Analysis of cross-reactive and specific anti-carbohydrate antibodies against lipopolysaccharide from Chlamydophila psittaci

Glycobiology

Volumn 20, Issue 4, 2009, Pages 461-472

  Gerstenbruch, Sandra ^a   Brooks, Cory L ^b   Kosma, Paul ^c   Brade, Lore ^a   MacKenzie, C Roger ^d   Evans, Stephen V ^b   Brade, Helmut ^a   Müller Loennies, Sven ^a  

^a RESEARCH CENTER BORSTEL   (Germany)

^b UNIVERSITY OF VICTORIA   (Canada)

^c UNIVERSITY OF NATURAL RESOURCES AND LIFE SCIENCES   (Austria)

^d NATIONAL RESEARCH COUNCIL CANADA   (Canada)

Author keywords

Antibody; Carbohydrate; Chlamydia; Kdo; Specificity

Indexed keywords

ANTIBODY; CARBOHYDRATE ANTIBODY; EPITOPE; KDO TRISACCHARIDE; LIPOPOLYSACCHARIDE; PHENYLALANINE; RECOMBINANT ANTIBODY; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; TRISACCHARIDE; TYROSINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY ISOLATION; ANTIBODY SPECIFICITY; ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; CHLAMYDOPHILA PSITTACI; CONTROLLED STUDY; CROSS REACTION; IMMUNOFLUORESCENCE; LIGAND BINDING; MOLECULAR RECOGNITION; MOUSE; NONHUMAN; PHAGE DISPLAY; PRIORITY JOURNAL; SEQUENCE ANALYSIS; STRUCTURE ANALYSIS; X RAY;

ANIMALS; ANTIBODIES; ANTIBODIES, ANTI-IDIOTYPIC; CARBOHYDRATES; CHLAMYDIACEAE; CHLAMYDOPHILA PSITTACI; EPITOPES; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; LIPOPOLYSACCHARIDES; MICE; OLIGOSACCHARIDES; RECOMBINANT PROTEINS; TRISACCHARIDES; X-RAYS;

CHLAMYDIA; CHLAMYDIACEAE; CHLAMYDIAE; CHLAMYDOPHILA PSITTACI; MUS;

EID: 77952317010     PISSN: 09596658     EISSN: 14602423     Source Type: Journal    
DOI: 10.1093/glycob/cwp198     Document Type: Article

References (31)

1. Abhinandan KR, Martin AC. 2008. Analysis and improvements to Kabat and structurally correct numbering of antibody variable domains. Mol Immunol. 45:3832-3839.
2. Anand NN, Mandal S, MacKenzie CR, Sadowska J, Sigurskjold B, Young NM, Bundle DR, Narang SA. 1991. Bacterial expression and secretion of various single-chain Fv genes encoding proteins specific for a Salmonella serotype B O-antigen. J Biol Chem. 266:21874-21879.
3. Barbas CF III, Burton DR, Scott JK, Silverman GJ. 2001. Phage Display: A Laboratory Manual. New York: Cold Spring Harbor Laboratory Press.
4. Brade H. 1999. Chlamydial lipopolysaccharide. In: Brade H, Opal SM, Vogel SN, Morrison DC, editors. Endotoxin in Health and Disease.New York/Basel: Marcel Dekker Inc. p 229-242.
5. Brade L, Holst O, Kosma P, Zhang YX, Paulsen H, Krausse R, Brade H. 1990. Characterization of murine monoclonal and murine, rabbit, and human polyclonal antibodies against chlamydial lipopolysaccharide. Infect Immun. 58:205-213.
6. Brade L, Rozalski A, Kosma P, Brade H. 2000. A monoclonal antibody recognizing the 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) trisaccharide (Kdo(2→4)(Kdo(2→4)(Kdo of Chlamydophila psittaci 6BC lipopolysaccharide. J Endotoxin Res. 6:361-368.
7. Brochet X, Lefranc MP, Giudicelli V. 2008. IMGT/V-QUEST: The highly customized and integrated system for IG and TR standardized V-J and V-D-J sequence analysis. Nucleic Acids Res. 36:W503-W508.
8. Brooks CL, Blackler RJ, Gerstenbruch S, Kosma P, Müller-Loennies S, Brade H, Evans SV. 2008. Pseudo-symmetry and twinning in crystals of homologous antibody Fv fragments. Acta Crystallogr D Biol Crystallogr. 64:1250-1258
9. Brooks CL, Blackler RJ, Sixta G, Kosma P, Müller-Loennies S, Brade L, Hirama T, MacKenzie CR, Brade H, Evans SV. 2009. Forthcoming. The role of CDR H3 in antibody recognition of a synthetic analogue of a lipopolysaccharide antigen. Glycobiology.
10. Brooks CL, Müller-Loennies S, Borisova SN, Brade L, Kosma P, Hirama T, MacKenzie CR, Brade H, Evans SV. 2009. Antibodies raised against chlamydial lipopolysaccharide antigens reveal convergence in germline gene usage and differential epitope recognition. Biochemistry. Advance access published December 15, 2009, doi: 10.1021/bi9011308.
11. Brooks CL, Müller-Loennies S, Brade L, Kosma P, Hirama T, MacKenzie CR, Brade H, Evans SV. 2008b. Exploration of specificity in germline monoclonal antibody recognition of a range of natural and synthetic epitopes. J Mol Biol. 377:450-468.
12. Corsaro D, Valassina M, Venditti D. 2003. Increasing diversity within chlamydiae. Crit Rev Microbiol. 29:37-78.
13. Dean D, Kandel RP, Adhikari HK, Hessel T. 2008. Multiple Chlamydiaceae species in trachoma: Implications for disease pathogenesis and control. PLoS Med. 5:e14.
14. Fu Y, Baumann M, Kosma P, Brade L, Brade H. 1992. A synthetic glycoconjugate representing the genus-specific epitope of chlamydial lipopolysaccharide exhibits the same specificity as its natural counterpart. Infect Immun. 60:1314-1321.
15. Holst O, Broer W, Thomas-Oates JE, Mamat U, Brade H. 1993. Structural analysis of two oligosaccharide bisphosphates isolated from the lipopolysaccharide of a recombinant strain of Escherichia coli F515 (Re chemotype) expressing the genus-specific epitope of Chlamydia lipopolysaccharide. Eur J Biochem. 214:703-710.
16. Kosma P, Hofinger A, Müller-Loennies S, Brade H. 2010. Synthesis of a neoglycoconjugate containing a Chlamydophila psittaci specific branched Kdo trisaccharide epitope. Carbohydr Res. doi:10.1016/j.carres.2009.12.015.
17. Lefranc MP, Giudicelli V, Ginestoux C, Jabado-Michaloud J, Folch G, Bellahcene F, Wu Y, Gemrot E, Brochet X, Lane J, et al. 2009. IMGT, the international ImMunoGeneTics information system. Nucleic Acids Res. 37:D1006-D1012.
18. MacKenzie R, To R. 1998. The role of valency in the selection of anticarbohydrate single-chain Fvs from phage display libraries. J Immunol Methods 220:39-49.
19. Mamat U, Baumann M, Schmidt G, Brade H. 1993. The genus-specific lipopolysaccharide epitope of Chlamydia is assembled in C. psittaci and C. trachomatis by glycosyltransferases of low homology. Mol Microbiol. 10:935-941.
20. Manimala JC, Roach TA, Li Z, Gildersleeve JC. 2007. High-throughput carbohydrate microarray profiling of 27 antibodies demonstrates widespread specificity problems. Glycobiology. 17:17C-23C.
21. Morea V, Tramontano A, Rustici M, Chothia C, Lesk AM. 1998. Conformations of the third hypervariable region in the VH domain of immunoglobulins. J Mol Biol. 275:269-294.
22. Moulder JW. 1991. Interaction of chlamydiae and host cells in vitro. Microbiol Rev. 55:143-190.
23. Müller-Loennies S, Grimmecke D, Brade L, Lindner B, Kosma P, Brade H. 2002. A novel strategy for the synthesis of neoglycoconjugates from deacylated deep rough lipopolysaccharides. J Endotoxin Res. 8:295-305.
24. Müller-Loennies S, Gronow S, Brade L, MacKenzie R, Kosma P, Brade H. 2006. A monoclonal antibody against a carbohydrate epitope in lipopolysaccharide differentiates Chlamydophila psittaci from Chlamydophila pecorum, Chlamydophila pneumoniae,andChlamydia trachomatis. Glycobiology. 16:184-196.
25. Müller-Loennies S, MacKenzie CR, Patenaude SI, Evans SV, Kosma P, Brade H, Brade L, Narang S. 2000. Characterization of high affinity monoclonal antibodies specific for chlamydial lipopolysaccharide. Glycobiology. 10:121-130.
26. Nguyen HP, Seto NO, MacKenzie CR, Brade L, Kosma P, Brade H, Evans SV. 2003. Germline antibody recognition of distinct carbohydrate epitopes. Nat Struct Biol. 10:1019-1025.
27. Rund S, Lindner B, Brade H, Holst O. 1999. Structural analysis of the lipopolysaccharide from Chlamydia trachomatis serotype L2. J Biol Chem. 274:16819-16824.
28. Rund S, Lindner B, Brade H, Holst O. 2000. Structural analysis of the lipopolysaccharide from Chlamydophila psittaci strain 6BC. Eur J Biochem. 267:5717-5726.
29. Schoonbroodt S, Steukers M, Viswanathan M, Frans N, Timmermans M, Wehnert A, Nguyen M, Ladner RC, Hoet RM. 2008. Engineering antibody heavy chain CDR3 to create a phage display Fab library rich in antibodies that bind charged carbohydrates. J Immunol. 181:6213-6221.
30. Shirai H, Kidera A, Nakamura H. 1996. Structural classification of CDR-H3 in antibodies. FEBS Lett. 399:1-8.
31. Shirai H, Kidera A, Nakamura H. 1999. H3-rules: Identification of CDR-H3 structures in antibodies. FEBS Lett. 455:188-197.