Intimate relationship between TGF-β/BMP signaling and urunt domain transcription factor, PEBP2/CBF

Journal of Bone and Joint Surgery

Volumn 83, Issue SUPPL. 1, 2001, Pages

  Bae, S C ^a   Lee, K S ^a   Zhang, Y W ^a   Ito, Y ^a  

^a Chungbuk National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; BONE MORPHOGENETIC PROTEIN; COMPLEMENTARY DNA; OSTEOGENIC PROTEIN 1; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2; RECOMBINANT TRANSFORMING GROWTH FACTOR BETA1; TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR BETA; BGB PROTEIN, DROSOPHILA; CORE BINDING FACTOR; DNA BINDING PROTEIN; DROSOPHILA PROTEIN; RUNX2 PROTEIN, HUMAN; SMAD PROTEIN; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR AP 2; TRANSCRIPTION FACTOR RUNX2; TUMOR PROTEIN;

ANIMAL CELL; CELL DIFFERENTIATION; CONFERENCE PAPER; CONTROLLED STUDY; DNA BINDING; GENE EXPRESSION; MUSCLE DEVELOPMENT; NONHUMAN; OSTEOBLAST; PLASMID; PRIORITY JOURNAL; PROMOTER REGION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; ANIMAL; CELL CULTURE; GENE EXPRESSION REGULATION; HUMAN; PHYSIOLOGY; REVIEW;

ANIMALS; BONE MORPHOGENETIC PROTEINS; CELLS, CULTURED; CORE BINDING FACTOR ALPHA 1 SUBUNIT; CORE BINDING FACTORS; DNA-BINDING PROTEINS; DROSOPHILA PROTEINS; GENE EXPRESSION REGULATION; HUMANS; NEOPLASM PROTEINS; SIGNAL TRANSDUCTION; SMAD PROTEINS; TRANS-ACTIVATORS; TRANSCRIPTION FACTOR AP-2; TRANSCRIPTION FACTORS; TRANSFORMING GROWTH FACTOR BETA;

EID: 0035087875     PISSN: 00219355     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (21)

1. Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage
2. PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 gene
3. Osf2/Cbfa1: A transcriptional activator of osteoblast differentiation
4. Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts
5. Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development
6. The cDNA cloning of the transcripts of human PEBP2alphaA/CBFA1 mapped to 6p12.3-p21.1, the locus for cleidocranial dysplasia
7. Mutations involving the transcription factor CBFA1 cause cleidocranial dysplasia
8. Missense mutations abolishing DNA binding of the osteoblast-specific transcription factor OSF2/CBFA1 in cleidocranial dysplasia
9. PEBP2alphaA/CBFA1 mutations in Japanese cleidocranial dysplasia patients
10. Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells
11. CBF alpha3 (AML2) is induced by TGF-beta1 to bind and activate the mouse germline Ig alpha promoter
12. Smad proteins exist as monomers in vive and undergo homo- and hetero-oligomerization upon activation by serine/threonine kinase receptors
13. Transient upregulation of CBFA1 in response to bone morphogenetic protein-2 and transforming growth factor beta1 in C2C12 myogenic cells coincides with suppression of the myogenic phenotype but is not sufficient for osteoblast differentiation
14. Expression of a single transfected cDNA converts fibroblasts to myoblasts
15. Structure of the rat osteocalcin gene and regulation of vitamin D-dependent expression
16. Interaction and functional cooperation of PEBP2/CBF with Smads. Synergistic induction of the immunoglobulin germline Calpha promoter
17. Smad5 and DPC4 are key molecules in mediating BMP-2-induced osteoblastic differentiation of the pluripotent mesenchymal precursor cell line C2C12
18. Cbfa1 isoforms exert functional differences in osteoblast differentiation
19. A novel transcript encoding an N-terminally truncated AML1/PEBP2 alphaB protein interferes with transactivation and blocks granulocytic differentiation of 32Dc13 myeloid cells
20. Smad6 inhibits signalling by the TGF-beta superfamily