Experimental study of flow fields in an airway closure model

Journal of Fluid Mechanics

Volumn 647, Issue , 2010, Pages 391-402

  Bian, S ^a   Tai, C F ^a   Halpern, D ^b   Zheng, Y ^a   Grotberg, J B ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF ALABAMA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AIR; CAPILLARY TUBES; FLOW FIELDS; LIQUIDS; SYRINGES; VELOCITY; VELOCITY MEASUREMENT; VISCOSITY;

AIRWAY EPITHELIAL CELLS; EXPONENTIAL GROWTH; GLASS CAPILLARY TUBES; MICRO-SCALE PARTICLES; THICKNESS OF THE FILM; VELOCITY CHANGES; VISCOSITY RATIOS; WALL SHEAR STRESS;

SHEAR STRESS;

EXPERIMENTAL STUDY; FILM; FLOW FIELD; FLOW MODELING; FLOW STABILITY; FLUID DYNAMICS; INSTABILITY; PHYSIOLOGY; SHEAR STRESS;

EID: 77952406593     PISSN: 00221120     EISSN: 14697645     Source Type: Journal    
DOI: 10.1017/S0022112010000091     Document Type: Article

References (40)

1. Baker, C. S., Evans, T. W., Randle, B. J. & Haslam, P. L. 1999 Damage to surfactant-specific protein in acute respiratory distress syndrome. Lancet 353 (9160), 1232-1237.
2. Bilek, A. M., Dee, K. C. & Gaver III, D. P. 2003 Mechanisms of surface-tension-induced epithelial cell damage in a model of pulmonary airway reopening. J. Appl. Physiol. 94 (2), 770-783.
3. Bretherton, F. P. 1961 The motion of long bubbles in tubes. J. Fluid Mech. 10 (2), 166-188.
4. Campana, D. M., Di Paolo, J. & Saita, F. A. 2004 A 2-D model of Rayleigh instability in capillary tubes: surfactant effects. Intl J. Multiphase Flow 30 (5), 431-454.
5. Cassidy, K. J., Halpern, D., Ressler, B. G., & Grotberg, J. B. 1999 Surfactant effects in model airway closure experiments. J. Appl. Physiol. 87 (1), 415-427.
6. Dargaville, P. A., South, M. & McDougall, P. N. 1996 Surfactant abnormalities in infants with severe viral bronchiolitis. Arch. Dis. Child. 75 (2), 133-136.
7. Everett, D. H. & Haynes, J. M. 1972 Model studies of capillary condensation. Part 1. Cylindrical pore model with zero contact angle. J. Colloid Interface Sci. 38 (1), 125-137.
8. Fairbrother, F. & Stubbs, A. E. 1935 Studies in electro-endosmosis. Part VI. The 'bubble-tube' method of measurement. J. Chem. Soc. 1, 527-529.
9. Fujioka, H. & Grotberg, J. B. 2004 Steady propagation of a liquid plug in a two-dimensional channel. J. Biomech. Engng Trans. Asme 126 (5), 567-577.
10. Fujioka, H. & Grotberg, J. B. 2005 The steady propagation of a surfactant-laden liquid plug in a two-dimensional channel. Phys. Fluids 17 (8), 082102.
11. Fujioka, H., Takayama, S. & Grotberg, J. B. 2008 Unsteady propagation of a liquid plug in a liquid-lined straight tube. Phys. Fluids 20 (6), 062104.
12. Gauglitz, P. A. & Radke, C. J. 1988 An extended equation for liquid-film break up in cylindrical capillaries. Chem. Engng Sci. 43 (7), 1457-1465.
13. Ghadiali, S. N. & Gaver III, D. P. 2008 Biomechanics of liquid-epithelium interactions in pulmonary airways. Respir. Physiol. Neurobiol. 163 (1-3), 232-243.
14. Goerke, J. & Clements, J. A. 1986 Alveolar Surface Tension and Lung Surfactant. American Physiology Society.
15. Goldsmith, H. L. & Mason, S. G. 1963 Flow of suspensions through tubes. Part 2. Single large bubbles. J. Colloid Sci. 18 (3), 237-261.
16. Greaves, I. A., Hildebrandt, J. & Hoppin, J. F. G. 1986 Handbook of Physiology. The Respiratory System. Mechanics of Breathing. American Physiology Society.
17. Green, F. H. Y., Schurch, S., Desanctis, G. T., Wallace, J. A., Cheng, S. & Prior, M. 1991 Effects of hydrogen sulfide exposure on surface properties of lung surfactant. J. Appl. Physiol. 70 (5), 1943-1949.
18. Griese, M., Essl, R., Schmidt, R., Rietschel, E., Ratjen, F., Ballmann M. & Paul, K. 2004 Pulmonary surfactant, lung function, and endobronchial inflammation in cystic fibrosis. Am. J. Respir. Crit. Care Med. 170 (9), 1000-1005.
19. Guerin, C., LeMasson, S., DeVarax, R., MilicEmili, J. & Fournier, G. 1997 Small airway closure and positive end-expiratory pressure in mechanically ventilated patients with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 155 (6), 1949-1956.
20. Gunther, A., Siebert, C., Schmidt, R., Ziegler, S., Grimminger, F., Yabut, M., Temmesfeld, B., Walmrath, D., Morr, H. & Seeger, W. 1996 Surfactant alterations in severe pneumonia, acute respiratory distress syndrome, and cardiogenic lung edema. Am. J. Respir. Crit. Care Med. 153 (1), 176-184.
21. Halpern, D. & Gaver III, D. P. 1994 Boundary-element analysis of the time-dependent motion of a semi-infinite bubble in a channel. J. Comput. Phys. 115 (2), 366-375.
22. Halpern, D. & Grotberg, J. B. 1992 Fluid-elastic instabilities of liquid-lined flexible tubes. J. Fluid Mech. 244, 615-632.
23. Halpern, D. & Grotberg, J. B. 1993 Surfactant effects on fluid-elastic instabilities of liquid-lined flexible tubes: a model of airway closure. J. Biomech. Engng Trans. Asme 115 (3), 271-277.
24. Halpern, D., Jensen, O. E. & Grotberg, J. B. 1998 A theoretical study of surfactant and liquid delivery into the lung. J. Appl. Physiol. 85 (1), 333-352.
25. Hammond, P. S. 1983 Nonlinear adjustment of a thin annular film of viscous-fluid surrounding a thread of another within a circular cylindrical pipe. J. Fluid Mech. 137, 363-384.
26. Heil, M., Hazel, A. L. & Smith, J. A. 2008 The mechanics of airway closure. Respir. Physiol. Neurobiol. 163 (1-3), 214-221.
27. Hof, V. I., Gehr, P., Gerber, V., Lee, M. M. & Schurch, S. 1997 In vivo determination of surface tension in the horse trachea and in vitro model studies. Respir. Physiol. 109 (1), 81-93.
28. Huh, D., Fujioka, H., Tung,Y.-C., Futai, N., Paine, III, R., Grotberg, J. B. & Takayama, S. 2007 Acoustically detectable cellular-level lung injury induced by fluid mechanical stresses in microfluidic airway systems. Proc. Natl Acad. Sci. USA 104 (48), 18886-18891.
29. Kamm, R. D. & Schroter, R. C. 1989 Is airway closure caused by a liquid-film instability. Respir. Physiol. 75 (2), 141-156.
30. Kay, S. S., Bilek, A. M., Dee, K. C. & Gaver III, D. P. 2004 Pressure gradient, not exposure duration, determines the extent of epithelial cell damage in a model of pulmonary airway reopening. J. Appl. Physiol. 97 (1), 269-276.
31. Lee, M. M., Schurch, S., Roth, S. H., Jiang, X., Cheng, S., Bjarnason, S. & Green, F. H. 1995 Effects of acid aerosol exposure of the surface properties of airway mucus. Exp. Lung Res. 21 (6), 835-851.
32. Macklem, P. T., Proctor, D. F. & Hogg J. C. 1970 Stability of peripheral airways. Respir. Physiol. 8 (2), 191-203.
33. Muscedere, J. G., Mullen, J. B., Gan, K. & Slutsky, A. S. 1994 Tidal ventilation at low airway pressures can augment lung injury. Am. J. Respir. Crit. Care Med. 149 (5), 1327-1334.
34. Piirila, P. & Sovijarvi, A. R. A. 1995 Crackles: recording, analysis and clinical significance. Eur. Respir. J. 8 (12), 2139-2148.
35. Rayleigh, L. 1892 On the instability of cylindrical fluid surfaces. Phil. Mag. 34, 177-180.
36. Reinelt, D. A. & Saffman, P. G. 1985 The penetration of a finger into a viscous fluid in a channel and tube. Siam J. Sci. Stat. Comput. 6 (3), 542-561.
37. Taskar, V., John, J., Evander, E., Robertson, B. & Jonson, B. 1997 Surfactant dysfunction makes lungs vulnerable to repetitive collapse and reexpansion. Am. J. Respir. Crit. Care Med. 155 (1), 313-320.
38. Taylor, G. I. 1961 Deposition of a viscous fluid on the wall of a tube. J. Fluid Mech. 10 (2), 161-165
39. t'Veen, J. C. C., Beekman, A. J., Bel, E. H. & Sterk, P. J. 2000 Recurrent exacerbations in severe asthma are associated with enhanced airway closure during stable episodes. Am. J. Respir. Crit. Care Med. 161 (6), 1902-1906.
40. Zheng, Y., Fujioka, H., Bian, S., Torisawa, Y., Huh, D., Takayama, S. & Grotberg, J. B. 2009 Liquid plug propagation in flexible microchannels: a small airway model. Phys. Fluids 21 (7), 071903.