Quinoxaline-2-carboxamide as a carrier ligand in two new platinum(ii) compounds: Synthesis, crystal structure, cytotoxic activity and DNA interaction

Dalton Transactions

Volumn 39, Issue 21, 2010, Pages 5152-5158

  Marqués Gallego, Patricia ^a   Gamiz Gonzalez, M Amparo ^a   Fortea Pérez, Francisco R ^a   Lutz, Martin ^b   Spek, Anthony L ^b   Pevec, Andrej ^c   Kozlevčar, Bojan ^c   Reedijk, Jan ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

^c UNIVERSITY OF LJUBLJANA   (Slovenia)

Author keywords

[No Author keywords available]

Indexed keywords

BIFUNCTIONAL; BIOLOGICAL ACTIVITIES; CARBOXAMIDES; CARRIER LIGANDS; CHELATING LIGANDS; CHLORIDE LIGANDS; CIS-PLATIN; CYTOTOXIC ACTIVITIES; DNA INTERACTION; MODEL BASE; MONODENTATES; PLASMID DNA; QUINOXALINES; SINGLE-CRYSTAL STRUCTURE; SPECTROSCOPIC METHOD; TUMOUR CELLS;

CHELATION; CRYSTAL STRUCTURE; DNA; GENES; LIGANDS; PLATINUM; PLATINUM COMPOUNDS; SPECTROSCOPIC ANALYSIS; SYNTHESIS (CHEMICAL); TRANSITION METAL COMPOUNDS; X RAY DIFFRACTION;

CHLORINE COMPOUNDS;

ANTINEOPLASTIC AGENT; CISPLATIN; DNA; LIGAND; PLATINUM COMPLEX; QUINOXALINE DERIVATIVE; QUINOXALINE-2-CARBOXAMIDE;

ANIMAL; BOVINE; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; HUMAN; MCF 7 CELL LINE; PLASMID; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE; X RAY CRYSTALLOGRAPHY;

ANIMALS; ANTINEOPLASTIC AGENTS; CATTLE; CELL LINE, TUMOR; CELL PROLIFERATION; CISPLATIN; CRYSTALLOGRAPHY, X-RAY; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; LIGANDS; MCF-7 CELLS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; ORGANOPLATINUM COMPOUNDS; PLASMIDS; QUINOXALINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77952648257     PISSN: 14779226     EISSN: 14779234     Source Type: Journal    
DOI: 10.1039/c001158d     Document Type: Article

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