Hypovitaminosis D and K are highly prevalent and independent of overall malnutrition in the institutionalized elderly

Asia Pacific Journal of Clinical Nutrition

Volumn 19, Issue 1, 2010, Pages 49-56

  Kuwabara, Akiko ^a   Himeno, Masako ^a   Tsugawa, Naoko ^b   Kamao, Maya ^b   Fujii, Minori ^c   Kawai, Nobuko ^c   Fukuda, Miyuki ^a   Ogawa, Yoko ^a   Kido, Shoko ^a   Okano, Toshio ^b   Tanaka, Kiyoshi ^a  

^a KYOTO WOMEN'S UNIVERSITY   (Japan)

^b KOBE PHARMACEUTICAL UNIVERSITY   (Japan)

^c Nursing Home Kayu Shirakawa ^*  (Japan)

Author keywords

Adequate intake; Hypovitaminosis D; Hypovitaminosis K; Institutionalized elderly; Principal component analysis

Indexed keywords

25 HYDROXYERGOCALCIFEROL; BIOLOGICAL MARKER; CALCIFEDIOL; DRUG DERIVATIVE; FARNOQUINONE; PARATHYROID HORMONE; PHYTOMENADIONE; VITAMIN MK 7;

AGED; ARTICLE; BLOOD; BODY MASS; COMPARATIVE STUDY; DIET; FEMALE; HUMAN; INSTITUTIONALIZATION; JAPAN; MALE; MALNUTRITION; NUTRITIONAL STATUS; PRINCIPAL COMPONENT ANALYSIS; SEXUAL DEVELOPMENT; STATISTICS; VITAMIN D DEFICIENCY; VITAMIN K DEFICIENCY;

25-HYDROXYVITAMIN D 2; AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; BODY MASS INDEX; CALCIFEDIOL; DIET; FEMALE; HUMANS; INSTITUTIONALIZATION; JAPAN; MALE; MALNUTRITION; NUTRITIONAL STATUS; PARATHYROID HORMONE; PRINCIPAL COMPONENT ANALYSIS; SEX CHARACTERISTICS; VITAMIN D DEFICIENCY; VITAMIN K 1; VITAMIN K 2; VITAMIN K DEFICIENCY;

EID: 77952313582     PISSN: 09647058     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. Bilezikian JP, Silverberg SJ. The role of parathyroid hormone and vitamin D in the pathogenesis of osteoporosis. In: Marcus R, Feldman D, Kelsey J, editors. Osteoporosis 2nd ed. San Diego CA: Academic Press; 2001. pp.71-84.
2. Lips P. How to define normal values for serum concentrations of 25-hydroxyvitamin D? An overview. In: Feldman D, Pike JW, Glorieux FG, editors. Vitamin D 2nd ed. San Diego CA: Academic Press; 2005. pp. 1019-28.
3. Bischoff-Ferrari HA, Dawson-Hughes B, Willett WC, Stae-helin HB, Bazemore MG, Zee RY, et al. Effect of Vitamin D on falls: a meta-analysis. JAMA. 2004;291:1999-2006.
4. Kuroda T, Shiraki M, Tanaka S, Ohta H. Contributions of 25-hydroxyvitamin D, co-morbidities and bone mass to mortality in Japanese postmenopausal women. Bone. 2009; 44:168-72.
5. Eastell R, Lawrence Riggs B. Vitamin D and osteoporosis. In: Feldman D, Pike JW, Glorieux FG, editors. Vitamin D 2nd ed. San Diego CA: Academic Press; 2005. pp.1101-20.
6. Nakamura K, Nishiwaki T, Ueno K, Yamamoto M. Agerelated decrease in serum 25-hydroxyvitamin D concentrations in the frail elderly: a longitudinal study. J Bone Miner Metab. 2007;25:232-6.
7. Lips P, van Ginkel FC, Jongen MJ, Rubertus F, van der Vijgh WJ, Netelenbos JC. Determinants of vitamin D status in patients with hip fracture and in elderly control subjects. Am J Clin Nutr. 1987;46:1005-10.
8. Lips P, Wiersinga A, van Ginkel FC, Jongen MJ, Netelen-bos JC, Hackeng WH, et al. The effect of vitamin D supplementation on vitamin D status and parathyroid function in elderly subjects. J Clin Endocrinol Metab. 1988;67:644-50.
9. Suominem M, Laine T, Routasalo P, Pitkala KH, Rasanen L. Nutrient content of served food, nutrient intake and nutritional status of residents with dementia in a finnish nursing home. J Nutr Health Aging. 2004;8:234-8.
10. Przybelski R, Agrawal S, Krueger D, Engelke JA, Walbrun F, Binkley N. Rapid correction of low vitamin D status in nursing home residents. Osteoporos Int. 2008;19:1621-8.
11. Holick MF, Matsuoka LY, Wortsman J. Age, vitamin D, and solar ultraviolet. Lancet. 1989;2:1104-5.
12. Nashimoto M, Nakamura K, Matsuyama S, Hatakeyama M, Yamamoto M. Hypovitaminosis D and hyperparathyroidism in physically inactive elderly Japanese living in nursing homes: relationship with age, sunlight exposure and activities of daily living. Aging Clin Exp Res. 2002;14:5-12.
13. Vermeer C. Gamma-carboxyglutamate-containing proteins and the vitamin K-dependent carboxylase. Biochem J. 1990; 266:625-36.
14. Booth SL. Skeletal functions of vitamin K-dependent proteins: not just for clotting anymore. Nutr Rev. 1997;55:282-4.
15. Booth SL, Tucker KL, Chen H, Hannan MT, Gagnon DR, Cupples LA, et al. Dietary vitamin K intakes are associated with hip fracture but not with bone mineral density in elderly men and women. Am J Clin Nutr. 2000;71:1201-8.
16. Tsugawa N, Shiraki M, Suhara Y, Kamao M, Ozaki R, Ta-naka K, et al. Low plasma phylloquinone concentration is associated with high incidence of vertebral fracture in Japanese women. J Bone Miner Metab. 2008;26:79-85.
17. Booth SL, Broe KE, Peterson JW, Cheng DM, Dawson-Hughes B, Gundberg CM, et al. Associations between vitamin K biochemical measures and bone mineral density in men and women. J Clin Endocrinol Metab. 2004;89:4904-9.
18. Seibel MJ, Robins SP, Bilezikian JP. Serum undercarboxy-lated osteocalcin and the risk of hip fracture. J Clin Endo-crinol Metab. 1997;82:717-8.
19. Vergnaud P, Garnero P, Meunier PJ, Bréart G, Kamihagi K, Delmas PD. Undercarboxylated osteocalcin measured with a specific immunoassay predicts hip fracture in elderly women: the EPIDOS Study. J Clin Endocrinol Metab. 1997; 82:719-24.
20. Sokoll LJ, Sadowski JA. Comparison of biochemical indexes for assessing vitamin K nutritional status in a healthy adult population. Am J Clin Nutr. 1996;63:566-73.
21. Tsugawa N, Shiraki M, Suhara Y, Kamao M, Tanaka K, Okano T. Vitamin K status of healthy Japanese women: age-related vitamin K requirement for gamma-carboxylation of osteocalcin. Am J Clin Nutr. 2006;83:380-6.
22. Sadowski JA, Hood SJ, Dallal GE, Garry PJ. Phylloquinone in plasma from elderly and young adults: factors influencing its concentration. Am J Clin Nutr. 1989;50:100-8.
23. Tse SL, Chan TY, Wu DM, Cheung AY, Kwok TC. Deficient dietary vitamin K intake among elderly nursing home residents in Hong Kong. Asia Pac J Clin Nutr. 2002;11:62-5.
24. Northstone K, Ness AR, Emmett PM, Rogers IS. Adjusting for energy intake in dietary pattern investigations using principal components analysis. Eur J Clin Nutr. 2008;62: 931-8.
25. Kesse-Guyot E, Bertrais S, Péneau S, Estaquio C, Dauchet L, Vergnaud AC, et al. Dietary patterns and their sociode-mographic and behavioural correlates in French middle-aged adults from the SU.VI.MAX cohort. Eur J Clin Nutr. 2009;63:521-9.
26. Suhara Y, Kamao M, Tsugawa N, Okano T. Suhara Y, Kamao M, et al. Method for the determination of vitamin K homologues in human plasma using high-performance liquid chromatography-tandem mass spectrometry. Anal Chem. 2005;77:757-63.
27. Resources Council, Science and Technology Agency, Japan. Standard Tables of Food Composition in Japan, 5th ed. Tokyo: Printing Bureau, Ministry of Finance; 2000. 2009/11/4 [cited 2000/11/22]; Available from: http://www.mext.go.jp/english/news/2000/11/001150.htm#top. (in Japanese).
28. Ministry of Health, Labour, and Welfare, Japan. Dietary reference intakes for Japanese 2010. Tokyo: Daiichi-Shuppan; 2010. 2009/11/4 [cited 2009/5/29]; Available from: http://www-bm.mhlw.go.jp/shingi/2009/05/s0529-4.html. (in Japanese).
29. Ministry of Health, Labour, and Welfare, Japan. Dietary reference intakes for Japanese 2005. Tokyo: Daiichi-Shuppan; 2005. 2009/11/4 [cited 2004/11/22]; Available from: http://www.mhlw.go.jp/houdou/2004/11/h1122-2.html. (in Japanese).
30. Nakamura K, Nashimoto M, Yamamoto M. Summer/winter differences in the serum 25-hydroxyvitamin D3 and parathyroid hormone levels of Japanese women. Int J Biometeorol. 2000;44:186-9.
31. Nakamura K, Nashimoto M, Hori Y, Yamamoto M. Serum 25-hydroxyvitamin D concentrations and related dietary factors in peri- and postmenopausal Japanese women. Am J Clin Nutr. 2000;71:1161-5.
32. Nakamura K, Nashimoto M, Yamamoto M. Are the serum 25-hydroxyvitamin D concentrations in winter associated with forearm bone mineral density in healthy elderly Japanese women? Int J Vit Nutr Res. 2001;71:25-9.
33. Kaneki M, Hodges SJ, Hosoi T, Fujiwara S, Lyons A, Crean SJ, et al. Japanese fermented soybean food as the major determinant of the large geographic difference in circulating levels of vitamin K2: possible implications for hip-fracture risk. Nutrition. 2001;17:315-21.
34. Nakamura K, Tsugawa N, Saito T, Ishikawa M, Tsuchiya Y, Hyodo K, et al. Vitamin D status, bone mass, and bone metabolism in home-dwelling postmenopausal Japanese women: Yokogoshi Study. Bone.2008;42:271-7.
35. Ministry of Health, Labour, and Welfare, Japan. The National Nutrition Survey 2006. Tokyo: Daiichi-Shuppan; 2009. 2009/11/4 [cited 2008/04]; Available from: http://www.mhlw.go.jp/houdou/2008/04/h0430-2.html. (in Japanese).
36. McKeown NM, Jacques PF, Gundberg CM, Peterson JW, Tucker KL, Kiel DP, et al. Dietary and nondietary determinants of vitamin K biochemical measures in men and women. J Nutr. 2002;132:1329-34.
37. Shea MK, Benjamin EJ, Dupuis J, Massaro JM, Jacques PF, D'Agostino RB Sr, et al. Genetic and non-genetic correlates of vitamins K and D. Eur J Clin Nutr. 2009;63:458-64.
38. Ikeda H, Doi Y. A vitamin-K2-binding factor secreted from Bacillus subtilis. Eur J Biochem. 1990;28:219-24.
39. Nakamura K, Nishiwaki T, Ueno K, Yamamoto M. Serum 25-hydroxyvitamin D levels and activities of daily living in noninstitutionalized elderly Japanese requiring care. J Bone Miner Metab. 2005;23:488-94.
40. Kuwabara A, Tanaka K, Tsugawa N, Nakase H, Tsuji H, Shide K, et al. High prevalence of vitamin K and D deficiency and decreased BMD in inflammatory bowel disease. Osteoporos Int. 2009;20:935-42.
41. Cashman KD, Wallace JM, Horigan G, Hill TR, Barnes MS, Lucey AJ, et al. Estimation of the dietary requirement for vitamin D in free-living adults >=64 y of age. Am J Clin Nutr. 2009;89:1366-74.
42. Kuchuk NO, Pluijm SM, van Schoor NM, Looman CW, Smit JH, Lips P. Relationships of serum 25-hydroxyvitamin D to bone mineral density and serum parathyroid hormone and markers of bone turnover in older persons. J Clin Endocrinol Metab.2009;94:1244-50.
43. Visvanathan R. Under-nutrition in older people: a serious and growing global problem!Visvanathan R. J Postgrad Med. 2003;49:352-60.
44. Kagansky N, Berner Y, Koren-Morag N, Perelman L, Kno-bler H, Levy S. Poor nutritional habits are predictors of poor outcome in very old hospitalized patients. Am J Clin Nutr. 2005;82:784-91.
45. Vellas B, Lauque S, Andrieu S, Nourhashemi F, Rolland Y, Baumgartner R, et al. Nutrition assessment in the elderly. Curr Opin Clin Nutr Metab Care. 2001;4:5-8.
46. Bikle DD, Gee E, Halloran B, Kowalski MA, Ryzen E, Haddad JG. Assessment of the free fraction of 25-hydroxyvitamin D in serum and its regulation by albumin and the vitamin D-binding protein. J Clin Endocrinol Metab. 1986;63:954-9.