Isolation and structure elucidation of an interaction product of aminotadalafil found in an illegal health food product

Journal of Pharmaceutical and Biomedical Analysis

Volumn 53, Issue 1, 2010, Pages 24-28

  Häberli, Adrian ^a   Girard, Philippe ^a   Low, Min Yong ^b   Ge, Xiaowei ^b  

^a Official Medicines Control Laboratory (OMCL)   (Switzerland)

^b HEALTH SCIENCES AUTHORITY   (Singapore)

Author keywords

Adulterant; Aminotadalafil; Health food; NMR; PDE 5 inhibitor

Indexed keywords

AMINOTADALAFIL; EXCIPIENT; PHOSPHODIESTERASE V INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL INTERACTION; CONTROLLED STUDY; DRUG INCOMPATIBILITY; DRUG ISOLATION; DRUG STRUCTURE; FOOD INDUSTRY; HEALTH FOOD; INFRARED SPECTROSCOPY; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; STRUCTURE ANALYSIS;

BENZODIOXOLES; CARBOLINES; DRUG CONTAMINATION; DRUG INCOMPATIBILITY; FURALDEHYDE; HEALTH FOOD; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MOLECULAR STRUCTURE; SPECTROPHOTOMETRY, INFRARED;

EID: 77952323048     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2010.03.008     Document Type: Article

References (8)

1. Neumeyer K., Kirkpatrick P. Tadalafil and vardenafil. Nat. Rev. Drug Discovery 2004, 3:295-296.
2. Hasegawa T., Saijo M., Ishii T., Nagata T., Haishima Y., Kawahara N., Goda Y. Structural elucidation of a tadalafil analogue found in a dietary supplement. J. Food Hyg. Soc. Jpn. 2008, 49:311-315.
3. Hasegawa T., Takahashi K., Saijo M., Ishii T., Nagata T., Kurihara M., Haishima Y., Goda Y., Kawahara N. Isolation and structural elucidation of cyclopentynafil and N-octylnortadalafil found in a dietary supplement. Chem. Pharm. Bull. 2009, 57:185-189.
4. Zou P., Hou P., Low M.-Y., Koh H.-L. Structural elucidation of a tadalafil analogue found as an adulterant of a herbal product. Food Addit. Contam. 2006, 23:446-451.
5. Oh S., Zou P., Low M.-Y., Koh H.-L. Detection of sildenafil analogues in herbal products for erectile dysfunction. J. Toxicol. Environ. Health A 2006, 69:1951-1958.
6. Liu S.-Y., Woo S.-O., Koh H.-L. HPLC and GC-MS screening of Chinese proprietary medicines for undeclared therapeutic substances. J. Pharm. Biomed. Anal. 2001, 24:983-992.
7. Kurita H., Mizuno K., Kuromi K., Suzuki N., Ueno C., Kamimura M., Fujiwara A., Owada K., Ogo N., Yamamoto M. Identification of aminotadalafil and its stereoisomers contained in health foods using chiral liquid chromatography-mass spectrometry. J. Health Sci. 2008, 54:310-314.
8. Akkan A.-A., Özdemir Y., Ekiz H.-L. Derivative spectrophotometric determination of 5-(hydroxymethyl)-2-furaldehyde (HMF) and furfural in Locust bean extract. Food 2001, 45:43-46.