Adverse Vaccinal Events in Dogs and Cats

Veterinary Clinics of North America - Small Animal Practice

Volumn 40, Issue 3, 2010, Pages 393-407

  Moore, George E ^a   HogenEsch, Harm ^a  

^a PURDUE UNIVERSITY   (United States)

Author keywords

Causality; Cytokines; Immunogenicity; Reactions; Vaccinal events

Indexed keywords

ACETYLSALICYLIC ACID; BACTERIAL VACCINE; COMPLEMENT; CYCLOPHOSPHAMIDE; DIPHENHYDRAMINE; GLUCOCORTICOID; HISTAMINE; INFLUENZA VACCINE; INTERLEUKIN 4; INTERLEUKIN 5; LEUKOTRIENE; NONSTEROID ANTIINFLAMMATORY AGENT; PARACETAMOL; PENTOXIFYLLINE; PREDNISOLONE; RABIES VACCINE; SEROTONIN; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; VACCINE;

ADAPTIVE IMMUNITY; ANTIINFLAMMATORY ACTIVITY; CAT; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DOG; DRUG EFFICACY; DRUG FORMULATION; DRUG HYPERSENSITIVITY; DRUG MEGADOSE; DRUG RESPONSE; GRANULOMATOUS INFLAMMATION; GUILLAIN BARRE SYNDROME; HUMAN; IMMUNOGENICITY; INFLUENZA; INFLUENZA A (H1N1); INNATE IMMUNITY; NEUROLOGIC DISEASE; NONHUMAN; OSTEODYSTROPHY; RABIES; REVIEW; SARCOMA; VACCINATION REACTION; VASCULITIS; VETERINARY MEDICINE;

ADVERSE DRUG REACTION REPORTING SYSTEMS; ANIMALS; CAT DISEASES; CATS; DOG DISEASES; DOGS; INJECTIONS; VACCINATION; VACCINES;

ANIMALIA; CANIS FAMILIARIS; FELIDAE;

EID: 77952777605     PISSN: 01955616     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cvsm.2010.02.002     Document Type: Review

References (83)

1. Bradford-Hill A.B. The environment and disease: association and causation. Proc R Soc Med 1965, 58:295-300.
2. Siev D. An introduction to analytical methods for the postmarketing surveillance of veterinary vaccines. Adv Vet Med 1999, 41:749-774.
3. Frana T.S., Clough N.E., Gatewood D.M., et al. Postmarketing surveillance of rabies vaccines for dogs to evaluate safety and efficacy. J Am Vet Med Assoc 2008, 232(7):1000-1002.
4. Moore G.E., Frana T.S., Guptill L.F., et al. Postmarketing surveillance for dog and cat vaccines: new resources in changing times. J Am Vet Med Assoc 2005, 227(7):1066-1069.
5. Moore G.E., Guptill L.F., Ward M.P., et al. Adverse events diagnosed within three days of vaccine administration in dogs. J Am Vet Med Assoc 2005, 227(7):1102-1108.
6. Klein N.P., Ray P., Carpenter D., et al. Rates of autoimmune diseases in Kaiser Permanente for use in vaccine adverse event safety studies. Vaccine 2009, 28(4):1062-1068.
7. Reif D.M., McKinney B.A., Motsinger A.A., et al. Genetic basis for adverse events after smallpox vaccination. J Infect Dis 2008, 198(1):16-22.
8. Reif D.M., Motsinger-Reif A.A., McKinney B.A., et al. Integrated analysis of genetic and proteomic data identifies biomarkers associated with adverse events following smallpox vaccination. Genes Immun 2009, 10(2):112-119.
9. Castellino F., Galli G., Del Giudice G., et al. Generating memory with vaccination. Eur J Immunol 2009, 39(8):2100-2105.
10. Kang S.M., Compans R.W. Host responses from innate to adaptive immunity after vaccination: molecular and cellular events. Mol Cells 2009, 27(1):5-14.
11. Medzhitov R., Janeway C. Innate immune recognition: mechanisms and pathways. Immunol Rev 2000, 173:89-97.
12. Akira S., Takeda K. Toll-like receptor signalling. Nat Rev Immunol 2004, 4(7):499-511.
13. Pashine A., Valiante N.M., Ulmer J.B. Targeting the innate immune response with improved vaccine adjuvants. Nat Med 2005, 11(Suppl 4):S63-S68.
14. Iwasaki A., Medzhitov R. Regulation of adaptive immunity by the innate immune system. Science 2010, 327(5963):291-295.
15. Starr R.M. Reaction rate in cats vaccinated with a new controlled-titer feline panleukopenia-rhinotracheitis-calicivirus-Chlamydia psittaci vaccine. Cornell Vet 1993, 83(4):311-323.
16. Moore G.E., DeSantis-Kerr A.C., Guptill L.F., et al. Adverse events after vaccine administration in cats: 2,560 cases (2002-2005). J Am Vet Med Assoc 2007, 231(1):94-100.
17. Ryan E.P., Malboeuf C.M., Bernard M., et al. Cyclooxygenase-2 inhibition attenuates antibody responses against human papillomavirus-like particles. J Immunol 2006, 177(11):7811-7819.
18. Georgitis J.W., Fasano M.B. Allergenic components of vaccines and avoidance of vaccination-related adverse events. Curr Allergy Rep 2001, 1(1):11-17.
19. Nokleby H. Vaccination and anaphylaxis. Curr Allergy Asthma Rep 2006, 6(1):9-13.
20. Sakaguchi M., Inouye S. IgE sensitization to gelatin: the probable role of gelatin-containing diphtheria-tetanus-acellular pertussis (DTaP) vaccines. Vaccine 2000, 18(19):2055-2058.
21. Pool V., Braun M.M., Kelso J.M., et al. Prevalence of anti-gelatin IgE antibodies in people with anaphylaxis after measles-mumps rubella vaccine in the United States. Pediatrics 2002, 110(6):e71.
22. Trujillo-Vargas C.M., Mayer K.D., Bickert T., et al. Vaccinations with T-helper type 1 directing adjuvants have different suppressive effects on the development of allergen-induced T-helper type 2 responses. Clin Exp Allergy 2005, 35(8):1003-1013.
23. Ohmori K., Masuda K., Maeda S., et al. IgE reactivity to vaccine components in dogs that developed immediate-type allergic reactions after vaccination. Vet Immunol Immunopathol 2005, 104(3-4):249-256.
24. Moore GE, HogenEsch H, Dunham A. Antigenic causes of vaccine-associated allergic reactions in dogs. Proceedings of the 5th International Veterinary Vaccines and Diagnostics Conference. Madison (WI), July 19-23, 2009.
25. HogenEsch H., Dunham A.D., Scott-Moncrieff C., et al. Effect of vaccination on serum concentrations of total and antigen-specific immunoglobulin E in dogs. Am J Vet Res 2002, 63(4):611-616.
26. Kelso J.M., Li J.T., Nicklas R.A., et al. Adverse reactions to vaccines. Ann Allergy Asthma Immunol 2009, 103(4 Suppl 2):S1-14.
27. Warman S.M., Murray J.K., Ridyard A., et al. Pattern of Coombs' test reactivity has diagnostic significance in dogs with immune-mediated haemolytic anaemia. J Small Anim Pract 2008, 49(10):525-530.
28. France E.K., Glanz J., Xu S., et al. Risk of immune thrombocytopenic purpura after measles-mumps-rubella immunization in children. Pediatrics 2008, 121(3):e687-e692.
29. Schattner A. Consequence or coincidence? The occurrence, pathogenesis and significance of autoimmune manifestations after viral vaccines. Vaccine 2005, 23(30):3876-3886.
30. Jadavji T., Scheifele D., Halperin S. Thrombocytopenia after immunization of Canadian children, 1992 to 2001. Pediatr Infect Dis J 2003, 22(2):119-122.
31. Seltsam A., Shukry-Schulz S., Salama A. Vaccination-associated immune hemolytic anemia in two children. Transfusion 2000, 40(8):907-909.
32. Straw B. Decrease in platelet count after vaccination with distemper-hepatitis (DH) vaccine. Vet Med Small Anim Clin 1978, 73(6):725-726.
33. Greene C.E., Schultz R.D. Immunoprophylaxis. Infectious diseases of the dog and cat 2006, 1069-1119. Elsevier Inc, Philadelphia. 3rd edition. C.E. Greene (Ed.).
34. Duval D., Giger U. Vaccine-associated immune-mediated hemolytic anemia in the dog. J Vet Intern Med 1996, 10(5):290-295.
35. Carr A.P., Panciera D.L., Kidd L. Prognostic factors for mortality and thromboembolism in canine immune-mediated hemolytic anemia: a retrospective study of 72 dogs. J Vet Intern Med 2002, 16(5):504-509.
36. Klotins KC, Martin SW, Kruth S. Vaccination as a risk factor for immune mediated anemia in dogs: a multi-centre case-control study. Proceedings of the 3rd International Veterinary Vaccines and Diagnostics Conference. Guelph, Ontario (Canada), July 13-18, 2003.
37. Shoenfeld Y., Aron-Maor A. Vaccination and autoimmunity-'vaccinosis': a dangerous liaison?. J Autoimmun 2000, 14(1):1-10.
38. Scott-Moncrieff J.C., Azcona-Olivera J., Glickman N.W., et al. Evaluation of antithyroglobulin antibodies after routine vaccination in pet and research dogs. J Am Vet Med Assoc 2002, 221(4):515-521.
39. Scott-Moncrieff J.C., Glickman N.W., Glickman L.T., et al. Lack of association between repeated vaccination and thyroiditis in laboratory Beagles. J Vet Intern Med 2006, 20(4):818-821.
40. Curtis R., Barnett K.C. The 'blue eye' phenomenon. Vet Rec 1983, 112(15):347-353.
41. Lappin M.R., Basaraba R.J., Jensen W.A. Interstitial nephritis in cats inoculated with Crandell Rees feline kidney cell lysates. J Feline Med Surg 2006, 8(5):353-356.
42. Lappin M.R., Jensen W.A., Jensen T.D., et al. Investigation of the induction of antibodies against Crandell-Rees feline kidney cell lysates and feline renal cell lysates after parenteral administration of vaccines against feline viral rhinotracheitis, calicivirus, and panleukopenia in cats. Am J Vet Res 2005, 66(3):506-511.
43. Cohen A.D., Shoenfeld Y. Vaccine-induced autoimmunity. J Autoimmun 1996, 9(6):699-703.
44. Dougherty S.A., Center S.A., Shaw E.E., et al. Juvenile-onset polyarthritis syndrome in Akitas. J Am Vet Med Assoc 1991, 198(5):849-856.
45. Kohn B., Garner M., Lubke S., et al. Polyarthritis following vaccination in four dogs. Vet Comp Orthop Traumatol 2003, 16(1):6-10.
46. Clements D.N., Gear R.N., Tattersall J., et al. Type I immune-mediated polyarthritis in dogs: 39 cases (1997-2002). J Am Vet Med Assoc 2004, 224(8):1323-1327.
47. Wilcock B.P., Yager J.A. Focal cutaneous vasculitis and alopecia at sites of rabies vaccination in dogs. J Am Vet Med Assoc 1986, 188(10):1174-1177.
48. Hendrick M.J., Dunagan C.A. Focal necrotizing granulomatous panniculitis associated with subcutaneous injection of rabies vaccine in cats and dogs: 10 cases (1988-1989). J Am Vet Med Assoc 1991, 198(2):304-305.
49. Vitale C.B., Gross T.L., Magro C.M. Vaccine-induced ischemic dermatopathy in the dog. Vet Dermatol 1999, 10(2):131-142.
50. Alkharfy K.M., Kellum J.A., Matzke G.R. Unintended immunomodulation: part II. Effects of pharmacological agents on cytokine activity. Shock 2000, 13(5):346-360.
51. Hendrick M.J., Goldschmidt M.H. Do injection site reactions induce fibrosarcomas in cats?. J Am Vet Med Assoc 1991, 199(8):968.
52. Hendrick M.J., Goldschmidt M.H., Shofer F.S., et al. Postvaccinal sarcomas in the cat: epidemiology and electron probe microanalytical identification of aluminum. Cancer Res 1992, 52(19):5391-5394.
53. McEntee M.C., Page R.L. Feline vaccine-associated sarcomas. J Vet Intern Med 2001, 15(3):176-182.
54. Kass P.H., Barnes W.G., Spangler W.L., et al. Epidemiologic evidence for a causal relation between vaccination and fibrosarcoma tumorigenesis in cats. J Am Vet Med Assoc 1993, 203(3):396-405.
55. Hendrick M.J., Shofer F.S., Goldschmidt M.H., et al. Comparison of fibrosarcomas that developed at vaccination sites and at nonvaccination sites in cats: 239 cases (1991-1992). J Am Vet Med Assoc 1994, 205(10):1425-1429.
56. Spickler A.R., Roth J.A. Adjuvants in veterinary vaccines: modes of action and adverse effects. J Vet Intern Med 2003, 17(3):273-281.
57. Hem S.L., Hogenesch H. Relationship between physical and chemical properties of aluminum-containing adjuvants and immunopotentiation. Expert Rev Vaccines 2007, 6(5):685-698.
58. Day M.J., Schoon H.A., Magnol J.P., et al. A kinetic study of histopathological changes in the subcutis of cats injected with non-adjuvanted and adjuvanted multi-component vaccines. Vaccine 2007, 25(20):4073-4084.
59. Norsworthy G.D. Counteracting the decline in feline visits and vaccinations. J Am Vet Med Assoc 2008, 233(9):1397.
60. Hendrick M.J. Feline vaccine-associated sarcomas. Cancer Invest 1999, 17(4):273-277.
61. Hershey A.E., Dubielzig R.R., Padilla M.L., et al. Aberrant p53 expression in feline vaccine-associated sarcomas and correlation with prognosis. Vet Pathol 2005, 42(6):805-811.
62. Banerji N., Kanjilal S. Somatic alterations of the p53 tumor suppressor gene in vaccine-associated feline sarcoma. Am J Vet Res 2006, 67(10):1766-1772.
63. Hwang S.J., Lozano G., Amos C.I., et al. Germline p53 mutations in a cohort with childhood sarcoma: sex differences in cancer risk. Am J Hum Genet 2003, 72(4):975-983.
64. Horzinek M.C., Thiry E. Vaccines and vaccination: the principles and the polemics. J Feline Med Surg 2009, 11(7):530-537.
65. Krakowka S., Olsen R.G., Axthelm M.K., et al. Canine parvovirus infection potentiates canine distemper encephalitis attributable to modified live-virus vaccine. J Am Vet Med Assoc 1982, 180(2):137-139.
66. Vucic S., Kiernan M.C., Cornblath D.R. Guillain-Barre syndrome: an update. J Clin Neurosci 2009, 16(6):733-741.
67. Hughes R.A., Rees J.H. Clinical and epidemiologic features of Guillain-Barre syndrome. J Infect Dis 1997, 176(Suppl 2):S92-S98.
68. Haber P., Sejvar J., Mikaeloff Y., et al. Vaccines and Guillain-Barre syndrome. Drug Saf 2009, 32(4):309-323.
69. Greene S.K., Kulldorff M., Lewis E.M., et al. Near real-time surveillance for influenza vaccine safety: proof-of-concept in the vaccine safety datalink project. Am J Epidemiol 2010, 171(2):177-188.
70. Cuddon P.A. Electrophysiologic assessment of acute polyradiculoneuropathy in dogs: comparison with Guillain-Barre syndrome in people. J Vet Intern Med 1998, 12(4):294-303.
71. Holmes D.F., Schultz R.D., Cummings J.F., et al. Experimental coonhound paralysis: animal model of Guillain-Barre syndrome. Neurology 1979, 29(8):1186-1187.
72. Northington J.W., Brown M.J. Acute canine idiopathic polyneuropathy. A Guillain-Barre-like syndrome in dogs. J Neurol Sci 1982, 56(2-3):259-273.
73. Gehring R., Eggars B. Suspected post-vaccinal acute polyradiculoneuritis in a puppy. J S Afr Vet Assoc 2001, 72(2):96.
74. Schrauwen E., van Ham L. Postvaccinal acute polyradiculoneuritis in a young puppy. Prog Vet Neurol 1995, 6:68-70.
75. LaFond E., Breur G.J., Austin C.C. Breed susceptibility for developmental orthopedic diseases in dogs. J Am Anim Hosp Assoc 2002, 38(5):467-477.
76. Abeles V., Harrus S., Angles J.M., et al. Hypertrophic osteodystrophy in six weimaraner puppies associated with systemic signs. Vet Rec 1999, 145(5):130-134.
77. Harrus S., Waner T., Aizenberg I., et al. Development of hypertrophic osteodystrophy and antibody response in a litter of vaccinated Weimaraner puppies. J Small Anim Pract 2002, 43(1):27-31.
78. Woodard J.C. Canine hypertrophic osteodystrophy, a study of the spontaneous disease in littermates. Vet Pathol 1982, 19(4):337-354.
79. Grondalen J. Metaphyseal osteopathy (hypertrophic osteodystrophy) in growing dogs. A clinical study. J Small Anim Pract 1976, 17(11):721-735.
80. Foale R.D., Herrtage M.E., Day M.J. Retrospective study of 25 young weimaraners with low serum immunoglobulin concentrations and inflammatory disease. Vet Rec 2003, 153(18):553-558.
81. Couto C.G., Krakowka S., Johnson G., et al. In vitro immunologic features of Weimaraner dogs with neutrophil abnormalities and recurrent infections. Vet Immunol Immunopathol 1989, 23(1-2):103-112.
82. Muir P., Dubielzig R.R., Johnson K.A., et al. Hypertrophic osteodystrophy and calvarial hyperostosis. Compend Contin Educ Pract Vet 1996, 18(2):143-150.
83. Gilad J., Barnea E., Klement E. Aspirin treatment of postvaccinal hypertrophic osteodystrophy in a weimaraner puppy. Vet Rec 2002, 150(14):456.