Common genetic coagulation variants are not associated with ischemic stroke in a case-control study

Neurological Research

Volumn 32, Issue 5, 2010, Pages 519-522

  Moskau, Susanna ^a   Smolka, Kerstin ^a   Semmler, Alexander ^a,b   Schweichel, Dirk ^a   Harbrecht, Ursula ^a   Müller, Jens ^a   Pohl, Christoph ^a   Klockgether, Thomas ^a   Linnebank, Michael ^a,b  

^a UNIVERSITY OF BONN   (Germany)

^b UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Factor V Leiden; Factor XIII Val34Leu; Hereditary thrombophilia; Ischemic stroke; Prothrombin

Indexed keywords

BLOOD CLOTTING FACTOR 13; BLOOD CLOTTING FACTOR 5 LEIDEN; PROTHROMBIN; BLOOD CLOTTING FACTOR 5;

ADULT; AGED; ARTICLE; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; GENE MUTATION; GENETIC ASSOCIATION; GENETIC VARIABILITY; HUMAN; MAJOR CLINICAL STUDY; MALE; AGE; BIOLOGICAL MODEL; BLOOD CLOTTING; BRAIN EMBOLISM; BRAIN ISCHEMIA; CASE CONTROL STUDY; CAUCASIAN; GENETIC POLYMORPHISM; GENETICS; GERMANY; METABOLISM; MIDDLE AGED; PHYSIOLOGY;

ADULT; AGE FACTORS; BLOOD COAGULATION; BRAIN ISCHEMIA; CASE-CONTROL STUDIES; EUROPEAN CONTINENTAL ANCESTRY GROUP; FACTOR V; FACTOR XIII; FEMALE; GENETIC ASSOCIATION STUDIES; GENETIC VARIATION; GERMANY; HUMANS; INTRACRANIAL EMBOLISM; MALE; MIDDLE AGED; MODELS, CARDIOVASCULAR; POLYMORPHISM, GENETIC; PROTHROMBIN; STROKE;

EID: 77952808303     PISSN: 01616412     EISSN: None     Source Type: Journal    
DOI: 10.1179/016164109X12464612122533     Document Type: Article

References (26)

1. Poort SR, Rosendaal FR, Reitsma PH, et al. A common genetic variation in the 3'-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Blood 1996; 88: 3698-3703
2. Bertina RM, Koeleman BP, Koster T, et al. Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature 1994; 369: 64-67
3. Juul K, Tybjaerg-Hansen A, Schnohr P, et al. Factor V Leiden and the risk for venous thromboembolism in the adult Danish population. Ann Intern Med 2004; 140: 330-337
4. Simioni P, Prandoni P, Lensing AW, et al. The risk of recurrent venous thromboembolism in patients with an Arg506RGln mutation in the gene for factor V (factor V Leiden). N Engl J Med 1997; 336: 399-403
5. Ridker PM, Hennekens CH, Lindpaintner K, et al. Mutation in the gene coding for coagulation factor V and the risk of myocardial infarction, stroke, and venous thrombosis in apparently healthy men. N Engl J Med 1995; 332: 912-917
6. de Stefano V, Martinelli I, Mannucci PM, et al. The risk of recurrent deep venous thrombosis among heterozygous carriers of both factor V Leiden and the G20210A prothrombin mutation. N Engl J Med 1999; 341: 801-806
7. Casas JP, Hingorani AD, Bautista LE, et al. Meta-analysis of genetic studies in ischemic stroke: Thirty-two genes involving approximately 18,000 cases and 58,000 controls. Arch Neurol 2004; 61: 1652-1661
8. Kohler HP, Stickland MH, Ossei-Gerning N, et al. Association of a common polymorphism in the factor XIII gene with myocardial infarction. Thromb Haemost 1998; 79: 8-13
9. Mikkola H, Syrjala M, Rasi V, et al. Deficiency in the A-subunit of coagulation factor XIII: Two novel point mutations demonstrate different effects on transcript levels. Blood 1994; 84: 517-525
10. Elbaz A, Poirier O, Canaple S, et al. The association between the Val34Leu polymorphism in the factor XIII gene and brain infarction. Blood 2000; 95: 586-591
11. Franco RF, Reitsma PH, Lourenco D, et al. Factor XIII Val34Leu is a genetic factor involved in the etiology of venous thrombosis. Thromb Haemost 1999; 81: 676-679
12. Catto AJ, Kohler HP, Bannan S, et al. Factor XIII Val 34 Leu: A novel association with primary intracerebral hemorrhage. Stroke 1998; 29: 813-816
13. Aleksic N, Ahn C, Wang YW, et al. Factor XIIIA Val34Leu polymorphism does not predict risk of coronary heart disease: The Atherosclerosis Risk in Communities (ARIC) Study. Arterioscler Thromb Vasc Biol 2002; 22: 348-352
14. Canavy I, Henry M, Morange PE, et al. Genetic polymorphisms and coronary artery disease in the south of France. Thromb Haemost 2000; 83: 212-216
15. Corral J, Gonzalez-Conejero R, Iniesta JA, et al. The FXIII Val34Leu polymorphism in venous and arterial thromboembolism. Haematologica 2000; 85: 293-297
16. Corral J, Iniesta JA, Gonzalez-Conejero R, et al. Factor XIII Val34Leu polymorphism in primary intracerebral haemorrhage. Hematol J 2000; 1: 269-273
17. Endler G, Funk M, Haering D, et al. Is the factor XIII 34Val/Leu polymorphism a protective factor for cerebrovascular disease? Br J Haematol 2003; 120: 310-314
18. Adams HP, Jr, Bendixen BH, Kappelle LJ, et al. Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. Stroke 1993; 24: 35-41
19. Happich D, Schwaab R, Hanfland P, et al. Allelic discrimination of factor V Leiden using a 5' nuclease assay. Thromb Haemost 1999; 82: 1294-1296 (Pubitemid 29473795)
20. Happich D, Madlener K, Schwaab R, et al. Application of the TaqMan-PCR for genotyping of the prothrombin G20210A mutation and of the thermolabile methylenetetrahydrofolate reductase mutation. Thromb Haemost 2000; 84: 144-145
21. Kraus JA, Stuper BK, Muller J, et al. Molecular analysis of thrombophilic risk factors in patients with dural arteriovenous fistulas. J Neurol 2002; 249: 680-682
22. Eterovic D, Titlic M, Culic V, et al. Lower contribution of factor V Leiden or G202104 mutations to ischemic stroke in patients with clinical risk factors: Pair-matched case-control study. Clin Appl Thromb Hemost 2007; 13: 188-193
23. BergeE,HaugKB, SandsetEC, et al.The factorVLeiden, prothrombin gene 20210GA, methylenetetrahydrofolate reductase 677CT and platelet glycoprotein IIIa 1565TC mutations in patients with acute ischemic stroke and atrial fibrillation. Stroke 2007; 38: 1069-1071
24. Lichy C, Reuner KH, Buggle F, et al. Prothrombin G20210A mutation, but not factor V Leiden, is a risk factor in patients with persistent foramen ovale and otherwise unexplained cerebral ischemia. Cerebrovasc Dis 2003; 16: 83-87
25. Karttunen V, Hiltunen L, Rasi V, et al. Factor V Leiden and prothrombin gene mutation may predispose to paradoxical embolism in subjects with patent foramen ovale. Blood Coagul Fibrinolysis 2003; 14: 261-268
26. Botto N, Spadoni I, Giusti S, et al. Prothrombotic mutations as risk factors for cryptogenic ischemic cerebrovascular events in young subjects with patent foramen ovale. Stroke 2007; 38: 2070-2073