The factor V Leiden, prothrombin gene 20210GA, methylenetetrahydrofolate reductase 677CT and platelet glycoprotein IIIa 1565TC mutations in patients with acute ischemic stroke and atrial fibrillation

Stroke

Volumn 38, Issue 3, 2007, Pages 1069-1071

  Berge, Eivind ^a   Haug, Kari Bente Foss ^a   Sandset, Else Charlotte ^a   Haugbro, Kaia Kristine ^a   Turkovic, Meliha ^a   Sandset, Per Morten ^a  

^a ULLEVÅL UNIVERSITY HOSPITAL   (Norway)

Author keywords

Atrial fibrillation; Ischemic stroke; Prothrombotic gene mutations

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); BLOOD CLOTTING FACTOR 5 LEIDEN; GLYCOPROTEIN; PLATELET GLYCOPROTEIN IIIA; PROTHROMBIN; UNCLASSIFIED DRUG; BETA3 INTEGRIN; BLOOD CLOTTING FACTOR 5; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2);

ARTICLE; CASE CONTROL STUDY; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; GENE MUTATION; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; GENETIC RISK; HEART ATRIUM FIBRILLATION; HETEROZYGOTE; HUMAN; MUTATION RATE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RECURRENT DISEASE; STROKE; THROMBOEMBOLISM; BLOOD; BRAIN ISCHEMIA; COMPARATIVE STUDY; ENZYMOLOGY; GENETICS; POINT MUTATION;

ATRIAL FIBRILLATION; BRAIN ISCHEMIA; CASE-CONTROL STUDIES; CEREBROVASCULAR ACCIDENT; FACTOR V; HUMANS; INTEGRIN BETA3; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); POINT MUTATION; PROTHROMBIN; RECURRENCE;

EID: 33947503053     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.STR.0000258076.04860.8e     Document Type: Article

References (12)

1. Svensson PJ, Dahlback B. Resistance to activated protein C as basis for venous thrombosis. N Engl J Med. 1994;330:517-522.
2. Poort SR, Rosendaal FR, Reitsma PH, Bertina RM. A common genetic variation in the 3′-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Blood. 1996;88:3698-3703.
3. Lalouschek W, Schillinger M, Hsieh K, Endler G, Tentschert S, Lang W, Cheng S, Mannhalter C. Matched case-control study on factor V Leiden and the prothrombin G20210A mutation in patients with ischemic stroke/transient ischemic attack up to the age of 60 years. Stroke. 2005;36:1405-1409.
4. Kim RJ, Becker RC. Association between factor V Leiden, prothrombin G20210A, and methylenetetrahydrofolate reductase C677T mutations and events of the arterial circulatory system: a meta-analysis of published studies. Am Heart J. 2003;146:948-957.
5. Weiss EJ, Bray PF, Tayback M, Schulman SP, Kickler TS, Becker LC, Weiss JL, Gerstenblith G, Goldschmidt-Clermont PJ. A polymorphism of a platelet glycoprotein receptor as an inherited risk factor for coronary thrombosis. N Engl J Med. 1996;334:1090-1094.
6. Carter AM, Catto AJ, Bamford JM, Grant PJ. Platelet GP IIIa PlA and GP Ib variable number tandem repeat polymorphisms and markers of platelet activation in acute stroke. Arterioscler Thromb Vasc Biol. 1998;18:1124-1131.
7. Berge E, Abdelnoor M, Nakstad PH, Sandset PM. Low molecular-weight heparin versus aspirin in patients with acute ischaemic stroke and atrial fibrillation: a double-blind randomised study. Lancet. 2000;355:1205-1210.
8. Bertina RM, Koeleman BP, Koster T, Rosendaal FR, Dirven RJ, de Ronde H, van der Velden PA, Reitsma PH. Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature. 1994;369:64-67.
9. Nauck MS, Gierens H, Nauck MA, Marz W, Wieland H. Rapid geno-typing of human platelet antigen 1 (HPA-1) with fluorophore-labelled hybridization probes on the LightCycler. Br J Haematol. 1999;105:803-810.
10. von Ahsen N, Schutz E, Armstrong VW, Oellerich M. Rapid detection of prothrombotic mutations of prothrombin (G20210A), factor V (G1691A), and methylenetetrahydrofolate reductase (C677T) by real-time fluorescence PCR with the LightCycler. Clin Chem. 1999;45:694-696.
11. Hankey GJ, Eikelboom JW, van B, Lofthouse E, Staples N, Baker RI. Inherited thrombophilia in ischemic stroke and its pathogenic subtypes. Stroke. 2001;32:1793-1799.
12. Go AS, Reed GL, Hylek EM, Phillips KA, Liu L, Henault LE, Selby JV, Singer DE. Factor V Leiden and risk of ischemic stroke in nonvalvular atrial fibrillation: the AnTicoagulation and Risk Factors in Atrial Fibrillation (ATRIA) Study. J Thromb Thrombolysis. 2003;15:41-46.