Vitamin E and evening primrose oil for management of cyclical mastalgia: A randomized pilot study

Alternative Medicine Review

Volumn 15, Issue 1, 2010, Pages 59-67

  Pruthi, Sandhya ^a   Wahner Roedler, Dietlind L ^a   Torkelson, Carolyn J ^b   Cha, Stephen S ^a   Thicke, Lori S ^a   Hazelton, Jennifer H ^a   Bauer, Brent A ^a  

^a MAYO CLINIC   (United States)

^b Department of Family Medicine and Community Health ^*  (United States)

Author keywords

Breast; Essential fatty acids; Evening primrose; GLA; Mastalgia; Menstrual cycle; PMS; Tocopherol; Vitamin E

Indexed keywords

ALPHA TOCOPHEROL; PLACEBO; PRIMROSE OIL;

ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MASTALGIA; MCGILL PAIN QUESTIONNAIRE; MULTICENTER STUDY; PILOT STUDY; RANDOMIZED CONTROLLED TRIAL; TREATMENT DURATION; TREATMENT OUTCOME;

ADULT; ANTIOXIDANTS; BREAST DISEASES; CHI-SQUARE DISTRIBUTION; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; FEMALE; GAMMA-LINOLENIC ACID; HUMANS; LINOLEIC ACIDS; MIDDLE AGED; PAIN; PAIN MEASUREMENT; PILOT PROJECTS; PLACEBOS; PLANT OILS; TREATMENT OUTCOME; VITAMIN E; YOUNG ADULT;

EID: 77952308495     PISSN: 10895159     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Smith RL, Pruthi S, Fitzpatrick LA. Evaluation and management of breast pain. Mayo Clin Proc 2004;79:353-372.
2. Ader DN, Browne MW. Prevalence and impact of cyclic mastalgia in a United States clinic-based sample. Am J Obstet Gynecol 1997;177:126-132.
3. Gateley CA, Maddox PR, Mansel RE, Hughes LE. Mastalgia refractory to drug treatment. Br J Surg 1990;77:1110-1112.
4. Pashby NL, Mansel RE, Hughes LE, et al. A clinical trial of evening primrose oil in mastalgia. Br J Surg 1981;68:801.
5. Ernster VL, Goodson WH 3rd, Hunt TK, et al. Vitamin E and benign breast "disease": a double-blind, randomized clinical trial. Surgery 1985;97:490-494.
6. Mansel RE, Harrison BJ, Melhuish J, et al. A randomized trial of dietary intervention with essential fatty acids in patients with categorized cysts. Ann N Y Acad Sci 1990;586:288-294.
7. Burton GW. Vitamin E: molecular and biological function. Proc Nutr Soc 1994;53:251-262.
8. London RS, Sundaram GS, Murphy L, et al. The effect of vitamin E on mammary dysplasia: a double-blind study. Obstet Gynecol 1985;65:104-106.
9. Horrobin DF. The role of essential fatty acids and prostaglandins in the premenstrual syndrome. J Reprod Med 1983;28:465-468. (Pubitemid 13035054)
10. Gateley CA, Maddox PR, Pritchard GA, et al. Plasma fatty acid profiles in benign breast disorders. Br J Surg 1992;79:407-409.
11. Pruthi S. Randomized clinical trial of vitamin E and evening oil of primrose for the management of cyclical breast pain, http://www.clinicaltrials. gov/ct2/ show/NCT00275600?term=NCT002756 00&rank=1 [Accessed January 27, 2010]
12. Melzack R. The short-form McGill Pain Questionnaire. Pain 1987;30:191-197.
13. Khan SA, Apkarian AV. The characteristics of cyclical and non-cyclical mastalgia: a prospective study using a modified McGill Pain Questionnaire. Breast Cancer Res Treat 2002;75:147-157.
14. Aickin M. Separation tests for earl phase complementary and alternative medicine comparative trials. Evid Based Integr Med 2004;1:225-231.
15. Meyer EC, Sommers DK, Reitz CJ, Mentis H. Vitamin E and benign breast disease. Surgery 1990;107:549-551.
16. Parsay S, Olfati F, Nahidi S. Therapeutic effects of vitamin E on cyclic mastalgia. Breast J 2009;15:510-514.
17. Preece PE, Baum M, Mansel RE, et al. Importance of mastalgia in operable breast cancer. Br Med J (Clin Res Ed) 1982;284:1299-1300. (Pubitemid 12150324)
18. Pye JK, Mansel RE, Hughes LE. Clinical experience of drug treatments for mastalgia. Lancet 1985;2:373-377. (Pubitemid 15012962)
19. McFayden IJ, Forrest AP, Chetty U, Raab G. Cyclical breast pain - some observations and the difficulties in treatment. Br J Clin Pract 1992;46:161-164.
20. Cheung AN, Shen DH, Khoo US, et al. Immunohistochemical and mutational analysis of p53 tumor suppressor gene in gestational trophoblastic disease: correlation with mdm2, proliferation index, and clinicopathologic parameters. Int J Gynecol Cancer 1999;9:123-130.
21. Blommers J, de Lange-De Klerk ES, Kuik DJ, et al. Evening primrose oil and fish oil for severe chronic mastalgia: a randomized, double-blind, controlled trial. Am J Obstet Gynecol 2002;187:1389-1394. (Pubitemid 35397491)
22. Goyal A, Mansel RE, Efamast Study Group. A randomized multicenter study of gamolenic acid (Efamast) with and without antioxidant vitamins and minerals in the management of mastalgia. Breast J 2005;11:41-47. (Pubitemid 40209343)
23. Srivastava A, Mansel RE, Arvind N, et al. Evidence-based management of mastalgia: a meta-analysis of randomised trials. Breast 2007;16:503-512.
24. Miller ER 3rd, Pastor-Barriuso R, Dalal D, et al. Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality. Ann Intern Med 2005;142:37-46. (Pubitemid 40066212)
25. Jiang Q, Christen S, Shigenaga MK, Ames BN. gamma-Tocopherol, the major form of vitamin E in the US diet, deserves more attention. Am J Clin Nutr 2001;74:714-722. (Pubitemid 33101790)