Microwave accelerated synthesis of PET image contrast agents for AD research

Current Alzheimer Research

Volumn 7, Issue 3, 2010, Pages 251-254

  Kallmerten, A E ^a   Jones, G B ^a  

^a NORTHEASTERN UNIVERSITY   (United States)

Author keywords

F18; Imaging agents; Microwave; PET; Radiochemistry; Synthesis

Indexed keywords

FLUORINE 18; N2 [2 (3,5 DIFLUOROPHENYL) 2 HYDROXYACETYL] N1 (6,7 DIHYDRO 5 METHYL 6 OXO 5H DIBENZ[B,D]AZEPIN 7 YL)ALANINAMIDE;

ALZHEIMER DISEASE; ARTICLE; CATALYSIS; HUMAN; ISOTOPE LABELING; MEDICAL RESEARCH; MICROWAVE IRRADIATION; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RADIOCHEMISTRY;

AFFINITY LABELS; ALZHEIMER DISEASE; ANIMALS; CONTRAST MEDIA; HUMANS; MICROWAVES; MOLECULAR STRUCTURE; POSITRON-EMISSION TOMOGRAPHY; RADIOCHEMISTRY; RADIOISOTOPES;

EID: 77952503299     PISSN: 15672050     EISSN: None     Source Type: Journal    
DOI: 10.2174/156720510791050830     Document Type: Article

References (16)

1. Phelps ME. Positron emission tomography provides molecular imaging of biological processes. Proc Natl Acad Sci USA 97: 9226-9233 (2000).
2. Hamacher K, Coenen HH, Stocklin G. Efficient stereospecific synthesis of no-carrier-added 2-[18 F]-fluoro-2-deoxy-d-glucose using aminopolyther supported nucleophilic substitution. J Nucl Med 27: 235-238 (1986).
3. nd ed.; Loupy A. Ed., Berlin, Germany: Wiley-VCH (2006).
4. Miller PW, Long NJ, Vilar R, Gee AD. Synthesis of 11C, 18F, 15O, and 13N radiolabels for positron emission tomography. Angew. Chem Intl Ed Engl 47: 8998-9033 (2008).
5. Mukherjee J, Head E, Pichika R, Easwaramoorthy B, Collins D, Chen I, et al. Radiotracers for a multi-target approach to the diagnosis of Alzheimer's disease. J Label Compd Radiopharm 50: 375-382 (2007).
6. Klunk WE, Lopresti BJ, Ikonomovic MD, Lefterov IM, Koldamova RP, Abrahamason EE, et al. Binding of the positron emission tomography tracer pittsburgh compound-B reflects the amount of amyloid-{beta} in Alzheimer's disease brain but not in transgenic mouse brain. J Neurosci 25: 10598-10606 (2005).
7. Agdeppa ED, Kepe V, Liu J, Flores-Torres S, Satayamurthy N, Petric A, et al. Binding characteristics of radiofluorinated 6-dialkylamino-2-naphthylethylidene derivatives as positron emission tomography imaging probes for beta-amyloid plaques in Alzheimer's disease. J Neurosci 21: RC189 (1-5) (2001).
8. Sperling R, Johnson K, Pontecorvo M, Safirstein B, Farmer M, Holub R, et al. Alzheimer's Association Update. Alzheimers Dement 5: 197-198 (2009).
9. Mukerjee J, Easwaramoorthy B, Chen I, Collins D, Pichika R, Wang CS, et al. Radiotracers for a multi-target approach to the diagnosis of Alzheimer's disease. J Nucl Med 47: 134 (2006).
10. Saigal N, Pichika R, Easwaramoorthy B, Collins D, Christian BT, Shi B, et al. Synthesis and biologic evaluation of a novel serotonin 5-HT1A receptor. J Nucl Med 47: 1697-1706 (2006).
11. Joyce JN, Meyers AJ, Gurevich E. Dopamine D2 receptor bands in normal human temporal cortex are absent in Alzheimer's disease. Brain Res 784: 7-17 (1998)
12. Kappe CO. Controlled Microwave Heating in Modern Organic Synthesis. Angew Chem Intl Ed 43: 6250-6284 (2004).
13. Gabriel C, Gabriel S, Grant EH, Halstead BSJ, Mingos DMP. Dielectric parameters relevant to microwave dielectric heating. Chem Soc Rev 27: 213-223 (1998).
14. Sun H, DiMagno SG. Fluoride relay: a new concept for the rapid preparation of anhydrous nucleophilic fluoride salts from KF. Chem Commun 528-529 (2007).
15. Chi DY, Kilbourn MR, Katzenellenbogen JA, Welch MJ. A rapid and efficient method for the fluoroalkylation of amines and amides. Development of a method suitable for incorporation of the short-lived positron emitting radionuclide fluorine-18. J Org Chem 52: 658-664 (1987).
16. Kallmerten AE, Jones GB. A new method for in situ fluoroalkylation of arenes. provisional patent, Northeastern University PCT Appl. No. 61/240,379.