Gastrin-releasing peptide receptor content in human glioma and normal brain

Brain Research Bulletin

Volumn 82, Issue 1-2, 2010, Pages 95-98

  Flores, Debora Gazzana ^a   Meurer, Luise ^b   Uberti, Augusto Frantz ^a   Macedo, Bruno R ^a   Lenz, Guido ^b   Brunetto, Algemir Lunardi ^a,b,c   Schwartsmann, Gilberto ^a,b,c   Roesler, Rafael ^a,b,c  

^a HOSPITAL DE CLÍNICAS DE PORTO ALEGRE   (Brazil)

^b FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^c National Institute for Translational Medicine INCT TM   (Brazil)

Author keywords

Brain tumor; G protein coupled receptors; Gastrin releasing peptide receptor; Glioma; Neuropeptides

Indexed keywords

GASTRIN RELEASING PEPTIDE RECEPTOR; PARAFFIN;

ADOLESCENT; ADULT; AGED; ARTICLE; BRAIN NERVE CELL; BRAIN TISSUE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DIGITAL IMAGING; DRUG TARGETING; FEMALE; GLIA CELL; GLIOMA; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; MALE; PRIORITY JOURNAL; PROTEIN ANALYSIS; SCHOOL CHILD; TISSUE SECTION;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BRAIN; BRAIN NEOPLASMS; CHILD; CHILD, PRESCHOOL; FEMALE; GLIOMA; HUMANS; MALE; MIDDLE AGED; RECEPTORS, BOMBESIN; YOUNG ADULT;

EID: 77952323338     PISSN: 03619230     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainresbull.2010.02.014     Document Type: Article

References (21)

1. Cancer Genome Atlas Research Network Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 2008, 455:1061-1068.
2. Chave H.S., Gough A.C., Palmer K., Preston S.R., Primrose J.N. Bombesin family receptor and ligand gene expression in human colorectal cancer and normal mucosa. Br. J. Cancer 2000, 82:124-130.
3. Cornelio D.B., Meurer L., Roesler R., Schwartsmann G. Gastrin-releasing peptide receptor expression in cervical cancer. Oncology 2007, 73:340-345.
4. Cornelio D., Roesler R., Schwartsmann G. Gastrin-releasing peptide receptor as a molecular target in experimental anticancer therapy. Ann. Oncol. 2007, 18:1457-1466.
5. de Oliveira M.S., Cechim G., Braganhol E., Santos D.G., Meurer L., de Castro C.G., Brunetto A.L., Schwarstmann G., Battastini A.M., Lenz G., Roesler R. Anti-proliferative effect of the gastrin-release peptide receptor antagonist RC-3095 plus temozolomide in experimental glioblastoma models. J. Neurooncol. 2009, 93:191-201.
6. Farias C.B., Lima R.C., Lima L.O., Flores D.G., Meurer L., Brunetto A.L., Schwartsmann G., Roesler R. Stimulation of proliferation of U138-MG glioblastoma cells by gastrin-releasing peptide in combination with agents that enhance cAMP signaling. Oncology 2008, 75:27-31.
7. Flores D.G., de Farias C.B., Leites J., Oliveira M.S., Lima R.C., Tamajusuku A.S., Di Leone L.P., Meurer L., Brunetto A.L., Schwartsmann G., Lenz G., Roesler R. Gastrin-releasing peptide receptors regulate proliferation of C6 glioma cells through a phosphatidylinositol 3-kinase-dependent mechanism. Curr. Neurovasc. Res. 2008, 5:99-105.
8. Flores D.G., Ledur P.F., Abujamra A.L., Brunetto A.L., Schwartsmann G., Lenz G., Roesler R. Cancer stem cells and the biology of brain tumors. Curr. Stem Cell Res. Ther. 2009, 4:306-313.
9. Gugger M., Reubi J.C. Gastrin-releasing peptide receptors in non-neoplastic and neoplastic human breast. Am. J. Pathol. 1999, 155:2067-2676.
10. Jensen R.T., Battey J.F., Spindel E.R., Benya R.V. International Union of Pharmacology. LXVIII. Mammalian bombesin receptors: nomenclature, distribution, pharmacology, signaling, and functions in normal and disease states. Pharmacol. Rev. 2008, 60:1-42.
11. Kamichi S., Wada E., Aoki S., Sekiguchi M., Kimura I., Wada K. Immunohistochemical localization of gastrin-releasing peptide receptor in the mouse brain. Brain Res. 2005, 1032:162-170.
12. Kiaris H., Schally A.V., Sun B., Armatis P., Groot K. Inhibition of growth of human malignant glioblastoma in nude mice by antagonists of bombesin/gastrin-releasing peptide. Oncogene 1999, 18:7168-7173.
13. Lango M.N., Dyer K.F., Lui V.W., Gooding W.E., Gubish C., Siegfried J.M., Grandis J.R. Gastrin-releasing peptide receptor-mediated autocrine growth in squamous cell carcinoma of the head and neck. J. Natl. Cancer Inst. 2002, 94:375-383.
14. Markwalder R., Reubi J.C. Gastrin-releasing peptide receptors in the human prostate: relation to neoplastic transformation. Cancer Res. 1999, 59:1152-1159.
15. Pansky A., De Weerth A., Fasler-Kan E., Boulay J.L., Schulz M., Ketterer S., Selck C., Beglinger C., Von Schrenck T., Hildebrand P. Gastrin releasing peptide-preferring bombesin receptors mediate growth of human renal cell carcinoma. J. Am. Soc. Nephrol. 2000, 11:1409-1418.
16. Patel O., Shulkes A., Baldwin G.S. Gastrin-releasing peptide and cancer. Biochim. Biophys. Acta 2006, 1766:23-41.
17. Pinski J., Schally A.V., Halmos G., Szepeshazi K., Groot K. Somatostatin analogues and bombesin/gastrin-releasing peptide antagonist RC-3095 inhibit the growth of human glioblastomas in vitro and in vivo. Cancer Res. 1994, 54:5895-5901.
18. Prados M.D., Levin V. Biology and treatment of malignant glioma. Semin. Oncol. 2000, 27:1-10.
19. Roesler R., Henriques J.A.P., Schwartsmann G. Gastrin-releasing peptide receptor as a molecular target for psychiatric and neurological disorders. CNS Neurol. Disord. Drug Targets 2006, 5:197-204.
20. Sharif T.R., Luo W., Sharif M. Functional expression of bombesin receptor in most adult and pediatric human glioblastoma cell lines; role in mitogenesis and in stimulating the mitogen-activated protein kinase pathway. Mol. Cell Endocrinol. 1997, 130:119-130.
21. Stiles C.D., Rowitch D.H. Glioma stem cells: a midterm exam. Neuron 2008, 58:832-846.