Isoform of fibronectin mediates bone loss in patients with primary biliary cirrhosis by suppressing bone formation

Journal of Bone and Mineral Research

Volumn 23, Issue 8, 2008, Pages 1278-1286

  Kawelke, Nina ^a,b   Bentmann, Anke ^a,b   Hackl, Norman ^a   Hager, Hans Dieter ^b   Feick, Peter ^b   Geursen, Anne ^b   Singer, Manfred V ^b   Nakchbandi, Inaam A ^a,b  

^a MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Bone formation; Bone loss; Fibronectin; Osteoblast; Primary biliary cirrhosis

Indexed keywords

CELL PROTEIN; FIBRONECTIN; ISOPROTEIN; OSTEOCALCIN; SCLEROPROTEIN;

ADULT; AMNION FLUID; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE ATROPHY; BONE DENSITY; BONE MASS; BONE MINERALIZATION; CELL CULTURE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; EXTRADOMAIN A; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; LIVER DISEASE; MALE; MOUSE; NONHUMAN; OSSIFICATION; OSTEOCLAST; PRIMARY BILIARY CIRRHOSIS; PROSPECTIVE STUDY; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN SYNTHESIS; PROTEIN SYNTHESIS INHIBITION; PROTEIN VARIANT; TRABECULAR BONE;

AMNIOTIC FLUID; ANIMALS; BIOLOGICAL MARKERS; BONE DENSITY; BONE RESORPTION; CALCIFICATION, PHYSIOLOGIC; CELLS, CULTURED; FEMALE; FIBRONECTINS; HUMANS; INJECTIONS, INTRAPERITONEAL; LIVER CIRRHOSIS, BILIARY; MALE; MICE; MIDDLE AGED; OSTEOBLASTS; OSTEOCALCIN; OSTEOGENESIS; PROTEIN ISOFORMS; TIBIA;

EID: 47849111054     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.080313     Document Type: Article

References (53)

1. Camisasca M, Albisetti W, Grandinetti G, Parodi M, Battezzati P, Bertolini E, Crosignani A, Zermiani P, Zuin M, Podda M 1991 Bone disease in primary biliary cirrhosis: A large scale prevalence study. Eur J Gastroenterol Hepatol 3:S26.
2. Diamond T, Stiel D, Lunzer M, Wilkinson M, Roche J, Posen S 1990 Osteoporosis and skeletal fractures in chronic liver disease. Gut 31:82-87.
3. Hay JE 1995 Bone disease in cholestatic liver disease. Gastroenterology 108:276-283.
4. Stellon AJ, Davies A, Compston J, Williams R 1985 Osteoporosis in chronic cholestatic liver disease. Q J Med 57:783-790.
5. Stellon AJ, Webb A, Compston J, Williams R 1986 Lack of osteomalacia in chronic cholestatic liver disease. Bone 7:181-185.
6. Diamond T, Stiel D, Mason R, Lissner D, Bikle D, Wilson S, Posen S 1989 Serum vitamin D metabolites are not responsible for low turnover osteoporosis in chronic liver disease. J Clin Endocrinol Metab 69:1234-1239.
7. Janes CH, Dickson ER, Okazaki R, Bonde S, McDonagh AF, Riggs BL 1995 Role of hyperbilirubinemia in the impairment of osteoblast proliferation associated with cholestatic jaundice. J Clin Invest 95:2581-2586.
8. Diamond TH, Stiel D, Lunzer M, McDowall D, Eckstein RP, Posen S 1989 Hepatic osteodystrophy. Static and dynamic bone histomorphometry and serum bone Gla-protein in 80 patients with chronic liver disease. Gastroenterology 96:213-221.
9. Guanabens N, Pares A, Marinoso L, Brancos MA, Piera C, Serrano S, Rivera F, Rodes J 1990 Factors influencing the development of metabolic bone disease in primary biliary cirrhosis. Am J Gastroenterol 85:1356-1362.
10. Leslie WD, Bernstein CN, Leboff MS 2003 AGA technical review on osteoporosis in hepatic disorders. Gastroenterology 125:941-966.
11. Cemborain A, Castilla-Cortazar I, Garcia M, Quiroga J, Muguerza B, Picardi A, Santidrian S, Prieto J 1998 Osteopenia in rats with liver cirrhosis: Beneficial effects of IGF-I treatment. J Hepatol 28:122-131.
12. Sjogren K, Jansson JO, Isaksson OG, Ohlsson C 2002 A model for tissue-specific inducible insulin-like growth factor-I (IGF-I) inactivation to determine the physiological role of liver-derived IGF-I. Endocrine 19:249-256.
13. Compston JE, Thompson RP 1977 Intestinal absorption of 25-hydroxyvitamin D and osteomalacia in primary biliary cirrhosis. Lancet 1:721-724.
14. Hodgson SF, Dickson ER, Eastell R, Eriksen EF, Bryant SC, Riggs BL 1993 Rates of cancellous bone remodeling and turnover in osteopenia associated with primary biliary cirrhosis. Bone 14:819-827.
15. Sakai T, Johnson K, Murozono M, Sakai K, Magnuson M, Wieloch T, Cronberg T, Isshiki A, Erickson H, Fassler R 2001 Plasma fibronectin supports neuronal survival and reduces brain injury following transient focal cerebral ischemia but is not essential for skin-wound healing and hemostasis. Nat Med 7:324-330.
16. Hynes R 1990 Distribution of fibronectins in vivo: Plasma. In: Rich A (ed.) Fibronectins. Springer, New York, NY, USA, pp. 27-30.
17. Satoi S, Kitade H, Hiramatsu Y, Kwon AH, Takahashi H, Sekiguchi K, Uehara M, Oda M, Yanagimoto Y, Miyashita K, Sakashita E, Kamiyama Y 2000 Increased extra domain-A containing fibronectin and hepatic dysfunction during septic response: An in vivo and in vitro study. Shock 13:492-496.
18. Hynes R 1990 Structure of fibronectins. In: Rich A (ed.) Fibronectins. Springer, New York, NY, USA, pp. 113-175.
19. Xu G, Niki T, Virtanen I, Rogiers V, De Bleser P, Geerts A 1997 Gene expression and synthesis of fibronectin isoforms in rat hepatic stellate cells. Comparison with liver parenchymal cells and skin fibroblasts. J Pathol 183:90-98.
20. Matsuura H, Takio K, Titani K, Greene T, Levery SB, Salyan ME, Hakomori S 1988 The oncofetal structure of human fibronectin defined by monoclonal antibody FDC-6. Unique structural requirement for the antigenic specificity provided by a glycosylhexapeptide. J Biol Chem 263:3314-3322.
21. Moursi AM, Damsky CH, Lull J, Zimmerman D, Doty SB, Aota S, Globus RK 1996 Fibronectin regulates calvarial osteoblast differentiation. J Cell Sci 109:1369-1380.
22. Moursi AM, Globus RK, Damsky CH 1997 Interactions between integrin receptors and fibronectin are required for calvarial osteoblast differentiation in vitro. J Cell Sci 110:2187-2196.
23. Chen Q, Zhao J, Dallas MR, Fassler R, Peters DM, Dallas SL 2006 Fibronectin plays a role in osteoblast differentiation which may be mediated via regulation of BMP activity. J Bone Miner Res 21:S13.
24. Bothe V, Schmidt-Gayk H 1990 Competitive protein-binding assay for the diagnosis of hyper- and hypovitaminosis D. In: Schmidt-Gayk H, Armbruster F, Bouillon R (eds.) Calcium Regulating Hormones, Vitamin D Metabolites, and Cyclic AMP. Springer, Berlin, Germany, pp. 258-279.
25. Kanters SD, Banga JD, Algra A, Frijns RC, Beutler JJ, Fijnheer R 2001 Plasma levels of cellular fibronectin in diabetes. Diabetes Care 24:323-327.
26. Akiyama SK 1999 Extracellular matrix. In: Bonifacino JS, Dasso M, Horford JB, Lipincott-Schwartz J, Yamada KM (eds.) Current Protocols in Cell Biology. John Wiley and Sons, New York, NY, USA, S2, pp. 10.5.1-10.5.13.
27. Bessey O, Lowry O, Brock M 1946 A method for the rapid determination of alkaline phosphatase with five cubic millimeters of serum. J Biol Chem 166:173-176.
28. Rickard D, Kassem M, Hefferan T, Sarkar G, Spelsberg T, Riggs B 1996 Isolation and characterization of osteoblast precursor cells from human bone marrow. J Bone Miner Res 11:312-324.
29. Parfitt AM, Drezner MK, Glorieux FH, Kanis JA, Malluche H, Meunier PJ, Ott SM, Recker RR 1987 Bone histomorphometry: Standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee. J Bone Miner Res 2:595-610.
30. Dickson ER, Grambsch PM, Fleming TR, Fisher LD, Langworthy A 1989 Prognosis in primary biliary cirrhosis: Model for decision making. Hepatology 10:1-7.
31. Guanabens N, Pares A, Alvarez L, Martinez de Osaba MJ, Monegal A, Peris P, Ballesta AM, Rodes J 1998 Collagen-related markers of bone turnover reflect the severity of liver fibrosis in patients with primary biliary cirrhosis. J Bone Miner Res 13:731-738.
32. Matsuura H, Hakomori S 1985 The oncofetal domain of fibronectin defined by monoclonal antibody FDC- 6: Its presence in fibronectins from fetal and tumor tissues and its absence in those from normal adult tissues and plasma. Proc Natl Acad Sci USA 82:6517-6521.
33. Satoi S, Hiramatsu Y, Kitade H, Kwon AH, Matsui K, Miyashita K, Sakashita E, Sekiguchi K, Takahashi H, Kamiyama Y 1999 Different responses to surgical stress between extra domain A+ and plasma fibronectins. Clin Exp Pharmacol Physiol 26:225-229.
34. Hynes R 1990 Expression of fibronectins by cells in culture: Hepatocytes. In: Rich A (ed.) Fibronectins. Springer, New York, NY, USA, pp. 73-76.
35. Hodgson S, Dickson E, Wahner H, Johnson K, Mann K, Riggs B 1985 Bone loss and reduced osteoblast function in primary biliary cirrhosis. Ann Intern Med 103:855-860.
36. Stellon AJ, Webb A, Compston J, Williams R 1987 Low bone turnover state in primary biliary cirrhosis. Hepatology 7:137-142.
37. Fonseca V, Epstein O, Gill DS, Menon RK, Thomas M, McIntyre N, Dandona P 1987 Hyperparathyroidism and low serum osteocalcin despite vitamin D replacement in primary biliary cirrhosis. J Clin Endocrinol Metab 64:873-877.
38. Boguslawski G, Hale LV, Yu XP, Miles RR, Onyia JE, Santerre RF, Chandrasekhar S 2000 Activation of osteocalcin transcription involves interaction of protein kinase A- and protein kinase C-dependent pathways. J Biol Chem 275:999-1006.
39. Ducy P, Karsenty G 1996 Skeletal Gla proteins: Gene structure, regulation of expression, and function. In: Bilezikian J, Raisz L, Rodan G (eds.) Principles of Bone Biology. Academic Press, San Diego, CA, USA, pp. 183-195.
40. Lian JB, Gundberg CM 1988 Osteocalcin. Biochemical considerations and clinical applications. Clin Orthop Relat Res 226:267-291.
41. Menon RK, Gill DS, Thomas M, Kernoff PB, Dandona P 1987 Impaired carboxylation of osteocalcin in warfarin-treated patients. J Clin Endocrinol Metab 64:59-61.
42. Akedo Y, Hosoi T, Inoue S, Ikegami A, Mizuno Y, Kaneki M, Nakamura T, Ouchi Y, Orimo H 1992 Vitamin K2 modulates proliferation and function of osteoblastic cells in vitro. Biochem Biophys Res Commun 187:814-820.
43. Newman P, Bonello F, Wierzbicki AS, Lumb P, Savidge GF, Shearer MJ 2002 The uptake of lipoprotein-borne phylloquinone (vitamin K1) by osteoblasts and osteoblast-like cells: Role of heparan sulfate proteoglycans and apolipoprotein E. J Bone Miner Res 17:426-433.
44. Rabinovitz M, Shapiro J, Lian J, Block GD, Merkel IS, Van Thiel DH 1992 Vitamin D and osteocalcin levels in liver transplant recipients. Is osteocalcin a reliable marker of bone turnover in such cases? J Hepatol 16:50-55.
45. Gallego-Rojo FJ, Gonzalez-Calvin JL, Munoz-Torres M, Mundi JL, Fernandez-Perez R, Rodrigo-Moreno D 1998 Bone mineral density, serum insulin-like growth factor I, and bone turnover markers in viral cirrhosis. Hepatology 28:695-699.
46. Polyak SJ, Khabar KS, Rezeiq M, Gretch DR 2001 Elevated levels of interleukin-8 in serum are associated with hepatitis C virus infection and resistance to interferon therapy. J Virol 75:6209-6211.
47. Gonzalez-Calvin JL, Gallego-Rojo F, Fernandez-Perez R, Casado-Caballero F, Ruiz-Escolano E, Olivares EG 2004 Osteoporosis, mineral metabolism, and serum soluble tumor necrosis factor receptor p55 in viral cirrhosis. J Clin Endocrinol Metab 89:4325-4330.
48. Bendre MS, Margulies AG, Walser B, Akel NS, Bhattacharrya S, Skinner RA, Swain F, Ramani V, Mohammad KS, Wessner LL, Martinez A, Guise TA, Chirgwin JM, Gaddy D, Suva LJ 2005 Tumor-derived interleukin-8 stimulates osteolysis independent of the receptor activator of nuclear factor-kappaB ligand pathway. Cancer Res 65:11001-11009.
49. Siggelkow H, Eidner T, Lehmann G, Viereck V, Raddatz D, Munzel U, Hein G, Hufner M 2003 Cytokines, osteoprotegerin, and RANKL in vitro and histomorphometric indices of bone turnover in patients with different bone diseases. J Bone Miner Res 18:529-538.
50. Triffitt JT, Gebauer U, Ashton BA, Owen ME, Reynolds JJ 1976 Origin of plasma alpha2HS-glycoprotein and its accumulation in bone. Nature 262:226-227.
51. McKee MD, Farach-Carson MC, Butler WT, Hauschka PV, Nanci A 1993 Ultrastructural immunolocalization of noncollagenous (osteopontin and osteocalcin) and plasma (albumin and alpha 2HS-glycoprotein) proteins in rat bone. J Bone Miner Res 8:485-496.
52. Johansson S, Svineng G, Wennerberg K, Armulik A, Lohikangas L 1997 Fibronectin-integrin interactions. Front Biosci 2:d126-d146.
53. Grzesik W, Robey P 1994 Bone matrix RGD glycoproteins: Immunolocalization and interaction with human primary osteoblastic bone cells in vitro. J Bone Miner Res 9:487-496.