Interventions for tubal ectopic pregnancy

Cochrane Database of Systematic Reviews

Volumn , Issue 1, 2007, Pages

  Hajenius, P J ^a   Mol, F ^b   Mol, B W J ^b   Bossuyt, P M M ^b   Ankum, W M ^b   Van Der Veen, F ^b  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b NONE

Author keywords

Abortifacient agents, nonsteroidal; Female; Humans; Methotrexate; Pregnancy; Pregnancy, tubal *therapy ; Randomized controlled trials as topic; Salpingostomy

Indexed keywords

CHORIONIC GONADOTROPIN ANTIBODY; CONJUGATED ESTROGEN; DACTINOMYCIN; ETOPOSIDE; FOLINIC ACID; GLUCOSE; IODINATED POPPYSEED OIL; METHOTREXATE; MIFEPRISTONE; OXYTOCIN; POTASSIUM CHLORIDE; PROSTAGLANDIN; PROSTAGLANDIN E2 DERIVATIVE; PROSTAGLANDIN F2 ALPHA; SODIUM CHLORIDE; SULPROSTONE; VASOPRESSIN;

ABSENCE OF SIDE EFFECTS; ALOPECIA; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; COST EFFECTIVENESS ANALYSIS; DRUG DOSE COMPARISON; DRUG WITHDRAWAL; DRY EYE; FEMALE; FEMALE FERTILITY; GASTRITIS; HUMAN; LAPAROSCOPIC SURGERY; LOW DRUG DOSE; MOUTH ULCER; OUTCOME ASSESSMENT; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; REVIEW; SALPINGECTOMY; SALPINGOSTOMY; SINGLE DRUG DOSE; STOMATITIS; TREATMENT OUTCOME; UNSPECIFIED SIDE EFFECT; UTERINE TUBE PREGNANCY; VAGINAL DRYNESS;

EID: 35248880254     PISSN: 1469493X     EISSN: None     Source Type: Journal    
DOI: 10.1002/14651858.CD000324.pub2     Document Type: Review

References (110)

1. Alleyassin 2006 {published data only} Alleyassin A, Khademi A, Aghahosseini M, Safdarian L, Badenoosh B, Akbari Hamed E. Comparison of success rates in the medical management of ectopic pregnancy with single-dose and multiple-dose administration of methotrexate: a prospective, randomized clinical trial. Fertility and Sterility 2006;85(6):1661-6.
2. Cohen 1996 {published data only} Cohen DR, Falcone T, Khalife S, Hemmings R. Methotrexate: Local versus intramuscular. Fertility & Sterility 1996;65:206-7.
3. Dias Pereira 1999 {published data only} Dias Pereira G, Hajenius PJ, Mol BWJ, Ankum WM, Hemrika DJ, Bossuyt PMM, et al.Fertility outcome after systemic methotrexate and laparoscopic salpingostomy for tubal pregnancy. Lancet 1999;353:724-5.
4. Egarter 1991 {published data only} Egarter C, Kiss H, Husslein P. Prostaglandin versus expectant management in early tubal pregnancy. Prostaglandins Leukotrienes & Essential Fatty Acids 1991;42:177-9.
5. El-Sherbiny 2003 {published data only} El-Sherbiny MT, El-Gharieb IH, Mera IM. Methotrexate verus laparoscopic surgery for the management of unruptured tubal pregnancy. Middle east Fertility Society Journal 2003;8(3):256-62.
6. Elmoghazy 2000 {published data only} Elmoghazy DAM, Nour-El-Dine NM. Prevention of persistent ectopic pregnancy with single dose methotrexate after surgical conservation of the tube. Abstracts of the XVI FIGO World Congress of Obstetrics & Gynecology. Washington DC, USA: 2000:57.
7. Fedele 1998 {published data only} Fedele L, Bianchi S, Tozzi L, Zanconato G, Silvestre V. Intramesosalpingeal injection of oxytocin in conservative laparoscopic treatment for tubal pregnancy: preliminary results. Human Reproduction 1998;13:3042-4.
8. Fernandez 1991 {published data only} Fernandez H, Baton C. Treatment of ectopic pregnancy by transvaginal aspiration: Prospective randomized clinical trial of Methotrexate versus Sulprostone by sonographic injection followed by systemic injection. Contraception, Fertilite, Sexualite 1990;18(4):261-5.
9. *Fernandez H, Baton C, Lelaidier C, Frydman R. Conservative management of ectopic pregnancy: prospective randomized clinical trial of methotrexate versus prostaglandin sulprostone by combined transvaginal and systemic administration. Fertility & Sterility 1991;55:746-50.
10. Fernandez 1994 {published data only} Fernandez H, Bourget P, Ville Y, Lelaidier C, Frydman R. Treatment of unruptured tubal pregnancy with methotrexate: pharmacokinetic analysis of local versus intramuscular administration. Fertility & Sterility 1994;62:943-7.
11. Fernandez 1995 {published data only} *Fernandez H, Pauthier S, Doumerc S, Lelaidier C, Olivennes F, Ville Y, et al.Ultrasound guided injection of methotrexate versus laparoscopic salpingotomy in ectopic pregnancy. Fertility & Sterility 1995;63:25-9.
12. Fernandez H, Pauthier S, Sitbon D, Vincent Y, Doumerc S. Role of conservative therapy and medical treatment in ectopic pregnancy: literature review and clinical trial comparing medical treatment and conservative laparoscopic treatment. Contraception Fertilite Sexualite 1996;24:297-302.
13. Fernandez 1998 {published data only} Fernandez H, Yves Vincent S, Pauthier S, Audibert F, Frydman R. Randomized trial of conservative laparoscopic treatment and methotrexate administration in ectopic pregnancy and subsequent fertility. Human Reproduction 1998;13:3239-43.
14. Fujishita 1995b {published data only} Fujishita A, Ishimaru T, Masuzaki H, Samejima T, Matsuwaki T, Ortega Chavez R, et al.Local injection of methotrexate dissolved in saline versusmethotrexate suspensions for the conservative treatment of ectopic pregnancy. Human Reproduction 1995;10:3280-3.
15. Fujishita 2004 {published data only} Fujishita A, Masuzaki H, Newaz Khan K, Kitajima M, Hiraki K, Ishimaru T. Laparoscopic salpingotomy for tubal pregnancy: comparison of linear salpingotomy with and without suturing. Human Reproduction 2004;19(5):1195-1200.
16. Gazvani 1998 {published data only} Gazvani MR, Baruah DN, Alfirevic Z, Emery SJ. Mifepristone in combination with methotrexate for the medical mangement of tubal pregnancy: a randomized controlled trial. Human Reproduction 1998;13:1987-90.
17. Gjelland 1995 {published data only} Gjelland K, Hordnes K, Tjugum J, Augensen K, Bergsjø P. Treatment of ectopic pregnancy by local injection of hypertonic glucose: a randomized trial comparing administration guided by transvaginal ultrasound or laparoscopy. Acta Obstetricia et Gynecologica Scandinavica 1995;74:629-34.
18. Graczykowski 1997 {published data only} Graczykowski JW, Mishell DR. Methotrexate prophylaxis for persistent ectopic pregnancy after conservative treatment by salpingostomy. Obstetrics & Gynecology 1997;89:118-22.
19. Gray 1995 {published data only} Gray DT, Thorburn J, Lundorff P, Strandell A, Lindblom B. A cost-effectiveness study of a randomised trial of laparoscopy versus laparotomy for ectopic pregnancy. Lancet 1995;345:1139-43.
20. Hajenius 1997 {published data only} *Hajenius PJ, Engelsbel S, Mol BWJ, Van der Veen F, Ankum WM, Bossuyt PMM, et al.Randomised trial of systemic methotrexate versus laparoscopic salpingostomy in tubal pregnancy. Lancet 1997;350:774-9.
21. Hordnes 1997 {published data only} Hordnes K. Reproductive outcome after treatment of ectopic pregnancy with local injection of hypertonic glucose. Acta Obstetricia et Gynecologica Scandinavica 1997;76:703-5.
22. Klauser 2005 {unpublished data only} Klauser CK, May WL, Johnson VK, Cowan BD, Hines RS. Methotrexate for ectopic pregnancy: a randomized single dose compared with multiple dose. Obstetrics and Gynaecology. 2005; Vol. 105:64S.
23. Korhonen 1996 {published data only} Korhonen J, Stenman U, Ylostalo P. Low-dose oralmethotrexate with expectant management of ectopic pregnancy. Obstetrics & Gynecology 1996;88:775-8.
24. Landstrom 1998 {published data only} Landstrom G, Bryman I, Ekstrom P, Engman M, Gunnarsson J, Hjersing M, et al.Ectopic pregnancy: local medical treatment versus oral methotrexate therapy - a multicentre pilot study. Human Reproduction 1998;13:38.
25. Lang 1990 {published data only} Lang PF, Weiss PA, Mayer HO, Haas JG, Honigl W. Conservative treatment of ectopic pregnancy with local injection of hyperosmolar glucose solution or prostaglandin F2a: a prospective randomised study. Lancet 1990;336:78-81.
26. Lundorff 1991a {published data only} Lundorff P. Laparoscopic surgery in ectopic pregnancy. Acta Obstetrica et Gynecologica Scandinavica 1997;164:81-4.
27. Lundorff P. Treatment of ectopics and subsequent adhesion formation. Progress in Clinical Biological Research 1993;381:139-47.
28. *Lundorff P, Thorburn J, Hahlin M, Kallfelt B, Lindblom B. Laparoscopic surgery in ectopic pregnancy. A randomized trial versus laparotomy. Acta Obstetricia et Gynecologica Scandinavica 1991;70:343-8.
29. Lundorff 1991b {published data only} Lindblom B, Lundorff P, Thorburn J. Second-look laparoscopy after ectopic pregnancy. Proceedings of the 6th annual Congress of the European Scociety for Gynaecological Endoscopy. Birmingham, UK: December 1997; Vol. Supplement 2:1.
30. Lundorff P. Treatment of ectopics and subsequent adhesion formation. Progress in Clinical Biological Research 1993;381:139-47.
31. *Lundorff P, Hahlin M, Kallfelt B, Thorburn J, Lindblom B. Adhesion formation after laparoscopic surgery in tubal pregnancy: a randomized trial versus laparotomy. Fertility& Sterility 1991;55:911-5.
32. Lundorff 1992 {published data only} Lundorff P. Treatment of ectopics and subsequent adhesion formation. Progress in Clinical Biological Research 1993;381:139-47.
33. Lundorff P, Thorburn J, Lindblom B. Fertility after conservative surgical treatment of ectopic pregnancy, evaluated in a ranomized trial. Ugeskr-Laeger 1993;155(41):3282-6.
34. *Lundorff P, Thorburn J, Lindblom B. Fertility outcome after conservative surgical treatment of ectopic pregnancy evaluated in a randomized trial. Fertility & Sterility 1992;57:998-1002.
35. Mol 1999a {published data only} Mol BWJ, Hajenius PJ, Engelsbel S, Ankum WM, Hemrika DJ, Van der Veen F, et al.The treatment of tubal pregnancy in The Netherlands: an economic evaluation of systemic methotrexate and laparoscopic salpingostomy. American Journal of Obstetrics & Gynecology 1999;181:945-51.
36. Mottla 1992 {published data only} Mottla GL, Rulin MC, Guzick DS. Lack of resolution of ectopic pregnancy by intratubal injection ofmethotrexate. Fertility & Sterility 1992;57:685-7.
37. Nieuwkerk 1998a {published data only} Nieuwkerk PT, Hajenius PJ, Ankum WM, Van der Veen F, Wijker W, Bossuyt PMM. Systemic methotrexate therapy versus laparoscopic salpingostomy in patients with tubal pregnancy. Part I. Impact on patients' health related quality of life. Fertility & Sterility 1998;70:511-7.
38. Rozenberg 2003 {published data only} Garbin O, de Tayrac R, de Poncheville L, Coiffic J, Lucot JP, Le Goueff F, et al.Medical treatment of ectopic pregnancy; a randomized clinical trial comparing methotrexate- mifepristone and methotrexate-placebo. J Gynecol Obstet Biol Reprod 2004;33(5):391-400.
39. *Rozenberg P, Chevret S, Camus E, de Tyrac R, Garbin O, Poncheville L, et al.Medical treatment of ectopic pregnancies: a randomized clinical trial comapring methotrexate-mifepristone and methotrexate-placebo. Human Reproduction 2003;18(9):1802-8.
40. Sadan 2001 {published data only} Sadan O, Ginath S, Debby A, Rotmensch S, Golan A, Zakut H, et al.Methotrexate versus hyperosmolar glucose in the treatment of extrauterine pregnancy. Archives of Gynecology Obstetrics 2001;265:82-4.
41. Saraj 1998 {published data only} Saraj AJ, Wilcox JG, Najmabadi S, Stein SM, Johnson MB, Paulson RJ. Resolution of hormonal markers of ectopic gestation: a randomized trial comparing single dose intramuscular methotrexate with salpingostomy. Obstetrics & Gynecology 1998;92:989-94.
42. Sharma 2003 {published data only} Sharma JB, Gupta S, Malhotra M, Arora R. A randomized controlled comparison of minilaparotomy and laparotomy in ectopic pregnancy cases. Indian Journal of Medical Sciences 2003;57(11):493-500.
43. Shulman 1992 {published data only} Shulman A, Maymon R, Zmira N, Lotan M, Holtzinger M, Bahary C. Conservative treatment of ectopic pregnancy and its effect on corpus luteum activity. Gynecologic Obstetric Investigation 1992;33:161-4.
44. Sowter 2001a {published data only} Sowter MC, Farquhar CM, Petrie KJ, Gudex G. A randomised trial comparing single dose systemic methotrexate and laparoscopic surgery for the treatment of unruptured ectopic pregnancy. British Journal of Obstetrics & Gynaecology 2001;108(2):192-203.
45. Sowter 2001b {published data only} Sowter MC, Farquhar CM, Gudex G. An economic evaluation of single dose systemic methotrexate and laparoscopic surgery for the treatment of unruptured ectopic pregnancy. British Journal of Obstetrics & Gynaecology 2001;108(2):204- 12.
46. Tulandi 1991a {published data only} Tulandi T, Guralnick M. Treatment of tubal ectopic pregnancy by salpingotomy with or without tubal suturing and salpingectomy. Fertility & Sterility 1991;55:53-5.
47. Tzafettas 1994 {published data only} Tzafettas J, Anapliotis S, Zournatzi V, Boucklis A, Oxouzoglou N, Bondis J. Transvaginal intra amniotic injection of methotrexate in early ectopic pregnancy. Advantages over the laparoscopic approach. Early Human Development 1994;39:101-7.
48. Ugur 1996 {published data only} Ugur M, Yesilyurt H, Soysal S, Gokmen O. Prophylactic vasopressin during laparoscopic salpingotomy for ectopic pregnancy. Journal of the American Association Gynecologic Laparoscopists 1996;3:365-8.
49. Vermesh 1989 {published data only} Vermesh M, Silva PD, Rosen GF, Stein AL, Fossum GT, Sauer MV. Management of unruptured ectopic gestation by linear salpingostomy: a prospective, randomized clinical trial of laparoscopy versus laparotomy. Obstetrics & Gynecology 1989;73:400-4.
50. Vermesh 1992 {published data only} Vermesh M, Presser SC. Reproductive outcome after linear salpingostomy for ectopic gestation: a prospective 3 year follow up. Fertility & Sterility 1992;57:682-4.
51. Wang 1998 {published data only} Wang J, Yang Q, Yu Z. Clinical study of tubal pregnancy treated with integrated traditional Chinese and Western medicine. Zhongguuo Zhong Xi Yi Jie Z Zhi (Chinese Journal of Integrated Traditional and Western Medicine) 1998;18:531-3.
52. Yalcinkaya 1996 {published data only} Yalcinkaya TM, Brown SE, Thomas DW, Heywood ER, Resley TC, DePond RT. A comparison of 25 mg/m2 and 50 mg/m2 dose of methotrexate for the treatment of ectopic pregnancy. Abstract of the Scientific Oral and Poster Sessions of the American Society for Reproductive Medicine. Boston, USA: November 1996:O-027.
53. Yalcinkaya 2000 {published data only} Yalcinkaya TM, Brown SE, Mertz HL, Thomas DW. A comparison of 25 mg/m2 vs 50 mg/m2 dose of methotrexate (MTX) for the treatment of ectopic pregnancy (EP). J Soc Gynecol Invest. 2000;Vol. 7, issue 1:179A.
54. Zilber 1996 {published data only} Zilber U, Pansky M, Bukovsky I, Golan A. Laparoscopic salpingostomy versus laparoscopic localmethotrexate injection in themanagement of unruptured ectopic gestation. American Journal of Obstetrics & Gynecology 1996;175:600-2.
55. Colacurci 1998 Colacurci N, De Franciscis P, Zarcone R, Fortunato N, Passaro M, Mollo A, et al.Time length of negativization of hCG serum values after either surgical or medical treatment of ectopic pregnancy. Panminerva Medica 1998;40(3):223-5.
56. Kaya 2002 Kaya H, Babar Y, Ozmen S, Ozkaya O, Karci M, Aydin AR, et al.Intra tubal methotrexate for prevention of persistent ectopic pregnancy after salpingostomy. J Am Assoc Gynecol Laparosc 2002;9(4):464-7.
57. Koninckx 1991 Koninckx PR, Witters K, Brosens J, Stemers N, Oosterlynck D, Meuleman C. Conservative laparoscopic treatment of ectopic pregnancies using the CO2 laser. British Journal of Obstetrics& Gynaecology 1991;98:1254-9.
58. Laatikainen 1993 Laatikainen T, Tuomivaara L, Kaar K. Comparison of a local injection of hyperosmolar glucose solution with salpingostomy for the conservative treatment of tubal pregnancy. Fertility & Sterility 1993;60:80-4.
59. Lund 1955 Lund J. Early ectopic pregnancy -comments on conservative treatment. Journal of Obstetrics & Gynecology of the British Empire 1955;62:70-6.
60. Murphy 1992 Murphy AA, Nager CW, Wujek JJ, Kettel LM, Torp VA, Chin HG. Operative laparoscopy versus laparotomy for the management of ectopic pregnancy: a prospective trial. Fertility & Sterility 1992;57:1180-5.
61. O'Shea 1994 OShea RT, Thompson GR, Harding A. Intra amniotic methotrexate versus CO2 laser laparoscopic salpingotomy in the management of tubal ectopic pregnancy a prospective randomized trial. Fertility & Sterility 1994;62:876-8.
62. Porpora 1996 Porpora MG, Oliva MM, DeCristofaro A, Montanino G, Cosmi EV. Comparison of local methotrexate and linear salpingostomy in the conservative laparoscopic treatment of ectopic pregnancy. Journal of the American Association of Gynecologic Laparoscopists 1996;3:271-6.
63. Hu 2003
64. Peng 1997
65. Su 2002
66. Wei 2003
67. Fernandez 1 Randomized controlled trial between medical treatment by methotrexate versus conservative surgical treatment to evaluate subsequent fertility. Ongoing study 08-2004.
68. Fernandez 2 Randomised controlled trial between conservative versus radical surgical treatment to evaluate subsequent fertility. Ongoing study 08-2004.
69. Hajenius 1 A randomised controlled trial of salpingostomy versus salpingectomy for tubal pregnancy; impact on future fertility. Ongoing study 01-09-2004.
70. Hajenius 2 Randomised controlled trial of systemic MTX in an intramuscular single shot regimen versus expectant management. Ongoing study 01-02-2006.
71. Jurkovic Randomised double blind placebo controlled trial of single dose methotrexate versus expectant management in women with tubal ectopic pregnancy. Ongoing study 01-09-2005.
72. Ankum 1993 Ankum WM, Van der Veen F, Hamerlynck JVThH, Lammes FB. Laparoscopy; A dispensable tool in the diagnosis of ectopic pregnancy?. Human Reproduction 1993;8:1301-6.
73. Ankum 1995 Ankum WM, van der Veen F, Hamerlynck HV, Lammes FB. Suspected ectopic pregnancy. What to do when human chorionic gonadotropin levels are below the discriminatory zone. Suspected ectopic pregnancy. What to do when human chorionic gonadotropin levels are below the discriminatory zone. Suspected ectopic pregnancy. What to do when human chorionic gonadotropin levels are below the discriminatory zone. suspected ectopic pregnancy. What to do when the serum human chorionic gonadotrophin levles. Journal of Reproductive Medicine 1995;40:525-8.
74. ASRM 2006 The Practice Committee of the American Society for Reproductive Medicine. Medical treatment of ectopic pregnancy. Fertility and Sterility 2006;86(Supplement 5):96-102.
75. Bagshawe 1989 Bagshawe KD, Kent J, Newlands ES, Begent RH, Rustin GJ. The role of low dosemethotrexate and folinic acid in gestational trophoblastic tumors. British Journal of Obstetrics and Gynaecology 1989;96:795-802.
76. Banerjee 2001 Banerjee S, Aslam N, Woelfer B, Lawrence A, Elson J, Jurkovic D. Expectant management of early pregnancies of unknown location: a prospective evaluation of methods to predict spontaneous resolution of pregnancy. British Journal of Obstetrics and Gynaecology 2001;108:158-63.
77. Chotiner 1985 Chotiner HC. Nonsurgical management of ectopic pregnancy associated with severe hyperstimulation syndrome. Obstetrics and Gynecology 1985;66:740-3.
78. Clausen 1996 Clausen I. Conservative versus radical surgery for tubal pregnancy. Acta Obstetrica Gynecologica Scandinavia 1996;75:8-12.
79. Condous 2004 Condous G, Okaro E, Khalid A, Timmerman D Lu C, Zhou Y, et al.The use of a new logistic regression model for prediciting the outcome of pregnancies of unknown location. Human Reproduction 2004;19:1900-10.
80. Condous 2005 Condous G, Kirk E, Lu C, Van Huffel S, Gevaert O, DeMoor B, et al.Diagnostic accuracy of varying discriminatory zones for the prediction of ectopic pregnancy in women with a pregnancy of unknown location. Ultrasound in Obstetrics and Gynecology 2005;26:770-775.
81. Egarter 1988 Egarter Ch, Husslein P. Treatment of tubal pregnancy by prostaglandins. Lancet 1988;14:1104-5.
82. Elson 2004 Elson J, Tailor A, Banerjee S, Salim R, Hillaby K, Jurkovic D. Expectant mangement of tubal ectopic pregnancy: prediction of succesful outcome using decision tree analysis. Ultrasound in Obstetrics and Gynaecology 2004;23:552-6.
83. Fernandez 1993 Fernandez H, Baton C, Beniflan JL, Frydman R, Lelaidier C. Methotrexate treatment of ectopic pregnancy: 100 cases treated by primary transvaginal injection under sonographic control. Fertility & Sterility 1993;59:773-7.
84. Fujishita 1995a Fujishita A, Ishimaru T, Masuzaki H, Samejima T, Matsuwaki T, Ortega Chavez R, et al.A new approach to methotrexate and lipiodol suspensions for ectopic pregnancy. Preliminary in vitro and animal experiments. International Journal of Obstetrics & Gynecology 1995;21:529- 35.
85. Goldstein 1976 Goldstein DP, Goldstein PR, Bottomly P, Osathanondh R, Marean AR. Methotrexate with citrovorum factor rescue for nonmetastatic gestational trophoblastic neoplasms. Obstetrics and Gynecology 1976;46:321-3.
86. Hajenius 1995a Hajenius PJ, Mol BWJ, Ankum WM, Veen van der F, Bossuyt PMM, Lammes FB. Clearance curves of serum human chorionic gonadotrophin for the diagnosis of persistent trophoblast. Human Reproduction 1995;10:683-7.
87. Hajenius 1995b Hajenius PJ, Mol BWJ, Ankum WM, van der Veen F, Bossuyt PMM, Lammes FB. Suspected ectopic pregnancy: Expectant management in patients with negative sonographic findings and low serum hCG concentrations. Early Pregnancy: Biology and Medicine 1995;1:258-62.
88. Hochner 1992 Hochner-Celniker D, Ron M, Goshen R, Zacut D, Amir G, Yagel S. Rupture of ectopic pregnancy following disappearance of serum beta subunit of hCG. Obstetrics & Gynecology 1992;79:826-7.
89. Kirk 2006 Kirk E, Condous G, Bourne T. The non-surgical management of ectopic pregnancy. Utrasound in Obstetrics and Gynecology 2006;27:91-100.
90. Korhonen 1994 Korhonen J, Stenman UH, Ylöstalo P. Serum human chorionic gonadotropin dynamics during spontaneous resolution of ectopic pregnancy. Fertility & Sterility 1994;61:632-6.
91. Lang 1989 Lang P, Weiss PAM, Mayer HO. Local application of hyperosmolar glucose solution in tubal pregnancy. Lancet 1989;2:922-3.
92. Lindblom 1987 Lindblom B, Hahlin M, Källfelt B, Hamberger L. Local Prostaglandin F2a injection for termination of ectopic pregnancy. Lancet 1987;4:776-7.
93. Mashiach 1982 Mashiach S, Carp HJA, Serr DM. Non operative management of ectopic pregnancy: a preliminary report. Journal of Reproductive Medicine 1982;27:127.
94. Maymon 1996 Maymon R, Shulman A. Controversies and problems in the current management of tubal pregnancy. Human Reproduction Update 1996;2:541-51.
95. Mol 1996 Mol BWJ, Hajenius PJ, Ankum WM, Van der Veen F, Bossuyt PMM. Conservative versus radical surgery for tubal pregnancy - letter to the editor. Acta Obstetricia et Gynecologica Scandinavica 1996;75:866-7.
96. Mol 1998a Mol BWJ, Matthijsse HM, Tinga DJ, Huynh VT, Hajenius PJ, Ankum WM, et al.Fertility after conservative and radical surgery for tubal pregnancy. Human Reproduction 1998;13:1804-9.
97. Mol 1998b Mol BWJ, Hajenius PJ, Engelsbel S, Ankum WM, Van der Veen F, Hemrika DJ, et al.Serum human chorionic gonadotropin measurement in the diagnosis of ectopic pregnancy when transvaginal sonography is inconclusive. Fertility & Sterility 1998;70:972-981.
98. Mol 1999b Mol BW, van der Veen F, Bossuyt PM. Implementation of probabilistic decision rules improves the predictive values of algorithms in the diagnostic management of ectopic pregnancy. Human Reproduction 1999;14:2855-62.
99. Natale 2004 Natale A, Candiani M, Barbieri M, Calia C, Odorizzi MP, Busacca M. Pre and post treatment patterns of human chorionic gonadotropin for early detection of persistence after a single dose of methotrexate for ectopic pregnancy. European Journal of Obstetrics and Gynecology and Reproductive Biology 2004;117:87-92.
100. Nieuwkerk 1998b Nieuwkerk PT, Hajenius PJ, Van der Veen F, Ankum WM, Wijker W, Bossuyt PMM. Systemic methotrexate therapy versus laparoscopic salpingostomy in tubal pregnancy. Part II Patient preferences for systemic methotrexate. Fertility & Sterility 1998;7:518-22.
101. Ory 1986 Ory SJ, Alelei L, Villanueva AL, Sand PK, Tamura RK. Conservative treatment of ectopic pregnancy with methotrexate. American Journal of Obstetrics & Gynecology 1986;154:1299-306.
102. Pansky 1989 Pansky M, Bukovsky I, Golan A, Langer R, Schneider D, Arieli S, et al.Local methotrexate injection: A nonsurgical treatment of ectopic pregnancy. Obstetrics & Gynecology 1989;161:393-6.
103. Seifer 1990 Seifer DB, Gutman JN, Doyle MB, Jones EE, Diamond MP, DeCherney AH. Persistent ectopic pregnancy following laparoscopic linear salpingostomy. Obstetrics & Gynecology 1990;76:1121-5.
104. Spandorfer 1997 Spandorfer SD, Sawin SW, Benjamin I, Barnhart KT. Postoperative day 1 serum human chorionic gonadotropin level as a predictor of persistent ectopic pregnancy after conservative surgicalmanagement. Fertility & Sterility 1997;68:430-4.
105. Stovall 1991 Stovall TG, Ling FW, Gray LA. Single-dose methotrexate for treatment of ectopic pregnancy. Obstetrics & Gynecology 1991;77:754-7.
106. Stovall 1993 Stovall TG, Ling FW. Single-dosemethotrexate:An expanded clinical trial. American Journal of Obstetrics & Gynecology 1993;168:1759-65.
107. Sultana 1992 Sultana CJ, Easley K, Collins RL. Outcome of laparoscopic versus traditional surgery for ectopic pregnancies. Fertility& Sterility 1992;57:285-9.
108. Tanaka 1982 Tanaka T, Haydshi H, Kutsuzawa T, Fujimoto S, Ichinoe K. Treatment of interstitial ectopic pregnancy with methotrexate: report of a successful case. Fertility and Sterility 1982;37:851-2.
109. Tulandi 1991b Tulandi T, Hemmings R, Khalifa F. Rupture of ectopic pregnancy in women with low and declining serum β-human chorionic gonadotropin concentrations. Fertility & Sterility 1991;56:786-7.
110. Whitehead 1992 Whitehead J. The design and analysis of sequential clinical trials. Ellis Horwood. Chichester: Ellis Horwood, 1992.