Modern management of severe platelet function disorders

British Journal of Haematology

Volumn 149, Issue 6, 2010, Pages 813-823

  Alamelu, Jayanthi ^a   Liesner, Ri ^b  

^a GUY'S AND ST THOMAS' NHS FOUNDATION TRUST   (United Kingdom)

^b GREAT ORMOND STREET HOSPITAL   (United Kingdom)

Author keywords

Bernard Soulier Syndrome; Glanzmann Thrombasthenia; Platelet function disorders

Indexed keywords

AMINOCAPROIC ACID; ANTIFIBRINOLYTIC AGENT; DESMOPRESSIN; OCTIM; RECOMBINANT BLOOD CLOTTING FACTOR 7A; TRANEXAMIC ACID; UNCLASSIFIED DRUG;

BERNARD SOULIER DISEASE; BONE MARROW TRANSPLANTATION; CLINICAL FEATURE; DIAGNOSTIC TEST; DRUG EFFICACY; FACIAL FLUSHING; FLUID RETENTION; GENE THERAPY; GLANZMANN DISEASE; HEADACHE; HUMAN; HYPONATREMIA; HYPOTENSION; LABORATORY TEST; MEDICAL EXPERT; PATIENT CARE; PATIENT REFERRAL; PRIORITY JOURNAL; RECOMMENDED DRUG DOSE; REVIEW; SIDE EFFECT; SURGERY; THROMBOCYTE DYSFUNCTION; THROMBOCYTE TRANSFUSION;

BERNARD-SOULIER SYNDROME; BLOOD PLATELET DISORDERS; FEMALE; HEMORRHAGE; HUMANS; PERIOPERATIVE CARE; PREGNANCY; PREGNANCY COMPLICATIONS, HEMATOLOGIC; THROMBASTHENIA;

EID: 77952703684     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2010.08191.x     Document Type: Review

References (100)

1. Almeida, A.M., Khair, K., Hann, I. Liesner, R. (2003) The use of recombinant factor VIIa in children with inherited platelet function disorders. British Journal of Haematology, 121, 477 481.
2. Avila, M.A., Jacyntho, C. Santos, M.L. (1992) Syndrome de Bernard-Soulier et grossesse; un cas. Journal of Gynaecology, Obstetrics and Reproductive Biology Paris, 21, 73 74.
3. Aydinok, Y., Egemen, A. Balkan, C. (2007) Menorrhagia due to abnormalities of the platelet function: evaluation of two young patients. Pediatrics International, 49, 106 108.
4. BCSH (2003) Guidelines for the use of platelet transfusions. British Journal of Haematology, 122, 10 23.
5. Bell, J.A. Savidge, G.F. (2003) Glanzmann's thrombasthenia proposed optimal management during surgery and delivery. Clinical and Applied Thrombosis/Hemostasis, 9, 167 170.
6. Bellucci, S. Caen, J. (2002) Molecular basis of Glanzmann's thrombasthenia and current strategies in treatment. Blood Reviews, 16, 193 202.
7. Bellucci, S., Devergie, A., Gluckman, E., Tobelem, G., Lethielleux, P., Benbunan, M., Schaison, G. Boiron, M. (1985) Complete correction of Glanzmann's thrombasthenia by allogeneic bone marrow transplantation. British Journal of Haematology, 59, 635 641.
8. Bellucci, S., Damaj, G., Boval, B., Rocha, V., Devergie, A., Yacoub Agha, I., Garderet, L., Ribaud, P., Traineau, R., Socie′, G. Gluckman, E. (2000) Bone marrow transplantation in severe Glanzmann's thrombasthenia with antiplatelet alloimmunization. Bone Marrow Transplantation, 25, 327 330. (Pubitemid 30103025)
9. Berndt, M.C., Gregory, C., Chong, B.H., Zola, H. Castaldi, P.A. (1983) Additional glycoprotein defects in Bernard-Soulier's syndrome: confirmation of genetic basis by parental analysis. Blood, 62, 800 807.
10. Bolton-Maggs, P.H.B., Chalmers, E.A., Collins, P.W., Harrison, P., Kitchen, S., Liesner, R.J., Minford, A., Mumford, A., Parapia, L.A., Perry, D.J., Watson, S.P., Wilde, J.T. Williams, M.D. (2006) A review of inherited platelet disorders with guidelines for their management on behalf of the UKHCDO. British Journal of Haematology, 135, 603 633.
11. Boval, B., Bellucci, S. Boyer-Neumann, C. 2001) Glanzmann's thrombasthenia and pregnancy: clinical observations and management of four affected women. Thrombosis and Haemostasis, 2001 (Suppl (Abstract) 1154.
12. Capuzzo, E., Polatti, F. Zara, C. (1997) Glanzmann's Thrombasthenia and puerperium. International Journal of Gynaecology & Obstetrics, 57, 313 314.
13. ten Cate, H., Bauer, K.A., Levi, M., Edgington, T.S., Sublett, R.D., Barzegar, S., Kass, B.L. Rosenberg, R.D. (1993) The activation of factor X and prothrombin by recombinant factor VIIa in vivo is mediated by tissue factor. The Journal of Clinical Investigation, 92, 1207 1212.
14. Cattaneo, M. (2002) Desmopressin in the treatment of patients with defects of platelet function. Haematologica, 87, 1122 1124.
15. Cattaneo, M., Zighetti, M.L., Lombardi, R. Mannucci, P.M. (1994) Role of ADP in platelet aggregation at high shear: studies in a patient with congenital defect of platelet responses to ADP. British Journal of Haematology, 88, 826 829.
16. Chuansumrit, A., Sangapreecha, C. Hathirat, P. (1999) Successful epistaxis control in a patient with Glanzmann's thrombasthenia by increased bolus injection dose of recombinant factor VIIa. Thrombosis and Haemostasis, 82, 1778.
17. Chuansumrit, A., Suwannuraks, M., Sri-Udomporn, N., Pongtanakul, B. Worapongpaiboon, S. (2003) Recombinant activated factor VII combined with local measures in preventing bleeding from invasive dental procedures in patients with Glanzmann thrombasthenia. Blood Coagulation & Fibrinolysis, 14, 187 190.
18. Clemetson, K.J., McGregor, J.L., James, E., Dechavanne, M. Luscher, E.F. (1982) Characterization of the platelet membrane glycoprotein abnormalities in Bernard Soulier syndrome and comparison with normal by surface-labeling techniques and high-resolution two-dimensional gel electrophoresis. The Journal of Clinical Investigation, 70, 304 311.
19. Connor, P., Khair, K., Liesner, R., Amrolia, P., Veys, P., Ancliff, P. Mathias, M. (2008) Stem cell transplantation for children with Glanzmann thrombasthenia. British Journal of Haematology, 140, 568 571.
20. Coppola, A. Di Minno, G. (2008) Desmopressin in inherited disorders of platelet function. Haemophilia, 14 (Suppl. 1 31 39.
21. Cuthbert, R.J., Watson, H.H.K., Handa, S.I., Abbott, I. Ludlam, C.A. (1988) DDAVP shortens the bleeding time in Bernard-Soulier syndrome. Thrombosis Research, 49, 649.
22. Dargaud, Y. (2006) A case of glanzmann's thrombasthenia successfully treated with recombinant factor VIIa during a surgical procedure: observations on the monitoring and the mechanism of action of this drug. Haematologica, 91 (Suppl. 6 ECR 20.
23. Dede, M., Ural, A.U., Yenen, M., Mesten, Z. Baser, I. (2007) Glanzmann's thrombasthenia in two pregnant females. American Journal of Hematology, 82, 330 331.
24. Di Michele, D.M. Hathaway, W.E. (1990) Use of DDAVP in inherited and acquired platelet dysfunction. American Journal of Hematology, 33, 39 45.
25. Diamandis, M., Velijkoviv, D.K., Maurer-Spurej, E., Rivard, G.E. Hayward, C.P.M. (2008) Quebec platelet disorder: features, pathogenesis and treatment. Blood Coagulation and Fibrinolysis, 19, 109 119.
26. Español, I., Hernández, A., Pujol, R.M., Urrutia, T. Pujol-Moix, N. (1998) Type IV Ehlers-Danlos syndrome with platelet delta-storage pool disease. Annals of Hematology, 77, 47 50.
27. Fang, J., Hodivala-Dilke, K., Johnson, B.D., Du, L.M., Hynes, R.O., White, G.C. Wilcox, D.A. (2005) Therapeutic expression of the platelet-specific integrin, alphaIIb-beta3, in a murine model for Glanzmann thrombasthenia. Blood, 106, 2671 2679.
28. Flood, V.H., Johnson, F.L., Boshkov, L.K., Thomas, G.A., Nugent, D.J., Bakke, A.C., Nicholson, H.S., Tilford, D., Brown, M.P. Godder, K.T. (2005) Sustained engraftment post bone marrow transplant despite anti-platelet antibodies in Glanzmann thrombasthenia. Pediatric Blood and Cancer, 45, 971 975.
29. Fujimori, K., Ohto, H., Honda, S. Sato, A. (1999) Antepartum diagnosis of fetal intracranial hemorrhage due to maternal Bernard-Soulier syndrome. Obstetrics and Gynecology, 94, 817 819.
30. Fujimoto, T.T., Kishimoto, M., Ide, K., Mizushima, M., Mita, M., Sezaki, N., Kojima, K., Shinagawa, K., Niiya, K., Tanimoto, M. Fujimura, K. (2005) Glanzmann thrombasthenia with acute myeloid leukemia successfully treated by bone marrow transplantation. International Journal of Hematology, 81, 77 80.
31. George, J.N., Caen, J.P. Nurden, A.T. (1990) Glanzmann's thrombasthenia: the spectrum of clinical disease. Blood, 75, 1383 1395.
32. Hayward, C.P. (2005) Diagnosis and management of mild bleeding disorders. Hematology, 2005, 423 428.
33. Hayward, C.P.M., Rao, A.K. Cattaneo, M. (2006) Congenital platelet disorders: overview of their mechanisms, diagnostic evaluation and treatment. Haemophilia, 12, 128 136.
34. Heslop, H.E., Hickton, C.M., Laird, E., Tait, J.D., Doig, J.R. Beard, M.E.J. (1986) Twin pregnancy and parturition in a patient with Bernard-Soulier Syndrome. Scandinavian Journal of Haematology, 37, 71 73.
35. Ishaqi, M.K., El-Hayek, M., Gassas, A., Khanani, M., Trad, O., Baroudi, M. Jamil, A. (2009) Allogeneic stem cell transplantation for Glanzmann Thrombasthenia. Pediatric Blood & Cancer, 52, 682 683.
36. Jallu, V., Bianchi, F. Kaplan, C. (2005) Fetal-neonatal alloimmune thrombocytopenia and unexpected Glanzmann thrombasthenia carrier: report of two cases. Transfusion, 45, 550 553.
37. Johnson, A., Goodall, A.H., Downie, C.J., Vellodi, A. Michael, D.P. (1994) Bone marrow transplantation for Glanzmann's thrombasthenia. Bone Marrow Transplantation, 14, 147 150. (Pubitemid 24228752)
38. Kadir, R.A., Lee, C.A., Sabin, C.A., Pollard, D. Economides, D.L. (2002) DDAVP nasal spray for treatment of menorrhagia in women with inherited bleeding disorders: a randomized placebo-controlled crossover study. Haemophilia, 8, 787 793.
39. Kahr, W.H.A., Zheng, S., Sheth, P.M., Pai, M., Cowie, A., Bouchard, M., Podor, T.J., Rivard, G.E. Hayward, C.P.M. (2001) Platelets from patients with the Quebec platelet disorder contain and secrete abnormal amounts of urokinase-type plasminogen activator. Blood, 98, 257 265.
40. Kale, A., Bayhan, G., Yalinkaya, A. Yayla, M. (2004) The use of recombinant factor VIla in a primigravida with Glanzmann's thrombasthenia during delivery. Journal of Perinatal Medicine, 32, 456 458.
41. Kashyap, R., Kriplani, A., Saxena, R., Takkar, D. Choudhry, V.P. (1997) Pregnancy in a patient of Glanzmann's thrombasthenia with antiplatelet antibodies. The Journal of Obstetrics and Gynaecology Research, 23, 247 250.
42. Khalil, A., Seoud, M., Tannous, R., Usta, I. Shamseddine, A. (1998) Bernard-Soulier syndrome in pregnancy: case report and review of the literature. Clinical and Laboratory Haematology, 20, 125 128.
43. Kopeć, I., Maślanko, K., Litmanowicz, M., Stefańska, E., Mikos, A. Warzocha, K. (2005) Bernard-Soulier syndrome during pregnancy: a case report. Ginekologia Polska, 76, 824 827.
44. Kosch, A., Kehrel, B., Nowak-Göttl, U., Häberle, J. Jürgens, H. (1999) Thrombocytic alpha-delta-storage-pool-disease: shortening of bleeding time after infusion of 1-desamino-8-D-arginine vasopressin. Klinische Padiatrie, 211, 198 200.
45. Kriplani, A., Singh, B.M., Sowbernika, R. Choudhry, V.P. (2005) Successful pregnancy outcome in Bernard-Soulier syndrome. The Journal of Obstetrics and Gynaecology Research, 31, 52 56.
46. Kunishima, S., Miura, H. Fakutani, H. (1994) Bernard-Soulier Kagoshima: Ser 444 - stop mutation of the glycoprotein (gp) Ib alpha and surface expression of gpIb beta and gpIX. Blood, 84, 3356 3362.
47. Lethagen, S. Nilsson, I.M. (1992) DDAVP-induced enhancement of platelet retention: its dependence on platelet-von Willebrand factor and the platelet receptor GP IIb/IIIa. European Journal of Haematology, 49, 7 13.
48. Léticée, N., Kaplan, C. Lémery, D. (2005) Pregnancy in mother with Glanzmann's thrombasthenia and isoantibody against GPIIb-IIIa: is there a foetal risk? European Journal of Obstetrics, Gynecology and Reproductive Biology, 121, 139 142.
49. Lisman, T., Mosnier, L.O., Lambert, T., Mauser-Bunschoten, E.P., Meijers, J.C.M., Nieuwenhuis, H.K. de Groot, P.G. (2002) Inhibition of fibrinolysis by recombinant factor VIIa in plasma from patients with severe haemophilia A. Blood, 99, 175 179.
50. Lisman, T., Adelmeijer, J., Heijnen, H.F.G. de Groot, P.G. (2004) Recombinant factor VIIa restores aggregation of αIIbβ3-deficient platelets via tissue factor-independent fibrin generation. Blood, 103, 1720 1727.
51. Locatelli, F., Rossi, G. Balduini, C. (2003) Hematopoietic stem-cell transplantation for the Bernard-Soulier syndrome. Annals of Internal Medicine, 138, 79.
52. Lopez, J.A., Andrews, R.K., Afshar-Kharghan, V. Berndt, M.C. (1998) Bernard-Soulier Syndrome. Blood, 91, 4397 4418.
53. Lozano, M., Escolar, G., Bellucci, S., Monteagudo, J., Pico, M., Ordinas, A. Caen, J.P. (1999) Hemostatic 1-Deamino (8-D-arginine) vasopressin infusion partially corrects platelet deposition on subendothelium in Bernard-Soulier syndrome: the role of factor VIII. Platelets, 10, 141 145.
54. Makris, M., Conlon, C.P. Watson, H.G. (2003) Immunization of patients with bleeding disorders. Haemophilia, 9, 541 546.
55. Malhotra, N., Chanana, C. Deka, D. (2006) Pregnancy in a patient of Glanzmann's Thrombasthenia. Indian Journal of Medical Sciences, 60, 111 113.
56. Mannucci, P.M. (1988) Desmopressin: a nontransfusional form of treatment for congenital and acquired bleeding disorders. Blood, 72, 1449 1455.
57. Mannucci, P.M. (1997) Desmopressin (DDAVP) in the treatment of bleeding disorders: the first 20 years. Blood, 90, 2515 2521.
58. Markovitch, O., Ellis, M., Holzinger, M., Goldberger, S. Beyth, Y. (1998) Severe juvenile vaginal bleeding due to Glanzmann's thrombasthenia: case report and review of the literature. American Journal of Hematology, 57, 225 227.
59. McColl, M.D. Gibson, B.E.S. (1997) Sibling allogeneic bone marrow transplantation in a patient with type I Glanzmann's thrombasthenia. British Journal of Haematology, 99, 58 60.
60. Mhawech, P. Saleem, A. (2000) Inherited giant platelet disorders. American Journal of Clinical Pathology, 113, 176 190.
61. Michalas, S., Malamitsi-Puchner, A. Tsevrenis, H. (1984) Pregnancy and delivery in Bernard-Soulier Syndrome. Acta Obstetrica et Gynecologica Scandinavica, 63, 185 186.
62. Miller, J.L., Lyle, V.A. Cunningham, D. (1992) Mutation of leucine-57 to phenylalanine in a platelet glycoprotein Ib alpha leucine tandem repeat occurring in patients with an autosomal dominant variant of Bernard-Soulier disease. Blood, 79, 439 446.
63. Miller, W., Dunn, A. Chiang, K.Y. (2009) Sustained engraftment and resolution of bleeding phenotype after unrelated cord blood hematopoietic stem cell transplantation for severe glanzmann thrombasthenia. Journal of Pediatric Hematology and Oncology, 31, 437 439.
64. Mitsui, T., Yokoyama, S. Yazaki, N. (1998) Severe bleeding tendency in a patient with Bernard-Soulier associated with a homozygous single base pair deletion in the gene coding for the human platelet glycoprotein Ib alpha. Journal of Pediatric Haematology & Oncology, 20, 246 251.
65. Nieuwenhuis, H.K. Sixma, J.J. (1988) 1-Desamino-8-D-arginine vasopressin (desmopressin) shortens the bleeding time in storage pool deficiency. Annals of Internal Medicine, 108, 65 67.
66. Noda, M., Fujimura, K. Takafuta, T. (1995) Heterogeneous expression of glycoprotein Ib, IX and V in platelets from two patients with Bernard-Soulier syndrome caused by different genetic abnormalities. Thrombosis & Haemostasis, 74, 1411 1415.
67. Nolan, B., White, B., Smith, J., O'reily, C., Fitzpatrick, B. Smith, O.P. (2000) Desmopressin: therapeutic limitations in children and adults with inherited coagulation disorders. British Journal of Haematology, 109, 865 869.
68. Novotny, V.M. (1999) Prevention and management of platelet transfusion refractoriness. Vox Sanguinis, 76, 1 13.
69. Nurden, A.T. (2006) Glanzmann thrombasthenia. Orphanet Journal of Rare Diseases, 1, 1 10.
70. Nurden, A.T. George, J.N. 2005) Haemostasis and Thrombosis, Basic Principles and Clinical Practice, 6th edn. Lippincott, Williams & Wilkins
71. Nurden, P. Nurden, A.T. (2008) Congenital disorders associated with platelet dysfunctions. Thrombosis and Haemostasis, 99, 253 263.
72. d'Oiron, R., Menart, C., Trzeciak, M.C., Nurden, P., Fressinaud, E., Dreyfus, M., Laurian, Y. Negrier, C. (2000) Use of recombinant factor VIIa in 3 patients with inherited type 1 Glanzmann's thrombasthenia undergoing invasive procedures. Thrombosis and Haemostasis, 83, 644 647.
73. Patel, R.K., Savidge, G.F. Rangarajan, S. (2001) Use of recombinant factor VIIa for post-operative haemorrhage in a patient with Glanzmann's thrombasthenia and human leucocyte antigen antibodies. British Journal of Haematology, 114, 245 246.
74. Patel, D., Vaananen, H., Jirouska, M., Hoffmann, T., Bodian, C. Coller, B.S. (2003) Dynamics of GPIIb/IIIa-mediated platelet-platelet interactions in platelet adhesion/thrombus formation on collagen in vitro as revealed by videomicroscopy. Blood, 101, 929 936.
75. Peaceman, A.H., Katz, A.R. Laville, M. (1989) Bernard-Soulier Syndrome complicating pregnancy: a case report. Obstetrics and Gynaecology, 73, 457 459.
76. Peng, T.C., Kickler, T.S., Bell, W.R. Haller, E. (1991) Obstetric complications in a patient with Bernard-Soulier Syndrome. American Journal of Obstetrics and Gynaecology, 165, 425 426.
77. Poon, M.C. (2007) Clinical use of rFVIIa in the prevention and treatment of bleeding episodes in patients with Glanzmann's thrombasthenia. Vascular Health Risk Management, 3, 655 664.
78. Poon, M.C., Demers, C., Jobin, F. Wu, J.W. (1999) Recombinant VIIa is effective for bleeding and surgery in patients with Glanzmann thrombasthenia. Blood, 94, 3951 3953.
79. Poon, M.C., d'Orion, R., Hann, I., Ne′grier, C., de Lumley, L., Thomas, A., Karafoulidou, A., Demers, C., Street, A., Huth-Kuhne, A., Petrini, P., Fressinaud, E., Morfini, M., Tengborn, L., Marque's-Verdier, A., Musso, R., Devecioglu, O., Houston, D.S., Lethagen, S., Van Geet, C., von Depka, M., Berger, C., Beurrier, P., Britton, H.A., Gerrits, W., Guthner, C., Kuhle, S., Lorenzo, J., Makris, P., Nohe, N., Paugy, P., Pautard, B., Torchet, M., Trillot, N., Vicariot, M., Wilde, J., Winter, M., Chambost, H., Ingerslev, J., Peters, M. Strauss, G. (2001) Use of recombinant factor VIIa (Novoseven) in patients with Glanzmann thrombasthenia. Seminars in Haematology, 38, s21 s25.
80. Poon, M.C., D'Oiron, R., Von Depka, M., Khair, K., Negrier, C., Karafoulidou, A., Huth-Kuehne, A. Morfini, M. (2004) Prophylactic and therapeutic recombinant factor VIIa administration to patients with Glanzmann's thrombasthenia: results of an international survey. Journal of Thrombosis & Haemostasis, 2, 1096 1103.
81. Prabu, P. Parapia, L.A. (2006) Bernard-Soulier Syndrome in pregnancy. Clinical and Laboratory Haematology, 28, 198 201.
82. Rahimi, G., Rellecke, S., Mallmann, P. Nawroth, F. (2005) Course of pregnancy and birth in a patient with Bernard-Soulier syndrome - a case report. Journal of Perinatal Medicine, 33, 264 266.
83. Rao, A.K., Ghosh, S., Sun, L., Yang, X., Disa, J., Pickens, P. Polansky, M. (1995) Mechanisms of platelet dysfunction and reponse to DDAVP in patients with congenital platelet function defects. A double-blind placebo-controlled trial. Thrombosis and Haemostasis, 74, 1071 1078.
84. Rieger, C., Rank, A., Fiegl, M., Tischer, J., Schiel, X., Ostermann, H. Kolb, H. (2006) Allogeneic stem cell transplantation as a new treatment for patients with severe Bernard-Soulier Syndrome. Thrombosis and Haemostasis, 95, 190 191.
85. Saade, G., Homsi, R. Seoud, M. (1991) Bernard-Soulier Syndrome in pregnancy; a report of four pregnancies in one patient, and review of the literature. European Journal of Obstetrics and Gynaecology, 40, 149 152.
86. Sherer, D.M. Lerner, R. (1999) Glanzmann's thrombasthenia in pregnancy: a case and review of the literature. American Journal of Perinatology, 16, 297 301.
87. Simon, D., Kunicki, T. Nugent, D. (2008) Platelet function defects. Haemophilia, 14, 1240 1249.
88. Sugihara, S., Katsutani, S., Hyodo, H., Hyodo, M., Kudo, Y., Fujii, T. Kimura, A. (2008) Postpartum hemorrhage successfully treated with recombinant factor VIIa in Glanzmann thromboasthenia. Rinsho Ketsueki, 49, 46 50.
89. Tengborn, L. Petruson, B. (1996) A patient with Glanzmann thrombasthenia and epistaxis successfully treated with recombinant factor VIIa. Thrombosis and Haemostasis, 75, 981 982.
90. Tsementzis, S.A. Marsh, J. (1991) Spontaneous subarachnoid haemorrhage occurring in association with a platelet function disorder. Neurosurgical Review, 14, 57 59.
91. Uotila, J., Tammela, O. Mäkipernaa, A. (2008) Fetomaternal platelet immunization associated with maternal Bernard-Soulier syndrome. American Journal of Perinatology, 25, 219 223.
92. Vettore, S., Scandellari, R., Moro, S., Lombardi, A.M., Scapin, M., Randi, M.L. Fabris, F. (2008) Novel point mutation in a leucine-rich repeat of the GPIbalpha chain of the platelet von Willebrand factor receptor, GPIb/IX/V, resulting in an inherited dominant form of Bernard-Soulier syndrome affecting two unrelated families: the N41H variant. Haematologica, 93, 1743 1747.
93. Vijapurkar, M., Mota, L., Shetty, S. Ghosh, K. (2009) Menorrhagia and reproductive health in rare bleeding disorders: a study from the Indian subcontinent. Haemophilia, 15, 199 202.
94. Vivier, M., Treisser, A., Naett, M., Diemunsch, P., Schmitt, J.P., Waller, C., Tongio, M.M., Hemmendinger, S. Lutz, P. (1989) Glanzmann's thrombasthenia and pregnancy. Contribution of plasma exchange before scheduled caesarean section. Journal de gynecologie, obstetrique etbiologie de la reproduction, 18, 507 513.
95. Ware, J., Russell, S.R. Vicente, V. (1990) Nonsense mutation in the glycoprotein Ib alpha coding sequence associated with Bernard-Soulier syndrome. Proceedings of the National Academy of Sciences of the United States of America, 87, 2026 2030.
96. Wijermans, P.W. van Dorp, D.B. (1989) Hermansky-Pudlak syndrome: correction of bleeding time by 1-desamino-8D-arginine vasopressin. American Journal of Hematology, 30, 154 157.
97. Wilcox, D.A. White, G.C. (2003) Gene therapy for platelet disorders: studies with Glanzmann's thrombasthenia. Journal of Thrombosis and Haemostasis, 1, 2300 2311.
98. Wilcox, D.A., Olsen, J.C., Ishizawa, L., Griffith, M. White, G.C. II. (1999) Integrin alphaIIb promoter-targeted expression of gene products in megakaryocytes derived from retrovirus-transduced human hematopoietic cells. Proceedings of the National Academy of Sciences of the United States of America, 96, 9654 9659.
99. Wilcox, D.A., Olsen, J.C. Ishizawa, L. (2000) Megakaryocyte-targeted synthesis of the integrin beta(3)-subunit results in the phenotypic correction of Glanzmann thrombasthenia. Blood, 95, 3645 3651.
100. Zatik, J., Póka, R., Borsos, A. Pfliegler, G. (2002) Variable response of Hermansky-Pudlak syndrome to prophylactic administration of 1-desamino 8D-arginine in subsequent pregnancies. European Journal of Obstetrics, Gynecology and Reproductive Biology, 104, 165 166.