Are early human chorionic gonadotropin levels after methotrexate therapy a predictor of response in ectopic pregnancy?

American Journal of Obstetrics and Gynecology

Volumn 202, Issue 6, 2010, Pages 630.e1-630.e5

  Nguyen, Quyen ^a   Kapitz, Martha ^a   Downes, Katheryne ^a   Silva, Celso ^a  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

ectopic pregnancy; human chorionic gonadotropin; methotrexate; treatment success

Indexed keywords

CHORIONIC GONADOTROPIN BETA SUBUNIT; METHOTREXATE;

ADULT; AGE DISTRIBUTION; ARTICLE; BLOOD CELL COUNT; DRUG RESPONSE; ECTOPIC PREGNANCY; FALSE POSITIVE RESULT; FEMALE; HUMAN; MAJOR CLINICAL STUDY; PREDICTION; PRIORITY JOURNAL; SINGLE DRUG DOSE; SMOKING; TRANSVAGINAL ECHOGRAPHY; TROPHOBLAST;

EID: 77952720264     PISSN: 00029378     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ajog.2010.03.022     Document Type: Article

References (14)

1. Centers for Disease Control and Prevention. Ectopic pregnancy: United States, 1990-1992. MMWR Morb Mortal Wkly Rep 44 (1995) 46-48
2. Bakken I.J. Chlamydia trachomatis and ectopic pregnancy: recent epidemiological findings. Curr Opin Infect Dis 21 (2008) 77-82
3. Van Den Eeden S.K., Shun J., Bruce C., and Glasser M. Ectopic pregnancy rate and treatment utilization in a large managed care organization. Obstet Gynecol 105 (2005) 1052-1057
4. Hejenius P.J., Mol F., Mol B.W., Bossuyt P.M., Ankum W.M., and van der Veen F. Interventions for tubal pregnancy. Cochrane Database Syst Rev 1 (2007) CD000324
5. Stovall T.G., Ling F.W., Carson S.A., and Buster J.E. Nonsurgical diagnosis and treatment of tubal pregnancy. Fertil Steril 54 (1990) 537-538
6. Bixby S., Tello R., and Kulihowska E. Presence of a yolk sac on transvaginal sonography is the most reliable predictor of single-dose methotrexate treatment failure in ectopic pregnancy. J Ultrasound Med 24 (2005) 591-598
7. Stovall T.G., Ling F.W., and Gray L.A. Single dose methotrexate for the treatment of ectopic pregnancy. Obstet Gynecol 77 (1991) 754-757
8. Stovall T.G., and Ling F.W. Single dose MTX: an expanded clinical trial. Am J Obstet Gynecol 168 (1993) 1759-1762
9. Kirk E., Condous G., Van Calster B., et al. A validation of the most commonly used protocol to predict the success of single-dose methotrexate in the treatment of ectopic pregnancy. Hum Reprod 22 (2007) 858-863
10. Dilbaz S., Caliskan E., Kilbaz B., Degirmenci O., and Haberal A. Predictors of methotrexate treatment failure in ectopic pregnancy. J Reprod Med 51 (2006) 87-93
11. Agostini A., Blanc K., Ronda I., et al. Prognostic value of human chorionic gonadotropin changes after methotrexate injection for ectopic pregnancy. Fertil Steril 88 (2007) 504-506
12. Gabbur N., Sherer D.M., Hellmann M., et al. Do serum beta-human chorionic gonadotropin levels on day 4 following MTX treatment of patients with ectopic pregnancy predict successful single dose therapy?. Am J Perinatol 23 (2006) 193
13. The Practice Committee of the American Society for Reproductive Medicine. Medical treatment of ectopic pregnancy. Fertil Steril 5 (2008) 206-212
14. Soares R., Elito J., and Camano L. Increment in β-hCG in the 48-h period prior to treatment: a new variable predictive of therapeutic success treatment of ectopic pregnancy with methotrexate. Arch Gynecol Obstet 278 (2008) 319-324