Desmopressin (DDAVP) in the treatment of bleeding disorders: The first 20 years

Blood

Volumn 90, Issue 7, 1997, Pages 2515-2521

  Mannucci, Pier Mannuccio ^a,b  

^a UNIVERSITY OF MILAN   (Italy)

^b NONE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

DESMOPRESSIN;

BLEEDING DISORDER; BLOOD TRANSFUSION; DRUG USE; HEMOPHILIA; HUMAN; PRIORITY JOURNAL; REVIEW; TREATMENT INDICATION; VON WILLEBRAND DISEASE;

EID: 0030767469     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v90.7.2515     Document Type: Review

References (66)

1. Mannucci PM, Ruggeri ZM, Pareti FI, Capitanio A: DDAVP: A new pharmacological approach to the management of hemophilia and von Willebrand disease. Lancet 1:869, 1977
2. Mannucci PM: Desmopressin: A non transfusional agent. Annu Rev Med 41:55, 1990
3. Schulman S: DDAVP: The multipotent drug in patients with coagulopathies. Transf Med Rev 5:132, 1991
4. Lethagen S: Desmopressin (DDAVP) and haemostasis. Ann Hematol 69:173, 1994
5. Hewson W: Experimental inquiries. Part I. An inquiry into the properties of the blood, with remarks on some of its morbid appearances, in Gulliver G (ed): The Works of William Hewson, FRS. London, UK, The Sydenham Society, 1846
6. Cannon WB, Gray H: Factors affecting the coagulation time of blood. II. The hastening or retarding of coagulation by adrenaline injections. Am J Physiol 34:231, 1914
7. Cannon WB, Mendenhall WL: Factors affecting the coagulation time of blood. IV. The hastening of coagulation in pain and emotional excitement. Am J Physiol 34:251, 1914
8. Marciniak E: The influence of adrenaline in blood coagulation. Acta Physiol Pol 8:224, 1957
9. Ingram GIC: Increase in antihemophilic globulin activity following infusion of adrenaline. J Physiol 156:217, 1961
10. Ingram GIC, Vaughan Jones R, Hershgold EJ, Denson KWE, Perkins JR: Factor VIII activity and antigen, platelet count and biochemical changes after adrenoceptor stimulation. Br J Haematol 35:81, 1977
11. Mannucci PM, Gagnatelli G, D'Alonzo R: Stress and blood coagulation, in Brinkhous KM, Hinnom S (eds): Thrombosis: Risk factors and diagnostic approaches. Stuttgart, Germany, Schattauer Verlag, 1972, p 105
12. Cash JD, Gader AMA, de Costa J: The release of plasminogen activator and factor VIII by LVP, AVP, DDAVP, AT III, and OT in man. Br J Haematol 27:363, 1974
13. Mannucci PM, Aberg M, Nilsson IM, Robertson B: Mechanism of plasminogen activator and factor VIII increase after vasoactive drugs. Br J Haematol 30:81, 1975
14. Warrier L, Lusher JM: DDAVP: A useful alternative to blood components in moderate hemophilia A and von Willebrand's disease. J Pediatr 102:228, 1983
15. Mariani G, Ciavarella N, Mazzucconi MG, Antoncecchi S, Solinas S, Ranieri P, Pettini P, Agrestini F, Mandelli F: Evaluation of the effectiveness of DDAVP in surgery and bleeding episodes in hemophilia and von Willebrand's disease. A study of 43 patients. Clin Lab Hematol 6:229, 1984
16. de la Fuente B, Kasper CK, Rickles FR, Hoyer LW: Response of patients with mild and moderate hemophilia A and von Willebrand disease to treatment with desmopressin. Ann Intern Med 103:6, 1985
17. Mannucci PM, Pareti FI, Holmberg L, Ruggeri ZM, Nilsson IM: Studies on the prolonged bleeding time in von Willebrand disease. J Lab Clin Med 88:62, 1976
18. Barnhart MI, Chen S, Lusher JM: DDAVP: Does the drug have a direct effect on the vessel wall. Thromb Res 31:239, 1983
19. Sakariassen KS, Cattaneo M, van der Berg A, Ruggeri ZM, Sixma JJ: DDAVP enhances platelet adherence and platelet aggregate growth on human artery subendothelium. Blood 64:229, 1984
20. Levi M, de Boer JP, Roem D, ten Cate JH, Hack CE: Plasminogen activation in vivo upon intravenous infusion of DDAVP. Quantitative assessment of plasmin-alpha2-antiplasmin complex with a novel monoclonal antibody based radioimmunoassay. Thromb Haemost 67:111, 1992
21. Kanwar S, Woodman RC, Poon MC, Murohara T, Lefer AM, Davenpeck KL, Kubus P: Desmopressin induces endothelial P-selectin expression and leukocyte rolling in post-capillary venules. Blood 86:2760, 1995
22. Takeuchi M, Naguza H, Kanedu T: DDAVP and epinephrine induce changes in the localization of von Willebrand factor antigen in endothelial cells of human oral mucosa. Blood 72:850, 1981
23. Booyse EM, Osikowicz G, Fedr S: Effects of various agents on ristocetin-Willebrand factor activity in long-term cultures of von Willebrand and normal human umbilical vein endothelial cells. Thromb Haemost 46:668, 1981
24. Hashemi S, Tackaberry ES, Palmer DS, Rock G, Ganz PR: DDAVP-induced release of von Willebrand factor from endothelial cells in vitro: The effect of plasma and blood cells. Biochim Biophys Acta 1052:63, 1990
25. Hashemi S, Palmer DS, Aye MT, Ganz PR: Platelet activating factor secreted by DDAVP-treated monocytes mediates von Willebrand factor release from endothelial cells. J Cell Physiol 154:496, 1993
26. Kobrinsky ML, Doyle JJ, Israel ED, Winter JSD, Chenay MS, Walker RD, Bishop AJ: Absent factor VIII response to synthetic vasopressin analogue (DDAVP) in nephrogenic diabetes insipidus. Lancet 1:1293, 1985
27. Ibbotson SH, Davies JA, Grant PJ: The influence of infusions of 1-desamino-8-D-arginine vasopressin (DDAVP) in vivo on thrombin generation in vitro. Thromb Haemost 68:37, 1992
28. Ruggeri ZM, Mannucci PM, Lombardi R, Federici AB, Zimmerman TS: Multimeric composition of factor VIII/von Willebrand factor following administration of DDAVP: Implications for pathophysiology and therapy of von Willebrand's disease subtypes. Blood 58:1272, 1982
29. Moake JL, Turner NA, Stathopoulos NA, Nolasco LH, Hellum JD: Involvement of large plasma von Willebrand factor (VEF) multimers and unusually large VWF forms derived from endothelial cells in shear-stress induced platelet aggregation. J Clin Invest 78:1456, 1986
30. Tsai J-M, Sussman II, Nagel RL, Kaul DK: Desmopressin induces adhesion of normal human erythrocytes to the endothelial surface of a perfused microvascular preparation. Blood 75:261, 1990
31. Setty BNY, Dampier CD, Stuart MJ: 1-Deamino-8-D-arginine vasopressin decreases the production of 13-hydroxyoctadecadienoic acid by endothelial cells. Thromb Res 67:545, 1992
32. Mannucci PM, Bettega D, Cattaneo M: Patterns of development of tachyphylaxis in patients with hemophilia and von Willebrand disease after repeated doses of desmopressin (DDAVP). Br J Haematol 82:87, 1992
33. Gralnick HR, William SB, McKeon LP, Rick ME, Maisonneuve P, Jenneau C, Sultan Y: DDAVP in type IIa von Willebrand's disease. Blood 67:465, 1986
34. Holmberg L, Nilsson IM, Borge L, Gunnarson M, Sjorin E: Platelet aggregation induced by 1-deamino-8-D-arginine vasopressin (DDAVP) in type IIB von Willebrand's disease. N Engl J Med 309:816, 1983
35. Castaman G, Rodeghiero F: Desmopressin and type IIB von Willebrand disease. Hemophilia 2:73, 1996
36. Rodeghiero F, Castaman G, Mannucci PM: Prospective multicenter study of subcutaneous concentrated desmopressin for home treatment of patients with von Willebrand disease and mild or moderate hemophilia A. Thromb Haemost 76:692, 1996
37. Rose EH, Aledort LM: Nasal spray desmopressin (DDAVP) for mild hemophilia A and von Willebrand disease. Ann Intern Med 114:563, 1991
38. Wun T, Paglieroni TG, Lachant NA: Desmopressin stimulates the expression of P-selectin on human platelets in vitro. J Lab Clin Med 125:40, 1995
39. Di Michele DM, Hathaway WE: Use of DDAVP in inherited and acquired platelet dysfunction. Am J Hematol 33:39, 1990
40. Rao AK, Ghosh S, Sum L, Yang X, Disa J, Pickens P, Polanski M: Mechanisms of platelet dysfunction and response to DDAVP in patients with congenital platelet function defects. A double-blind placebo controlled trial. Thromb Haemost 74:1071, 1995
41. Mannucci PM, Ghirardini A: Desmopressin twenty years after. Thromb Haemost 78:958, 1997
42. Mannucci PM, Remuzzi G, Pusineri F, Lombardi R, Valsecchi C, Mecca G, Zimmerman TS: Deamino-8-D-arginine vasopressin shortens the bleeding time in uremia. N Engl J Med 308:8, 1983
43. Livio M, Mannucci PM, Viganò G, Mingardi G, Lombardi R, Mecca G, Remuzzi G: Conjugated estrogens for the management of bleeding associated with renal failure. N Engl J Med 315:731, 1986
44. Moia M, Mannucci PM, Vizzotto L, Casati S, Cattaneo M, Ponticelli C: Improvement in the hemostatic defect of uremia after treatment with recombinant human erythropoietin. Lancet 2:1227, 1987
45. Burroughs AK, Matthews K, Qadiri M, Thomas N, Kernoff PBS, Tuddenham EGD, McIntyre N: Desmopressin and bleeding time in patients with cirrhosis. Br J Med 291:1377, 1985
46. Mannucci PM, Vicente V, Vianello L, Cattaneo M, Alberca I, Coccato MP, Faioni E, Mari D: Controlled trial of desmopressin (DDAVP) in liver cirrhosis and other conditions associated with a prolonged bleeding time. Blood 67:1148, 1986
47. de Franchis F, Arcidiacono PG, Carpinelli PG, Andreoni B, Cestari L, Brunati S, Zambelli A, Battaglia G, Mannucci PM: Randomized controlled trial of desmopressin plus terlipressin and terlipressin alone for the treatment of acute variceal hemorrhage in cirrhotic patients: A multicenter, double blind study. Hepatology 18:1102, 1993
48. Schulman S, Johnsson H: Heparin, DDAVP and the bleeding time. Thromb Hemost 65:242, 1991
49. Johnstone MT, Andrews T, Ware JA, Rudd MA, George D, Weinstein M, Loscalzo J: Bleeding time prolongation with streptokinase and its reduction with 1-deamino-8-D-arginine vasopressin. Circulation 82:2142, 1990
50. Bove CM, Casey B, Marder VJ: DDAVP reduces bleeding during continued hirudin administration in the rabbit. Thromb Haemost 75:471, 1996
51. Flordal PA, Ljungstrom KG, Svensson J: Desmopressin reverses effects of dextran on von Willebrand factor. Thromb Hemost 61:541, 1989
52. Salzman EW, Weinstein MJ, Weintraub RM, Ware JA, Thurer RL, Robertson L, Donovan A, Gaffney T, Bertelé V, Troll J: Treatment with desmopressin acetate to reduce blood loss after cardiac surgery. N Engl J Med 314:1402, 1986
53. Rocha E, Llorens R, Paramo JA, Areas R, Cuesta B, Trenor A: Does desmopressin acetate reduce blood loss after surgery in patients on cardiopulmonary bypass? Circulation 77:1319, 1988
54. Hackmann T, Gascoyne R, Naiman SC, Growe GH, Burchill LD, Jamieson WR, Sheps SB, Schechter MT, Townsend GE: A trial of desmopressin to reduce blood loss in uncomplicated cardiac surgery. N Engl J Med 321:1437, 1989
55. Anderson TL, Solem JO, Tengborn L, Vinge E: Effects of desmopressin acetate on platelet aggregation, von Willebrand factor and blood loss after cardiac surgery with extracorporeal circulation. Circulation 81:872, 1990
56. Sean MD, Wadsworth LD, Rogers PC: The effect of desmopressin acetate (DDAVP) on postoperative blood loss after cardiac operations in children. J Thorac Cardiovasc Surg 48:217, 1988
57. Cattaneo M, Harris AS, Stromberg U, Mannucci PM: The effect of desmopressin on reducing blood loss in cardiac surgery. A meta-analysis of double-blind, placebo-controlled trials. Thromb Haemost 74:1064, 1988
58. Horrow JC, van Riper DF, Strong MD, Brodsky I, Parmet JL: Hemostatic effects of tranexamic acid and desmopressin during cardiac surgery. Circulation 84:2063, 1991
59. Rocha E, Hidalgo F, Llorens R, Melero JM, Arroyo SL, Paramo JA: Randomized trial of aprotinin and DDAVP to reduce post-operative bleeding after cardiopulmonary surgery. Circulation 90:921, 1994
60. Aron KV, Emery RW: Decreased postoperative drainage with addition of epsilonaminocaproic acid before cardiopulmonary bypass. Ann Thorac Surg 57:1108, 1994
61. Fremes SE, Wong BI, Lee E, Mai R, Christakis GT, McLean RF, Goldman BS, Naylor CD: Meta-analysis of prophylactic drug treatment in the prevention of postoperative bleeding. Ann Thorac Surg 58:1580, 1994
62. Kobrinsky NL, Letts RP, Patel R, Israels ED, Monson RC, Schwetz N, Cheang MS: DDAVP shortens the bleeding time and decreases blood loss in hemostatically normal subjects undergoing spinal fusion surgery. Ann Intern Med 107:446, 1987
63. Guay J, Rainberg C, Poitras B, David M, Mathews S, Lortie L, Rivard GE: A trial of desmopressin to reduce blood loss in patients undergoing spinal fusion for idiopathic scoliosis. Anesth Analg 75:405, 1992
64. Karnezis TA, Stulberg SD, Wixson RL, Reilly P: The hemostatic effects of desmopressin on patients who had total joint arthroplasty. A double-blind randomized trial. J Bone Joint Surg Am 76:1545, 1994
65. Haith LR, Patton ML, Goldman WT, McCutchan KM: Diminishing blood loss after operation for burns. Surg Gynaecol Obstet 176:119, 1993
66. AHCPR: Acute Pain Management: Operative or Medical Procedures and Trauma (Agency for Health Care Policy and Research Publications). Bethesda, MD, US Department of Health and Human Services, 1992