Oral glucose solution as pain relief in newborns: Results of a clinical trial

Birth

Volumn 37, Issue 2, 2010, Pages 98-105

  Dilen, Ben ^a   Elseviers, Monique ^b  

^a Heilig Hart Hospital   (Belgium)

^b Department of Research Methodology ^*  (Belgium)

Author keywords

Glucose solution; Newborn; Nonpharmacologic pain relief; Pain; Venipuncture

Indexed keywords

GLUCOSE;

ARTICLE; CLINICAL TRIAL; COMPARATIVE STUDY; DOUBLE BLIND PROCEDURE; FEMALE; HUMAN; MALE; NEWBORN; ORAL DRUG ADMINISTRATION; PAIN; PAIN ASSESSMENT; PHLEBOTOMY;

ADMINISTRATION, ORAL; DOUBLE-BLIND METHOD; FEMALE; GLUCOSE; HUMANS; INFANT, NEWBORN; MALE; PAIN; PAIN MEASUREMENT; PHLEBOTOMY;

EID: 77952494667     PISSN: 07307659     EISSN: 1523536X     Source Type: Journal    
DOI: 10.1111/j.1523-536X.2010.00389.x     Document Type: Article

References (34)

1. Bellieni CV, Bagnoli F, Perrone S, et al. Effect of multisensory stimulation on analgesia in term newborns: A randomized controlled trial. Pediatr Res 2002 51 (4 460 463.
2. Warnock F, Lander J. Foundations of knowledge about neonatal pain. J Pain Symptom Manage 2004 27 (2 170 179.
3. Akcam M, Örmeci AR. Oral hypertonic spray: A practical alternative for analgesia in the newborn. Acta Paediatr 2004 93 : 1330 1333.
4. Lee SJ, Ralston HJP, Drey EA, et al. Fetal pain: A systematic multidisciplinary review of the evidence. JAMA 2005 294 (8 947 954.
5. Deshmukh LS, Udani RH. Analgesic effect of oral glucose in preterm infants during venipuncture - A double-blind, randomized, controlled trial. J Trop Pediatr 2002 48 : 138 141.
6. Gaspardo CM, Linhares MBM, Martinez FE. The efficacy of sucrose for the relief of pain in neonates: A systematic review of the literature. J Pediatr (Rio J) 2005 81 (6 435 442.
7. Eriksson M, Gradin M, Schollin J. Oral glucose and venepuncture reduce blood sampling pain in newborns. Early Hum Dev 1999 55 : 211 218.
8. Abad F, Díaz-Gómez NM, Domenech E, et al. Oral sucrose compares favourably with lidocaine-prilocaine cream for pain relief during venepuncture in neonates. Acta Paediatr 2001 90 : 160 165.
9. Carbajal R, Chauvet X, Couderc S, Olivier-Martin M. Randomised trial of analgesic effects of sucrose, glucose, and pacifiers in term neonates. BMJ 1999 319 : 1393 1397.
10. Branco A, Fekete SMW, Rugolo LMSS, Rehder MI. The newborn pain cry: Descriptive acoustic spectrographic analysis. Int J Pediatr Otorhinolaryngol 2007 71 : 539 546.
11. Anand KJS. Consensus statement for the prevention and management of pain in the newborn. Arch Pediatr Adolesc Med 2001 155 : 173 180.
12. Gradin M, Finnström O, Schollin J. Feeding and oral glucose - Additive effects on pain reduction in newborns. Early Hum Dev 2004 77 : 57 65.
13. Committee on Fetus and Newborn, Committee on Drugs, Section on Anesthesiology, Section on Surgery. Prevention and management of pain and stress in the neonate. Pediatrics 2000 105 (2 454 461.
14. Akcam M. Oral fructose solution as an analgesic in the newborn: A randomized, placebo-controlled and masked study. Pediatr Int 2004 46 : 459 462.
15. Henry PR, Haubold K, Dobrzykowski TM. Pain in the healthy full-term neonate: Efficacy and safety of interventions. Newborn Infant Nurs Rev 2004 4 (2 106 113.
16. Franck L, Gilbert R. Reducing pain during blood sampling in infants. Clin Evid 2002 7 : 352 366.
17. Anseloni VCZ, Weng HR, Terayama R, et al. Age-dependency of analgesia elicited by intraoral sucrose in acute an persistent pain models. Pain 2007 97 : 93 103.
18. Blass EM, Shide DJ. Some comparisons among the calming and pain-relieving effects of sucrose, glucose, fructose and lactose in infant rats. Chem Senses 1994 19 (3 239 249.
19. Leslie A, Marlow N. Non-pharmacological pain relief. Semin Fetal Neonatal Med 2006 11 : 246 250.
20. Horwitz N. Does oral sucrose reduce the pain of neonatal procedures? Arch Dis Child Fetal Neonatal Ed 2002 87 : 80 81.
21. Bauer K, Ketteler J, Hellwig M, et al. Oral glucose before venepuncture relieves neonates of pain, but stress is still evidenced by increase in oxygen consumption, energy expenditure, and heart rate. Pediatr Res 2004 55 : 695 700.
22. Skogsdal Y, Eriksson M, Schollin J. Analgesia in newborns given oral glucose. Acta Paediatr 1997 86 : 217 220.
23. Gradin M, Eriksson M, Holmqvist G, et al. Pain reduction at venipuncture in newborns: Oral glucose compared with local anesthetic cream. Pediatrics 2002 110 (6 1053 1057.
24. Allegaert K, Tibboel D, Naulaers G, et al. Systematic evaluation of pain in neonates: Effect on the number of intravenous analgesics prescribed. Eur J Clin Pharmacol 2003 59 : 87 90.
25. SPSS Inc. SSPSS for Windows, Rel. 11.0.1.
26. Carbajal R. Nonpharmacologic management of pain in neonates. Arch Pediatr 2005 12 : 110 116.
27. Carbajal R, Veerapen S, Couderc S, et al. Analgesic effect of breastfeeding in term neonates: Randomised controlled trial. BMJ 2003 326 (13 1 5.
28. Gradin M. Effect of oral glucose on the heart rate of healthy newborns. Acta Paediatr 2005 94 : 324 328.
29. Eriksson M, Finnström O. Can daily repeated doses of orally administered glucose induce tolerance when given for neonatal pain relief? Acta Paediatr 2004 93 : 246 249.
30. Taddio A, Shah V, Gilbert-MacLeod G, Katz J. Conditioning and hypersensitivity to pain in newborns exposed to repeated heel lances. JAMA 2002 288 : 857 861.
31. Johnston CC, Filion F, Snider L, et al. Routine sucrose analgesia during the first week of life in neonates younger than 31 weeks' postconceptional age. Pediatrics 2002 110 (3 523 528.
32. Maisels MJ, McDonagh AF. Phototherapy for neonatal jaundice. N Engl J Med 2008 358 : 920 928.
33. Guinsburg R, Peres CA, Almeida MFB, et al. Differences in pain expression between male and female newborn infants. Pain 2000 85 : 127 133.
34. Isik U, Ozek E, Bilgen H, Cebeci D. Comparison of oral glucose and sucrose solutions on pain response in neonates. J Pain 2000 1 (4 275 278.