Endogenous tissue plasminogen activator increases hemorrhagic transformation induced by heparin after ischemia reperfusion in rat brains

Neurological Research

Volumn 32, Issue 5, 2010, Pages 541-546

  Tang, Jin ^a   Li, Ya Jun ^a   Li, Qi ^a   Mu, Jun ^a   Yang, De Yu ^a   Xie, Peng ^a,b  

^a THE FIRST AFFILIATED HOSPITAL OF CHONGQING MEDICAL UNIVERSITY   (China)

^b CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

Cerebral hemorrhage; Cerebral infarction; Heparin; Tissue plasminogen activator

Indexed keywords

GELATINASE B; HEPARIN; TISSUE PLASMINOGEN ACTIVATOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN HEMORRHAGE; BRAIN ISCHEMIA; CONTROLLED STUDY; ENZYME ACTIVITY; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; OCCLUSIVE CEREBROVASCULAR DISEASE; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY; ANIMAL; BRAIN; CEREBRAL ARTERY DISEASE; CHEMICALLY INDUCED; COMPLICATION; DISEASE MODEL; METABOLISM; PATHOLOGY; RANDOMIZATION; SEVERITY OF ILLNESS INDEX; SPRAGUE DAWLEY RAT; TIME;

ANIMALS; BRAIN; BRAIN ISCHEMIA; DISEASE MODELS, ANIMAL; HEPARIN; INFARCTION, MIDDLE CEREBRAL ARTERY; INTRACRANIAL HEMORRHAGES; MALE; MATRIX METALLOPROTEINASE 9; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; SEVERITY OF ILLNESS INDEX; TIME FACTORS; TISSUE PLASMINOGEN ACTIVATOR;

EID: 77952789873     PISSN: 01616412     EISSN: None     Source Type: Journal    
DOI: 10.1179/174313209X414560     Document Type: Article

References (18)

1. Alexandrov AV, Black SE, Ehrlich LE, et al. Predictors of hemorrhagic transformation occurring spontaneously and on anticoagulants in patients with acute ischemic stroke. Stroke 1997; 28: 1198-1202
2. Bowes MP, Zivin JA, Thomas GR, et al. Acute hypertension, but not thrombolysis, increases the incidence and severity of hemorrhagic transformation following experimental stroke in rabbits. Exp Neurol 1996; 141: 40-46
3. del Zoppo GJ, Copeland BR, Anderchek K, et al. Hemorrhagic transformation following tissue plasminogen activator in experimental cerebral infarction. Stroke 1990; 21: 596-601
4. Aoki T, Sumii T, Mori T, et al. Blood-brain barrier disruption and matrix metalloproteinase-9 expression during reperfusion injury: Mechanical versus embolic focal ischemia in spontaneously hypertensive rats. Stroke 2002; 33: 2711-2717
5. Hu K, Yang J, Tanaka S, et al. Tissue-type plasminogen activator acts as a cytokine that triggers intracellular signal transduction and induces matrix metalloproteinase-9 gene expression. J Biol Chem 2006; 281: 2120-2127
6. Kahles T, Foerch C, Sitzer M, et al. Tissue plasminogen activator mediated blood-brain barrier damage in transient focal cerebral ischemia in rats: Relevance of interactions between thrombotic material and thrombolytic agent. Vasc Pharmacol 2005; 43: 254-259
7. Pfefferkorn T, Rosenberg GA. Closure of the blood-brain barrier by matrix metalloproteinase inhibition reduces rtPA-mediated mortality in cerebral ischemia with delayed reperfusion. Stroke 2003; 34: 2025-2030
8. Wang X, Lee SR, Arai K, et al. Lipoprotein receptor-mediated induction of matrix metalloproteinase by tissue plasminogen activator. Nat Med 2003; 9: 1313-1317
9. Asahi M, Wang X, Mori T, et al. Effects of matrix metalloproteinase- gene knock-out on the proteolysis of blood-brain barrier and white matter components after cerebral ischemia. J Neurosci 2001; 21: 7724-7732
10. Aoki T, Sumii T, Mori T, et al. Blood-brain barrier disruption and matrix metalloproteinase-9 expression during reperfusion injury: Mechanical versus embolic focal ischemia in spontaneously hypertensive rats. Stroke 2002; 33: 2711-2717
11. Benchenane K, Berezowski V, Ali C, et al. Tissue-type plasminogen activator crosses the intact blood-brain barrier by low-density lipoprotein receptor-related protein-mediated transcytosis. Circulation 2005; 111: 2241-2249
12. Wang YF, Tsirka SE, Strickland S, et al. Tissue plasminogen activator (tPA) increases neuronal damage after focal cerebral ischemia in wild-type and tPA-deficient mice. Nat Med 1998; 4: 228-231
13. Pekelharing HL, Kleinveld HA, Duif PF, et al. Effect of lipoprotein(a) and LDL on plasminogen binding to extracellular matrix and on matrix-dependent plasminogen activation by tissue plasminogen activator. Thromb Haemost 1996; 75: 497-502
14. Hu K, Yang J, Tanaka S, et al. Tissue-type plasminogen activator acts as a cytokine that triggers intracellular signal transduction and induces matrix metalloproteinase-9 gene expression. J Biol Chem 2006; 281: 2120-2127
15. Yang DY, Pan HC, Chen CJ, et al. Effects of tissue plasminogen activator on cerebral microvessels of rats during focal cerebral ischemia and reperfusion. Neurol Res 2007; 29: 274-282
16. Horwood JM, Ripley TL, Stephens DN. Evidence for disrupted NMDA receptor function in tissue plasminogen activator knockout mice. Behav Brain Res 2004; 150: 127-138.
17. Fagan SC, Nagaraja TN, Fenstermacher JD, et al. Hemorrhagic transformation is related to the duration of occlusion and treatment with tissue plasminogen activator in a nonembolic stroke model. Neurol Res 2003; 25: 377-382
18. Zhang W, Sato K, Hayashi T, et al. Extension of ischemic therapeutic time window by a free radical scavenger, Edaravone, reperfused with tPA in rat brain. Neurol Res 2004; 26: 342-348