IGF-1 can either protect against or increase LPS-induced damage in the developing rat brain

Pediatric Research

Volumn 67, Issue 6, 2010, Pages 579-584

  Pang, Yi ^a   Zheng, Baoying ^a   Campbell, Leigh R ^a   Fan, Lir Wan ^a   Cai, Zhengwei ^a   Rhodes, Philip G ^a  

^a UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; MYELIN BASIC PROTEIN; SOMATOMEDIN C;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN DAMAGE; BRAIN DEVELOPMENT; BRAIN HEMORRHAGE; CELL ACTIVATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG FATALITY; ENCEPHALITIS; ENCEPHALOMALACIA; FEMALE; LOW DRUG DOSE; MALE; NEUTROPHIL CHEMOTAXIS; NEWBORN; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; RAT;

ANIMALS; ANIMALS, NEWBORN; ASTROCYTES; BLOOD-BRAIN BARRIER; BRAIN; CAPILLARY PERMEABILITY; CELL DEATH; CEREBRAL HEMORRHAGE; CHEMOTAXIS, LEUKOCYTE; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENCEPHALITIS; FEMALE; HUMANS; INFANT, NEWBORN; INFLAMMATION MEDIATORS; INJECTIONS, INTRAVENTRICULAR; INSULIN-LIKE GROWTH FACTOR I; INTERLEUKIN-1BETA; LEUKOMALACIA, PERIVENTRICULAR; LIPOPOLYSACCHARIDES; MALE; MICROGLIA; NEUROPROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS;

EID: 77952546865     PISSN: 00313998     EISSN: 15300447     Source Type: Journal    
DOI: 10.1203/PDR.0b013e3181dc240f     Document Type: Article

References (25)

1. Volpe JJ 2003 Cerebral white matter injury of the premature infant-more common than you think. Pediatrics 112:176-180
2. Khwaja O, Volpe JJ 2008 Pathogenesis of cerebral white matter injury of prematurity. Arch Dis Child Fetal Neonatal Ed 93:F153-F161
3. Leviton A, Dammann O 2004 Coagulation, inflammation, and the risk of neonatal white matter damage. Pediatr Res 55:541-545
4. Pang Y, Cai Z, Rhodes PG 2003 Disturbance of oligodendrocyte development, hypomyelination and white matter injury in the neonatal rat brain after intracerebral injection of lipopolysaccharide. Brain Res Dev Brain Res 140:205-214
5. McQuillen PS, Ferriero DM 2004 Selective vulnerability in the developing central nervous system. Pediatr Neurol 30:227-235
6. Pang Y, Zheng B, Fan LW, Rhodes PG, Cai Z 2007 IGF-1 protects oligodendrocyte progenitors against TNFalpha-induced damage by activation of PI3K/Akt and interruption of the mitochondrial apoptotic pathway. Glia 55:1099-1107
7. Cui QL, Zheng WH, Quirion R, Almazan G 2005 Inhibition of Src-like kinases reveals Akt-dependent and-independent pathways in insulin-like growth factor I-mediated oligodendrocyte progenitor survival. J Biol Chem 280:8918-8928
8. Ness JK, Scaduto RC Jr, Wood TL 2004 IGF-I prevents glutamate-mediated bax translocation and cytochrome C release in O4+ oligodendrocyte progenitors. Glia 46:183-194
9. Brywe KG, Mallard C, Gustavsson M, Hedtjarn M, Leverin AL, Wang X, Blomgren K, Isgaard J, Hagberg H 2005 IGF-I neuroprotection in the immature brain after hypoxia-ischemia, involvement of Akt and GSK3beta? Eur J Neurosci 21:1489-1502
10. Wood TL, Loladze V, Altieri S, Gangoli N, Levison SW, Brywe KG, Mallard C, Hagberg H 2007 Delayed IGF-1 administration rescues oligodendrocyte progenitors from glutamate-induced cell death and hypoxic-ischemic brain damage. Dev Neurosci 29:302-310
11. Zhong J, Zhao L, Du Y, Wei G, Yao WG, Lee WH 2009 Delayed IGF-1 treatment reduced long-term hypoxia-ischemia-induced brain damage and improved behavior recovery of immature rats. Neurol Res 31:483-489
12. Johnston MV, Hagberg H 2007 Sex and the pathogenesis of cerebral palsy. Dev Med Child Neurol 49:74-78
13. Lin S, Fan LW, Pang Y, Rhodes PG, Mitchell HJ, Cai Z 2005 IGF-1 protects oligodendrocyte progenitor cells and improves neurological functions following cerebral hypoxia-ischemia in the neonatal rat. Brain Res 1063:15-26
14. Carvey PM, Zhao CH, Hendey B, Lum H, Trachtenberg J, Desai BS, Snyder J, Zhu YG, Ling ZD 2005 6-Hydroxydopamine-induced alterations in blood-brain barrier permeability. Eur J Neurosci 22:1158-1168
15. Vig PJ, Subramony SH, D'Souza DR, Wei J, Lopez ME 2006 Intranasal administration of IGF-1 improves behavior and Purkinje cell pathology in SCA1 mice. Brain Res Bull 69:573-579
16. Cao Y, Gunn AJ, Bennet L, Wu D, George S, Gluckman PD, Shao XM, Guan J 2003 Insulin-like growth factor (IGF)-1 suppresses oligodendrocyte caspase-3 activation and increases glial proliferation after ischemia in near-term fetal sheep. J Cereb Blood Flow Metab 23:739-747
17. Genoud S, Maricic I, Kumar V, Gage FH 2005 Targeted expression of IGF-1 in the central nervous system fails to protect mice from experimental autoimmune encephalomyelitis. J Neuroimmunol 168:40-45
18. Escartin C, Boyer F, Bemelmans AP, Hantraye P, Brouillet E 2007 IGF-1 exacerbates the neurotoxicity of the mitochondrial inhibitor 3NP in rats. Neurosci Lett 425:167-172
19. Balaram SK, Agrawal DK, Edwards JD 1999 Insulin like growth factor-1 activates nuclear factor-kappaB and increases transcription of the intercellular adhesion molecule-1 gene in endothelial cells. Cardiovasc Surg 7:91-97
20. Che W, Lerner-Marmarosh N, Huang Q, Osawa M, Ohta S, Yoshizumi M, Glassman M, Lee JD, Yan C, Berk BC, Abe J 2002 Insulin-like growth factor-1 enhances inflammatory responses in endothelial cells: role of Gab1 and MEKK3 in TNF-alpha-induced c-Jun and NF-kappaB activation and adhesion molecule expression. Circ Res 90:1222-1230
21. Kooijman R, Coppens A, Hooghe-Peters E 2003 IGF-I stimulates IL-8 production in the promyelocytic cell line HL-60 through activation of extracellular signal-regulated protein kinase. Cell Signal 15:1091-1098
22. Vallee S, Fouchier F, Bremond P, Briand C, Marvaldi J, Champion S 2003 Insulin-like growth factor-1 downregulates nuclear factor kappa B activation and upregulates interleukin-8 gene expression induced by tumor necrosis factor alpha. Biochem Biophys Res Commun 305:831-839
23. Mauro L, Bartucci M, Morelli C, Ando S, Surmacz E 2001 IGF-I receptor-induced cell-cell adhesion of MCF-7 breast cancer cells requires the expression of junction protein ZO-1. J Biol Chem 276:39892-39897
24. Tonra JR, Mendell LM 1997 Rabbit IgG distribution in skin, spinal cord and DRG following systemic injection in rat. J Neuroimmunol 80:97-105
25. Kovacs GT, Worgall S, Schwalbach P, Steichele T, Mehls O, Rosivall L 1999 Hypoglycemic effects of insulin-like growth factor-1 in experimental uremia: can concomitant growth hormone administration prevent this effect? Horm Res 51:193-200