Neurophamacology of yawning

Frontiers of Neurology and Neuroscience

Volumn 28, Issue , 2010, Pages 90-106

  Collins, Gregory T ^a   Eguibar, Jose R ^b  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b BENEMÉRITA UNIVERSIDAD AUTÓNOMA DE PUEBLA   (Mexico)

Author keywords

[No Author keywords available]

Indexed keywords

1 (3 TRIFLUOROMETHYLPHENYL)PIPERAZINE; 2 ETHYL 8 METHYL 2,8 DIAZASPIRO[4.5]DECANE 1,3 DIONE; 2,8 DIMETHYL 3 METHYLENE 1 OXA 8 AZASPIRO[4.5]DECANE; 4 AMINOBUTYRIC ACID; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; APOMORPHINE; ATROPINE; CHOLINESTERASE INHIBITOR; CORTICOTROPIN; GLUTAMIC ACID; GLYCERYL TRINITRATE; HALOPERIDOL; HYDROXYLAMINE; INTERMEDIN; MECAMYLAMINE; METHYLSCOPOLAMINE; N METHYL DEXTRO ASPARTIC ACID; NITRIC OXIDE; NITROPRUSSIDE SODIUM; OPIATE; OXYTOCIN ANTAGONIST; PHYSOSTIGMINE; PILOCARPINE; PIRENZEPINE; PROOPIOMELANOCORTIN; SCOPOLAMINE; SEROTONIN 2 ANTAGONIST; SPIPERONE; SULPIRIDE; UNINDEXED DRUG;

ADRENERGIC ACTIVITY; CHOLINERGIC NERVE CELL; CHOLINERGIC TRANSMISSION; HIPPOCAMPUS; HUMAN; HYPOPHYSECTOMY; HYPOPHYSIS; HYPOTHALAMUS PERIVENTRICULAR NUCLEUS; NERVE TRACT; NONHUMAN; OXYTOCIN RELEASE; PRIORITY JOURNAL; REVIEW; YAWNING;

EID: 77952761230     PISSN: 16604431     EISSN: 16622804     Source Type: Book Series    
DOI: 10.1159/000307085     Document Type: Review

References (104)

1. Barbizet J: Yawning. J Neurol Neurosurg Psychiatry 1958;21:203-209.
2. Baenninger R: On yawning and its functions. Psychonomic Bull Rev 1997;4:198-207.
3. Baenninger R, Greco M: Some antecedents and consequences of yawning. Psychological Record 1991;41:453-460.
4. Greco M, Baenninger R: Effects of yawning and related activities on skin conductance and heart rate. Physiol Behav 1991;50:1067-1069.
5. Provine RR, Hamernik HB: Yawning, Effects of stimulus interest. B Psychonomic Soc 1986;24:437-438.
6. Cummings P, et al: Drowsiness, counter-measures to drowsiness, and the risk of a motor vehicle crash. Inj Prev 2001;7:194-199.
7. Kishida K: Temporal change of subsidiary behavior in monotonous work. J Hum Ergol (Tokyo) 1973;2: 75-89.
8. Koch SW, Koe BK, Bacopoulos NG: Differential effects of the enantiomers of 3-(3-hydroxyphenyl)-N-n-propylpiperidine (3-PPP) at dopamine receptor sites. Eur J Pharmacol 1983;92:279-283.
9. Sakai K, Takahashi Y: Driving and subsidiary behavior of taxi drivers working alternate-day shifts. J Hum Ergol (Tokyo) 1975;4:115-127.
10. Baenninger R, Binkley S, Baenninger M: Field observations of yawning and activity in humans. Physiol Behav 1996;59:421-425.
11. Provine RR, Bamernik HB, Curchack BC: Yawning: Relation to Sleeping and Stretching in Humans. Ethology 1987;76:152-160.
12. Sato-Suzuki I, et al: Cortical arousal induced by microinjection of orexins into the paraventricular nucleus of the rat. Behav Brain Res 2002;128:169-177.
13. Anias J, et al: Circadian variation of yawning behavior. Acta Neurobiol Exp (Wars) 1984;44:179-186.
14. Holmgren B, et al: Food anticipatory yawning rhythm in the rat. Acta Neurobiol Exp (Wars) 1991; 51:97-105.
15. Anderson JR, Wunderlich D: Food-reinforced yawning in Macaca tonkeana. Am J Primatol 1988; 16:165-169.
16. Baenninger R: Some comparative aspects of yawning in Beta splendens, Homo sapiens, Panthera leo, and Papio shinx. J Comp Psychol 1987;101:349-354.
17. Gallup AC, Gallup GG Jr: Yawning and thermoregulation. Physiol Behav 2008;95:10-16.
18. Collins GT, et al: Yawning and hypothermia in rats: effects of dopamine D3 and D2 agonists and antagonists. Psychopharmacology (Berl) 2007;193:159-170.
19. Provine RR: Yawning as a stereotyped action pattern and releasing stimulus. Ethology 1986;72:109-122.
20. Provine RR: Contagious yawning and infant imitation. B Psychonomic Soc 1989;27:125-126.
21. Rizzolatti G, et al: Resonance behaviors and mirror neurons. Arch Ital Biol 1999;137:85-100.
22. Ferrari W, Gessa GL, Vargiu L: Behavioral effects induced by intracisternally injected ACTH and MSH. Ann N Y Acad Sci 1963;104:330-345.
23. Serra G, et al: Hypophysectomy prevents ACTHinduced yawning and penile erection in rats. Pharmacol Biochem Behav 1987;26:277-279.
24. Gessa GL, et al: Stretching and yawning movements after intracerebral injection of ACTH. Rev Can Biol 1967;26:229-236.
25. Argiolas A, et al: ACTH-and alpha-MSH-induced grooming, stretching, yawning and penile erection in male rats: site of action in the brain and role of melanocortin receptors. Brain Res Bull 2000;51:425-431.
26. Argiolas A, et al: Paraventricular nucleus lesion prevents yawning and penile erection induced by apomorphine and oxytocin but not by ACTH in rats. Brain Res 1987;421:349-352.
27. Argiolas A, Melis MR, Gessa GL: Yawning and penile erection: central dopamine-oxytocin-adrenocorticotropin connection. Ann NY Acad Sci 1988; 525:330-337.
28. Argiolas A, et al: d(CH2)5Tyr(Me)-[Orn8]vasotocin, a potent oxytocin antagonist, antagonizes penile erection and yawning induced by oxytocin and apomorphine, but not by ACTH-(1-24). Eur J Pharmacol 1987;134:221-224.
29. Urba-Holmgren R, Gonzalez RM, Holmgren B: Is yawning a cholinergic response? Nature 1977;267: 261-262.
30. Kimura H, et al: Role of adrenergic neuronal activity in the yawning induced by tacrine and NIK-247 in rats. Pharmacol Biochem Behav 1992;43:985-991.
31. Ogura H, et al: Central and peripheral activity of cholinesterase inhibitors as revealed by yawning and fasciculation in rats. Eur J Pharmacol 2001;415: 157-164.
32. Zarrindast MR, Poursoltan M: Interactions of drugs acting on central dopamine receptors and cholinoceptors on yawning responses in the rat induced by apomorphine, bromocriptine or physostigmine. Br J Pharmacol 1989;96:843-848.
33. Ushijima I, et al: Modification of apomorphine-, physostigmine-and pilocarpine-induced yawning after long-term treatment with neuroleptic or cholinergic agents. Arch Int Pharmacodyn Ther 1984; 271:180-188.
34. Yamada K, Furukawa T: Direct evidence for involvement of dopaminergic inhibition and cholinergic activation in yawning. Psychopharmacology (Berl) 1980;67:39-43.
35. Fujikawa M, et al: The new muscarinic M1-receptor agonist YM796 evokes yawning and increases oxytocin secretion from the posterior pituitary gland in rats. Pharmacol Biochem Behav 1996;55:55-60.
36. Fujikawa M, et al: Involvement of beta-adrenoceptors in regulation of the yawning induced by neuropeptides, oxytocin and alpha-melanocyte-stimulating hormone, in rats. Pharmacol Biochem Behav 1995; 50:339-343.
37. Gower AJ: Effects of acetylcholine agonists and antagonists on yawning and analgesia in the rat. Eur J Pharmacol 1987;139:79-89.
38. Wood PL, et al: Increase of hippocampal acetylcholine turnover rate and the stretching-yawning syndrome elicited by alpha-MSH and ACTH. Life Sci 1978;22:673-678.
39. Argiolas A, Melis MR, Gessa GL: Oxytocin: an extremely potent inducer of penile erection and yawning in male rats. Eur J Pharmacol 1986;130:265-272.
40. Collins GT, et al: Dopamine Agonist-Induced Yawning in Rats: A Dopamine D3 Receptor-Mediated Behavior. J Pharmacol Exp Ther 2005;314: 310-319.
41. Melis MR, Stancampiano R, Argiolas A: Hippocampal oxytocin mediates apomorphine-induced penile erection and yawning. Pharmacol Biochem Behav 1992;42:61-66.
42. Melis MR, Argiolas A, Gessa GL: Oxytocin-induced penile erection and yawning: site of action in the brain. Brain Res 1986;398:259-265.
43. Melis MR, Argiolas A, Gessa GL: Evidence that apomorphine induces penile erection and yawning by releasing oxytocin in the central nervous system. Eur J Pharmacol 1989;164:565-570.
44. Melis MR, Stancampiano R, Argiolas A: Penile erection and yawning induced by paraventricular NMDA injection in male rats are mediated by oxytocin. Pharmacol Biochem Behav 1994;48:203-207.
45. Melis MR, et al: Effect of apomorphine on oxytocin concentrations in different brain areas and plasma of male rats. Eur J Pharmacol 1990;182:101-107.
46. Melis MR, Argiolas A: Role of central nitric oxide in the control of penile erection and yawning. Prog Neuropsychopharmacol Biol Psychiatry 1997;21: 899-922.
47. Melis MR, Argiolas A: Nitric oxide donors induce penile erection and yawning when injected in the central nervous system of male rats. Eur J Pharmacol 1995;294:1-9.
48. Melis MR, et al: Nitroglycerin-induced penile erection and yawning in male rats: mechanism of action in the brain. Brain Res Bull 1995;36:527-531.
49. Melis MR, Argiolas A: Nitric oxide synthase inhibitors prevent apomorphine-and oxytocin-induced penile erection and yawning in male rats. Brain Res Bull 1993;32:71-74.
50. Melis MR, Stancampiano R, Argiolas A: Prevention by NG-nitro-L-arginine methyl ester of apomorphine-and oxytocin-induced penile erection and yawning: site of action in the brain. Pharmacol Biochem Behav 1994;48:799-804.
51. Melis MR, Argiolas A: Reduction of drug-induced yawning and penile erection and of noncontact erections in male rats by the activation of GABAA receptors in the paraventricular nucleus: involvement of nitric oxide. Eur J Neurosci 2002;15:852-860.
52. Melis MR, Succu S, Argiolas A: Dopamine agonists increase nitric oxide production in the paraventricular nucleus of the hypothalamus: correlation with penile erection and yawning. Eur J Neurosci 1996;8: 2056-2063.
53. Melis MR, Stancampiano R, Argiolas A: Role of nitric oxide in penile erection and yawning induced by 5-HT1c receptor agonists in male rats. Naunyn Schmiedebergs Arch Pharmacol 1995;351:439-445.
54. Poggioli R, et al: Nitric oxide is involved in the ACTH-induced behavioral syndrome. Peptides 1995;16:1263-1268.
55. Mogilnicka E, Klimek V: Drugs affecting dopamine neurons and yawning behavior. Pharmacol Biochem Behav 1977;7:303-305.
56. Dubuc I, et al: Antagonism of the apomorphineinduced yawning by 'atypical' neuroleptics. Neuropharmacology 1982;21:1203-1206.
57. Holmgren B, Urba-Holmgren R: Interaction of cholinergic and dopaminergic influences on yawning behavior. Acta Neurobiol Exp (Wars) 1980;40:633-642.
58. Stahle L, Ungerstedt U: Assessment of dopamine autoreceptor agonist properties of apomorphine, (+)-3-PPP and (-)-3-PPP by recording of yawning behaviour in rats. Eur J Pharmacol 1984;98:307-310.
59. Dourish CT, Cooper SJ, Philips SR: Yawning elicited by systemic and intrastriatal injection of piribedil and apomorphine in the rat. Psychopharmacology (Berl) 1985;86:175-181.
60. Yamada K, et al: Involvement of septal and striatal dopamine D-2 receptors in yawning behavior in rats. Psychopharmacology (Berl) 1986;90:9-13.
61. Melis MR, Argiolas A, Gessa GL: Apomorphineinduced penile erection and yawning: site of action in brain. Brain Res 1987;415:98-104.
62. Urba-Holmgren R, Holmgren B, Anias J: Pre-and post-synaptic dopaminergic receptors involved in apomorphine-induced yawning. Acta Neurobiol Exp (Wars) 1982;42:115-125.
63. Yamada K, et al: Possible involvement of differing classes of dopamine D-2 receptors in yawning and stereotypy in rats. Psychopharmacology (Berl) 1990; 100:141-144.
64. Stahle L: Do autoreceptors mediate dopamine agonist-induced yawning and suppression of exploration? A critical review. Psychopharmacology (Berl) 1992;106:1-13.
65. Stahle L, Ungerstedt U: Reduction of extracellular dopamine levels can be dissociated from suppression of exploratory behaviour in rats. Acta Physiol Scand 1987;130:533-534.
66. Stahle L, Ungerstedt U: Yawning and suppression of exploration in amphetamine-treated rats, incompatibility with the autoreceptor hypothesis. Psychopharmacology (Berl) 1989;97:553-560.
67. Stahle L, Ungerstedt U: Discrepancy in the time course of EMD 23448 induced yawning and reduction of extracellular dopamine. Psychopharmacology (Berl) 1989;97:275-276.
68. Stahle L, Ungerstedt U: Yawning and suppression of exploration induced by dopamine agonists: no relation to extracellular striatal levels of dopamine. Pharmacol Biochem Behav 1990;35:201-209.
69. Collins GT, et al: Proerectile effects of dopamine D2-like agonists are mediated by the D3 receptor in rats and mice. J Pharmacol Exp Ther 2009;329:210-217.
70. Baladi MG, Newman AH, France CP: Dopamine D3 receptors mediate the discriminative stimulus effects of quinpirole in free-feeding rats. J Pharmacol Exp Ther 2009.
71. Collins GT, et al: Food restriction alters pramipexole-induced yawning, hypothermia, and locomotor activity in rats: Evidence for sensitization of dopamine D2 receptor-mediated effects. J Pharmacol Exp Ther 2008.
72. Collins GT, Woods JH: Drug and Reinforcement History as Determinants of the Response-Maintaining Effects of Quinpirole in the Rat. J Pharmacol Exp Ther 2007;323:599-605.
73. Roeling TA, et al: Behavioural effects of NMDA injected into the hypothalamic paraventricular nucleus of the rat. Brain Res 1991;550:220-224.
74. Melis MR, Stancampiano R, Argiolas A: Effect of excitatory amino acid receptor antagonists on apomorphine-, oxytocin-and ACTH-induced penile erection and yawning in male rats. Eur J Pharmacol 1992;220:43-48.
75. Melis MR, Stancampiano R, Argiolas A: Nitric oxide synthase inhibitors prevent N-methyl-D-aspartic acid-induced penile erection and yawning in male rats. Neurosci Lett 1994;179:9-12.
76. Melis MR, et al: N-methyl-D-aspartic acid-induced penile erection and yawning: role of hypothalamic paraventricular nitric oxide. Eur J Pharmacol 1997; 328:115-123.
77. Urba-Holmgren R, et al: Serotonergic modulation of yawning. Pharmacol Biochem Behav 1979;11:371-372.
78. Berendsen HH, Jenck F, Broekkamp CL: Involvement of 5-HT1C-receptors in drug-induced penile erections in rats. Psychopharmacology (Berl) 1990;101: 57-61.
79. Stancampiano R, Melis MR, Argiolas A: Penile erection and yawning induced by 5-HT1C receptor agonists in male rats: relationship with dopaminergic and oxytocinergic transmission. Eur J Pharmacol 1994;261:149-155.
80. Protais P, et al: Post-synaptic 5-HT1A receptor involvement in yawning and penile erections induced by apomorphine, physostigmine and mCPP in rats. Psychopharmacology (Berl) 1995;120: 376-383.
81. Matsumoto S, et al: Potentiation by serotonergic inhibition of yawning induced by dopamine receptor agonists in rats. Pharmacol Biochem Behav 1989;32:815-818.
82. Okuyama S, et al: Relation between yawning behavior and central serotonergic neuronal system in rats. Naunyn Schmiedebergs Arch Pharmacol 1987;335: 667-672.
83. Simon P, et al: 5-HT1A receptor agonists prevent in rats the yawning and penile erections induced by direct dopamine agonists. Psychopharmacology (Berl) 1992;108:47-50.
84. Fratta W, et al: Reciprocal antagonism between ACTH1-24 and beta-endorphin in rats. Neurosci Lett 1981;24:71-74.
85. Vergoni AV, et al: Tolerance develops to the behavioural effects of ACTH-(1-24) during continuous i.c.v. infusion in rats, and is associated with increased hypothalamic levels of beta-endorphin. Neuropeptides 1989;14:93-98.
86. Melis MR, et al: Prevention by morphine of apomorphine-and oxytocin-induced penile erection and yawning: site of action in the brain. Neuropsychopharmacology 1992;6:17-21.
87. Melis MR, Succu S, Argiolas A: Prevention by morphine of N-methyl-D-aspartic acid-induced penile erection and yawning: involvement of nitric oxide. Brain Res Bull 1997;44:689-694.
88. Melis MR, et al: Prevention by morphine of apomorphine-and oxytocin-induced penile erection and yawning: involvement of nitric oxide. Naunyn Schmiedebergs Arch Pharmacol 1997;355:595-600.
89. Zarrindast MR, Jamshidzadeh A: Inhibitory effect of morphine on yawning induced by cholinoceptor and dopamine D2 receptor activation in rats. Br J Pharmacol 1992;105:675-678.
90. Zharkovsky A, et al: Role of dopamine receptors in the dual effect of naloxone on quinpirole-induced yawning in morphine pretreated rats. Naunyn Schmiedebergs Arch Pharmacol 1993;347:478-482.
91. Himmelsbach CK: Studies of certain addiction characteristics of (a) dihydromorphine ('paramorphan'), (b) dihydrodesoxymorphine-D ('desomorphine'), (c) dihydrodesoxycodeine-D ('desocodeine'), and (d) methyldihydromorphinone ('metopon'). J Pharmacol Exp Ther 1939;67:239-249.
92. Seevers MH: Opiate addiction in the monkey I. Methods of study. J Pharmacol Exp Ther 1936;56: 147-156.
93. Zharkovsky A, et al: Concurrent nimodipine attenuates the withdrawal signs and the increase of cerebral dihydropyridine binding after chronic morphine treatment in rats. Naunyn Schmiedebergs Arch Pharmacol 1993;347:483-486.
94. Doger E, et al: GABAergic modulation of yawning behavior. Pharmacol Biochem Behav 1989;34:237-240.
95. Zarrindast MR, Toloui V, Hashemi B: Effects of GABAergic drugs on physostigmine-induced yawning in rats. Psychopharmacology (Berl) 1995;122: 297-300.
96. Melis MR, et al: Activation of gamma-aminobutyric acid(A) receptors in the paraventricular nucleus of the hypothalamus reduces apomorphine-, N-methyl-D-aspartic acid-and oxytocin-induced penile erection and yawning in male rats. Neurosci Lett 2000; 281:127-130.
97. Nava F, et al: gamma-Hydroxybutyric acid and baclofen decrease extracellular acetylcholine levels in the hippocampus via GABA(B) receptors. Eur J Pharmacol 2001;430:261-263.
98. Ferrari F, Giuliani D: Influence of idazoxan on the dopamine D2 receptor agonist-induced behavioural effects in rats. Eur J Pharmacol 1993;250:51-57.
99. Mogilnicka E, Boissard CG, Delini-Stula A: Effects of apomorphine, TL-99 and 3-PPP on yawning in rats. Neuropharmacology 1984;23:19-22.
100. Gower AJ, Berendsen HH, Broekkamp CL: Antagonism of drug-induced yawning and penile erections in rats. Eur J Pharmacol 1986;122:239-244.
101. Zarrindast MR, et al: Influence of different adrenoceptor agonists and antagonists on physostigmineinduced yawning in rats. Pharmacol Biochem Behav 1999;62:1-5.
102. Baladi MG, France CP: High fat diet and food restriction differentially modify the behavioral effects of quinpirole and raclopride in rats. Eur J Pharmacol 2009;610:55-60.
103. Chen J, et al: Design, synthesis, and evaluation of potent and selective ligands for the dopamine 3 (D3) receptor with a novel in vivo behavioral profile. J Med Chem 2008;51:5905-5908.
104. Sevak RJ, et al: Insulin replacement restores the behavioral effects of quinpirole and raclopride in streptozotocin-treated rats. J Pharmacol Exp Ther 2007;320:1216-1223.