Polymethylmethacrylate particle exposure causes changes in p38 MAPK and TGF-β signaling in differentiating MC3T3-E1 cells

Journal of Biomedical Materials Research - Part A

Volumn 94, Issue 1, 2010, Pages 234-240

  Ma, Gene K ^a   Chiu, Richard ^a   Huang, Zhinong ^a   Pearl, Jeremy ^a   Ma, Ting ^a   Smith, R Lane ^a   Goodman, Stuart B ^a  

^a STANFORD UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Bone morphogenetic protein; Mitogen activated protein kinases; Osteolysis; Polymethylmethacrylate; Transforming growth factor beta

Indexed keywords

BONE MORPHOGENETIC PROTEINS; DOWN-REGULATION; JOINT REPLACEMENT; MC3T3-E1; MC3T3-E1 CELL; MITOGEN ACTIVATED PROTEIN KINASE; MOLECULAR MECHANISM; NEGATIVE REGULATORS; OSTEOBLAST DIFFERENTIATION; OSTEOGENIC DIFFERENTIATION; OSTEOLYSIS; P38 MAPK; P38 MITOGEN-ACTIVATED PROTEIN KINASE; PERIPROSTHETIC OSTEOLYSIS; PMMA PARTICLE; SCLEROSTIN; SIGNALING PATHWAYS; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTORS; UP-REGULATION; WEAR DEBRIS;

BIOACTIVITY; BONE; DEBRIS; PEPTIDES; POLYESTERS; SIGNALING;

JOINT PROSTHESES;

ALKALINE PHOSPHATASE; BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN 4; MITOGEN ACTIVATED PROTEIN KINASE; OSTEOCALCIN; OSTEOGENIN; POLY(METHYL METHACRYLATE); PROCOLLAGEN C PROTEINASE; SCLEROSTIN; SMAD1 PROTEIN; SMAD2 PROTEIN; SYNAPTOPHYSIN; TRANSCRIPTION FACTOR RUNX2; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA ANTIBODY; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ARTICLE; CELL ACTIVATION; CELL DIFFERENTIATION; CELL LINE; CELL STRAIN MC3T3 E1; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; JOINT PROSTHESIS; MOUSE; NONHUMAN; OSTEOBLAST; OSTEOLYSIS; PROTEIN ANALYSIS; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UPREGULATION;

3T3 CELLS; ANIMALS; BIOCOMPATIBLE MATERIALS; BIOLOGICAL MARKERS; BONE CEMENTS; BONE MORPHOGENETIC PROTEINS; CELL DIFFERENTIATION; ENZYME ACTIVATION; GENE EXPRESSION; MATERIALS TESTING; MICE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PARTICLE SIZE; POLYMETHYL METHACRYLATE; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA;

EID: 77952678288     PISSN: 15493296     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.32686     Document Type: Article

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