3′-Bromo analogues of pyrimidine nucleosides as a new class of potent inhibitors of mycobacterium tuberculosis

Journal of Medicinal Chemistry

Volumn 53, Issue 10, 2010, Pages 4130-4140

  Shakya, Neeraj ^a   Srivastav, Naveen C ^a   Desroches, Nancy ^a   Agrawal, Babita ^a   Kunimoto, Dennis Y ^a   Kumar, Rakesh ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

1 (2 BROMO 2 DEOXY BETA DEXTRO XYLOFURANOSYL) 5 FLUOROURACIL; 1 (2 BROMO 2 DEOXY BETA DEXTRO XYLOFURANOSYL)THYMINE; 1 (2 BROMO 2 DEOXY BETA DEXTRO XYLOFURANOSYL)URACIL; 1 (2 DEOXY 5 O TRITYL BETA DEXTRO ERYTHRO PENTOFURANOSYL) 5 FLUOROURACIL; 1 (3 BROMO 2,3 DIDEOXY BETA DEXTRO ERYTHRO PENTOFURANOSYL) 5 FLUOROURACIL; 1 (3 BROMO 2,3 DIDEOXY BETA DEXTRO ERYTHRO PENTOFURANOSYL)THYMINE; 1 (3 BROMO 2,3 DIDEOXY BETA DEXTRO THREO PENTOFURANOSYL) 5 FLUOROURACIL; 1 (3 BROMO 3 DEOXY BETA DEXTRO ARABINOFURANOSYL) 5 FLUOROURACIL; 1 (3 BROMO 3 DEOXY BETA DEXTRO ARABINOFURANOSYL)THYMINE; 1 (3 BROMO 3 DEOXY BETA DEXTRO ARABINOFURANOSYL)URACIL; 1 (3 CHLORO 2,3 DIDEOXY BETA DEXTRO ERYTHRO PENTOFURANOSYL) 5 FLUOROURACIL; 1 (3 CHLORO 2,3 DIDEOXY BETA DEXTRO ERYTHRO PENTOFURANOSYL)THYMINE; 1 (3 CHLORO 2,3 DIDEOXY BETA DEXTRO THREO PENTOFURANOSYL) 5 FLUOROURACIL; 1 (3 IODO 2,3 DIDEOXY BETA DEXTRO ERYTHRO PENTOFURANOSYL) 5 FLUOROURACIL; 1 (3 IODO 2,3 DIDEOXY BETA DEXTRO ERYTHRO PENTOFURANOSYL)THYMINE; 1 (3 IODO 2,3 DIDEOXY BETA DEXTRO THREO PENTOFURANOSYL) 5 FLUOROURACIL; 1 (3 O METHANESULFONYL 2 DEOXY BETA DEXTRO ERYTHRO PENTOFURANOSYL) 5 FLUOROURACIL; 3' FLUOROTHYMIDINE; 3',5' DIFLUORO 2',3' DIDEOXYURIDINE; CYCLOSERINE; ISONIAZID; PYRIMIDINE NUCLEOSIDE DERIVATIVE; RIFAMPICIN; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG; 3' BROMO 3' DEOXYARABINOFURANOSYLTHYMINE; 3'-BROMO-3'-DEOXYARABINOFURANOSYLTHYMINE; ARABINONUCLEOSIDE; PYRIMIDINE NUCLEOSIDE;

ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; MONOCYTE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; CELL LINE; CHEMISTRY; DRUG EFFECT; MICROBIOLOGICAL EXAMINATION; MICROBIOLOGY; MULTIDRUG RESISTANCE; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANTITUBERCULAR AGENTS; ARABINONUCLEOSIDES; CELL LINE; DRUG RESISTANCE, MULTIPLE, BACTERIAL; HUMANS; ISONIAZID; MICROBIAL SENSITIVITY TESTS; MONOCYTES; MYCOBACTERIUM TUBERCULOSIS; PYRIMIDINE NUCLEOSIDES; RIFAMPIN; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77952686116     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm100165w     Document Type: Article

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