. Is substance P a primary afferent neurotransmitter for nociceptive input? I. Analysis of pain-related behaviors resulting from inthrathecal administration of substance P and 6 excitatory compounds. Brain Res. 1988, 455:223-231.
9. Gao Y.-J., Zhang Y.-Q., Zhao Z.-Q. Involvement of spinal neurokinin-1 receptors in the maintenance but not induction of carrageenan-induced thermal hyperalgesia in the rat. Brain Res. Bull. 2003, 61:587-593.
10. 3 receptors in the modulation of visceral hypersensitivity in the rat. Neurosci. Lett. 2004, 351:59-62.
11. Hargreaves K., Dubner R., Brown F., Flores C., Joris J. A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain 1988, 32:77-88.
12. Hwang S.J., Burette A., Rustioni A., Valtschanoff J.G. Vanilloid receptor VR1-positive primary afferents are glutamatergic and contact spinal neurons that co-express neurokinin receptor NK1 and glutamate receptors. J. Neurocytol. 2004, 33:321-329.
13. Jang J.H., Nam T.S., Paik K.S., Leam J.W. Involvement of peripherally released substance P and calcitonin gene-related peptide in mediating mechanical hyperalgesia in a traumatic neuropathy model of rat. Neurosci. Lett. 2004, 360:129-132.
14. Ji R.-R., Woolf C.J. Neuronal plasticity and signal transduction in nociceptive neurons: implications for the initiation and maintenance of pathological pain. Neurobiol. Dis. 2001, 8:1-10.
15. Karim F., Wang C.-C., Geraus R.W. Metabotropic glutamate receptor subtype 1 and 5 are activators of extracellular signal-regulated kinase signaling required for inflammatory pain in mice. J. Neurosci. 2001, 21:3771-3779.
16. Kawasaki Y., Kohno T., Zhuang Z.-Y., Brenner G.J., Wang H., Van de Meer C., Befort K., Woolf C.J., Ji R.-R. Ionotropic and metabotropic receptors, protein kinase A, protein kinase C, and Src contribute to C-fiber-induced ERK activation and cAMP response element-binding protein phosphorylation in dorsal horn neurons, leading to central sensitization. J. Neurosci. 2004, 24:8310-8321.
17. Liu H., Manthy P.W., Basbaum A.I. NMDA-receptor regulation of substance P release from primary afferent nociceptors. Nature 1997, 386:721-724.
18. Liu H., Wang H., Sheng M., Jan L.Y., Jan Y.N., Basbaum A.I. Evidence for presynaptic N-methyl-d-aspartate autoreceptors in the spinal cord dorsal horn. Proc. Natl. Acad. Sci. U.S.A. 1994, 91:8383-8387.
19. Ma P.-P., Allchorne A.J., Woolf C.J. Morphine, the NMDA receptor antagonist MK801 and the tachykinin NK1 receptor antagonist RP67580 attenuate the development of inflammation-induced progressive tactile hypersensitivity. Pain 1998, 77:49-57.
20. Malmberg A.B., Yaksh T.L. Hyperalgesia mediated by spinal glutamate or substance P receptor blocked by spinal cyclooxygenase inhibition. Science 1992, 257:1276-1279.
21. Manthy P.W., DeMaster E., Malhotra A., Ghilardi J.R., Rogers S.D., Manthy C.R., Liu H., Basbaum A.I., Vigna S.R., Maggio J.E., Simone D.A. Receptor endocytosis and dendrite reshaping in spinal neurons after somatosensory stimulation. Science 1995, 268:1629-1632.
22. Naono R., Yoshioka D., Ikeda T., Nakayama T., Nishimori T. The common carboxyl-terminal region of novel tachykinin peptides contributes to induce desensitization in scratching behavior of rats. Brain Res. Bull. 2007, 71:461-465.
23. Naono R., Nakayama T., Ikeda T., Matsushima O., Nishimori T. Leucine at the carboxyl-terminal of endokinin C and D contributes to elicitation of the antagonistic effect on substance P in rat pain processing. Brain Res. 2007, 1165:71-80.
24. Naono R., Nakayama T., Ikeda T., Matsushima O., Nishimori T. Pharmacological characterization of desensitization in scratching behavior induced by intrathecal administration of hemokinin-1. Neuropeptides 2008, 42:47-55.
25. Wajima J., Hua X.-X., Yaksh T.L. Inhibition of spinal protein kinase C blocks substance P-mediated hyperalgesia. Brain Res. 2000, 877:314-321.
26. Willis W.D. Long-term potentiation in spinothalamic neurons. Brain Res. Rev. 2002, 40:202-214.
27. Yaksh T.L., Ruddy T.A. Chronic catheterization of the spinal subarachnoid space. Physiol. Behav. 1976, 17:1031-1036.
28. Yoshioka D., Takebuchi F., Nishimori T., Naono R., Ikeda T., Nakayama T. Intrathecal administration of the common C-terminal decapeptide in endokinin A and endokinin B evokes scratching behavior and thermal hyperalgesia in the rat. Neurosci. Lett. 2006, 410:193-197.
29. Zhang H., Cang C.-L., Kawasaki Y., Liang L.-L., Zhang Y.-Q., Ji R.-R., Zhao Z.-Q. Neurokinin-1 receptor enhances TRPV1 activity in primary sensory neurons via PKCe{open}: a novel pathway for heat hyperalgesia. J. Neurosci. 2007, 27:12067-12077.
30. Zimmerman M. Ethical guidelines for investigation of experimental pain in conscious animals. Pain 1983, 16:282-286.