Efficacy of a norvancomycin-loaded, PDLLA-coated plate in preventing early infection of rabbit tibia fracture

Orthopedics

Volumn 33, Issue 5, 2010, Pages

  Fei, Jun ^a,d   Yu, Hong Jun ^c   Pan, Chang Jiang ^b   Zhao, Chang Hong ^b   Zhou, Yong Gang ^d   Wang, Yan ^a,d  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

^b CHONGQING UNIVERSITY   (China)

^c SOUTHWEST HOSPITAL   (China)

^d CHINESE PLA GENERAL HOSPITAL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

POLYLACTIC ACID; VANCOMYCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIUM CULTURE; BONE INFECTION; DRUG COATING; DRUG EFFICACY; FEMALE; INFECTION PREVENTION; MALE; NONHUMAN; PLATE FIXATION; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS INFECTION; TIBIA FRACTURE;

ANIMALS; ANTI-BACTERIAL AGENTS; BLOOD SEDIMENTATION; BONE PLATES; C-REACTIVE PROTEIN; POLYESTERS; PROSTHESIS-RELATED INFECTIONS; RABBITS; TIBIA; TIBIAL FRACTURES; VANCOMYCIN;

EID: 77952747763     PISSN: 01477447     EISSN: None     Source Type: Journal    
DOI: 10.3928/01477447-20100329-06     Document Type: Article

References (25)

1. Darouiche RO. Treatment of infections associated with surgical implants. N Engl J Med. 2004; 350 (14):1422-1429.
2. Flock JI, Brennan F. Antibodies that block adherence of to fibronectin. Trends Microbiol. 1999; 7 (4):140-141.
3. Hebert CK, Williams RE, Levy RS, Barrack RL. Cost of treating an infected total knee replacement. Clin Orthop Relat Res. 1996; (331):140-145. (Pubitemid 26357698)
4. Obremskey WT, Bhandari M, Dirschl DR, Shemitsch E. Internal fixation versus arthroplasty of comminuted fractures of the distal humerus. J Orthop Trauma. 2003; 17(6):463-465. (Pubitemid 36939338)
5. Perren SM. Evolution of the internal fixation of long bone fractures. The scientific basis of biological internal fixation: choosing a new balance between stability and biology. J Bone Joint Surg Br. 2002; 84(8):1093-1110.
6. Faisham WI, Nordin S, Aidura M. Bacteriological study and its role in the management of open tibial fracture. Med J Malaysia. 2001; 56(2):201-206.
7. Gustilo RB, Anderson JT. Prevention of infection in the treatment of one thousand and twenty-five open fractures of long bones: retrospective and prospective analyses. J Bone Joint Surg Am. 1976; 58(4):453-458.
8. Gustilo RB, Merkow RL, Templeman D. The management of open fractures. J Bone Joint Surg Am. 1990; 72(2):299-304.
9. Bach AW, Hansen ST Jr. Plates versus external fixation in severe open tibial shaft fractures. A randomized trial. Clin Orthop Relat Res. 1989; (241):89-94. (Pubitemid 19101246)
10. Worlock P, Slack R, Harvey L, Mawhinney R. The prevention of infection in open fractures: an experimental study of the effect of fracture stability. Injury. 1994; 25(1):31-38. (Pubitemid 24014855)
11. Lucke M, Schmidmaier G, Sadoni S, et al. Gentamicin coating of metallic implants reduces implantrelated osteomyelitis in rats. Bone. 2003; 32(5):521-531. (Pubitemid 39665711)
12. Tang L, Zhao C, Xiong Y,et al. Preparation, release profiles, and antibacterial properties of vancomycin-loaded poly(D,L-lactic) titanium alloy plates. Orthopedics. 2009; 32(5):324.
13. Arens S, Schlegel U, Printzen G, Ziegler WJ, Perren SM, Hansis M. Influence of materials for fixation implants on local infection. An experimental study of steel versus titanium DCP in rabbits. J Bone Joint Surg Br. 1996; 78(4):647-651. (Pubitemid 26241770)
14. Worlock P, Slack R, Harvey L, Mawhinney R. An experimental model of post-traumatic osteomyelitis in rabbits. Br J Exp Pathol. 1988; 69(2):235-244.
15. Lucke M, Wildemann B, Sadoni S, et al. Systemic versus local application of gentamicin in prophylaxis of implant-related osteomyelitis in a rat model. Bone. 2005; 36(5):770-778.
16. Petty W, Spanier S, Shuster JJ, Silverthorne C. The influence of skeletal implants on incidence of infection. Experiments in a canine model. J Bone Joint Surg Am. 1985; 67(8):1236-1244.
17. Alturfan AA, Eralp L, Emekli N. Investigation of inflammatory and hemostatic parameters in female patients undergoing total knee arthroplasty surgery. Inflammation. 2008; 31(6):414-421.
18. Wei J, Gu J. High efficiency liquid chromatography for the detection of blood concentration of norvancomycin. China Journal of Hospital Pharmacy. 2000; 20(8):458.
19. Barth E, Myrvik QM, Wagner W, Gristina AG. In vitro and in vivo comparative colonization of Staphylococcus aureus and Staphylococcus epidermidis on orthopaedic implant materials. Biomaterials. 1989; 10(5):325-328.
20. von Eiff C, Proctor RA, Peters G. Coagulase-negative staphylococci. Pathogens have major role in nosocomial infections. Postgrad Med. 2001; 110(4):63-64.
21. Ozaki T, Yoshitaka T, Kunisada T, Dan'ura T, Naito N, Inoue H. Vancomycin-impregnated polymethylmethacrylate beads for methicillin-resistant Staphylococcus aureus (MRSA) infection: report of two cases. J Orthop Sci. 1998; 3(3):163-168. (Pubitemid 28259346)
22. Kelm J, Anagnostakos K, Regitz T, Schmitt E, Schneider G, Ahlhelm F. MRSA-infections-treatment with intraoperatively produced gentamycin-vancomycin PMMA beads [in German]. Chirurg. 2004; 75(10):988-995.
23. Trampuz A, Zimmerli W. Diagnosis and treatment of infections associated with fracture-fixation devices. Injury. 2006; 37(Suppl 2):S59-66.
24. Ochsner PE, Hailemariam S. Histology of osteosynthesis associated bone infection. Injury. 2006; 37(Suppl 2):S49-58.
25. Riise ØR, Kirkhus E, Handeland KS, et al. Childhood osteomyelitis-incidence and differentiation from other acute onset musculoskeletal features in a population-based study. BMC Pediatr. 2008; (8):45.