Zinc: A complementary factor in the treatment of chronic hepatitis C? (Review)

Molecular Medicine Reports

Volumn 3, Issue 3, 2010, Pages 371-375

  Grüngreiff, Kurt ^a   Reinhold, Dirk ^b  

^a Otto Von Guericke University Magdeburg ^*  (Germany)

^b OTTO VON GUERICKE UNIVERSITY   (Germany)

Author keywords

Hepatitis C; Zinc

Indexed keywords

ALPHA INTERFERON; ANTIOXIDANT; DNA; PEGINTERFERON; RIBAVIRIN; ZINC; ZINC ION;

ADD ON THERAPY; BIOLOGICAL ACTIVITY; CELL DIFFERENTIATION; CELL FUNCTION; CELL MATURATION; CELLULAR IMMUNITY; DNA DAMAGE; DRUG COST; DRUG EFFECT; FINGER NAIL; GASTROINTESTINAL SYMPTOM; GENOTYPE; HAIR LOSS; HEALTH; HEPATITIS C; HEPATITIS VIRUS; HOMEOSTASIS; HUMAN; IMMUNE SYSTEM; IMMUNOCOMPETENT CELL; IMMUNOPATHOGENESIS; INCIDENCE; INNATE IMMUNITY; LIVER; LIVER FAILURE; LIVER FUNCTION; LIVER TRANSPLANTATION; NUTRIENT; OUTCOME ASSESSMENT; OXIDATION; OXIDATIVE STRESS; REVIEW; SUPPLEMENTATION; T LYMPHOCYTE; TREATMENT CONTRAINDICATION; UNSPECIFIED SIDE EFFECT; WEIGHT REDUCTION; ZINC DEFICIENCY;

HEPATITIS C VIRUS;

EID: 77952347108     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr_00000267     Document Type: Review

References (32)

1. Manns MP, Wedemeyer H and Cornberg M: Treating viral hepatitis C: Efficacy, side effects and complications. Gut 55: 1350-1359, 2006.
2. Spengler U and Nattermann J: Immunopathogenesis of hepatitis C cirrhosis. Clin Sci 12: 141-155, 2007.
3. Bowen DG and Walker CM: Adaptive immune responses in acute and chronic hepatitis virus infection. Nature 436: 946-952, 2005. (Pubitemid 41191670)
4. Jacobson Brown PM and Neuman MG: Immunopathogenesis of hepatitis C viral infection: Th1/Th2 responses and the role of cytokines. Clin Biochem 34: 167-171, 2001. (Pubitemid 32537667)
5. Rehermann B: Chronic infections with hepatotropic viruses: Mechanisms of impairment of cellular immune responses. Sem Liver Dis 27: 152-160, 2007.
6. Dolganiuc A and Szabo G: T cells with regulatory activity in hepatitis C virus infection. What we can know and what we don't. J Leukoc Biol 84: 614-622, 2008.
7. Dolganiuc A, Norkina O, Kodys K, Catalano D, Bakis G, Marshall C, Mandrekar P and Szabo G: Viral and host factors induce macrophage activation and loss of toll-like receptor tolerance in chronic HCV infection. Gastroenterology 133: 1627-1636, 2007. (Pubitemid 350029734)
8. Kitamura H, Morikawa H, Kamon H, et al: Toll-like receptor-mediated regulation of zinc homeostasis influences dendritic cell function. Nat Immunol 7: 971-977, 2006. (Pubitemid 44263911)
9. Jarousse V, Castex-Rizzi N, Khammari A, Charveron M and Dreno B: Zinc salts inhibit in vitro Toll-like receptor 2 surface expression by keratinocytes. Eur J Dermatol 17: 492-496, 2007. (Pubitemid 350207159)
10. Seki E and Brenner D: Toll-like receptors and adaptor molecules in liver disease: update. Hepatology 48: 322-335, 2008. (Pubitemid 351975556)
11. Maret W: Zinc and sulfur: A critical biological partnership. Biochemistry 4: 3301-3309, 2004.
12. Grüngreiff K and Reinhold D: Zink: Bedeutung in der ärztlichen Praxis. J. Hartmann Verlag, Hessdorf-Klebheim, 2007.
13. Wellinghausen N, Kirchner H and Rink L: The immunbiology of zinc. Immunol Today 18: 519-521, 1997.
14. Rink L and Kirchner H: Zinc altered immune function and cytokine production. J Nutr 130: 1407S-1411S, 2000.
15. Reinhold D, Ansorge S and Grüngreiff K: Zinc regulates DNA synthesis on IL-2, IL-6, and IL-10 production of PWM-stimulated PBMC and normalizes the peripheral cytokine concentration in chronic liver disease. J Trace Elem Exp Med 10: 19-27, 1997. (Pubitemid 27312010)
16. Lin RS, Rodriguez C, Veillette A and Lodish HF: Zinc is essential for binding of p561ck to CD4 and CD8alpha. J Biol Chem 273: 32878-32882, 1998. (Pubitemid 28557678)
17. Rajagopalan S and Long EO: Zinc bound to the killer cell-inhibitory receptor modulates the negative signal in human NK cells. J Immunol 161: 1299-1305, 1998. (Pubitemid 28380557)
18. Rink L and Haase H: Zinc homeostasis and immunity. Trends Immunol 28: 1-4, 2007.
19. Grüngreiff K: Betreuung Hepatitiskranker in der Praxis. Med Welt 58: 251-258, 2007.
20. Grüngreiff K, Reinhold D and Ansorge S: Serum concentrations of sIL-2, IL-6, TGF-β1, neopterin, and zinc in chronic hepatitis C patients treated with interferon-alpha. Cytokine 11: 1076-1080, 1999.
21. Tagaki H, Nagamine T, Abe T, et al: Zinc supplementation enhances the response to interferon therapy in patients with chronic hepatitis C. J Viral Hepat 8: 367-371, 2001.
22. Beard MR and Jones BE: Hepatitis C virus and oxidative stress: A dangerous liaison. Future Virol 1: 223-232, 2006.
23. Wang T and Weinman SA: Causes and consequences of mitochondrial reactive oxygen species generation in hepatitis C. J Gastroenterol Hepatol 21: S34-S37, 2006. (Pubitemid 44266547)
24. Okuda M, Li K, Beard MR, Showalter LA, Scholle F, Lemon SM and Weinman SA: Mitochondrial injury, oxidative stress, and antioxidant gene expression are induced by hepatitis C virus core protein. Gastroenterology 122: 366-375, 2002. (Pubitemid 34116988)
25. Maret W and Krezel A: Cellular zinc and redox buffering capacity of metallothionein/thionein in health and disease. Mol Med 13: 371-375, 2007. (Pubitemid 47378138)
26. Murakami Y, Koyabu T, Kawashima A, et al: Zinc supplementation prevents the increase of transaminase in chronic hepatitis C patients during combination therapy with pegylated interferon alpha-2b and ribavirin. J Nutr Sci Vitaminol 53: 213-218, 2007. (Pubitemid 47217217)
27. Himoto T, Hosomi N, Nakai S, et al: Efficacy of zinc administration in patients with hepatitis C virus-related chronic liver disease. Scand J Gastroenterol 42: 1078-1087, 2007. (Pubitemid 47301142)
28. Sun B and Karin M: NF-κB signaling, liver disease and hepato-protective agents. Oncogene 27: 6228-6244, 2008.
29. Prasad AS: Zinc. Mechanisms of host defense. J Nutr 137: 1345-1349, 2007.
30. Yuasa K, Naganuma A, Sato K, Ikeda M, Kato N, Takagi H and Mori M: Zinc is a negative regulator of hepatitis C virus RNA replication. Liver Int 26: 1111-1118, 2006. (Pubitemid 44541752)
31. Overbeck S, Rink L and Haase H: Modulating immune response by oral zinc supplementation. Arch Immunol Ther Exp 56: 15-30, 2008.
32. Grüngreiff K: Zink - ein Adjuvans in der chronischen Hepatitis B. Hep Net J 1: 12-13, 2007.