A Β-adrenergic antagonist reduces traumatic memories and PTSD symptoms in female but not in male patients after cardiac surgery

Psychological Medicine

Volumn 40, Issue 5, 2010, Pages 861-869

  Krauseneck, T ^a   Padberg, F ^a   Roozendaal, B ^b   Grathwohl, M ^a   Weis, F ^a   Hauer, D ^a,b   Kaufmann, I ^a   Schmoeckel, M ^c   Schelling, G ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^c UNIVERSITY OF MUNICH   (Germany)

Author keywords

Adrenergic antagonists; Cardiac surgery; Intensive care unit; Stress disorders; Traumatic memory

Indexed keywords

ADRENALIN; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; METOPROLOL;

AGED; ARTICLE; CORONARY ARTERY BYPASS GRAFT; DOSE RESPONSE; DRUG EFFECT; FEMALE; HEART VALVE REPLACEMENT; HUMAN; INTENSIVE CARE UNIT; MALE; MIDDLE AGED; ORAL DRUG ADMINISTRATION; POSTTRAUMATIC STRESS DISORDER; PROSPECTIVE STUDY; PSYCHOLOGICAL ASPECT; QUESTIONNAIRE; RECALL; SEX DIFFERENCE;

ADMINISTRATION, ORAL; ADRENERGIC BETA-AGONISTS; ADRENERGIC BETA-ANTAGONISTS; AGED; CORONARY ARTERY BYPASS; DOSE-RESPONSE RELATIONSHIP, DRUG; EPINEPHRINE; FEMALE; HEART VALVE PROSTHESIS IMPLANTATION; HUMANS; INTENSIVE CARE UNITS; MALE; MENTAL RECALL; METOPROLOL; MIDDLE AGED; PROSPECTIVE STUDIES; QUESTIONNAIRES; SEX FACTORS; STRESS DISORDERS, POST-TRAUMATIC;

EID: 77952409569     PISSN: 00332917     EISSN: 14698978     Source Type: Journal    
DOI: 10.1017/S0033291709990614     Document Type: Article

References (39)

1. Andreano JM, Arjomandi H, Cahill L (2008). Menstrual cycle modulation of the relationship between cortisol and long-term memory. Psychoneuroendocrinology 33, 874-882.
2. Andreano JM, Cahill L (2009). Sex influences on the neurobiology of learning and memory. Journal of Learning and Memory 16, 248-266.
3. Boer KR, Mahler CW, Unlu C, Lamme B, Vroom MB, Sprangers MA, Gouma DJ, Reitsma JB, de Borgie CA, Boermeester MA (2007). Long-term prevalence of post-traumatic stress disorder symptoms in patients after secondary peritonitis. Critical Care 11: R30, doi:10.1186/cc5710. (Pubitemid 46470534)
4. Boer KR, van Ruler O, van Emmerik AA, Sprangers MA, de Rooij SE, Vroom MB, de Borgie CA, Boermeester MA, Reitsma JB (2008). Factors associated with posttraumatic stress symptoms in a prospective cohort of patients after abdominal sepsis: a nomogram. Intensive Care Medicine 34, 664-674.
5. Cahill L (2005). His brain, her brain. Scientific American 292, 40-47.
6. Cahill L (2006). Why sex matters for neuroscience. Nature Reviews Neuroscience 7, 477-484.
7. Cahill L, Alkire MT (2003). Epinephrine enhancement of human memory consolidation: interaction with arousal and encoding. Neurobiology of Learning and Memory 79, 194-198. (Pubitemid 36263443)
8. Cahill L, Pham CA, Setlow B (2000). Impaired memory consolidation in rats produced with beta-adrenergic blockade. Neurobiology of Learning and Memory 74, 259-266.
9. Cahill L, van Stegeren A (2003). Sex-related impairment of memory for emotional events with beta-adrenergic blockade. Neurobiology of Learning and Memory 79, 81-88.
10. Cruickshank JM, Neil-Dwyer G (1985). Beta-blocker brain concentrations in man. European Journal of Clinical Pharmacology 28 (Suppl.), 21-23.
11. de Quervain DJ, Aerni A, Roozendaal B (2007). Preventive effect of beta-adrenoceptor blockade on glucocorticoid-induced memory retrieval deficits. American Journal of Psychiatry 164, 967-969.
12. Drayer DE (1987). Lipophilicity, hydrophilicity, and the central nervous system side effects of beta blockers. Pharmacotherapy 7, 87-91.
13. Famularo R, Kinscherff R, Fenton T (1988). Propranolol treatment for childhood posttraumatic stress disorder, acute type. A pilot study. American Journal of Diseases of Children 142, 1244-1247.
14. Introini-Collison I, Saghafi D, Novack GD, McGaugh JL (1992). Memory-enhancing effects of post-training dipivefrin and epinephrine: involvement of peripheral and central adrenergic receptors. Brain Research 572, 81-86.
15. Jones C, Giffiths RD, Humphris G, Skirrow PM (2001). Memory, delusions, and the development of acute posttraumatic stress disorder-related symptoms after intensive care. Critical Care Medicine 29, 573-580.
16. Kapfhammer HP, Rothenhausler HB, Krauseneck T, Stoll C, Schelling G (2004). Posttraumatic stress disorder and health-related quality of life in long-term survivors of acute respiratory distress syndrome. American Journal of Psychiatry 161, 45-52.
17. Luzier AB, Killian A, Wilton JH, Wilson MF, Forrest A, Kazierad DJ (1999). Gender-related effects on metoprolol pharmacokinetics and pharmacodynamics in healthy volunteers. Journal of Clinical Pharmacy and Therapeutics 66, 594-601.
18. Maheu FS, Joober R, Beaulieu S, Lupien SJ (2004). Differential effects of adrenergic and corticosteroid hormonal systems on human short-and long-term declarative memory for emotionally arousing material. Behavioural Neuroscience 118, 420-428.
19. McGaugh JL, Roozendaal B (2002). Role of adrenal stress hormones in forming lasting memories in the brain. Current Opinion in Neurobiology 12, 205-210.
20. Moody DM (2006). The blood-brain barrier and blood-cerebral spinal fluid barrier. Seminars in Cardiothoracic and Vascular Anesthesia 10, 128-131.
21. O'Carroll RE, Drysdale E, Cahill L, Shajahan P, Ebmeier KP (1999). Stimulation of the noradrenergic system enhances and blockade reduces memory for emotional material in man. Psychological Medicine 29, 1083-1088.
22. Olff M, Langeland W, Draijer N, Gersons BP (2007). Gender differences in posttraumatic stress disorder. Psychological Bulletin 133, 183-204.
23. Pitman RK, Sanders KM, Zusman RM, Healy AR, Cheema F, Lasko NB, Cahill L, Orr SP (2002). Pilot study of secondary prevention of posttraumatic stress disorder with propranolol. Biological Psychiatry 51, 189-192.
24. Roozendaal B, Barsegyan A, Lee S (2008). Adrenal stress hormones, amygdala activation, and memory for emotionally arousing experiences. Progress in Brain Research 167, 79-97.
25. Roozendaal B, Quirarte GL, McGaugh JL (2002). Glucocorticoids interact with the basolateral amygdala beta-adrenoceptor-cAMP/PKA system in influencing memory consolidation. European Journal of Neuroscience 15, 553-560.
26. Samuelson KA, Lundberg D, Fridlund B (2007). Stressful memories and psychological distress in adult mechanically ventilated intensive care patients-a 2-month follow-up study. Acta Anaesthesiologica Scandinavica 51, 671-678.
27. Schelling G (2007). Post-traumatic stress disorder in somatic disease: lessons from critically ill patients. Progress in Brain Research 167, 229-237.
28. Schelling G, Kilger E, Roozendaal B, Briegel J, Dagge A, Rothenhausler HB, Nollert G, Kapfhammer H (2004). Stress doses of hydrocortisone, traumatic memories and post-traumatic stress disorder in patients after cardiac surgery: a randomized study. Biological Psychiatry 55, 627-633.
29. Schelling G, Richter M, Roozendaal B, Rothenhäusler HB, Stoll C, Nollert G, Schmidt M, Kapfhammer H (2003). Exposure to high stress in the ICU may have negative effects on health-related quality of life outcomes after cardiac surgery. Critical Care Medicine 31, 1971-1980.
30. Schelling G, Stoll C, Haller M, Briegel J, Manert W, Hummel T, Lenhart A, Heyduck M, Polasek J, Meier M, Preuss U, Bullinger M, Schüffel W, Peter K (1998). Health-related quality of life and post-traumatic stress disorder in survivors of the acute respiratory distress syndrome. Critical Care Medicine 25, 651-659. (Pubitemid 28201410)
31. Stein MB, Kerridge C, Dimsdale JE, Hoyt DB (2007). Pharmacotherapy to prevent PTSD: results from a randomized controlled proof-of-concept trial in physically injured patients. Journal of Traumatic Stress 20, 923-932.
32. Stoll C, Kapfhammer HP, Haller H, Briegel J, Krauseneck T, Durst K, Schelling G (1999). Sensitivity and specificity of a screening test to document traumatic experiences and to diagnose post-traumatic stress disorder in patients after intensive care treatment. Intensive Care Medicine 25, 697-704.
33. Tedstone JE, Tarrier N (2003). Posttraumatic stress disorder following medical illness and treatment. Clinical Psychology Review 23, 409-448.
34. Tolin DF, Foa EB (2006). Sex differences in trauma and posttraumatic stress disorder: a quantitative review of 25 years of research. Psychological Bulletin 132, 959-992.
35. Tollenaar MS, Elzinga BM, Spinhoven P, Everaerd W (2009). Immediate and prolonged effects of cortisol, but not propranolol, on memory retrieval in healthy young men. Neurobiology of Learning and Memory 91, 23-31.
36. Vaiva G, Ducrocq F, Jezequel K, Averland B, Lestavel P, Brunet A, Marmar CR (2003). Immediate treatment with propranolol decreases posttraumatic stress disorder two months after trauma. Biological Psychiatry 54, 947-949.
37. van Stegeren AH (2008). The role of the noradrenergic system in emotional memory. Acta Psychologica (Amsterdam) 127, 532-541.
38. van Stegeren AH, Everaerd W, Cahill L, McGaugh JL, Gooren LJ (1998). Memory for emotional events: differential effects of centrally versus peripherally acting beta-blocking agents. Psychopharmacology (Berlin) 138, 305-310.
39. van Stegeren AH, Goekoop R, Everaerd W, Scheltens P, Barkhof F, Kuijer JP, Rombouts SA (2005). Noradrenaline mediates amygdala activation in men and women during encoding of emotional material. Neuroimage 24, 898-909.