Protection of hippocampal neurogenesis by TAT-Bcl-xL after cerebral ischemia in mice

Experimental Neurology

Volumn 223, Issue 2, 2010, Pages 548-556

  Doeppner, Thorsten R ^a   Dietz, Gunnar P H ^b,d   Weise, Jens ^c   Bähr, Mathias ^a,d  

^a UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

^b H LUNDBECK A S   (Denmark)

^c JENA UNIVERSITY HOSPITAL   (Germany)

^d DFG Research Center for the Molecular Physiology of the Brain CMPB   (Germany)

Author keywords

Cerebral ischemia; Endogenous neurogenesis; Hippocampus; Neuroprotection; Stroke; TAT Bcl xL

Indexed keywords

BROXURIDINE; DOUBLECORTIN; NEURON SPECIFIC NUCLEAR PROTEIN; PROTEIN BCL XL; SODIUM CHLORIDE; TRANSACTIVATOR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; CELL ACTIVATION; CELL COUNT; CELL DIFFERENTIATION; CELL MIGRATION; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; HIPPOCAMPUS; MALE; MICROGLIA; MOUSE; NERVE CELL LESION; NERVOUS SYSTEM DEVELOPMENT; NEURAL STEM CELL; NEUROPROTECTION; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; BCL-X PROTEIN; BRAIN ISCHEMIA; BROMODEOXYURIDINE; CELL DIFFERENTIATION; CELL DIVISION; CELL SURVIVAL; ENCEPHALITIS; HIPPOCAMPUS; MALE; MICE; MICE, INBRED C57BL; MICROGLIA; NEUROGENESIS; NEURONS; NEUROPROTECTIVE AGENTS; RECOMBINANT FUSION PROTEINS; STROKE; TAT GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS;

EID: 77952553933     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2010.02.001     Document Type: Article

References (39)

1. Alvarez-Buylla A., Garcia-Verdugo J.M. Neurogenesis in adult subventricular zone. J. Neurosci. 2002, 22:629-634.
2. Arvidsson A., Kokaia Z., Lindvall O. N-methyl-d-aspartate receptor-mediated increase of neurogenesis in adult rat dentate gyrus following stroke. Eur. J. Neurosci. 2001, 14:10-18.
3. Arvidsson A., Collin T., Kirik D., Kokaia Z., Lindvall O. Neuronal replacement from endogenous precursors in the adult brain after stroke. Nat. Med. 2002, 8:963-970.
4. Buchan A.M., Li H., Cho S., Pulsinelli W.A. Blockade of the AMPA receptor prevents CA1 hippocampal injury following severe but transient forebrain ischemia in adult rats. Neurosci. Lett. 1991, 132:255-258.
5. Cameron H.A., McKay R. Stem cells and neurogenesis in the adult brain. Curr. Opin. Neurobiol. 1998, 8:677-680.
6. Cao G., Pei W., Ge H., Liang Q., Luo Y., Sharp F.R., Lu A., Ran R., Graham S.H., Chen J. In vivo delivery of a Bcl-xL fusion protein containing the TAT protein transduction domain protects against ischemic brain injury and neuronal apoptosis. J. Neurosci. 2002, 22:5423-5431.
7. Colbourne F., Li H., Buchan A.M., Clemens J.A. Continuing postischemic neuronal death in CA1: influence of ischemia duration and cytoprotective doses of NBQX and SNX-111 in rats. Stroke 1999, 30:662-668.
8. Dietz G.P., Bähr M. Synthesis of cell-penetrating peptides and their application in neurobiology. Methods Mol. Biol. 2007, 399:181-198.
9. Dietz G.P., Kilic E., Bahr M. Inhibition of neuronal apoptosis in vitro and in vivo using TAT-mediated protein transduction. Mol. Cell. Neurosci. 2002, 21:29-37.
10. Dietz G.P., Dietz B., Bähr M. Bcl-xL protects cerebellar granule neurons against the late phase, but not against the early phase of glutamate-induced cell death. Brain Res. 2007, 1164:136-141.
11. Dirnagl U., Iadecola C., Moskowitz M.A. Pathobiology of ischaemic stroke: an integrated view. Trends Neurosci. 1999, 22:391-397.
12. Doeppner T.R., Dietz G.P., El Aanbouri M., Gerber J., Witte O.W., Bahr M., Weise J. TAT-Bcl-x(L) improves survival of neuronal precursor cells in the lesioned striatum after focal cerebral ischemia. Neurobiol. Dis. 2009, 34:87-94.
13. Gage F.H., Kempermann G., Palmer T.D., Peterson D.A., Ray J. Multipotent progenitor cells in the adult dentate gyrus. J. Neurobiol. 1998, 36:249-266.
14. Haas S., Weidner N., Winkler J. Adult stem cell therapy in stroke. Curr. Opin. Neurol. 2005, 18:59-64.
15. Jin K., Minami M., Lan J.Q., Mao X.O., Batteur S., Simon R.P., Greenberg D.A. Neurogenesis in dentate subgranular zone and rostral subventricular zone after focal cerebral ischemia in the rat. Proc. Natl. Acad. Sci. USA 2001, 98:4710-4715.
16. Kilic E., Dietz G.P., Hermann D.M., Bahr M. Intravenous TAT-Bcl-Xl is protective after middle cerebral artery occlusion in mice. Ann. Neurol. 2002, 52:617-622.
17. Kluska M.M., Witte O.W., Bolz J., Redecker C. Neurogenesis in the adult dentate gyrus after cortical infarcts: effects of infarct location, N-methyl-d-aspartate receptor blockade and anti-inflammatory treatment. Neuroscience 2005, 135:723-735.
18. Kreutzberg G.W. Microglia: a sensor for pathological events in the CNS. Trends Neurosci. 1996, 19:312-317.
19. Liu J., Solway K., Messing R.O., Sharp F.R. Increased neurogenesis in the dentate gyrus after transient global ischemia in gerbils. J. Neurosci. 1998, 18:7768-7778.
20. Love S. Apoptosis and brain ischaemia. Prog. Neuropsychopharmacol. Biol. Psychiatry 2003, 27:267-282.
21. Morris R.G., Garrud P., Rawlins J.N., O'Keefe J. Place navigation impaired in rats with hippocampal lesions. Nature 1982, 297:681-683.
22. Panickar K.S., Nonner D., Barrett J.N. Overexpression of Bcl-xl protects septal neurons from prolonged hypoglycemia and from acute ischemia-like stress. Neuroscience 2005, 135:73-80.
23. Parent J.M. Injury-induced neurogenesis in the adult mammalian brain. Neuroscientist 2003, 9:261-272.
24. Parent J.M., Vexler Z.S., Gong C., Derugin N., Ferriero D.M. Rat forebrain neurogenesis and striatal neuron replacement after focal stroke. Ann. Neurol. 2002, 52:802-813.
25. Schmidt W., Reymann K.G. Proliferating cells differentiate into neurons in the hippocampal CA1 region of gerbils after global cerebral ischemia. Neurosci. Lett. 2002, 334:153-156.
26. Sharp F.R., Liu J., Bernabeu R. Neurogenesis following brain ischemia. Brain Res. Dev. Brain Res. 2002, 134:23-30.
27. Silva M.T., do Vale A., dos Santos N.M. Secondary necrosis in multicellular animals: an outcome of apoptosis with pathogenic implications. Apoptosis 2008, 13:463-482.
28. Takasawa K., Kitagawa K., Yagita Y., Sasaki T., Tanaka S., Matsushita K., Ohstuki T., Miyata T., Okano H., Hori M., Matsumoto M. Increased proliferation of neural progenitor cells but reduced survival of newborn cells in the contralateral hippocampus after focal cerebral ischemia in rats. J. Cereb. Blood Flow Metab. 2002, 22:299-307.
29. Tanaka R., Yamashiro K., Mochizuki H., Cho N., Onodera M., Mizuno Y., Urabe T. Neurogenesis after transient global ischemia in the adult hippocampus visualized by improved retroviral vector. Stroke 2004, 35:1454-1459.
30. Taupin P. BrdU immunohistochemistry for studying adult neurogenesis: paradigms, pitfalls, limitations, and validation. Brain Res. Rev. 2007, 53:198-214.
31. Taupin P., Gage F.H. Adult neurogenesis and neural stem cells of the central nervous system in mammals. J. Neurosci. Res. 2002, 69:745-749.
32. Tsujimoto Y., Shimizu S., Eguchi Y., Kamiike W., Matsuda H. Bcl-2 and Bcl-xL block apoptosis as well as necrosis: possible involvement of common mediators in apoptotic and necrotic signal transduction pathways. Leukemia 1997, 11(Suppl 3):380-382.
33. Wang F., Jiang Y., Zhang S., Xiao W., Zhu S. Protective effects of overexpression of bcl-xl gene on local cerebral infarction in transgenic mice undergoing permanent occlusion of middle cerebral artery. J. Huazhong Univ. Sci. Technolog. Med. Sci. 2008, 28:56-59.
34. Wang S.H., Zhang Z.J., Guo Y.J., Teng G.J., Chen B.A. Hippocampal neurogenesis and behavioural studies on adult ischemic rat response to chronic mild stress. Behav. Brain Res. 2008, 189:9-16.
35. Westerberg E., Monaghan D.T., Kalimo H., Cotman C.W., Wieloch T.W. Dynamic changes of excitatory amino acid receptors in the rat hippocampus following transient cerebral ischemia. J. Neurosci. 1989, 9:798-805.
36. Wiessner C., Allegrini P.R., Rupalla K., Sauer D., Oltersdorf T., McGregor A.L., Bischoff S., Bottiger B.W., van der Putten H. Neuron-specific transgene expression of Bcl-XL but not Bcl-2 genes reduced lesion size after permanent middle cerebral artery occlusion in mice. Neurosci. Lett. 1999, 268:119-122.
37. Xu L., Koumenis I.L., Tilly J.L., Giffard R.G. Overexpression of bcl-xL protects astrocytes from glucose deprivation and is associated with higher glutathione, ferritin, and iron levels. Anesthesiology 1999, 91:1036-1046.
38. Yamashita T., Ninomiya M., Hernandez Acosta P., Garcia-Verdugo J.M., Sunabori T., Sakaguchi M., Adachi K., Kojima T., Hirota Y., Kawase T., Araki N., Abe K., Okano H., Sawamoto K. Subventricular zone-derived neuroblasts migrate and differentiate into mature neurons in the post-stroke adult striatum. J. Neurosci. 2006, 26:6627-6636.
39. Zhang R., Zhang Z., Zhang C., Zhang L., Robin A., Wang Y., Lu M., Chopp M. Stroke transiently increases subventricular zone cell division from asymmetric to symmetric and increases neuronal differentiation in the adult rat. J. Neurosci. 2004, 24:5810-5815.