Methylation analysis of 79 patients with growth restriction reveals novel patterns of methylation change at imprinted loci

European Journal of Human Genetics

Volumn 18, Issue 6, 2010, Pages 648-655

  Turner, Claire Louise Susan ^a,b   MacKay, Deborah M ^a,b   Callaway, Jonathan L A ^a,b   Docherty, Louise E ^a,b   Poole, Rebecca L ^a,b   Bullman, Hilary ^b   Lever, Margaret ^b   Castle, Bruce M ^b   Kivuva, Emma C ^c   Turnpenny, Peter D ^c   Mehta, Sarju G ^d   Mansour, Sahar ^e   Wakeling, Emma L ^f   Mathew, Verghese ^g   Madden, Jackie ^a   Davies, Justin H ^h   Temple, I Karen ^a,b  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^b SALISBURY DISTRICT HOSPITAL   (United Kingdom)

^c ROYAL DEVON AND EXETER NHS FOUNDATION TRUST   (United Kingdom)

^d ADDENBROOKE S HOSPITAL   (United Kingdom)

^e ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

^f EALING HOSPITAL NHS TRUST   (United Kingdom)

^g HULL ROYAL INFIRMARY   (United Kingdom)

^h UNIVERSITY HOSPITAL SOUTHAMPTON NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

11p15 epimutation; Growth restriction; H19; Hypomethylation of imprinted loci; IGF2R; Russell Silver syndrome

Indexed keywords

GENE PRODUCT; GROWTH FACTOR RECEPTOR BOUND PROTEIN 10; POTASSIUM CHANNEL KCNQ; POTASSIUM CHANNEL KCNQ10T1; PROTEIN DLK1; PROTEIN MEST1; PROTEIN NESPAS; PROTEIN PEG10; PROTEIN PEG3; PROTEIN PLAGL1; RNA H19; SOMATOMEDIN B PO; SOMATOMEDIN B RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DNA METHYLATION; EPIGENETICS; GENE LOCUS; GENE SEQUENCE; GROWTH RETARDATION; HUMAN; INTRAUTERINE GROWTH RETARDATION; MAJOR CLINICAL STUDY; MOLECULAR IMPRINTING; PHENOTYPE; PRIORITY JOURNAL; PYROSEQUENCING; SHORT STATURE; SILVER RUSSELL SYNDROME;

CHILD; CHILD, PRESCHOOL; COHORT STUDIES; DEVELOPMENTAL DISABILITIES; DNA METHYLATION; EPIGENESIS, GENETIC; FEMALE; FETAL GROWTH RETARDATION; GENETIC LOCI; GENOMIC IMPRINTING; GROWTH DISORDERS; HUMANS; INFANT, NEWBORN; PREGNANCY; RECEPTOR, IGF TYPE 2; RNA, UNTRANSLATED; SEQUENCE ANALYSIS, DNA; SILVER-RUSSELL SYNDROME;

EID: 77952671659     PISSN: 10184813     EISSN: 14765438     Source Type: Journal    
DOI: 10.1038/ejhg.2009.246     Document Type: Article

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