Mechanical and geometric property characterization of dry-coated tablets with contact ultrasonic techniques

International Journal of Pharmaceutics

Volumn 392, Issue 1-2, 2010, Pages 148-155

  Liu, Jingfei ^a   Cetinkaya, Cetin ^a  

^a Clarkson University   (United States)

Author keywords

Acoustic monitoring techniques; Core eccentricity; Dry coated tablets; Mechanical properties; Process Analytical Technology (PAT); Real time compaction monitoring

Indexed keywords

DRUG;

ARTICLE; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DRUG COATING; DRUG DOSAGE FORM; DRY COATED TABLET; GEOMETRY; PRIORITY JOURNAL; TABLET; TABLET THICKNESS; ULTRASOUND; YOUNG MODULUS;

DRUG COMPOUNDING; DRUG STABILITY; MECHANICAL PROCESSES; SURFACE PROPERTIES; TABLETS, ENTERIC-COATED; TECHNOLOGY, PHARMACEUTICAL; ULTRASONICS;

EID: 77952745053     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2010.03.060     Document Type: Article

References (11)

1. Akseli I., Becker D.C., Cetinkaya C. Ultrasonic determination of Young's moduli of the coat and core materials of a drug tablet. Int. J. Pharm. 2009, 370:17-25.
2. Akseli I., Cetinkaya C. Drug tablet thickness estimations using air-coupled acoustics. Int. J. Pharm. 2008, 351:165-173.
3. Akseli I., Cetinkaya C. Air-coupled non-contact mechanical property determination of drug tablets. Int. J. Pharm. 2008, 359:25-34.
4. Akseli I., Hancock B., Cetinkaya C. Nondestructive determination of anisotropic mechanical properties of pharmaceutical dosage forms. Int. J. Pharm. 2009, 377:35-44.
5. Hussain A.S., Watts C., Afnan A.M., Wu H. Foreword. J. Process Anal. Technol. 2004, 1:3-4.
6. Lin S.Y., Lin K.H., Li M.J. Formulation design of double-layer in the outer shell of dry-coated tablet to modulate lag time and time-controlled dissolution function: studies on micronized ethylcellulose for dosage form design (VII). AAPS J. 2004, 6.
7. Mullarney M.P., Hancock B.C. Mechanical property anisotropy of pharmaceutical excipient compacts. Int. J. Pharm. 2006, 314:9-14.
8. Takeuchi H., Yasuji T., Yamamoto H., Kawashima Y. Spray-dried lactose composite particles containing an ion complex of alginate-chitosan for designing a dry-coated tablet having a time-controlled releasing function. Pharm. Res. 2000, 17:94-99.
9. Ozeki Y., Watanabe Y., Inoue S., Danjo K. Evaluation of the compression characteristics and physical properties of the newly invented one-step dry-coated tablets. Int. J. Pharm. 2003, 267:69-78.
10. Ozeki Y., Ando M., Watanabe Y., Danjo K. Evaluation of novel one-step dry-coated tablets as a platform for delayed-release tablets. J. Control. Release 2004, 95:51-60.
11. Varghese I., Cetinkaya C. Non-contact photo-acoustic defect detection in drug tablets. J. Pharm. Sci. 2007, 96:2125-2133.