Blocking of Plasmodium transmission by cooperative action of Cecropin a and Defensin a in transgenic Aedes aegypti mosquitoes

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 18, 2010, Pages 8111-8116

  Kokoza, Vladimir ^a   Ahmed, Abdouelaziz ^a   Shin, Sang Woon ^a   Okafor, Nwando ^a   Zou, Zhen ^a   Raikhel, Alexander S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Antimicrobial peptide; Immunity; Malaria; Vector borne disease; Vitellogenin

Indexed keywords

CECROPIN A; DEFENSIN; DEFENSIN A; UNCLASSIFIED DRUG; VITELLOGENIN;

AEDES AEGYPTI; ARTICLE; AVIAN MALARIA; CELL COUNT; CONTROLLED STUDY; GENE OVEREXPRESSION; HYBRID; NONHUMAN; OOCYST; PARASITE TRANSMISSION; PHENOTYPE; PLASMODIUM; PRIORITY JOURNAL; PROMOTER REGION; PSEUDOMONAS INFECTION; SALIVARY GLAND; TRANSGENICS; WILD TYPE;

AEDES; AMINO ACID SEQUENCE; ANIMALS; ANIMALS, GENETICALLY MODIFIED; ANTIMICROBIAL CATIONIC PEPTIDES; CHICKENS; DEFENSINS; MALARIA; MOLECULAR SEQUENCE DATA; PLASMODIUM GALLINACEUM; RNA INTERFERENCE;

AEDES AEGYPTI; BACTERIA (MICROORGANISMS); PLASMODIUM GALLINACEUM; PSEUDOMONAS AERUGINOSA;

EID: 77952405582     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1003056107     Document Type: Article

References (34)

1. Gratz NG (1999) Emerging and resurging vector-borne diseases. Annu Rev Entomol 44:51-75.
2. Hill CA, Kafatos FC, Stansfield SK, Collins FH (2005) Arthropod-borne diseases: vector control in the genomics era. Nat Rev Microbiol 3(3):262-268.
3. Alphey L, et al. (2002) Malaria control with genetically manipulated insect vectors. Science 298(5591):119-121.
4. James AA (2005) Gene drive systems in mosquitoes: rules of the road. Trends Parasitol 21(2):64-67.
5. Jasinskiene N, et al. (1998) Stable transformation of the yellow fever mosquito, Aedes aegypti, with the Hermes element from the housefly. Proc Natl Acad Sci USA 95 (7):3743-3747. (Pubitemid 28173199)
6. Catteruccia F, et al. (2000) Stable germline transformation of the malaria mosquito Anopheles stephensi. Nature 405(6789):959-962. (Pubitemid 30435053)
7. Kokoza V, et al. (2000) Engineering blood meal-activated systemic immunity in the yellow fever mosquito, Aedes aegypti. Proc Natl Acad Sci USA 97(16):9144-9149. (Pubitemid 30626688)
8. Lombardo F, Lycett GJ, Lanfrancotti A, Coluzzi M, Arca B (2009) Analysis of apyrase 5′ upstream region validates improved Anopheles gambiae transformation technique. BMC Res Notes 2:24.
9. Shin SW, Kokoza V, Lobkov I, Raikhel AS (2003) Relish-mediated immune deficiency in the transgenic mosquito Aedes aegypti. Proc Natl Acad Sci USA 100(5):2616-2621. (Pubitemid 36297547)
10. Bian G, Shin SW, Cheon HM, Kokoza V, Raikhel AS (2005) Transgenic alteration of Toll immune pathway in the female mosquito Aedes aegypti. Proc Natl Acad Sci USA 102 (38):13568-13573. (Pubitemid 41420889)
11. Antonova Y, Alvarez KS, Kim YJ, Kokoza V, Raikhel AS (2009) The role of NF-kappaB factor REL2 in the Aedes aegypti immune response. Insect Biochem Mol Biol 39 (4):303-314.
12. Ito J, Ghosh A, Moreira LA, Wimmer EA, Jacobs-Lorena M (2002) Transgenic anopheline mosquitoes impaired in transmission of a malaria parasite. Nature 417 (6887):452-455. (Pubitemid 34563538)
13. Kim W, et al. (2004) Ectopic expression of a cecropin transgene in the human malaria vector mosquito Anopheles gambiae (Diptera: Culicidae): Effects on susceptibility to Plasmodium. J Med Entomol 41(3):447-455. (Pubitemid 38700077)
14. Franz AW, et al. (2006) Engineering RNA interference-based resistance to dengue virus type 2 in genetically modified Aedes aegypti. Proc Natl Acad Sci USA 103 (11):4198-4203.
15. Jasinskiene N, et al. (2007) Genetic control of malaria parasite transmission: Threshold levels for infection in an avian model system. Am J Trop Med Hyg 76(6):1072-1078. (Pubitemid 351837868)
16. Lemaitre B, Hoffmann J (2007) The host defense of Drosophila melanogaster. Annu Rev Immunol 25:697-743.
17. Waterhouse RM, et al. (2007) Evolutionary dynamics of immune-related genes and pathways in disease-vector mosquitoes. Science 316(5832):1738-1743.
18. Lowenberger C, et al. (1995) Insect immunity: isolation of three novel inducible antibacterial defensins from the vector mosquito, Aedes aegypti. Insect Biochem Mol Biol 25(7):867-873.
19. Lowenberger CA, et al. (1999) Mosquito-Plasmodium interactions in response to immune activation of the vector. Exp Parasitol 91(1):59-69. (Pubitemid 29372102)
20. Vizioli J, et al. (2000) Cloning and analysis of a cecropin gene from the malaria vector mosquito, Anopheles gambiae. Insect Mol Biol 9(1):75-84. (Pubitemid 30121216)
21. Kokoza VA, et al. (2001) Transcriptional regulation of the mosquito vitellogenin gene via a blood meal-triggered cascade. Gene 274(1-2):47-65.
22. Kokoza V, Ahmed A, Wimmer EA, Raikhel AS (2001) Efficient transformation of the yellow fever mosquito Aedes aegypti using the piggyBac transposable element vector pBac[3xP3-EGFP afm]. Insect Biochem Mol Biol 31(12):1137-1143. (Pubitemid 33032523)
23. Callaway JE, et al. (1993) Modification of the C terminus of cecropin is essential for broad-spectrum antimicrobial activity. Antimicrob Agents Chemother 37 (8):1614-1619.
24. Lau GW, et al. (2003) The Drosophila melanogaster toll pathway participates in resistance to infection by the Gram-negative human pathogen Pseudomonas aeruginosa. Infect Immun 71(7):4059-4066.
25. Apidianakis Y, et al. (2005) Profiling early infection responses: Pseudomonas aeruginosaeludes host defenses by suppressing antimicrobial peptide gene expression. Proc Natl Acad Sci USA 102(7):2573-2578. (Pubitemid 40279418)
26. Cho KH, Cheon HM, Kokoza V, Raikhel AS (2006) Regulatory region of the vitellogenin receptor gene sufficient for high-level, germ line cell-specific ovarian expression in transgenic Aedes aegypti mosquitoes. Insect Biochem Mol Biol 36(4):273-281.
27. Hillyer JF, Barreau C, Vernick KD (2007) Efficiency of salivary gland invasion by malaria sporozoites is controlled by rapid sporozoite destruction in the mosquito haemocoel. Int J Parasitol 37(6):673-681. (Pubitemid 46440942)
28. Shahabuddin M, Fields I, Bulet P, Hoffmann JA, Miller LH (1998) Plasmodium gallinaceum: Differential killing of some mosquito stages of the parasite by insect defensin. Exp Parasitol 89(1):103-112. (Pubitemid 28377379)
29. Akuffo H, Hultmark D, Engstom A, Frohlich D, Kimbrell D (1998) Drosophila antibacterial protein, cecropin A, differentially affects non-bacterial organisms such as Leishmania in a manner different from other amphipathic peptides. Int J Mol Med 1 (1):77-82.
30. Meister S, et al. (2005) Immune signaling pathways regulating bacterial and malaria parasite infection of the mosquito Anopheles gambiae. Proc Natl Acad Sci USA 102 (32):11420-11425. (Pubitemid 41153835)
31. Garver LS, Dong Y, Dimopoulos G (2009) Caspar controls resistance to Plasmodium falciparum in diverse anopheline species. PLoS Pathog 5(3):e1000335.
32. Dong Y, et al. (2006) Anopheles gambiae immune responses to human and rodent Plasmodiumparasite species. PLoS Pathog 2(6):e52.
33. Blandin S, et al. (2002) Reverse genetics in the mosquito Anopheles gambiae: Targeted disruption of the Defensin gene. EMBO Rep 3(9):852-856.
34. Zou Z, et al. (2008) Mosquito RUNX4 in the immune regulation of PPO gene expression and its effect on avian malaria parasite infection. Proc Natl Acad Sci USA 105 (47):18454-18459.