Novel sol-gel organic-inorganic hybrid materials for drug delivery

Journal of Applied Biomaterials and Biomechanics

Volumn 8, Issue 1, 2010, Pages 42-51

  Catauro, Michelina ^a   Verardi, Duilio ^a   Melisi, Daniela ^b   Belotti, Federico ^c   Mustarelli, Piercarlo ^c  

^a SECOND UNIVERSITY OF NAPLES   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c UNIVERSITY OF PAVIA   (Italy)

Author keywords

Organic inorganic hybrid; Sol gel; Solid state NMR

Indexed keywords

CARBOXYL GROUP; CHLOROFORM; HYDROGEN; INDOMETACIN; KETOPROFEN; MICROSPHERE; POLYCAPROLACTONE; WATER; YTTRIUM; ZIRCONIUM OXIDE; INORGANIC COMPOUND; LACTIDE-CAPROLACTONE COPOLYMER; NONSTEROID ANTIINFLAMMATORY AGENT; ORGANIC COMPOUND; OXIDE; POLYESTER; ZIRCONIUM;

ARTICLE; BODY FLUID; CHEMICAL STRUCTURE; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG RELEASE; HYDROGEN BOND; INFRARED SPECTROSCOPY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRECIPITATION; SIMULATION; SOLID STATE; TIMED DRUG RELEASE; ULTRAVIOLET SPECTROSCOPY; CHEMISTRY; INFUSION PUMP; KINETICS; PHASE TRANSITION; PROCEDURES;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; INDOMETHACIN; INFUSION PUMPS, IMPLANTABLE; INORGANIC CHEMICALS; KETOPROFEN; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; ORGANIC CHEMICALS; OXIDES; PHASE TRANSITION; POLYESTERS; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; ZIRCONIUM;

EID: 77952496913     PISSN: 17226899     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Hutmacher DW, Schantz T, Zein I, Ng KW, Teoh SH, Tan KC. Mechanical properties and cell cultural response of polycaprolactone scaffolds designed and fabricated via fused deposition modeling. J Biomed Mater Res 2001; 55: 203-216 (Pubitemid 32198503)
2. Khor HL, Ng KW, Schantz JT, et al. Poly(ε-caprolactone) films as a potential substrate for tissue engineering an epidermal equivalent. Mater Sci Eng C 2002; 20: 71-75
3. Allen C, Han J, Yu Y, Maysinger D, Eisenberg A. Polycaprolactone-b-poly (ethylene oxide) copolymer micelles as a delivery vehicle for dihydrotestosterone. J Control Release 2000; 63: 275-286
4. Chen B, Evans JRG. Poly(ε-caprolactone)-clay nanocomposites: structure and mechanical properties. Macromolecules 2005; 39: 747-754
5. Messersmith PB, Giannelis EP. Polymer-layered silicate nanocomposites: in situ intercalative polymerization of epsilon-caprolactone in layered silicates. Chem Mater 1993; 5: 1064-1066
6. Nie K, Pang W, Wang Y, Lu F, Zhu Q. Effects of specific bonding interactions in poly(ε-caprolactone)/silica hybrid materials on optical transparency and melting behavior. Mater Lett 2005; 59: 1325-1328 (Pubitemid 40308963)
7. Wu CS. In situ polymerization of titanium isopropoxide in polycaprolactone: properties and characterization of the hybrid nanocomposites. J Appl Polym Sci 2004; 92: 1749-1757
8. Young SK, Gemeinhardt GC, Sherman JW, et al. Covalent and non-covalently coupled polyester-inorganic composite materials. Polymer 2002; 43: 6101-6114
9. 2 hybrid material. J Mater Sci Mter Med 2003; 38: 3097-3106
10. 2. J Mater Sci Mater Med 2004; 15: 991-999
11. De Gaetano F, Ambrosio L, Raucci MG, Marotta A, Catauro M. Sol-gel processing of drug delivery materials and release kinetics. J Mater Sci Mater Med 2005; 16: 261-268
12. 2/PCL hybrid materials synthesized by sol-gel processing. J Biomed Mater Res 2006; 77: 340-346
13. Catauro M, Raucci MG, Ausanio. Sol-gel processing of drug delivery zirconia/polycaprolactone hybrid materials. J Mater Sci Mater Med 2008; 19: 531-546
14. Fedotov VD, Schneider H. Structure and dynamics of bulk polymers by NMR methods. In: Diehl P, et al, eds. NMR Basic Principles and Progress. Berlin: Springer 1989; 242-257
15. Kaji H, Horii F. Solid-state NMR analyses of the structure and dynamics of polymers in the different states. Macromolecules 1997; 30: 5791-5797
16. Wang J, Cheung MK, Mi Y. Miscibility and morphology in crystalline/amorphous blends of poly(caprolactone)/poly(4-vinylphenol) as studied by DSC, FTIR, and 13C solid state NMR. Polymer 2002; 43: 1357-1364
17. Hrobarikova J, Robert JL, Calberg C, Jerome R, Grandjean. Solid-state NMR study of intercalated species in poly(ε-caprolactone)/clay nanocomposites. Langmuir 2004; 20: 9828-9833
18. Ito T, Yamaguchi Y, Watanabe H, Asakura T. Structural analysis of oriented poly(ε-caprolactone) including CaCO3 particles with 13C solid-state NMR. J Appl Polym Sci 2001; 80: 2376-2382 (Pubitemid 32372066)
19. Queiroz AC, Santos JD, Monteiro FJ, Gibson IR, Knowles JC. Adsorption and release studies of sodium ampicillin from hydroxyapatite and glass-reinforced hydroxyapatite composites. Biomaterials 2001; 22: 1393-1400
20. Arcos D, Ragel CV, Vallet-Regi M. Bioactivity in glass/PMMA composites used as drug delivery system. Biomaterials 2001; 22: 701-708 (Pubitemid 32114124)
21. Yilmaz E, Bengisu M. Drug entrapment in silica microspheres through a single step sol-gel process and in vitro release behavior. J Biomed Mater Res B Appl Biomater 2006; 19: 149-155
22. Somayasi BV, Jariwalau U, Jaya Chandran P, Vidyalakshimi K, Dulhami RV. Evaluation of antimicrobial efficacy and release pattern of tetracycline and metronidazole using a local delivery system. J Periodontol 1998; 69: 409-413
23. Teoli D, Parisi L, Realdon N, Guglielmi M, Rosato A, Morpurgo M. Wet sol-gel derived silica for controlled release of proteins. J Control Release 2006; 116: 295-303. (Pubitemid 44827407)
24. Shinto Y, Uchida A, Korkusuz F, Avaki M, Ono K. Calcium hydroxyapatite ceramic used as a delivery system for antibiotics. J Bone Joint Surg Br 1992; 74: 600-604
25. Itokazu M, Itoh Y, Fukuta M, et al. Treatment of osteomyelitis by using antibiotic-loaded porous ceramic. Bioceramics 1999; 12: 3-6.
26. Ragel CV, Vallet-Regì M. In vitro bioactivity and gentamicin release from glass-polymer-antibiotic composites. J Biomed Mater Res 2000; 51: 424-429
27. Hench LL. Bioceramics. J Am Ceram Soc 1998; 81: 1705-1728
28. Hench LL, Kokubo T. Handbook of Biomaterial Properties. In: Black J, Hasting G, eds. London: Chapman & Hall, 1988; 355-362
29. Kokubo T, Kushitani H, Sakka S, Kitsugi T, Yamamuro T. Solutions able to reproduce in vivo surface-structure changes in bioactive glass-ceramics A-W. J Biomed Mater Res 1990; 24: 721-734 (Pubitemid 20236523)
30. Thomas M. Ultraviolet and visible spectroscopy. In: Ando DJ, ed. England: Wiley 1996; 16-30.
31. Young SK, Gemeinhardt GC, Sherman JW, et al. Covalent and non-covalently coupled polyester-inorganic composite materials. Polymer 2002; 42: 6101-6109
32. He Y, Zhu B, Inoue Y. Hydrogen bonds in polymer blends. Prog Polym Sci 2004; 29: 1021-1051
33. Baez JE, Martinez-Richa A, Marcos-Fernandez A. One-step route to α-hydroxyl-ω-(carboxylic acid) polylactones using catalysis by decamolybdate anion. Macromolecules 2005; 38: 1599-1608 (Pubitemid 40384575)
34. Radlein E, Frischot GH. Atomic force microscopy as a tool to correlate nanostructure to properties of glasses. J Non-Cryst Solids 1997; 222: 69-82. (Pubitemid 127377933)
35. Wei Y, Danliang J, Brennan D, et al. Atomic force microscopy study of organic-inorganic hybrid materials. Chem Mater 1998. 10: 769-772 (Pubitemid 128485539)
36. Catauro M, Melisi D, Curcio A, Rimoli MG. Sol-gel processing of anti-inflammatory entrapment in silica, release kinetics, and bioactivity. J Biomed Mater Res A 2008; 87: 843-849