Obesity: Ectopic fat distribution and the heart;Adipositas: Ektope Fettverteilung und Herz

Herz

Volumn 35, Issue 3, 2010, Pages 198-205

  Müller Wieland, Dirk ^a   Knebel, Birgit ^b   Haas, Jutta ^a   Merkel, Martin ^a   Kotzka, Jörg ^b  

^a DEPARTMENT OF CARDIOLOGY   (Germany)

^b LEIBNIZ CENTER FOR DIABETES RESEARCH AT HEINRICH HEINE UNIVERSITY DÜSSELDORF   (Germany)

Author keywords

Epicardial fat; Insulin resistance; Metabolic syndrome; NAFLD; Steatosis hepatis; Visceral obesity

Indexed keywords

FIBRIC ACID DERIVATIVE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; NICOTINIC ACID; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRIACYLGLYCEROL;

ABDOMINAL OBESITY; BODY FAT DISTRIBUTION; BODY MASS; HEART FAILURE; HUMAN; INSULIN RESISTANCE; INTRAABDOMINAL FAT; LIPID STORAGE; LIPOATROPHY; NON INSULIN DEPENDENT DIABETES MELLITUS; NONALCOHOLIC FATTY LIVER; OBESITY; REVIEW; WAIST CIRCUMFERENCE;

ADIPOSE TISSUE; CHORISTOMA; HEART; HUMANS; MODELS, CARDIOVASCULAR; OBESITY;

EID: 77952793377     PISSN: 03409937     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00059-010-3344-0     Document Type: Review

References (35)

1. S.M. Grundy H.B. Brewer J.I. Cleeman 2004 Definition of metabolic syndrome. Report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related definition Circulation 109 433 8 10.1161/01.CIR.0000111245.75752.C6 14744958 (Pubitemid 38133916)
2. K.G. Alberti R.H. Eckel S.M. Grundy 2009 Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity Circulation 120 1640 5 10.1161/CIRCULATIONAHA.109.192644 1:CAS:528: DC%2BD1MXht1OrtrrK 19805654
3. O. Bayturan E.M. Tuzcu A. Lavoie 2010 The metabolic syndrome, its component risk factors, and progression of coronary atherosclerosis Arch Intern Med 170 478 84 10.1001/archinternmed.2009.551 1:CAS:528:DC%2BC3cXkt1Sit78%3D 20212186
4. M.A. Cornier D. Dabelea T.L. Hernandez 2008 The metabolic syndrome Endocr Rev 29 777 822 10.1210/er.2008-0024 1:CAS:528:DC%2BD1MXmt1yjtg%3D%3D 18971485
5. Manolopoulos KN, Karpe F, Frayn KN. Gluteofemoral body fat as a determinant of metabolic health. Int J Obes (Lond): in press (Epub 2010 Jan 12).
6. D. Tripathy P. Mohanty S. Dhindsa 2003 Elevation of free fatty acids induces inflammation and impairs vascular reactivity in healthy subjects Diabetes 52 2882 7 10.2337/diabetes.52.12.2882 1:CAS:528:DC%2BD3sXpsFagsLo%3D 14633847 (Pubitemid 37466856)
7. R.J. Grekin A.P. Vollmer R.S. Sider 1995 Pressor effects of portal venous oleate infusion. A proposed mechanism for obesity hypertension Hypertension 26 193 8 1:CAS:528:DyaK2MXnsF2lu78%3D 7607723
8. D.B. Savage K.F. Petersen G.I. Shulman 2007 Disordered lipid metabolism and the pathogenesis of insulin resistance Physiol Rev 87 507 20 10.1152/physrev.00024.2006 1:CAS:528:DC%2BD2sXoslGmu7Y%3D 17429039 (Pubitemid 47084679)
9. R.H. Unger 2002 Lipotoxic diseases Annu Rev Med 53 319 36 10.1146/annurev.med.53.082901.104057 1:CAS:528:DC%2BD38Xitl2mtrc%3D 11818477 (Pubitemid 34177884)
10. J.D. McGarry 2002 Banting lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetes Diabetes 51 7 18 10.2337/diabetes.51.1.7 1:CAS:528:DC%2BD38Xlt1ejsQ%3D%3D 11756317
11. N. Stefan K. Kantartzis H.U. Häring 2008 Causes and metabolic consequences of fatty liver Endocr Rev 29 939 60 10.1210/er.2008-0009 1:CAS:528:DC%2BD1MXmt1yjug%3D%3D 18723451
12. A. Kotronen H. Yki-Järvinen 2008 Fatty liver: a novel component of the metabolic syndrome Arterioscler Thromb Vasc Biol 28 27 38 10.1161/ATVBAHA.107.147538 1:CAS:528:DC%2BD2sXhsVeiu7nI 17690317
13. T.C. Schreuder B.J. Verwer C.M. van Nieuwkerk 2008 Nonalcoholic fatty liver disease: an overview of current insights in pathogenesis, diagnosis and treatment World J Gastroenterol 14 2474 86 10.3748/wjg.14.2474 1:CAS:528:DC%2BD1cXptlWgs7s%3D 18442193 (Pubitemid 352037734)
14. M.S. Brown J.L. Goldstein 2009 Cholesterol feedback: from Schoenheimer's bottle to Scap's MELADL J Lipid Res 50 S15 27 10.1194/jlr.R800054-JLR200 18974038
15. J. Kotzka D. Müller-Wieland 2004 Sterol regulatory element-binding protein (SREBP)-1: gene regulatory target for insulin resistance? Expert Opin Ther Targets 8 141 9 10.1517/14728222.8.2.141 1:CAS:528:DC%2BD2cXis1yjsr4%3D 15102555 (Pubitemid 38489539)
16. Knebel B, Haas J, Jacob S, et al. Visceral obesity caused by overexpressing SREBP-1c in liver. American Heart Association, Scientific Sessions, Orlando, FL, 2009.
17. G. Iacobellis 2009 Epicardial and pericardial fat: close, but very different Obesity (Silver Spring) 17 625 10.1038/oby.2008.575
18. J.J. Carr J. Ding 2009 Response to "Epicardial and pericardial fat: close, but very different" Obesity (Silver Spring) 17 626 7 10.1038/oby.2008.622
19. R.H. Unger G.O. Clark P.E. Scherer L. Orci 2010 Lipid homeostasis, lipotoxicity and the metabolic syndrome Biochim Biophys Acta 1801 209 14 1:CAS:528:DC%2BC3cXitVejt7k%3D 19948243
20. J.M. McGavock R.G. Victor R.H. Unger 2006 Adiposity of the heart, revisited Ann Intern Med 144 517 24 1:CAS:528:DC%2BD28Xkt1KqsLc%3D 16585666
21. S.W. Rabkin 2007 Epicardial fat: properties, function and relationship to obesity Obes Rev 8 253 61 10.1111/j.1467-789X.2006.00293.x 1:CAS:528: DC%2BD2sXmtFKns7c%3D 17444966 (Pubitemid 46632691)
22. G. Iacobellis D. Corradi A.M. Sharma 2005 Epicardial adipose tissue: anatomic, biomolecular and clinical relationships with the heart Nat Clin Pract Cardiovasc Med 2 536 43 10.1038/ncpcardio0319 16186852 (Pubitemid 41670345)
23. L.S. Szczepaniak R.G. Victor L. Orci 2007 The rediscovery of fatty heart, the most common unrecognized disease in America Circ Res 101 759 67 10.1161/CIRCRESAHA.107.160457 1:CAS:528:DC%2BD2sXhtFejsL7L 17932333 (Pubitemid 350287190)
24. H.S. Sacks J.N. Fain 2007 Human epicardial adipose tissue: a review Am Heart J 153 907 17 10.1016/j.ahj.2007.03.019 1:CAS:528:DC%2BD2sXmtVaqs7Y%3D 17540190 (Pubitemid 46809849)
25. G.A. Rosito J.M. Massaro U. Hoffmann 2008 Pericardial fat, visceral abdominal fat, cardiovascular disease risk factors, and vascular calcification in a community-based sample: the Framingham Heart Study Circulation 117 605 13 10.1161/CIRCULATIONAHA.107.743062 18212276
26. C.S. Fox P. Gona U. Hoffmann 2009 Pericardial fat, intrathoracic fat, and measures of left ventricular structure and function: the Framingham Heart Study Circulation 119 1586 91 10.1161/CIRCULATIONAHA.108.828970 19289634
27. J. Ding F.C. Hsu T.B. Harris 2009 The association of pericardial fat with incident coronary heart disease: the Multi-Ethnic Study of Atherosclerosis (MESA) Am J Clin Nutr 90 499 504 10.3945/ajcn.2008.27358 1:CAS:528: DC%2BD1MXhtVKmtrnL 19571212
28. J.M. McGavock I. Lingvay I. Zib 2007 Cardiac steatosis in diabetes mellitus: a 1 H-magnetic resonance spectroscopy study Circulation 116 1170 5 10.1161/CIRCULATIONAHA.106.645614 17698735 (Pubitemid 47360218)
29. A.M. Sironi A. Pingitore S. Ghione 2008 Early hypertension is associated with reduced regional cardiac function, insulin resistance, epicardial, and visceral fat Hypertension 51 282 8 10.1161/HYPERTENSIONAHA.107.098640 1:CAS:528:DC%2BD1cXmt1Oiug%3D%3D 18172058 (Pubitemid 351159940)
30. M. Kankaanpää H.R. Lehto J.P. Pärkkä 2006 Myocardial triglyceride content and epicardial fat mass in human obesity: relationship to left ventricular function and serum free fatty acid levels J Clin Endocrinol Metab 91 4689 95 10.1210/jc.2006-0584 16926257 (Pubitemid 44833458)
31. M.K. Kim T. Tomita M.J. Kim 2009 Aerobic exercise training reduces epicardial fat in obese men J Appl Physiol 106 5 11 10.1152/japplphysiol.90756. 2008 18927266
32. P. Iozzo R. Lautamaki R. Borra 2009 Contribution of glucose tolerance and gender to cardiac adiposity J Clin Endocrinol Metab 94 4472 82 10.1210/jc.2009-0436 1:CAS:528:DC%2BD1MXhsVejtb7L 19820028
33. M. Prentki E. Joly W. El-Assaad R. Roduit 2002 Malonyl-CoA signaling, lipid partitioning, and glucolipotoxicity: role in beta-cell adaptation and failure in the etiology of diabetes Diabetes 51 Suppl3 S405 13 10.2337/diabetes.51.2007.S405 1:CAS:528:DC%2BD38XpsVagtLc%3D 12475783
34. S. Khosla J.J. Westendorf M.J. Oursler 2008 Building bone to reverse osteoporosis and repair fractures J Clin Invest 118 421 8 10.1172/JCI33612 1:CAS:528:DC%2BD1cXhsFOnurg%3D 18246192 (Pubitemid 351206529)
35. J.A. Pospisilik D. Schramek H. Schnidar 2010 Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate Cell 140 148 60 10.1016/j.cell.2009.12.027 1:CAS:528: DC%2BC3cXkvVWiu74%3D 20074523