Rapid determination of finasteride in human plasma by UPLC-MS/MS and its application to clinical pharmacokinetic study

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 878, Issue 20, 2010, Pages 1718-1723

  Phapale, Prasad B ^a,b   Lee, Hae Won ^a,b   Lim, Mi sun ^a,b   Kim, Eun Hee ^b   Kim, Sung Doo ^b   Park, Jeonghyeon ^a,b   Lee, Miran ^a,b   Hwang, Sung Kyu ^b   Yoon, Young Ran ^a,b  

^a Kyungpook National University School of Medicine   (South Korea)

^b Kyungpook National University Hospital   (South Korea)

Author keywords

Finasteride; Human plasma; Method validation; Pharmacokinetic study; UPLC MS MS

Indexed keywords

ANALYTES; AUTOSAMPLERS; CARBAMAZEPINE; CLINICAL PHARMACOKINETICS; CONTROL LEVEL; ETHYL ACETATES; EXTRACTION RECOVERY; HIGH-THROUGHPUT ANALYSIS; HUMAN PLASMAS; INTERNAL STANDARDS; ION PAIRS; LIMIT OF QUANTITATIONS; LINEAR RESPONSE; LIQUID-LIQUID EXTRACTION; MS/MS ANALYSIS; ORAL ADMINISTRATION; PHARMACOKINETIC STUDIES; PLASMA SAMPLES; PROTONATED; QUADRUPOLES; RAPID DETERMINATION; RELATIVE STANDARD DEVIATIONS; REVERSED PHASE; SENSITIVE METHOD; ULTRAPERFORMANCE LIQUID CHROMATOGRAPHY; UPLC-MS/MS;

AMIDES; ESTERS; LIQUID CHROMATOGRAPHY; LIQUIDS; MASS SPECTROMETRY; PHARMACOKINETICS; PLASMA (HUMAN); SOLVENT EXTRACTION;

PLASMAS;

ACETIC ACID ETHYL ESTER; CARBAMAZEPINE; FINASTERIDE;

ACCURACY; ADULT; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG STRUCTURE; EVAPORATION; HIGH THROUGHPUT SCREENING; HUMAN; KOREA; LIQUID LIQUID EXTRACTION; MALE; NORMAL HUMAN; PRIORITY JOURNAL; QUALITY CONTROL; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; VALIDATION STUDY; VOLUNTEER;

ADULT; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FINASTERIDE; HUMANS; MALE; TANDEM MASS SPECTROMETRY;

EID: 77952742186     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2010.04.029     Document Type: Article

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