A conserved distal segment of the mouse CSF-1 receptor promoter is required for maximal expression of a reporter gene in macrophages and osteoclasts of transgenic mice

Journal of Leukocyte Biology

Volumn 87, Issue 5, 2010, Pages 815-822

  Ovchinnikov, Dmitry A ^a   DeBats, Claire E E ^a   Sester, David P ^b   Sweet, Matthew J ^a   Hume, David A ^a,b  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Knockout mice; Transgenic

Indexed keywords

COLONY STIMULATING FACTOR 1 RECEPTOR; COLONY STIMULATING FACTOR RECEPTOR; GENOMIC DNA; UNCLASSIFIED DRUG; MESSENGER RNA;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; GENE EXPRESSION; HUMAN; HUMAN CELL; MACROPHAGE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OSTEOCLAST; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; TRANSGENIC MOUSE; TROPHOBLAST; 5' UNTRANSLATED REGION; AMINO ACID SEQUENCE; ANIMAL; CELL DIFFERENTIATION; CELL SEPARATION; CYTOLOGY; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; IMMUNOLOGY; METABOLISM; MOLECULAR GENETICS; PREGNANCY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

MUS; MUS MUSCULUS; RODENTIA;

5' UNTRANSLATED REGIONS; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CELL DIFFERENTIATION; CELL SEPARATION; CONSERVED SEQUENCE; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENES, REPORTER; HUMANS; MACROPHAGES; MICE; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; OSTEOCLASTS; PREGNANCY; PROMOTER REGIONS, GENETIC; RECEPTOR, MACROPHAGE COLONY-STIMULATING FACTOR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSFECTION; TROPHOBLASTS;

EID: 77952529955     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0809557     Document Type: Article

References (20)

1. Bonifer, C., Hume, D. A. (2008) The transcriptional regulation of the colony-stimulating factor 1 receptor (Csf1r) gene during hematopoiesis. Front. Biosci. 13, 549-560.
2. Chitu, V., Stanley, E. R. (2006) Colony-stimulating factor-1 in immunity and inflammation. Curr. Opin. Immunol. 18, 39-48.
3. Hume, D. A. (2006) The mononuclear phagocyte system. Curr. Opin. Immunol. 18, 49-53.
4. Sasmono, R. T., Oceandy, D., Pollard, J. W., Tong, W., Pavli, P., Wainwright, B. J., Ostrowski, M. C., Himes, S. R., Hume, D. A. (2003) A macrophage colony-stimulating factor receptor-green fluorescent protein transgene is expressed throughout the mononuclear phagocyte system of the mouse. Blood 101, 1155-1163. (Pubitemid 36139391)
5. Favot, P., Yue, X., Hume, D. A. (1995) Regulation of the c-fms promoter in murine tumor cell lines. Oncogene 11, 1371-1381.
6. Himes, S. R., Cronau, S., Mulford, C., Hume, D. A. (2005) The Runx1 transcription factor controls CSF-1-dependent and -independent growth and survival of macrophages. Oncogene 24, 5278-5286. (Pubitemid 43080098)
7. Hume, D. A., Sasmono, T., Himes, S. R., Sharma, S. M., Bronisz, A., Constantin, M., Ostrowski, M. C., Ross, I. L. (2008) The Ewing sarcoma protein (EWS) binds directly to the proximal elements of the macrophage-specific promoter of the CSF-1 receptor (Csf1r) gene. J. Immunol. 180, 6733-6742.
8. Ross, I. L., Yue, X., Ostrowski, M. C., Hume, D. A. (1998) Interaction between PU.1 and another Ets family transcription factor promotes macrophage-specific basal transcription initiation. J. Biol. Chem. 273, 6662-6669.
9. Yan, C., Lian, X., Li, Y., Dai, Y., White, A., Qin, Y., Li, H., Hume, D. A., Du, H. (2006) Macrophage-specific expression of human lysosomal acid lipase corrects inflammation and pathogenic phenotypes in lal-/- mice. Am. J. Pathol. 169, 916-926.
10. Ovchinnikov, D. A., van Zuylen, W. J., Debats, C. E., Alexander, K. A., Kellie, S., Hume, D. A. (2008) Expression of Gal4-dependent transgenes in cells of the mononuclear phagocyte system labeled with enhanced cyan fluorescent protein using Csf1r-Gal4VP16/UAS-ECFP double-transgenic mice. J. Leukoc. Biol. 83, 430-433.
11. Meadows, N. A., Sharma, S. M., Faulkner, G. J., Ostrowski, M. C., Hume, D. A., Cassady, A. I. (2007) The expression of chloride channel 7 (CLCN7) and OstM1 in osteoclasts is co-regulated by microphthalmia transcription factor. J. Biol. Chem. 282, 1891-1904.
12. Sasmono, R. T., Ehrnsperger, A., Cronau, S. L., Ravasi, T., Kandane, R., Hickey, M. J., Cook, A. D., Himes, S. R., Hamilton, J. A., Hume, D. A. (2007) Mouse neutrophilic granulocytes express mRNA encoding the macrophage colony-stimulating factor receptor (CSF-1R) as well as many other macrophage-specific transcripts and can transdifferentiate into macrophages in vitro in response to CSF-1. J. Leukoc. Biol. 82, 111-123.
13. Auffray, C., Fogg, D. K., Narni-Mancinelli, E., Senechal, B., Trouillet, C., Saederup, N., Leemput, J., Bigot, K., Campisi, L., Abitbol, M., Molina, T., Charo, I., Hume, D. A., Cumano, A., Lauvau, G., Geissmann, F. (2009) CX3CR1+ CD115+ CD135+ common macrophage/DC precursors and the role of CX3CR1 in their response to inflammation. J. Exp. Med. 206, 595-606.
14. Sunderkotter, C., Nikolic, T., Dillon, M. J., Van Rooijen, N., Stehling, M., Drevets, D. A., Leenen, P. J. (2004) Subpopulations of mouse blood monocytes differ in maturation stage and inflammatory response. J. Immunol. 172, 4410-4417. (Pubitemid 38375256)
15. Irvine, K. M., Burns, C. J., Wilks, A. F., Su, S., Hume, D. A., Sweet, M. J. (2006) A CSF-1 receptor kinase inhibitor targets effector functions and inhibits pro-inflammatory cytokine production from murine macrophage populations. FASEB J. 20, 1921-1923.
16. Chang, M. K., Raggatt, L. J., Alexander, K. A., Kuliwaba, J. S., Fazzalari, N. L., Schroder, K., Maylin, E. R., Ripoll, V. M., Hume, D. A., Pettit, A. R. (2008) Osteal tissue macrophages are intercalated throughout human and mouse bone lining tissues and regulate osteoblast function in vitro and in vivo. J. Immunol. 181, 1232-1244.
17. Hume, D. A. (2008) Differentiation and heterogeneity in the mononuclear phagocyte system. Mucosal Immunol. 1, 432-441.
18. Ovchinnikov, D. A. (2008) Macrophages in the embryo and beyond: much more than just giant phagocytes. Genesis 46, 447-462.
19. Walsh, N. C., Cahill, M., Carninci, P., Kawai, J., Okazaki, Y., Hayashizaki, Y., Hume, D. A., Cassady, A. I. (2003) Multiple tissue-specific promoters control expression of the murine tartrate-resistant acid phosphatase gene. Gene 307, 111-123. (Pubitemid 36428867)
20. Pang, M., Martinez, A. F., Fernandez, I., Balkan, W., Troen, B. R. (2007) AP-1 stimulated the cathepsin K promoter in RAW264.7 cells. Gene 403, 151-158. (Pubitemid 47488713)