Cardiovascular risk factors and γ-glutamyltransferase fractions in healthy individuals

Clinical Chemistry and Laboratory Medicine

Volumn 48, Issue 5, 2010, Pages 713-717

  Franzini, Maria ^a   Paolicchi, Aldo ^b   Fornaciari, Irene ^a   Ottaviano, Virginia ^b   Fierabracci, Vanna ^b   Maltinti, Maristella ^c   Ripoli, Andrea ^c   Zyw, Luc ^c   Scatena, Fabrizio ^d   Passino, Claudio ^a,c   Pompella, Alfonso ^b   Emdin, Michele ^c  

^a SCUOLA SUPERIORE SANT ANNA   (Italy)

^b UNIVERSITY OF PISA   (Italy)

^c CNR   (Italy)

^d UNIVERSITY HOSPITAL OF PISA   (Italy)

Author keywords

glutamyltransferase activity; glutamyltransferase fractions; Gel filtration chromatography; Risk factors

Indexed keywords

ALANINE AMINOTRANSFERASE; C REACTIVE PROTEIN; GAMMA GLUTAMYLTRANSFERASE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

ADULT; AGE; ARTERIAL PRESSURE; ARTICLE; BODY MASS; CARDIOVASCULAR RISK; FEMALE; GENDER; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN EXPERIMENT; MALE; MULTIPLE LINEAR REGRESSION ANALYSIS; NORMAL HUMAN; PRIORITY JOURNAL;

ADULT; AGE FACTORS; BLOOD GLUCOSE; BLOOD PRESSURE; BODY MASS INDEX; C-REACTIVE PROTEIN; CARDIOVASCULAR DISEASES; CHOLESTEROL, HDL; CHOLESTEROL, LDL; FEMALE; GAMMA-GLUTAMYLTRANSFERASE; HUMANS; MALE; MIDDLE AGED; REGRESSION ANALYSIS; RISK FACTORS; SEX FACTORS; TRIGLYCERIDES;

EID: 77952505613     PISSN: 14346621     EISSN: 14374331     Source Type: Journal    
DOI: 10.1515/CCLM.2010.125     Document Type: Article

References (28)

1. Whitfield JB. Gamma glutamyl transferase. Crit Rev Clin Lab Sci 2001;38:263-355.
2. Paolicchi A, Emdin M, Ghliozeni E, Ciancia E, Passino C, Popoff G, et al. Human atherosclerotic plaques contain gamma-glutamyl transpeptidase enzyme activity [Images in cardiovascular medicine]. Circulation 2004;109:1440.
3. Emdin M, Pompella A, Paolicchi A. Gamma-glutamyltransfe-rase, atherosclerosis, and cardiovascular disease: triggering oxi-dative stress within the plaque [editorial]. Circulation 2005;112:2078-80.
4. Lee DH, Jacobs DR Jr, Gross M, Kiefe CI, Roseman J, Lewis CE, et al. Gamma-glutamyltransferase is a predictor of incident diabetes and hypertension: the Coronary Artery Risk Development in Young Adults (CARDIA) study. Clin Chem 2003;49:1358-66. (Pubitemid 36900623)
5. Lee DH, Jacobs DR Jr, Gross M, Steffes M. Serum gamma-glutamyltransferase was differently associated with microalbu-minuria by status of hypertension or diabetes: the Coronary Artery Risk Development in Young Adults (CARDIA) study. Clin Chem 2005;51:1185-91.
6. Lee DH, Silventoinen K, Jacobs DR Jr, Jousilahti P, Tuomileto J. Gamma-glutamyltransferase, obesity, and the risk of type 2 diabetes: observational cohort study among 20, 158 middle-aged men and women. J Clin Endocr Metab 2004;89:5410-4.
7. Lim JS, Lee DH, Park JY, Jin SH, Jacobs DR Jr. A strong interaction between serum gamma-glutamyltransferase and obesity on the risk of prevalent type 2 diabetes: results from the Third National Health and Nutrition Examination Survey. Clin Chem 2007;53:1092-8.
8. Targher G, Zoppini G, Lippi G, Guidi GC, Muggeo M. Effect of serum gamma-glutamyltransferase and obesity on the risk of dyslipidemia and poor glycemic control in type 2 diabetic patients: cross-sectional findings from the Verona diabetes study. Clin Chem 2007;53:1867-9.
9. Lippi G, Targher G, Guidi GC. Relationship between gamma- glutamyltransferase, fasting plasma glucose, and triglycerides in the general population. Clin Chem 2007;53:1866-7. (Pubitemid 47509685)
10. Lee DS, Evans JC, Robins SJ, Wilson PW, Albano I, Fox CS, et al. Gamma glutamyl transferase and metabolic syndrome, cardiovascular disease, and mortality risk: the Framingham Heart study. Arterioscler Thromb Vasc Biol 2007;27:127-33.
11. Ruttmann E, Brant LJ, Concin H, Diem G, Rapp K, Ulmer H. Gamma-glutamyltransferase as a risk factor for cardiovascular disease mortality. An investigation in a cohort of 163, 944 Austrian adults. Circulation 2005;112:2130-7.
12. Lee DH, Silventoinen K, Hu G, Jacobs DR Jr, Jousilahti P, Sundvall J, et al. Serum gamma-glutamyltransferase predicts non-fatal myocardial infarction and fatal coronary heart disease among 28, 838 middle-aged men and women. Eur Heart J 2006;27:2170-6.
13. Meisinger C, Doring A, Schneider A, Lowel H, KORA Study Group. Serum gamma-glutamyltransferase is a predictor of incident coronary events in apparently healthy men from the general population. Atherosclerosis 2006;189:297-302.
14. Emdin M, Passino C, Michelassi C, Titta F, L'Abbate A, Dona-to L, et al. Prognostic value of serum gamma-glutamyl trans-ferase activity after myocardial infarction. Eur Heart J 2001;22:1802-7.
15. Conigrave KM, Saunders JB, Reznik RB, Whitfield JB. Prediction of alcohol-related harm by laboratory test results. Clin Chem 1993;39:2266-70.
16. Wannamethee G, Ebrahim S, Shaper AG. Gamma-glutamyl-transferase: determinants and association with mortality from ischaemic heart disease and all causes. Am J Epidemiol 1995;142:699-708.
17. Brenner H, Rothenbacher D, Arndt V, Schuberth S, Fraisse E, Fliedner TM. Distribution, determinants, and prognostic value of gamma-glutamyltranspeptidase for all-cause mortality in a cohort of construction workers from south Germany. Prev Med 1997;26:305-10.
18. Lee DH, Blomhoff R, Jacobs DR Jr. Is serum gamma gluta-myltransferase a marker of oxidative stress? Free Radic Res 2004;38:535-9.
19. Lee DH, Jacobs DR Jr. Association between serum concentrations of persistent organic pollutants and gamma glutamyltrans-ferase: results from the National Health and Examination Survey 1999-2002. Clin Chem 2006;52:1825-7.
20. Paolicchi A, Minotti G, Tonarelli P, Tongiani R, De Cesare D, Mezzetti A, et al. Gamma-glutamyl transpeptidase-dependent iron reduction and LDL oxidation - a potential mechanism in atherosclerosis. J Investig Med 1999;47:151-60.
21. Dominici S, Paolicchi A, Lorenzini E, Maellaro E, Comporti M, Pieri L, et al. Gamma-glutamyltransferase-dependent prooxidant reactions: a factor in multiple processes. Biofactors 2003;17:187-98.
22. Emdin M, Passino C, Donato L, Paolicchi A, Pompella A. Serum gamma-glutamyltransferase as a risk factor of ischemic stroke might be independent of alcohol consumption. Stroke 2002;33:1163-4.
23. Franzini M, Bramanti E, Ottaviano V, Ghiri E, Scatena F, Bar-sacchi R, et al. A high performance gel filtration chromatog-raphy method for gamma-glutamyltransferase fraction analysis. Anal Biochem 2008;374:1-6.
24. Franzini M, Ottaviano V, Fierabracci V, Bramanti E, Zyw L, Barsacchi R, et al. Fractions of plasma gamma-glutamyltrans-ferase in healthy individuals: reference values. Clin Chim Acta 2008;395:188-9.
25. Franzini M, Corti A, Martinelli B, Del Corso A, Emdin M, Parenti GF, et al. Gamma-glutamyltransferase activity in human atherosclerotic plaques - biochemical similarities with the circulating enzyme. Atherosclerosis 2009;202:119-27.
26. Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med 1998;15:539-53.
27. World Health Organization. Definition, diagnosis and classification of diabetes mellitus and its complications: report of a WHO Consultation. Part 1: diagnosis and classification of diabetes mellitus. Geneva, Switzerland: World Health Organization; 1999. Available at: http://whqlibdoc.who.int/hq/1999/WHO- NCD-NCS-99.2pdf Accessed April 2009.
28. Schellenberg F, Schwan R, Mennetrey L, Loiseaux MN, Pagès JC, Reynaud M. Dose-effect relation between daily ethanol intake in the range 0-70 grams and %CDT value: validation of a cut-off value. Alcohol Alcohol 2005;40:531-4.