Oral fructose solution as an analgesic in the newborn: A randomized, placebo-controlled and masked study

Pediatrics International

Volumn 46, Issue 4, 2004, Pages 459-462

  Akçam, Mustafa ^a,b  

^a SULEYMAN DEMIREL UNIVERSITY   (Turkey)

^b NONE   (Turkey)

Author keywords

Analgesia; Fructose; Glucose; Heel lance; Newborn; Oral intake

Indexed keywords

ANALGESIC AGENT; FRUCTOSE; GLUCOSE;

ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEMOGRAPHY; FEMALE; HUMAN; INFANT; MALE; PAIN; PAIN ASSESSMENT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RATING SCALE;

ADMINISTRATION, ORAL; ANALGESICS; ANALYSIS OF VARIANCE; DOUBLE-BLIND METHOD; FEMALE; FRUCTOSE; GLUCOSE; HUMANS; INFANT, NEWBORN; MALE; PAIN; PAIN MEASUREMENT; PLACEBOS; SWEETENING AGENTS;

EID: 4344685264     PISSN: 13288067     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1442-200x.2004.01932.x     Document Type: Article

References (16)

1. Anand KJS, Phil D, Carr DB. The neuroanatomy, neurophysiology, and neurochemistry of pain, stress, and analgesia in newborns and children. Pediatr. Clin. North Am. 1989; 36: 795-822.
2. Porter FL, Grunau RE, Anand KJ. Long-term effects of pain in infants. J. Dev. Behav. Pediatr. 1999; 20: 253-61.
3. Porter FL, Wolf CM, Gold J, Lotsoff D, Miller JP. Pain and pain management in newborn infants: a survey of physicians and nurses. Pediatrics 1997; 100: 626-32.
4. Anand KJS, Hickey PR. Pain and its effects in the human neonate and fetus. N. Engl. J. Med. 1987; 317: 1321-9.
5. Stevens B, Johnston C, Taddio A et al. Management of pain from heel lance with lidocain-prilocain (EMLA) cream: is it safe and efficacious in preterm infants? J. Dev. Behav. Pediatr. 1999; 20: 216-21.
6. Abad F, Diaz NM, Domenech E, Robayna M, Rico J. Oral sweet solution reduces pain-related behaviour in preterm infants. Acta Paediatr. 1996; 85: 854-8.
7. Skogsdal Y, Eriksson M, Schollin J. Analgesia in newborns given oral glucose. Acta Paediatr. 1997; 86: 217-20.
8. Carbajal R, Chauvet X, Couderc S, Oliver-Martin M. Randomised trial of analgesic effects of sucrose, glucose, and pacifiers in term neonates. BMJ 1999; 319: 1393-7.
9. Ramenghi LA, Griffith GC, Wood CM, Levene MI. Effect of non-sucrose sweet tasting solution on neonatal heel prick responses. Arch. Dis. Child. 1996; 74: F129-31.
10. Blass EM, Watt LB. Suckling- and sucrose-induced analgesia in human newborns. Pain 1999; 83: 611-23.
11. Bucher H, Moser T, Siebenthal KV, Keel M, Wolf M, Duc G. Sucrose reduces pain reaction to heel lancing in preterm infants: a placebo-controlled, randomized and masked study. Pediatr. Res. 1995; 38: 332-5.
12. Ramenghi LA, Evans DJ, Levene MI. 'Sucrose analgesia': absorptive mechanism or taste perception? Arch. Dis. Child. Fetal Neonatal Ed. 1999; 80: F146-7.
13. Blass EM, Hoffmeyer LB. Sucrose as an analgesic for newborn infants. Pediatrics 1991; 87: 215-8.
14. Carbajal R, Lenclen R, Gajdos V, Jugie M, Paupe A. Crossover trial of analgesic efficacy of glucose and pacifier in very preterm neonates during subcutaneous injections. Pediatrics 2002; 110: 389-93.
15. Blass EM, Shide DJ. Some comparisons among the calming and pain-relieving effects of sucrose, glucose, fructose and lactose in infant rats. Chem. Senses 1994; 19: 239-49.
16. Carbajal R, Paupe A, Hoenn E, Lenclen R, Oliver-Martin M. DAN: une echelle comportementale d'evaluation de la douleur aigue du nouveau-ne. Arch. Pediatr. 1997; 4: 623-8 (in French with English abstract).