The new muscarinic M1-Receptor agonist YM796 evokes yawning and increases oxytocin secretion from the posterior pituitary gland in rats

Pharmacology Biochemistry and Behavior

Volumn 55, Issue 1, 1996, Pages 55-60

  Fujikawa, Maiko ^a   Yamada, Katsushi ^b   Nagashima, Mariko ^a   Domae, Mariko ^a   Furukawa, Tatsuo ^a  

^a FUKUOKA UNIVERSITY   (Japan)

^b KAGOSHIMA UNIVERSITY   (Japan)

Author keywords

Muscarinic M1 receptors; Oxytocin secretion; Posterior pituitary gland; Radioimmunoassay; Yawning; YM796; Adrenoceptor antagonists

Indexed keywords

2 ETHOXY 1(2H) QUINOLINECARBOXYLIC ACID ETHYL ESTER; 2,8 DIMETHYL 3 METHYLENE 1 OXA 8 AZASPIRO[4.5]DECANE; 4 DIPHENYLACETOXY 1 METHYLPIPERIDINE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; DOPAMINE 2 RECEPTOR BLOCKING AGENT; MECAMYLAMINE; MUSCARINIC AGENT; MUSCARINIC M1 RECEPTOR; MUSCARINIC M1 RECEPTOR AGONIST; MUSCARINIC M1 RECEPTOR ANTAGONIST; MUSCARINIC M3 RECEPTOR ANTAGONIST; MUSCARINIC RECEPTOR BLOCKING AGENT; NEW DRUG; NICOTINIC RECEPTOR BLOCKING AGENT; OXYTOCIN; OXYTOCIN ANTAGONIST; PINDOLOL; PIRENZEPINE; PROLACTIN; SCOPOLAMINE; SPIPERONE; UNCLASSIFIED DRUG; VASOTOCIN DERIVATIVE; 2,8 DIMETHYL 3 METHYLENE 1 OXA 8 AZASPIRO(4,5)DECANE; 2,8-DIMETHYL-3-METHYLENE-1-OXA-8-AZASPIRO(4,5)DECANE; CHOLINERGIC RECEPTOR STIMULATING AGENT; DOPAMINE RECEPTOR BLOCKING AGENT; OXYTOCIN RECEPTOR; SPIRO COMPOUND;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG INHIBITION; DRUG POTENTIATION; HORMONE BLOOD LEVEL; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NEUROHYPOPHYSIS; NONHUMAN; OXYTOCIN RELEASE; PRIORITY JOURNAL; RADIOIMMUNOASSAY; RAT; SUBCUTANEOUS DRUG ADMINISTRATION; YAWNING; ANIMAL; DRUG ANTAGONISM; DRUG EFFECT; IN VITRO STUDY; METABOLISM; WISTAR RAT;

ANIMALIA; POROMITRA OSCITANS;

ADRENERGIC BETA-ANTAGONISTS; ANIMALS; DOPAMINE ANTAGONISTS; INJECTIONS, INTRAVENTRICULAR; MALE; MUSCARINIC ANTAGONISTS; OXYTOCIN; PARASYMPATHOMIMETICS; PINDOLOL; PITUITARY GLAND, POSTERIOR; RATS; RATS, WISTAR; RECEPTORS, OXYTOCIN; SPIRO COMPOUNDS; YAWNING;

EID: 0030229327     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/0091-3057(95)02216-3     Document Type: Article

References (32)

1. 1. Argiolas, A.; Melis, M. R.; Gessa, G. L. Oxytocin: An extremely potent inducer of penile erection and yawning in male rats. Eur. J. Pharmacol. 130:265-272; 1986.
2. 8]-Vasotocin, a potent oxytocin antagonist, antagonizes penile erection and yawning induced by oxytocin and apomorphine, but not by ACTH-(1-24). Eur. J. Pharmacol. 135:221-224; 1987.
3. 3. Bicknell, R. J.; Leng, G. Endogenous opiates regulate oxytocin but not vasopressin secretion from the neurohypophysis. Nature 298:161-162; 1982.
4. 4. Bisset, G. W.; Fairhall, K. M.; Tsuji, K. The effect of neosurugatoxin on the release of neurohypophyseal hormones by nicotine, hypotension and an osmotic stimulus in the rats. Br. J. Pharmacol. 106:685-692; 1992.
5. 5. Bonner, T. I. The molecular basis of muscarinic receptor diversity. Trends Neurosci. 12:148-151; 1989.
6. 6. Bouson, A.; Moser, P. C. Yawning induced by apomorphine, physostigmine or pilocarpine is potentiated by dihydropyridine calcium channel blockers. Psychopharmacology (Berlin) 100:168-172; 1990.
7. 7. Clarke, G.; Caroline, H. D.; Fall, D. W.; Lincolin, P. M.; Lynda, P. M. Effects of cholinoceptor antagonists on the suckling-induced and experimentally evoked release of oxytocin. Br. J. Pharmacol. 63:519-527; 1978.
8. 8. Domae, M.; Yamada, K.; Hanabusa, Y.; Matsumoto, S.; Furukawa, T. Decrease of prolactin secretion via stimulation of pituitary dopamine D-2 receptors after application of talipexole and SND 919. Eur. J. Pharmacol. 179:75-82; 1990.
9. 1 agonist attenuates cognitive dysfunctions in AF64A-treated rats. Neurosci. Lett. 102:325-331; 1989.
10. 10. Fujikawa, M.; Yamada, K.; Nagashima, M.; Furukawa, T. Involvement of β-adrenoceptors in regulation of the yawning induced by neuropeptides, oxytocin and α-melanocyte-stimulating hormone, in rats. Pharmacol. Biochem. Behav. 50:339-343; 1995.
11. 11. Gower, A. J. Effects of acetylcholine agonists and antagonists on yawning and analgesia in the rat. Eur. J. Pharmacol. 139:79-89; 1987.
12. 12. Hammer, R.; Giachetti, A. Muscarinic receptor subtypes: M1 and M2 biochemical and functional characterization. Life Sci. 31:2991-2998; 1982.
13. 13. Higuchi, T.; Honda, K.; Fukuoka, T.; Negoro, H.; Wakabayashi. K. Release of oxytocin during suckling and parturition in the rat. J. Endocrinol. 105:339-346; 1985.
14. 14. Hulme, E. C.; Birdsall, N. J. M.; Buckley, N. J. Muscarinic receptor subtypes. Annu. Rev. Pharmacol. Toxicol. 30:633-673; 1993.
15. 15. Janus, J.; Guzek, J. W. The vasopressin and oxytocin content in the neurohypophysis under conditions of increased beta-adrenergic transmission in euhydrated and dehydrated rats. Exp. Clin. Endocrinol. 95:293-299; 1990.
16. 16. Kimura, H.; Yamada, K.; Nagashima, M.; Matsumoto, S.; Ishii, Y.; Yoshida, S.; Fujii, K.; Furukawa, T. Role of adrenergic neuronal activity in the yawning induced by tacrine and NIK-247 in rats. Pharmacol. Biochem. Behav. 43:985-991; 1992a.
17. 17. Kimura, H.; Yamada, K.; Nakaoda, M.; Nagashima, M.; Furukawa, T. Different roles of central α-and β-adrenoceptors in the regulation of yawning responses in rats. In: Fujiwara, M.; Sugimoto, T.; Kogure, K., eds. α-Adrenoceptors: Signal transduction, ionic channels and effector organs. Tokyo: Excerpta Medica; 1992b: 209-212.
18. 18. Luck, M. R. Cholinergic stimulation, through muscarinic receptors, of oxytocin and progesterone secretion from bovine granulosa cells undergoing spontaneous luteinization in serum-free culture. Endocrinology 90:1256-1262; 1990.
19. 2-receptors after administration of SND 919 in rats. Naunyn Schmiedebergs Arch. Pharmacol. 340:21-25; 1989.
20. 20. Melis, M. R.; Stancampiano, R.; Argiolas, A. Hippocampal oxytocin mediates apomorphine-induced penile erection and yawning. Pharmacol. Biochem. Behav. 42:61-66; 1992.
21. 1 muscarinic receptor agonist on the central cholmergic system, evaluated by brain microdialysis. Neurosci. Lett. 144:95-100; 1990.
22. 22. Pellegrino, L. J.; Pellegrino, A. S.; Cushman, A. J. A stereotaxic atlas of the rat brain. New York: Plemium Press; 1979.
23. 23. Suemaru, K.; Oishi, R.; Gomita, Y. Characteristics of tail-tremor induced by nicotine in rats. Naunyn Schmiedebergs Arch. Pharmacol. 350:153-157; 1994.
24. 24. Urba-Holmgren, R.; Gonzalez, M. R.; Holmgren, B. Is yawning a cholinergic responses? Nature 267:261-262; 1977.
25. 25. Ushijima, I.; Yamada, K.; Inoue, T.; Tokunaga, T.; Furukawa, T.; Noda Y. Muscarinic and nicotinic effects on yawning and tongue protruding in the rats. Pharmacol. Biochem. Behav. 21:297-300; 1984.
26. 26. Wanibuchi, F.; Konishi, T.; Harada, M.; Terai, M.; Hidaka, K.; Tamura, T.; Tsukamoto, S.; Usuda, S. Pharmacological studies on novel muscarinic agonists, 1-oxa-8-azaspiro[4.5]decane derivatives, YM796 and YM954. Eur. J. Pharmacot. 187:479-486; 1990.
27. 27. Yamada, K.; Furukawa, T. Direct evidence for involvement of dopaminergic inhibition and cholinergic activation in yawning. Psychopharmacology (Berlin) 67:39-43; 1980.
28. 28. Yamada, K.; Matsumoto, S.; Nagashima, M.; Kumagai, M.; Kimura, H.; Furukawa, T. Involvement of central β-adrenoceptors in the regulation of yawning responses. Naunyn Schmiedebergs Arch. Pharmacol. 340:26-30; 1989.
29. 29. Yamada, K.; Matsumoto, S.; Nagashima, M.; Shirakawa, K.; Furukawa, T. Potentiation of yawning responses to the dopamine receptor agonists B-HT 920 and SND 919 by pindolol in the rat. J. Neural Transm. 79:19-24; 1990.
30. 30. Yamada, K.; Matsuo, N.; Matsuda, T.; Tanaka, M.; Furukawa, T.; Koja, T.; Fukuda, T. Effects of new neuroleptics, isofloxythepin and zotepine, on post-decapitation convulsions and prolactin secretion in rats. Pharmacol. Biochem. Behav. 24:1445-1449; 1986.
31. 31. Yamashita, H.; Wanibuchi, F.; Nishida, T.; Hidaka, K.; Tsukamoto, S.; Koshiya, K.; Usuda, S. Effects of a novel muscarinic agonist YM796 on spatial and working memory impairments in rats. Jpn. J. Pharmacol. 61 (Suppl. I):91; 1993.
32. 32. Zarrindast, M. R.; Poursoltan, M. Interactions of drugs acting on central dopamine receptors and cholinoceptors on yawning responses in the rat induced by apomorphine, bromocriptine or physostigmine. Br. J. Pharmacol. 96:843-848; 1989.